China Biggest Factory manufacturer supply Indole-3-Carbinol CAS NO.700-06-1

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Indole-3-carbinol Basic information Product Name: Indole-3-carbinol Synonyms: Indole-3-carbinol,99.5%;Indole-3-carbinol 98%;(1H-Indol-3-yl)-methano;Indol-3-yl-methanol;3-INDOLAMETHANOL;INDOLE-3-CARBINOL:3-INDOLE METHANOL;INDOLE-3-CARBINOL(RG);3-HYDROXYMETHYLINDOLE(INDOLE-3-CARBINOL) CAS: 700-06-1 MF: C9H9NO MW: 147.17 EINECS: 211-836-2 Product Categories: Heterocycle-Indole series;Antioxidant;Biochemistry;Simple Indoles;Nutritional Supplements;Aromatics;Indoles and derivatives;IndoleDerivative;Pyrroles & Indoles;Indole;Indoles;Heterocycles;Inhibitors;Pyrroles & Indoles;blocks;IndolesOxindoles;indole derivative;Halogenated Heterocycles ,Others;pharmaceutical raw material Mol File: 700-06-1.mol   Indole-3-carbinol Chemical Properties Melting point  96-99 °C (lit.) Boiling point  267.28°C (rough estimate) density  1.1135 (rough estimate) refractive index  1.5670 (estimate) storage temp.  2-8°C pka 15.10±0.10(Predicted) form  Crystalline Powder or Flakes color  Off-white to yellow-orange BRN  121323 Stability: 2-80C InChIKey IVYPNXXAYMYVSP-UHFFFAOYSA-N CAS DataBase Reference 700-06-1(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/38 Safety Statements  26-36 WGK Germany  3 RTECS  NL9483000 Hazard Note  Irritant HS Code  29339900 MSDS Information Provider Language SigmaAldrich English ACROS English ALFA English   Indole-3-carbinol Usage And Synthesis Chemical Properties Off-White Powder Uses Inhibits cancinogenesis at the initiation stage. A metabolite of 3-methylindole Uses antineoplastic; inhibitor of Amyloid-beta deposition Uses nutritional supplement Uses Indole-3-carbinol has been used for encapsulation with poly-lactic-co-glycolic acid (PLGA), to study its in-vitro anti-cancerogenic effects on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. It has also been used as a cytochrome P4501A (CYP1A) inducer. Definition ChEBI: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity. Synthesis Reference(s) Canadian Journal of Chemistry, 31, p. 775, 1953 DOI: 10.1139/v53-106 The Journal of Organic Chemistry, 61, p. 1493, 1996 DOI: 10.1021/jo951219c General Description Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts. Biochem/physiol Actions Inhibits cancinogenesis at the initiation stage. Has be shown to inhibit carcinogenesis in several animal species, but it enhances tumor incidence if administered at a post-initiation stage. Found in cruciferous vegetables. Anticancer Research I3C is a bioactive compound majorly found in Brassica vegetables including broccoli,cauliflower, and collard greens. I3C and its derivative diindolylmethane (DIM)have been investigated for cancer prevention and treatment of breast, prostate, andovarian cancers. I3C partially modulates the tyrosine kinase/PI3K/Akt signalingpathway which leads to the prevention of lung adenocarcinoma which is induced byusing tobacco carcinogen in A/J mice. DIM transduces signaling via aryl hydrocarbon(Ah) receptor, NF-κB/Wnt/Akt/mTOR signaling pathways, cell cycle arrest,modulated cytochrome P450 enzymes, and altered angiogenetic and invasive,metastatic, and epigenetic behavior of cancer cells. Combination of DIM and I3Cinduces Nrf2-mediated phase II drug metabolizing genes (GSTm2, UGT1A1, andNQO1) and antioxidant genes (HO-1, SOD-1) (Weng et al. 2008; 2012).   Indole-3-carbinol Preparation Products And Raw materials Raw materials 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE-->Dimethylamine-->Gramine-->Indole-3-carboxaldehyde

                                Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

Indole-3-carbinol Basic information Product Name: Indole-3-carbinol Synonyms: Indole-3-carbinol,99.5%;Indole-3-carbinol 98%;(1H-Indol-3-yl)-methano;Indol-3-yl-methanol;3-INDOLAMETHANOL;INDOLE-3-CARBINOL:3-INDOLE METHANOL;INDOLE-3-CARBINOL(RG);3-HYDROXYMETHYLINDOLE(INDOLE-3-CARBINOL) CAS: 700-06-1 MF: C9H9NO MW: 147.17 EINECS: 211-836-2 Product Categories: Heterocycle-Indole series;Antioxidant;Biochemistry;Simple Indoles;Nutritional Supplements;Aromatics;Indoles and derivatives;IndoleDerivative;Pyrroles & Indoles;Indole;Indoles;Heterocycles;Inhibitors;Pyrroles & Indoles;blocks;IndolesOxindoles;indole derivative;Halogenated Heterocycles ,Others;pharmaceutical raw material Mol File: 700-06-1.mol   Indole-3-carbinol Chemical Properties Melting point  96-99 °C (lit.) Boiling point  267.28°C (rough estimate) density  1.1135 (rough estimate) refractive index  1.5670 (estimate) storage temp.  2-8°C pka 15.10±0.10(Predicted) form  Crystalline Powder or Flakes color  Off-white to yellow-orange BRN  121323 Stability: 2-80C InChIKey IVYPNXXAYMYVSP-UHFFFAOYSA-N CAS DataBase Reference 700-06-1(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/38 Safety Statements  26-36 WGK Germany  3 RTECS  NL9483000 Hazard Note  Irritant HS Code  29339900 MSDS Information Provider Language SigmaAldrich English ACROS English ALFA English   Indole-3-carbinol Usage And Synthesis Chemical Properties Off-White Powder Uses Inhibits cancinogenesis at the initiation stage. A metabolite of 3-methylindole Uses antineoplastic; inhibitor of Amyloid-beta deposition Uses nutritional supplement Uses Indole-3-carbinol has been used for encapsulation with poly-lactic-co-glycolic acid (PLGA), to study its in-vitro anti-cancerogenic effects on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. It has also been used as a cytochrome P4501A (CYP1A) inducer. Definition ChEBI: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity. Synthesis Reference(s) Canadian Journal of Chemistry, 31, p. 775, 1953 DOI: 10.1139/v53-106 The Journal of Organic Chemistry, 61, p. 1493, 1996 DOI: 10.1021/jo951219c General Description Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts. Biochem/physiol Actions Inhibits cancinogenesis at the initiation stage. Has be shown to inhibit carcinogenesis in several animal species, but it enhances tumor incidence if administered at a post-initiation stage. Found in cruciferous vegetables. Anticancer Research I3C is a bioactive compound majorly found in Brassica vegetables including broccoli,cauliflower, and collard greens. I3C and its derivative diindolylmethane (DIM)have been investigated for cancer prevention and treatment of breast, prostate, andovarian cancers. I3C partially modulates the tyrosine kinase/PI3K/Akt signalingpathway which leads to the prevention of lung adenocarcinoma which is induced byusing tobacco carcinogen in A/J mice. DIM transduces signaling via aryl hydrocarbon(Ah) receptor, NF-κB/Wnt/Akt/mTOR signaling pathways, cell cycle arrest,modulated cytochrome P450 enzymes, and altered angiogenetic and invasive,metastatic, and epigenetic behavior of cancer cells. Combination of DIM and I3Cinduces Nrf2-mediated phase II drug metabolizing genes (GSTm2, UGT1A1, andNQO1) and antioxidant genes (HO-1, SOD-1) (Weng et al. 2008; 2012).   Indole-3-carbinol Preparation Products And Raw materials Raw materials 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE-->Dimethylamine-->Gramine-->Indole-3-carboxaldehyde