China Largest Manufacturer factory Supply FCC/USP/EP/BP Calcium Gluconate CAS 299-28-5 CAS NO.299-28-5

              PRODUCT DETAILS       

1. Chemical Name: Calcium Gluconate
2. Molecular Formula: C₁₂H ₂₂CaO₁₄ Anhydrous   C₁₂H₂₂CaO₁₄·H₂O Monohydrate
3. Structural Formula:
4. Molecular Weight: 430.38 Anhydrous    448.39 Monohydrate
5. CAS No.: 18016-24-5  299-28-5 Monohydrate
6. Specification: USP/FCC/BP grade
7. Characters: Occurs as white, crystalline granules or powder. It is anhydrous or contains one molecule of water of hydration. It is stable in air. One gram dissolves slowly in about 30 mL of water at 25 0 and in about 5 mL of boiling water. It is in soluble in alcohol and in many other organic solvents. Its solutions are neutral to litmus.
8. Application: Nutrient, Firming agent, Stabilizer, Texturizer
The product is an effective and non-toxic calcium supply nutrition. It's nutrient and helpful to the bone formation and maintenance of normal excitability of nerve and muscle, to be used in Calcium supplement for Calcium deficiency of children, pregnant women, nursing mothers and the aged. Calcium nutrition enhancer: used in grain products and beverages.
9. Package: Fiber drum or all paper drum or kraft paper bag, 25Kg net each
10. Storage: Stored in well-closed containers in a dry place at room temperature
11. Transportation: Handle with care in order to avoid damaging the package, protect them from sunshine or rain.

Calcium gluconate Basic information Description References Product Name: Calcium gluconate Synonyms: CALCIUM D-GLUCONATE;CALCIUM GLUCONATE;GLUCONIC ACID CALCIUM SALT;GLUCONIC ACID HEMICALCIUM SALT;D-GLUCONIC ACID CALCIUM SALT;D-GLUCONIC ACID HEMICALCIUM SALT;2,3,4,5,6-PENTAHYDROXYCAPROIC ACID HEMICALCIUM SALT;calcicol CAS: 299-28-5 MF: C12H22CaO14 MW: 430.37 EINECS: 206-075-8 Product Categories: Food & Flavor Additives;Biochemistry;Ca (Calcium) Compounds;Classes of Metal Compounds;Glucose;Sugar Acids;Sugars;Typical Metal Compounds;ANTIFEBRIN;stabilizer Mol File: 299-28-5.mol   Calcium gluconate Chemical Properties Melting point  195°C alpha  10.2 º (c=1, H2O 22 ºC) storage temp.  Inert atmosphere,Room Temperature solubility  Sparingly soluble in water, freely soluble in boiling water. form  Crystals or Crystalline Powder color  White PH pH;6.0～8.0 Water Solubility  3.3 g/100mL Hydrolytic Sensitivity 0: forms stable aqueous solutions Merck  14,1669 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey KYUVBRZSDFBLTH-OSQBQZLYSA-M CAS DataBase Reference 299-28-5(CAS DataBase Reference) EPA Substance Registry System D-Gluconic acid, calcium salt (2:1) (299-28-5)   Safety Information Hazard Codes  Xn Risk Statements  20/21/22-36/37/38 Safety Statements  24/25-36-26 WGK Germany  1 RTECS  EW2100000 TSCA  No HS Code  29181600 Hazardous Substances Data 299-28-5(Hazardous Substances Data) MSDS Information Provider Language Calciofon English SigmaAldrich English ACROS English ALFA English   Calcium gluconate Usage And Synthesis Description Calcium gluconate is the calcium salt of gluconate, being an oxidative product of glucose containing 9.3% calcium. Calcium gluconate is a kind of mineral supplement and medication. It can be used for vein injection to treat the low blood calcium, high blood potassium, and magnesium toxicity. It is required only when there is not enough calcium in the diet. It is also used for the treatment of black widow spider bites to relieve muscle cramping and treatment of osteoporosis or rickets. It can also be used to decrease the capillary permeability in allergic conditions, nonthrombocytopenic purpura and exudative dermatoses. References # # Chemical Properties white crystalline powder or granules Uses analgesic, antipyretic Uses Calcium Gluconate is used as an inert ingredient in pesticide formulations applied to crops. It is also used as a supplement to fortify beverages and foods lacking a sufficient amount of calcium. Uses In sewage purification; in coffee powders to prevent caking. Uses Calcium Gluconate is a white crystalline granule or powder that functions as a firming agent, formulation aid, sequestrant, and sta- bilizer. at room temperature the anhydrous form has a solubility of approximately 1 g in 30 ml of water, which improves in boiling water to approximately 1 g in 5 ml of water. it also exists as calcium gluconate (monohydrate). it is used as a source of calcium ions for sodium alginate gels, and as a calcium fortifier in baked goods, pud- dings, and dairy product analogs. it functions as a coagulation aid in milk and instant pudding powders and as a means of masking the bitter aftertaste of some artificial sweeteners. Brand name Calglucon (Novartis). Industrial uses calcium gluconate [Ca(C6H11O7)2] is used as a food additive in vitamin pills.injection of a 10% calcium gluconate has been recommended. It has to be kept in mind that the plasma Ca2+ level and any changes to the electrocardiogram (ECG) have to be carefully monitored. Clinical Use Hypocalcaemia Safety Profile Moderately toxic by subcutaneous, intraperitoneal, and intravenous routes. Human systemic effects in infants by intramuscular route: dermatitis and fever. When heated to decomposition it emits acrid smoke and fumes. See also CALCIUM COMPOUNDS. Veterinary Drugs and Treatments Calcium salts are used for the prevention or treatment of hypocalcemic conditions. Drug interactions Potentially hazardous interactions with other drugs Can impair absorption of some drugs, e.g. iron, ciprofloxacin. Metabolism Calcium is absorbed mainly from the small intestine by active transport and passive diffusion. About one-third of ingested calcium is absorbed although this can vary depending upon dietary factors and the state of the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vitamin D, enhances the active phase of absorption. Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, together with that secreted in the bile and pancreatic juice. Minor amounts are lost in the sweat, skin, hair, and nails. Purification Methods Dissolve it in H2O, filter and precipitate it by adding MeOH. Filter off the solid and dry it in a vacuum at 85o. Alternatively, dissolve it in H2O, filter (from insoluble inorganic Ca) and evaporate it to dryness under vacuum at 85o. [March et al. J Am Pharm Assoc 41 366 1952, Beilstein 3 IV 1255.]   Calcium gluconate Preparation Products And Raw materials Raw materials Calcium carbonate-->D(+)-Glucose-->Potassium Phosphate Monobasic-->Ammonium phosphate dibasic-->AMBERLITE(R) IRC-50-->Agar-->Potassium benzylpenicillin-->CATION STANDARD - SODIUM-->Sodium gluconate-->Glucose oxidase Preparation Products D-(+)-Glucono-1,5-lactone-->COPPER (II) GLUCONATE, MIN. 98-->2,2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride-->FERROUS GLUCONATE DIHYDRATE-->beta-D-(-)-Arabinose-->Sodium gluconate-->1-deoxy-1-(6-phenylazo-3,4-xylidino)-D-ribitol-->Zinc gluconate-->Erythorbic Acid-->Copper(II) gluconate-->Sodium Stibogluconate-->D(-)-Arabinose

                                                                         About US 

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

                                                                       Group profiles

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse 

                                                       Product information

1. Chemical Name: Calcium Gluconate
2. Molecular Formula: C₁₂H ₂₂CaO₁₄ Anhydrous   C₁₂H₂₂CaO₁₄·H₂O Monohydrate
3. Structural Formula:
4. Molecular Weight: 430.38 Anhydrous    448.39 Monohydrate
5. CAS No.: 18016-24-5  299-28-5 Monohydrate
6. Specification: USP/FCC/BP grade
7. Characters: Occurs as white, crystalline granules or powder. It is anhydrous or contains one molecule of water of hydration. It is stable in air. One gram dissolves slowly in about 30 mL of water at 25 0 and in about 5 mL of boiling water. It is in soluble in alcohol and in many other organic solvents. Its solutions are neutral to litmus.
8. Application: Nutrient, Firming agent, Stabilizer, Texturizer
The product is an effective and non-toxic calcium supply nutrition. It's nutrient and helpful to the bone formation and maintenance of normal excitability of nerve and muscle, to be used in Calcium supplement for Calcium deficiency of children, pregnant women, nursing mothers and the aged. Calcium nutrition enhancer: used in grain products and beverages.
9. Package: Fiber drum or all paper drum or kraft paper bag, 25Kg net each
10. Storage: Stored in well-closed containers in a dry place at room temperature
11. Transportation: Handle with care in order to avoid damaging the package, protect them from sunshine or rain.

Calcium gluconate Basic information Description References Product Name: Calcium gluconate Synonyms: CALCIUM D-GLUCONATE;CALCIUM GLUCONATE;GLUCONIC ACID CALCIUM SALT;GLUCONIC ACID HEMICALCIUM SALT;D-GLUCONIC ACID CALCIUM SALT;D-GLUCONIC ACID HEMICALCIUM SALT;2,3,4,5,6-PENTAHYDROXYCAPROIC ACID HEMICALCIUM SALT;calcicol CAS: 299-28-5 MF: C12H22CaO14 MW: 430.37 EINECS: 206-075-8 Product Categories: Food & Flavor Additives;Biochemistry;Ca (Calcium) Compounds;Classes of Metal Compounds;Glucose;Sugar Acids;Sugars;Typical Metal Compounds;ANTIFEBRIN;stabilizer Mol File: 299-28-5.mol   Calcium gluconate Chemical Properties Melting point  195°C alpha  10.2 º (c=1, H2O 22 ºC) storage temp.  Inert atmosphere,Room Temperature solubility  Sparingly soluble in water, freely soluble in boiling water. form  Crystals or Crystalline Powder color  White PH pH;6.0～8.0 Water Solubility  3.3 g/100mL Hydrolytic Sensitivity 0: forms stable aqueous solutions Merck  14,1669 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey KYUVBRZSDFBLTH-OSQBQZLYSA-M CAS DataBase Reference 299-28-5(CAS DataBase Reference) EPA Substance Registry System D-Gluconic acid, calcium salt (2:1) (299-28-5)   Safety Information Hazard Codes  Xn Risk Statements  20/21/22-36/37/38 Safety Statements  24/25-36-26 WGK Germany  1 RTECS  EW2100000 TSCA  No HS Code  29181600 Hazardous Substances Data 299-28-5(Hazardous Substances Data) MSDS Information Provider Language Calciofon English SigmaAldrich English ACROS English ALFA English   Calcium gluconate Usage And Synthesis Description Calcium gluconate is the calcium salt of gluconate, being an oxidative product of glucose containing 9.3% calcium. Calcium gluconate is a kind of mineral supplement and medication. It can be used for vein injection to treat the low blood calcium, high blood potassium, and magnesium toxicity. It is required only when there is not enough calcium in the diet. It is also used for the treatment of black widow spider bites to relieve muscle cramping and treatment of osteoporosis or rickets. It can also be used to decrease the capillary permeability in allergic conditions, nonthrombocytopenic purpura and exudative dermatoses. References # # Chemical Properties white crystalline powder or granules Uses analgesic, antipyretic Uses Calcium Gluconate is used as an inert ingredient in pesticide formulations applied to crops. It is also used as a supplement to fortify beverages and foods lacking a sufficient amount of calcium. Uses In sewage purification; in coffee powders to prevent caking. Uses Calcium Gluconate is a white crystalline granule or powder that functions as a firming agent, formulation aid, sequestrant, and sta- bilizer. at room temperature the anhydrous form has a solubility of approximately 1 g in 30 ml of water, which improves in boiling water to approximately 1 g in 5 ml of water. it also exists as calcium gluconate (monohydrate). it is used as a source of calcium ions for sodium alginate gels, and as a calcium fortifier in baked goods, pud- dings, and dairy product analogs. it functions as a coagulation aid in milk and instant pudding powders and as a means of masking the bitter aftertaste of some artificial sweeteners. Brand name Calglucon (Novartis). Industrial uses calcium gluconate [Ca(C6H11O7)2] is used as a food additive in vitamin pills.injection of a 10% calcium gluconate has been recommended. It has to be kept in mind that the plasma Ca2+ level and any changes to the electrocardiogram (ECG) have to be carefully monitored. Clinical Use Hypocalcaemia Safety Profile Moderately toxic by subcutaneous, intraperitoneal, and intravenous routes. Human systemic effects in infants by intramuscular route: dermatitis and fever. When heated to decomposition it emits acrid smoke and fumes. See also CALCIUM COMPOUNDS. Veterinary Drugs and Treatments Calcium salts are used for the prevention or treatment of hypocalcemic conditions. Drug interactions Potentially hazardous interactions with other drugs Can impair absorption of some drugs, e.g. iron, ciprofloxacin. Metabolism Calcium is absorbed mainly from the small intestine by active transport and passive diffusion. About one-third of ingested calcium is absorbed although this can vary depending upon dietary factors and the state of the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vitamin D, enhances the active phase of absorption. Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, together with that secreted in the bile and pancreatic juice. Minor amounts are lost in the sweat, skin, hair, and nails. Purification Methods Dissolve it in H2O, filter and precipitate it by adding MeOH. Filter off the solid and dry it in a vacuum at 85o. Alternatively, dissolve it in H2O, filter (from insoluble inorganic Ca) and evaporate it to dryness under vacuum at 85o. [March et al. J Am Pharm Assoc 41 366 1952, Beilstein 3 IV 1255.]   Calcium gluconate Preparation Products And Raw materials Raw materials Calcium carbonate-->D(+)-Glucose-->Potassium Phosphate Monobasic-->Ammonium phosphate dibasic-->AMBERLITE(R) IRC-50-->Agar-->Potassium benzylpenicillin-->CATION STANDARD - SODIUM-->Sodium gluconate-->Glucose oxidase Preparation Products D-(+)-Glucono-1,5-lactone-->COPPER (II) GLUCONATE, MIN. 98-->2,2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride-->FERROUS GLUCONATE DIHYDRATE-->beta-D-(-)-Arabinose-->Sodium gluconate-->1-deoxy-1-(6-phenylazo-3,4-xylidino)-D-ribitol-->Zinc gluconate-->Erythorbic Acid-->Copper(II) gluconate-->Sodium Stibogluconate-->D(-)-Arabinose