China Biggest Factory Manufacturer Supply Diatrizoate Sodium CAS 737-31-5 CAS NO.737-31-5

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Diatrizoate sodium Basic information Description References Product Name: Diatrizoate sodium CAS: 737-31-5 MF: C11H8I3N2NaO4 MW: 635.9 EINECS: 212-004-1 Product Categories: Organics Mol File: 737-31-5.mol   Diatrizoate sodium Chemical Properties Melting point  261-262° (dec) storage temp.  Keep in dark place,Inert atmosphere,Room temperature solubility  H2O: 0.35 g/mL, slightly turbid, colorless form  White Powder BRN  4082984 InChIKey ZEYOIOAKZLALAP-UHFFFAOYSA-M CAS DataBase Reference 737-31-5(CAS DataBase Reference) EPA Substance Registry System Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt (737-31-5)   Safety Information Hazard Codes  Xn Risk Statements  42/43 Safety Statements  36 WGK Germany  3 RTECS  DG6125000 F  8-10 HS Code  29242100 Hazardous Substances Data 737-31-5(Hazardous Substances Data) Toxicity LD50 i.v. in rats: 14.7 g/kg (Langecker) MSDS Information Provider Language SigmaAldrich English   Diatrizoate sodium Usage And Synthesis Description Diatrizoate sodium is a contrast agent used during the X-rays test. It can be used as a diagnostic aid agent during angiography, urography and radiography. It can be applied during visualizing veins, the urinary system, gastrointestinal tract, spleen and joints as well as during the computer tomography (CT scan). It is used in cases where barium is not suitable for application such as patient being allergic to barium. The mechanism of action of Diatrizoate sodium is that it can block the X-rays so that the body structure containing iodine to be delineated in contrast to those structures that free of iodine, further allowing the visualization of those related areas. References # # Chemical Properties A white or almost white powder Originator Hypaque Sodium,Winthrop,US,1955 Uses Diagnostic aid (radiopaque medium). Definition ChEBI: The sodium salt of a benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, often as a mixture with the meglumine salt, as an X-ray contrast medium in gastrointestinal studies, ngiography, and urography. Manufacturing Process 3,5-Dinitrobenzoic acid (15.9 g) was dissolved in an equivalent amount of sodium hydroxide solution, and the solution was diluted to 310 ml with water. The solution was refluxed with Raney nickel for fifteen minutes, filtered, and the filtrate was hydrogenated at elevated pressure using platinum oxide catalyst. After the amount of hydrogen calculated to reduce both nitro groups had been absorbed, the mixture was filtered, and the filtrate was acidified with an equal volume of concentrated hydrochloric acid. Iodine monochloride (17 ml) in 100 ml of 6N HCl was then added with stirring. The reaction mixture was allowed to stand for two and one-half hours at room temperature, then diluted with an equal amount of water with vigorous stirring, and the solid material was collected by filtration and recrystallized from dilute methanol, giving 18.5 g of 3,5-diamino-2,4,6-triiodobenzoic acid, MP about 135°C with decomposition. The 18.5 g of 3,5-diamino-2,4,6- triiodobenzoic acid was suspended in 150 ml of acetic anhydride containing 5 drops of 70% perchloric acid, and the mixture was heated on a steam bath for three and one-half hours. The reaction mixture was poured into 300 ml of ice water, and then heated on a steam bath until crystallization took place. The solid material was collected by filtration, dissolvedin dilute sodium hydroxide solution, filtered, and hydrochloric acid was added to the filtrate to reprecipitate the acid product. The latter was again dissolved in sodium hydroxide and reprecipitated with acid, giving 9 g of 3,5-diacetamido-2,4,6- triiodobenzoic acid, MP above 250°C. The acid may be used as the sodium salt or as the meglumate. Brand name Md (Mallinckrodt); Urovist Sodium (Berlex). Therapeutic Function Diagnostic aid (radiopaque medium)   Diatrizoate sodium Preparation Products And Raw materials Raw materials Iodine monochloride-->Sodium hydroxide-->Hydrogen-->2-Chloro-3,5-dinitrobenzoic acid-->DIATRIZOIC ACID

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Diatrizoate sodium Basic information Description References Product Name: Diatrizoate sodium CAS: 737-31-5 MF: C11H8I3N2NaO4 MW: 635.9 EINECS: 212-004-1 Product Categories: Organics Mol File: 737-31-5.mol   Diatrizoate sodium Chemical Properties Melting point  261-262° (dec) storage temp.  Keep in dark place,Inert atmosphere,Room temperature solubility  H2O: 0.35 g/mL, slightly turbid, colorless form  White Powder BRN  4082984 InChIKey ZEYOIOAKZLALAP-UHFFFAOYSA-M CAS DataBase Reference 737-31-5(CAS DataBase Reference) EPA Substance Registry System Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt (737-31-5)   Safety Information Hazard Codes  Xn Risk Statements  42/43 Safety Statements  36 WGK Germany  3 RTECS  DG6125000 F  8-10 HS Code  29242100 Hazardous Substances Data 737-31-5(Hazardous Substances Data) Toxicity LD50 i.v. in rats: 14.7 g/kg (Langecker) MSDS Information Provider Language SigmaAldrich English   Diatrizoate sodium Usage And Synthesis Description Diatrizoate sodium is a contrast agent used during the X-rays test. It can be used as a diagnostic aid agent during angiography, urography and radiography. It can be applied during visualizing veins, the urinary system, gastrointestinal tract, spleen and joints as well as during the computer tomography (CT scan). It is used in cases where barium is not suitable for application such as patient being allergic to barium. The mechanism of action of Diatrizoate sodium is that it can block the X-rays so that the body structure containing iodine to be delineated in contrast to those structures that free of iodine, further allowing the visualization of those related areas. References # # Chemical Properties A white or almost white powder Originator Hypaque Sodium,Winthrop,US,1955 Uses Diagnostic aid (radiopaque medium). Definition ChEBI: The sodium salt of a benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, often as a mixture with the meglumine salt, as an X-ray contrast medium in gastrointestinal studies, ngiography, and urography. Manufacturing Process 3,5-Dinitrobenzoic acid (15.9 g) was dissolved in an equivalent amount of sodium hydroxide solution, and the solution was diluted to 310 ml with water. The solution was refluxed with Raney nickel for fifteen minutes, filtered, and the filtrate was hydrogenated at elevated pressure using platinum oxide catalyst. After the amount of hydrogen calculated to reduce both nitro groups had been absorbed, the mixture was filtered, and the filtrate was acidified with an equal volume of concentrated hydrochloric acid. Iodine monochloride (17 ml) in 100 ml of 6N HCl was then added with stirring. The reaction mixture was allowed to stand for two and one-half hours at room temperature, then diluted with an equal amount of water with vigorous stirring, and the solid material was collected by filtration and recrystallized from dilute methanol, giving 18.5 g of 3,5-diamino-2,4,6-triiodobenzoic acid, MP about 135°C with decomposition. The 18.5 g of 3,5-diamino-2,4,6- triiodobenzoic acid was suspended in 150 ml of acetic anhydride containing 5 drops of 70% perchloric acid, and the mixture was heated on a steam bath for three and one-half hours. The reaction mixture was poured into 300 ml of ice water, and then heated on a steam bath until crystallization took place. The solid material was collected by filtration, dissolvedin dilute sodium hydroxide solution, filtered, and hydrochloric acid was added to the filtrate to reprecipitate the acid product. The latter was again dissolved in sodium hydroxide and reprecipitated with acid, giving 9 g of 3,5-diacetamido-2,4,6- triiodobenzoic acid, MP above 250°C. The acid may be used as the sodium salt or as the meglumate. Brand name Md (Mallinckrodt); Urovist Sodium (Berlex). Therapeutic Function Diagnostic aid (radiopaque medium)   Diatrizoate sodium Preparation Products And Raw materials Raw materials Iodine monochloride-->Sodium hydroxide-->Hydrogen-->2-Chloro-3,5-dinitrobenzoic acid-->DIATRIZOIC ACID