China Largest Manufacturer factory Supply 6-Methylcoumarin CAS 92-48-8 CAS NO.92-48-8

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6-Methylcoumarin Basic information Product Name: 6-Methylcoumarin Synonyms: 6-MC;6-Methyl-1,2-benzopyrone;6-methyl-2h-1-benzopyran-2-on;6-methyl-2H-1-Benzopyran-2-one;6-Methyl-2-oxo-2H-benzopyran;6-Methyl-2-oxochronene;6-Methyl-chromen-2-one;6-methyl-coumari CAS: 92-48-8 MF: C10H8O2 MW: 160.17 EINECS: 202-158-8 Product Categories: Building Blocks;Heterocyclic Building Blocks;Alphabetical Listings;Flavors and Fragrances;M-N;Building Blocks;Pharmaceutical Raw Materials;Coumarins;Miscellaneous;Chemical Synthesis;Heterocyclic Building Blocks Mol File: 92-48-8.mol   6-Methylcoumarin Chemical Properties Melting point  73-76 °C (lit.) Boiling point  303 °C/725 mmHg (lit.) density  1.0924 (rough estimate) refractive index  1.5300 (estimate) FEMA  2699 | 6-METHYLCOUMARIN Fp  303°C/725mm storage temp.  Sealed in dry,Room Temperature JECFA Number 1172 BRN  4222 CAS DataBase Reference 92-48-8(CAS DataBase Reference) NIST Chemistry Reference 2H-1-Benzopyran-2-one, 6-methyl-(92-48-8) EPA Substance Registry System 6-Methylcoumarin (92-48-8)   Safety Information Hazard Codes  Xn Risk Statements  22-42/43 Safety Statements  22-36/37-45 WGK Germany  3 RTECS  GN7792000 TSCA  Yes HS Code  29321900 Hazardous Substances Data 92-48-8(Hazardous Substances Data) toxicity The acute oral LD50 value in rats was reported to be 1.68 g/kg (1.43-1.93 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits exceeded 5 g/kg (Moreno, 1973). MSDS Information Provider Language 6-Methyl-2H-chromen-2-one English ACROS English SigmaAldrich English ALFA English   6-Methylcoumarin Usage And Synthesis Chemical Properties 6-methylcoumarin is a white to almost white crystalline powder with has a somewhat coconut-like odor. the odor is also characterized as having a delicate fig or date sweetness. it has an almost bitter taste above 50 ppm, turning sweet and vanilla-like at lower levels. soluble in benzene, hot ethanol and non-volatile oil, insoluble in hot water. Occurrence Has apparently not been reported to occur in nature Uses 6-Methylcoumarin is a synthetic fragrance in cosmetics, toiletries and soaps. It mainly used to prepare flavors such as coconut, vanilla and caramel. Preparation 6-methylcoumarin is synthesized from p-cresol and fumaric acid. Preheat 72% sulfuric acid to 80 °C, add a mixture of fumaric acid and p-cresol, keep the reaction at 160-170 °C for 3-4 hours, cool, pour into crushed ice to precipitate a precipitate, and filter. The filtrate was extracted with benzene, and after adding benzene, the obtained crude product was subjected to vacuum distillation to obtain 6-methylcoumarin. synthesis of 6-methylcoumarin: By heating 6-methyl coumarin-3-carboxylic acid to 300 to 340°C; by condensation of p-cresol-disulfonic acid with fumaric acid in the presence of H2SO4; by condensation of p-homosalicyclic aldehyde with malonic acid in the presence of aniline, followed by heating for the lactone; from salicylaldehyde with propionic acid anhydride and sodium propionate. Definition ChEBI: 6-methylcoumarin is a member of the class of coumarins that is coumarin in which the hydrogen at position 6 is replaced by a methyl group. It has a role as a fragrance and an allergen. Aroma threshold values Aroma characteristics at 1.0%: sweet vanilla cake, creamy, coconut, coumarin-like and powdery, with herbaceous hay and tonka-like nuances. Taste threshold values Taste characteristics at 5 ppm: coconut, sweet vanilla, dairy creamy, hay-like with anisic and coumarin nuances. Synthesis Reference(s) Tetrahedron, 62, p. 6918, 2006 DOI: 10.1016/j.tet.2006.04.080 General Description 6-methylcoumarin appears as white crystals with a flavor of vanilla. Insoluble in water. (NTP, 1992) Air & Water Reactions Insoluble in water. Reactivity Profile Ketones, such as 6-Methylcoumarin, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. Fire Hazard 6-Methylcoumarin is combustible. Biochem/physiol Actions Taste at 5 ppm Safety Profile Poison by subcutaneous route. Moderately toxic by ingestion. A skin irritant. Mutation data reported. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.   6-Methylcoumarin Preparation Products And Raw materials Raw materials Sulfurous Acid-->Salicylaldehyde-->Fumaric acid-->Propionic anhydride-->Sodium propionate-->Coumarin-3-carboxylic acid-->Phenol, 2-ethenyl-4-methyl--->ethyl (E)-3-(2-hydroxy-5-methylphenyl)acrylate-->MONOTHIOLPHENYL MALONATE-->3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products 3,4-dihydro-6-methyl-2H-1-benzopyran-2-one

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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6-Methylcoumarin Basic information Product Name: 6-Methylcoumarin Synonyms: 6-MC;6-Methyl-1,2-benzopyrone;6-methyl-2h-1-benzopyran-2-on;6-methyl-2H-1-Benzopyran-2-one;6-Methyl-2-oxo-2H-benzopyran;6-Methyl-2-oxochronene;6-Methyl-chromen-2-one;6-methyl-coumari CAS: 92-48-8 MF: C10H8O2 MW: 160.17 EINECS: 202-158-8 Product Categories: Building Blocks;Heterocyclic Building Blocks;Alphabetical Listings;Flavors and Fragrances;M-N;Building Blocks;Pharmaceutical Raw Materials;Coumarins;Miscellaneous;Chemical Synthesis;Heterocyclic Building Blocks Mol File: 92-48-8.mol   6-Methylcoumarin Chemical Properties Melting point  73-76 °C (lit.) Boiling point  303 °C/725 mmHg (lit.) density  1.0924 (rough estimate) refractive index  1.5300 (estimate) FEMA  2699 | 6-METHYLCOUMARIN Fp  303°C/725mm storage temp.  Sealed in dry,Room Temperature JECFA Number 1172 BRN  4222 CAS DataBase Reference 92-48-8(CAS DataBase Reference) NIST Chemistry Reference 2H-1-Benzopyran-2-one, 6-methyl-(92-48-8) EPA Substance Registry System 6-Methylcoumarin (92-48-8)   Safety Information Hazard Codes  Xn Risk Statements  22-42/43 Safety Statements  22-36/37-45 WGK Germany  3 RTECS  GN7792000 TSCA  Yes HS Code  29321900 Hazardous Substances Data 92-48-8(Hazardous Substances Data) toxicity The acute oral LD50 value in rats was reported to be 1.68 g/kg (1.43-1.93 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits exceeded 5 g/kg (Moreno, 1973). MSDS Information Provider Language 6-Methyl-2H-chromen-2-one English ACROS English SigmaAldrich English ALFA English   6-Methylcoumarin Usage And Synthesis Chemical Properties 6-methylcoumarin is a white to almost white crystalline powder with has a somewhat coconut-like odor. the odor is also characterized as having a delicate fig or date sweetness. it has an almost bitter taste above 50 ppm, turning sweet and vanilla-like at lower levels. soluble in benzene, hot ethanol and non-volatile oil, insoluble in hot water. Occurrence Has apparently not been reported to occur in nature Uses 6-Methylcoumarin is a synthetic fragrance in cosmetics, toiletries and soaps. It mainly used to prepare flavors such as coconut, vanilla and caramel. Preparation 6-methylcoumarin is synthesized from p-cresol and fumaric acid. Preheat 72% sulfuric acid to 80 °C, add a mixture of fumaric acid and p-cresol, keep the reaction at 160-170 °C for 3-4 hours, cool, pour into crushed ice to precipitate a precipitate, and filter. The filtrate was extracted with benzene, and after adding benzene, the obtained crude product was subjected to vacuum distillation to obtain 6-methylcoumarin. synthesis of 6-methylcoumarin: By heating 6-methyl coumarin-3-carboxylic acid to 300 to 340°C; by condensation of p-cresol-disulfonic acid with fumaric acid in the presence of H2SO4; by condensation of p-homosalicyclic aldehyde with malonic acid in the presence of aniline, followed by heating for the lactone; from salicylaldehyde with propionic acid anhydride and sodium propionate. Definition ChEBI: 6-methylcoumarin is a member of the class of coumarins that is coumarin in which the hydrogen at position 6 is replaced by a methyl group. It has a role as a fragrance and an allergen. Aroma threshold values Aroma characteristics at 1.0%: sweet vanilla cake, creamy, coconut, coumarin-like and powdery, with herbaceous hay and tonka-like nuances. Taste threshold values Taste characteristics at 5 ppm: coconut, sweet vanilla, dairy creamy, hay-like with anisic and coumarin nuances. Synthesis Reference(s) Tetrahedron, 62, p. 6918, 2006 DOI: 10.1016/j.tet.2006.04.080 General Description 6-methylcoumarin appears as white crystals with a flavor of vanilla. Insoluble in water. (NTP, 1992) Air & Water Reactions Insoluble in water. Reactivity Profile Ketones, such as 6-Methylcoumarin, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. Fire Hazard 6-Methylcoumarin is combustible. Biochem/physiol Actions Taste at 5 ppm Safety Profile Poison by subcutaneous route. Moderately toxic by ingestion. A skin irritant. Mutation data reported. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.   6-Methylcoumarin Preparation Products And Raw materials Raw materials Sulfurous Acid-->Salicylaldehyde-->Fumaric acid-->Propionic anhydride-->Sodium propionate-->Coumarin-3-carboxylic acid-->Phenol, 2-ethenyl-4-methyl--->ethyl (E)-3-(2-hydroxy-5-methylphenyl)acrylate-->MONOTHIOLPHENYL MALONATE-->3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products 3,4-dihydro-6-methyl-2H-1-benzopyran-2-one