China Original Largest Manufacturer factory sales mercaptopurine CAS 50-44-2 CAS NO.50-44-2

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6-Mercaptopurine Basic information Product Name: 6-Mercaptopurine Synonyms: THIOPURINE;mercaptopurine，6-MP;mercaptopurin;mercapurin;merkaptopuryna;mern;nci-c04886;nsc755 CAS: 50-44-2 MF: C5H4N4S MW: 152.18 EINECS: 200-037-4 Product Categories: Purines;Bases & Related Reagents;Pharmaceutical Raw Materials;Nucleotides;Sulfur & Selenium Compounds;Pyrimidine purine;6-MP Mol File: 50-44-2.mol   6-Mercaptopurine Chemical Properties Melting point  241-244°C Boiling point  498.6±37.0 °C(Predicted) density  1.463 (estimate) refractive index  1.5605 (estimate) storage temp.  Inert atmosphere,2-8°C pka 7.77, 11.17(at 25℃) form  solid Water Solubility  124mg/L(25 ºC) CAS DataBase Reference 50-44-2(CAS DataBase Reference) IARC 3 (Vol. 26, Sup 7) 1987 EPA Substance Registry System Mercaptopurine (50-44-2)   Safety Information RIDADR  3249 HazardClass  6.1(b) PackingGroup  III Hazardous Substances Data 50-44-2(Hazardous Substances Data) Toxicity LD50 oral in rat: 277mg/kg MSDS Information   6-Mercaptopurine Usage And Synthesis Chemical Properties Yellowish-Greenish Solid Originator Purinethol,Sandoz,France,1950 Uses antineoplastic, immonusupressant;inhibits purine nucleotide synthesis and metabolism Uses Has a cytotoxicity effect Definition A sulfurcontaining purine base not found in animal nucleoproteins. Manufacturing Process 7.5 g of 4-amino-6-chloro-5-nitropyrimidine was suspended in 200 ml of 1 N potassium hydrosulfide and heated on the steam bath for 2 hours while passing hydrogen sulfide through the reaction mixture. The reaction mixture was allowed to cool slowly, acidified with 10 N sulfuric acid and chilled. The precipitate consisted of 4,5-diamino-6-mercaptopyrimidine and sulfur. It was boiled with 300 ml of water, filtered hot and then chilled. The product precipitated as pale yellow needles (4.2 g); an additional 0.95 g was obtained by concentration of the mother liquors to 100 ml. A mixture of 2 g of 4,5-diamino-6-mercaptopyrimidine and 10 ml of 98% formic acid was heated at 70°C for two hours and then evaporated to dryness on the steam bath to give as a residue, 7-amino-thiazolo (5,4-d) pyrimidine. To 820 mg of 7-amino-thiazolo[5,4-d]pyrimidine was added 2.5 cc of 2 N sodium hydroxide. The water was removed under reduced pressure. The sodium salt was then heated at 240°C for one hour, during which time it melted, gave off water and resolidified. The sodium salt of 6-mercaptopurine was dissolved in 15 ml of water and acidified to pH 5 with acetic acid. Yellow crystals of 6-mercaptopurine hydrate precipitated, according to US Patent 2,933,498. Brand name Purinethol (Teva). Therapeutic Function Cancer chemotherapy Hazard Questionable carcinogen. Safety Profile Poison by ingestion, intraperitoneal, subcutaneous, parenteral, and intravenous routes. Human systemic effects by ingestion: dermatitis. Experimental teratogenic and reproductive effects. Questionable human carcinogen producing Hodgkin's disease and leukemia. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also MERCAPTANS. Veterinary Drugs and Treatments Veterinary uses of mercaptopurine include adjunctive therapy of lymphosarcoma, acute leukemias, and severe rheumatoid arthritis. It may have potential benefit in treating other autoimmune conditions (e.g., unresponsive ulcerative colitis) as well.   6-Mercaptopurine Preparation Products And Raw materials Raw materials Ethanol-->Government regulation-->Ethyl cyanoacetate-->Sodium ethoxide-->Sodium dithionite-->Phosphorus pentasulfide-->6-Hydroxypurine-->6-Aminothiouracil-->2,6-Dihydroxypurine-->Tetrabromobisphenol A-->4,5-Diamino-6-hydroxypyrimidine-->Sodium hydroxide-->Formic acid-->6-CHLORO-5-NITROPYRIMIDIN-4-AMINE-->Hydrogen Sulfide Preparation Products Azathioprine-->Purine

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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6-Mercaptopurine Basic information Product Name: 6-Mercaptopurine Synonyms: THIOPURINE;mercaptopurine，6-MP;mercaptopurin;mercapurin;merkaptopuryna;mern;nci-c04886;nsc755 CAS: 50-44-2 MF: C5H4N4S MW: 152.18 EINECS: 200-037-4 Product Categories: Purines;Bases & Related Reagents;Pharmaceutical Raw Materials;Nucleotides;Sulfur & Selenium Compounds;Pyrimidine purine;6-MP Mol File: 50-44-2.mol   6-Mercaptopurine Chemical Properties Melting point  241-244°C Boiling point  498.6±37.0 °C(Predicted) density  1.463 (estimate) refractive index  1.5605 (estimate) storage temp.  Inert atmosphere,2-8°C pka 7.77, 11.17(at 25℃) form  solid Water Solubility  124mg/L(25 ºC) CAS DataBase Reference 50-44-2(CAS DataBase Reference) IARC 3 (Vol. 26, Sup 7) 1987 EPA Substance Registry System Mercaptopurine (50-44-2)   Safety Information RIDADR  3249 HazardClass  6.1(b) PackingGroup  III Hazardous Substances Data 50-44-2(Hazardous Substances Data) Toxicity LD50 oral in rat: 277mg/kg MSDS Information   6-Mercaptopurine Usage And Synthesis Chemical Properties Yellowish-Greenish Solid Originator Purinethol,Sandoz,France,1950 Uses antineoplastic, immonusupressant;inhibits purine nucleotide synthesis and metabolism Uses Has a cytotoxicity effect Definition A sulfurcontaining purine base not found in animal nucleoproteins. Manufacturing Process 7.5 g of 4-amino-6-chloro-5-nitropyrimidine was suspended in 200 ml of 1 N potassium hydrosulfide and heated on the steam bath for 2 hours while passing hydrogen sulfide through the reaction mixture. The reaction mixture was allowed to cool slowly, acidified with 10 N sulfuric acid and chilled. The precipitate consisted of 4,5-diamino-6-mercaptopyrimidine and sulfur. It was boiled with 300 ml of water, filtered hot and then chilled. The product precipitated as pale yellow needles (4.2 g); an additional 0.95 g was obtained by concentration of the mother liquors to 100 ml. A mixture of 2 g of 4,5-diamino-6-mercaptopyrimidine and 10 ml of 98% formic acid was heated at 70°C for two hours and then evaporated to dryness on the steam bath to give as a residue, 7-amino-thiazolo (5,4-d) pyrimidine. To 820 mg of 7-amino-thiazolo[5,4-d]pyrimidine was added 2.5 cc of 2 N sodium hydroxide. The water was removed under reduced pressure. The sodium salt was then heated at 240°C for one hour, during which time it melted, gave off water and resolidified. The sodium salt of 6-mercaptopurine was dissolved in 15 ml of water and acidified to pH 5 with acetic acid. Yellow crystals of 6-mercaptopurine hydrate precipitated, according to US Patent 2,933,498. Brand name Purinethol (Teva). Therapeutic Function Cancer chemotherapy Hazard Questionable carcinogen. Safety Profile Poison by ingestion, intraperitoneal, subcutaneous, parenteral, and intravenous routes. Human systemic effects by ingestion: dermatitis. Experimental teratogenic and reproductive effects. Questionable human carcinogen producing Hodgkin's disease and leukemia. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also MERCAPTANS. Veterinary Drugs and Treatments Veterinary uses of mercaptopurine include adjunctive therapy of lymphosarcoma, acute leukemias, and severe rheumatoid arthritis. It may have potential benefit in treating other autoimmune conditions (e.g., unresponsive ulcerative colitis) as well.   6-Mercaptopurine Preparation Products And Raw materials Raw materials Ethanol-->Government regulation-->Ethyl cyanoacetate-->Sodium ethoxide-->Sodium dithionite-->Phosphorus pentasulfide-->6-Hydroxypurine-->6-Aminothiouracil-->2,6-Dihydroxypurine-->Tetrabromobisphenol A-->4,5-Diamino-6-hydroxypyrimidine-->Sodium hydroxide-->Formic acid-->6-CHLORO-5-NITROPYRIMIDIN-4-AMINE-->Hydrogen Sulfide Preparation Products Azathioprine-->Purine