China Biggest Factory manufacturer supply Ethyl Ferulate CAS NO.4046-02-0

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Ethyl 4'-hydroxy-3'-methoxycinnamate Basic information Product Name: Ethyl 4'-hydroxy-3'-methoxycinnamate Synonyms: ETHYL 4-HYDROXY-3-METHOXYCINNAMATE;Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate;ETHYL TRANS-3-(4'-HYDROXY-3'-METHOXYPHENYL)ACRYLATE;ETHYL FERULATE;FERULIC ACID ETHYL ESTER;BUTTPARK 121\04-55;4-HYDROXY-3-METHOXYCINNAMIC ACID ETHYL ESTER;RARECHEM AL BI 0735 CAS: 4046-02-0 MF: C12H14O4 MW: 222.24 EINECS: 223-745-5 Product Categories: Building Blocks;C12 to C63;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;Aromatic Esters;Cinnamic acid;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors Mol File: 4046-02-0.mol   Ethyl 4'-hydroxy-3'-methoxycinnamate Chemical Properties Melting point  63-65 °C(lit.) Boiling point  164-166 °C0.5 mm Hg(lit.) density  1.0643 (rough estimate) refractive index  1.4560 (estimate) storage temp.  Sealed in dry,Room Temperature solubility  Chloroform (Slightly), Ethyl Acetate (Slightly) form  Solid pka 8.88±0.18(Predicted) color  White to Off-White Sensitive  Light Sensitive BRN  2696807 Stability: Hygroscopic, Light Sensitive InChIKey ATJVZXXHKSYELS-FNORWQNLSA-N CAS DataBase Reference 4046-02-0(CAS DataBase Reference) NIST Chemistry Reference ethyl ferulate(4046-02-0)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-37/39-36 WGK Germany  3 Hazard Note  Irritant HS Code  29189900 MSDS Information Provider Language SigmaAldrich English ALFA English   Ethyl 4'-hydroxy-3'-methoxycinnamate Usage And Synthesis Description Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide. Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70. Uses Ferulic acid ethyl ester is an ethyl ester derivative of Ferulic acid (F308900), which is used as an antioxidant and food preservative.   Ethyl 4'-hydroxy-3'-methoxycinnamate Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Ethyl 4'-hydroxy-3'-methoxycinnamate Basic information Product Name: Ethyl 4'-hydroxy-3'-methoxycinnamate Synonyms: ETHYL 4-HYDROXY-3-METHOXYCINNAMATE;Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate;ETHYL TRANS-3-(4'-HYDROXY-3'-METHOXYPHENYL)ACRYLATE;ETHYL FERULATE;FERULIC ACID ETHYL ESTER;BUTTPARK 121\04-55;4-HYDROXY-3-METHOXYCINNAMIC ACID ETHYL ESTER;RARECHEM AL BI 0735 CAS: 4046-02-0 MF: C12H14O4 MW: 222.24 EINECS: 223-745-5 Product Categories: Building Blocks;C12 to C63;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;Aromatic Esters;Cinnamic acid;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors Mol File: 4046-02-0.mol   Ethyl 4'-hydroxy-3'-methoxycinnamate Chemical Properties Melting point  63-65 °C(lit.) Boiling point  164-166 °C0.5 mm Hg(lit.) density  1.0643 (rough estimate) refractive index  1.4560 (estimate) storage temp.  Sealed in dry,Room Temperature solubility  Chloroform (Slightly), Ethyl Acetate (Slightly) form  Solid pka 8.88±0.18(Predicted) color  White to Off-White Sensitive  Light Sensitive BRN  2696807 Stability: Hygroscopic, Light Sensitive InChIKey ATJVZXXHKSYELS-FNORWQNLSA-N CAS DataBase Reference 4046-02-0(CAS DataBase Reference) NIST Chemistry Reference ethyl ferulate(4046-02-0)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-37/39-36 WGK Germany  3 Hazard Note  Irritant HS Code  29189900 MSDS Information Provider Language SigmaAldrich English ALFA English   Ethyl 4'-hydroxy-3'-methoxycinnamate Usage And Synthesis Description Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide. Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70. Uses Ferulic acid ethyl ester is an ethyl ester derivative of Ferulic acid (F308900), which is used as an antioxidant and food preservative.   Ethyl 4'-hydroxy-3'-methoxycinnamate Preparation Products And Raw materials