China Largest Manufacturer factory sales N-ACETYL-4-HYDROXY-L-PROLINE CAS 33996-33-7 CAS NO.33996-33-7

                                PRODUCT DETAILS                           

Oxaceprol Basic information Product Name: Oxaceprol Synonyms: TRANS-1-ACETYL-4-HYDROXY-L-PROLINE;N-ACETYLHYDROXY-L-PROLINE;N-ACETYL-L-HYDROXYPROLINE;N-ALPHA-ACETYL-TRANS-4-HYROXY-L-PYROLLIDINE;N-ALPHA-ACETYL-L-4-TRANS-HYDROXYPROLINE;N-ALPHA-ACETYL-L-HYROXYPROLINE;(-)-1-Acetyl-4β-hydroxy-L-proline;(4R)-1-Acetyl-4-hydroxy-L-proline CAS: 33996-33-7 MF: C7H11NO4 MW: 173.17 EINECS: 251-780-6 Product Categories: Hydroxyproline [Hyp];PYRROLE;API intermediates;Amino Acids;Peptide Synthesis;Proline Derivatives;Unnatural Amino Acid Derivatives Mol File: 33996-33-7.mol   Oxaceprol Chemical Properties Melting point  132-133 °C (dec.)(lit.) alpha  -119 º (c=4 in H2O) Boiling point  303.8°C (rough estimate) density  1.3346 (rough estimate) refractive index  1.4490 (estimate) storage temp.  Sealed in dry,2-8°C pka 3.48±0.40(Predicted) form  Crystalline Powder color  White optical activity [α]20/D 119°, c = 4 in H2O Merck  14,6903 BRN  84043 InChIKey BAPRUDZDYCKSOQ-RITPCOANSA-N CAS DataBase Reference 33996-33-7(CAS DataBase Reference) EPA Substance Registry System L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7)   Safety Information Hazard Codes  Xi Risk Statements  41 Safety Statements  26-36 WGK Germany  3 F  10 TSCA  Yes HS Code  29339900 MSDS Information Provider Language Oxaceprol English SigmaAldrich English ALFA English   Oxaceprol Usage And Synthesis Chemical Properties White powder Originator Jonctum,Merrell,France,1970 Uses trans-1-Acetyl-4-hydroxy-L-proline can be used: In the stereospecific synthesis of 4-fluoroglutamic acid. To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase. As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline). Manufacturing Process 16.7 g (0.127 mol) of L-hydroxyproline are dissolved in 400 ml of pure boiling acetic acid. With vigorous boiling and agitation, a mixture of 13.7 ml (0.154 mol) of rectified acetic anhydride and 250 ml of pure acetic acid is added during 25 minutes. Without discontinuing the stirring, contents of the flask are cooled by simply causing fresh air to circulate externally round the flask until the temperature of the mixture is reduced to about 35°C. The acetic acid is removed by using a rotary evaporator without exceeding 35°C under a vacuum of about 15 mm Hg. After one hour, 20 ml of anhydrous toluene are added, then 10 ml of anhydrous acetone; the mixture is homogenized and concentrated again as above during 30 minutes. Then 25 ml of acetone are added again, and subsequently 20 ml of toluene, the product being concentrated again; gradually the solution is converted into an amber-colored crystallized paste. Finally, 30 ml of acetone are added to the residue, and stirring is carried out until the oily fraction surrounding the crystals is dissolved. The product is then cooled in an ice chamber, centrifuged, washed with anhydrous acetone and eventually dried, After recrystallization from acetone, crystals are obtained, melting point 132°C. Therapeutic Function Antirheumatic   Oxaceprol Preparation Products And Raw materials Raw materials L-Hydroxyproline-->Acetic anhydride

                                                                       Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Our Factories production lines

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                                                       Product information

Oxaceprol Basic information Product Name: Oxaceprol Synonyms: TRANS-1-ACETYL-4-HYDROXY-L-PROLINE;N-ACETYLHYDROXY-L-PROLINE;N-ACETYL-L-HYDROXYPROLINE;N-ALPHA-ACETYL-TRANS-4-HYROXY-L-PYROLLIDINE;N-ALPHA-ACETYL-L-4-TRANS-HYDROXYPROLINE;N-ALPHA-ACETYL-L-HYROXYPROLINE;(-)-1-Acetyl-4β-hydroxy-L-proline;(4R)-1-Acetyl-4-hydroxy-L-proline CAS: 33996-33-7 MF: C7H11NO4 MW: 173.17 EINECS: 251-780-6 Product Categories: Hydroxyproline [Hyp];PYRROLE;API intermediates;Amino Acids;Peptide Synthesis;Proline Derivatives;Unnatural Amino Acid Derivatives Mol File: 33996-33-7.mol   Oxaceprol Chemical Properties Melting point  132-133 °C (dec.)(lit.) alpha  -119 º (c=4 in H2O) Boiling point  303.8°C (rough estimate) density  1.3346 (rough estimate) refractive index  1.4490 (estimate) storage temp.  Sealed in dry,2-8°C pka 3.48±0.40(Predicted) form  Crystalline Powder color  White optical activity [α]20/D 119°, c = 4 in H2O Merck  14,6903 BRN  84043 InChIKey BAPRUDZDYCKSOQ-RITPCOANSA-N CAS DataBase Reference 33996-33-7(CAS DataBase Reference) EPA Substance Registry System L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7)   Safety Information Hazard Codes  Xi Risk Statements  41 Safety Statements  26-36 WGK Germany  3 F  10 TSCA  Yes HS Code  29339900 MSDS Information Provider Language Oxaceprol English SigmaAldrich English ALFA English   Oxaceprol Usage And Synthesis Chemical Properties White powder Originator Jonctum,Merrell,France,1970 Uses trans-1-Acetyl-4-hydroxy-L-proline can be used: In the stereospecific synthesis of 4-fluoroglutamic acid. To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase. As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline). Manufacturing Process 16.7 g (0.127 mol) of L-hydroxyproline are dissolved in 400 ml of pure boiling acetic acid. With vigorous boiling and agitation, a mixture of 13.7 ml (0.154 mol) of rectified acetic anhydride and 250 ml of pure acetic acid is added during 25 minutes. Without discontinuing the stirring, contents of the flask are cooled by simply causing fresh air to circulate externally round the flask until the temperature of the mixture is reduced to about 35°C. The acetic acid is removed by using a rotary evaporator without exceeding 35°C under a vacuum of about 15 mm Hg. After one hour, 20 ml of anhydrous toluene are added, then 10 ml of anhydrous acetone; the mixture is homogenized and concentrated again as above during 30 minutes. Then 25 ml of acetone are added again, and subsequently 20 ml of toluene, the product being concentrated again; gradually the solution is converted into an amber-colored crystallized paste. Finally, 30 ml of acetone are added to the residue, and stirring is carried out until the oily fraction surrounding the crystals is dissolved. The product is then cooled in an ice chamber, centrifuged, washed with anhydrous acetone and eventually dried, After recrystallization from acetone, crystals are obtained, melting point 132°C. Therapeutic Function Antirheumatic   Oxaceprol Preparation Products And Raw materials Raw materials L-Hydroxyproline-->Acetic anhydride