China Largest Manufacturer factory Supply Formononetin CAS 485-72-3 CAS NO.485-72-3

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Formononetin Basic information Product Name: Formononetin Synonyms: Formononetin (50 mg);red clover extract_formononetin;Flavosil;ForMonentin;Myconate;NSC 93360;ForMononetin (ForMononetol);ForMoononetin CAS: 485-72-3 MF: C16H12O4 MW: 268.26 EINECS: 207-623-9 Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Iso-Flavones;The group of Astralosides;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors Mol File: 485-72-3.mol   Formononetin Chemical Properties Melting point  256-260 °C Boiling point  331.43°C (rough estimate) density  1.1529 (rough estimate) refractive index  1.4350 (estimate) storage temp.  2-8°C solubility  Soluble in DMSO (up to 100 mg/ml). pka 6.99±0.20(Predicted) form  Powder color  White to light beige λmax 300nm(EtOH)(lit.) Merck  14,4244 BRN  237979 Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. InChIKey HKQYGTCOTHHOMP-UHFFFAOYSA-N CAS DataBase Reference 485-72-3(CAS DataBase Reference) EPA Substance Registry System 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  37/39-26-36 WGK Germany  3 RTECS  DJ3100114 HS Code  29329990 MSDS Information Provider Language 7-Hydroxy-3-(4-methoxyphenyl)chromone English ACROS English   Formononetin Usage And Synthesis Description Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1 Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2 Accelerates wound repair by increasing expression of Egr-1 transcription factor.3 Potential cancer chemopreventive and chemotherapeutic.4 Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5 Chemical Properties off-white powder Uses An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen. Uses Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen. Uses phytoestrogen Uses Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity. General Description Formononetin belongs to the isoflavones class of polyphenols. Biochem/physiol Actions Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa. References 1) Nie et al. (2018), The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol., 175 1439 2) Gautam et al. (2017), Formononetin, an isoflavone, activates AMO-activated protein kinase/ β-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit., 117 645 3) Huh et al. (2011), Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol., 11 46 4) Ong et al. (2019), Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel), 11 E611 5) Li et al. (2018), Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother., 106 349   Formononetin Preparation Products And Raw materials Raw materials 3-(4-methoxyphenyl)-7-phenylmethoxychromen-4-one-->1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone-->2-Bromo-4'-methoxyacetophenone

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Formononetin Basic information Product Name: Formononetin Synonyms: Formononetin (50 mg);red clover extract_formononetin;Flavosil;ForMonentin;Myconate;NSC 93360;ForMononetin (ForMononetol);ForMoononetin CAS: 485-72-3 MF: C16H12O4 MW: 268.26 EINECS: 207-623-9 Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Iso-Flavones;The group of Astralosides;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors Mol File: 485-72-3.mol   Formononetin Chemical Properties Melting point  256-260 °C Boiling point  331.43°C (rough estimate) density  1.1529 (rough estimate) refractive index  1.4350 (estimate) storage temp.  2-8°C solubility  Soluble in DMSO (up to 100 mg/ml). pka 6.99±0.20(Predicted) form  Powder color  White to light beige λmax 300nm(EtOH)(lit.) Merck  14,4244 BRN  237979 Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. InChIKey HKQYGTCOTHHOMP-UHFFFAOYSA-N CAS DataBase Reference 485-72-3(CAS DataBase Reference) EPA Substance Registry System 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  37/39-26-36 WGK Germany  3 RTECS  DJ3100114 HS Code  29329990 MSDS Information Provider Language 7-Hydroxy-3-(4-methoxyphenyl)chromone English ACROS English   Formononetin Usage And Synthesis Description Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1 Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2 Accelerates wound repair by increasing expression of Egr-1 transcription factor.3 Potential cancer chemopreventive and chemotherapeutic.4 Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5 Chemical Properties off-white powder Uses An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen. Uses Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen. Uses phytoestrogen Uses Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity. General Description Formononetin belongs to the isoflavones class of polyphenols. Biochem/physiol Actions Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa. References 1) Nie et al. (2018), The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol., 175 1439 2) Gautam et al. (2017), Formononetin, an isoflavone, activates AMO-activated protein kinase/ β-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit., 117 645 3) Huh et al. (2011), Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol., 11 46 4) Ong et al. (2019), Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel), 11 E611 5) Li et al. (2018), Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother., 106 349   Formononetin Preparation Products And Raw materials Raw materials 3-(4-methoxyphenyl)-7-phenylmethoxychromen-4-one-->1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone-->2-Bromo-4'-methoxyacetophenone