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Home > Products >  China Biggest Factory & Manufacturer supply Madecassic Acid 50MT/Year

China Biggest Factory & Manufacturer supply Madecassic Acid 50MT/Year CAS NO.18449-41-7

  • FOB Price: USD: 1.00-2.00 /Kilogram Get Latest Price
  • Min.Order: 50 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,Other
  • Available Specifications:

    AAAAA(50-100)KilogramAAAAA(100-500)Kilogram

  • Product Details

Keywords

  • Madecassic Acid
  • Madecassic Acid
  • 18449-41-7

Quick Details

  • ProName: China Biggest Factory & Manufacturer s...
  • CasNo: 18449-41-7
  • Molecular Formula: 464-92-6
  • Appearance: white powder
  • Application: chemicals industry
  • DeliveryTime: 3-5 days
  • PackAge: 25KG/Drum
  • Port: Shanghai Guangzhou Qingdao Shenzhen
  • ProductionCapacity: 20 Metric Ton/Month
  • Purity: 99%
  • Storage: 2-8°C
  • Transportation: By air /Sea/ coruier
  • LimitNum: 50 Kilogram
  • Plant of Origin: QS
  • Testing Method: HPLC
  • Product Ecification: 99%
  • Heavy Metal: 10PPM
  • Voluntary Standards: QS
  • Color: white
  • Melting point: ≥350°C
  • Boiling point: 363.24°C (rough estimate)
  • density: 1.667
  • solubility: 1 M NaOH: 10 mg/mL, dark green
  • Water Solubility: <0.1 g/100 mL at 21 oC
  • Stability: Stable. Combustible. Incompatible with...

Superiority

Madecassic acid Basic information
Product Name: Madecassic acid
Synonyms: (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxy-urs-12-en-28-oic acid;MADECASSIC ACID;Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2.alpha.,3.beta.,4.alpha.,6.beta.)-;(1S,2R,4aS,6aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bR)-8,10,11-trihydroxy -9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,1 1,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid;Hydroxy asiaticoside;MADECASSIC ACID(P);6BETA-HYDROXYASIATIC ACID;2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid
CAS: 18449-41-7
MF: C30H48O6
MW: 504.71
EINECS:  
Product Categories: Inhibitors;Cofactor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;Miscellaneous Natural Products;The group of Asiaticoside;standardized herbal extract
Mol File: 18449-41-7.mol
Madecassic acid Structure
 
Madecassic acid Chemical Properties
Melting point  270°C (dec.)
Boiling point  641.7±55.0 °C(Predicted)
density  1.23±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO (Sparingly), Methanol (Slightly, Heated)
pka 4.63±0.70(Predicted)
 
Safety Information
Hazard Codes  Xi
Safety Statements  24/25
HS Code  29389090
MSDS Information
 
Madecassic acid Usage And Synthesis
Description Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 μg/ml. Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104). It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.
Chemical Properties White powder
Uses wound healing
Uses Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.
Uses Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.
Definition ChEBI: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).
 
Madecassic acid Preparation Products And Raw materials

 

Details

Madecassic acid Basic information
Product Name: Madecassic acid
Synonyms: (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxy-urs-12-en-28-oic acid;MADECASSIC ACID;Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2.alpha.,3.beta.,4.alpha.,6.beta.)-;(1S,2R,4aS,6aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bR)-8,10,11-trihydroxy -9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,1 1,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid;Hydroxy asiaticoside;MADECASSIC ACID(P);6BETA-HYDROXYASIATIC ACID;2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid
CAS: 18449-41-7
MF: C30H48O6
MW: 504.71
EINECS:  
Product Categories: Inhibitors;Cofactor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;Miscellaneous Natural Products;The group of Asiaticoside;standardized herbal extract
Mol File: 18449-41-7.mol
Madecassic acid Structure
 
Madecassic acid Chemical Properties
Melting point  270°C (dec.)
Boiling point  641.7±55.0 °C(Predicted)
density  1.23±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO (Sparingly), Methanol (Slightly, Heated)
pka 4.63±0.70(Predicted)
 
Safety Information
Hazard Codes  Xi
Safety Statements  24/25
HS Code  29389090
MSDS Information
 
Madecassic acid Usage And Synthesis
Description Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 μg/ml. Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104). It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.
Chemical Properties White powder
Uses wound healing
Uses Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.
Uses Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.
Definition ChEBI: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).
 
Madecassic acid Preparation Products And Raw materials

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