China Biggest Factory & Manufacturer supply High quality Lactobionic Acid CAS NO.96-82-2

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Lactobionic acid Basic information Description Properties Preparation Extraction and Purification Physiological & Commercial Applications Product Name: Lactobionic acid Synonyms: 4-O-BETA-D-GALACTOPYRANOSYL-D-GLUCONIC ACID;LACTOBIONIC ACID;4-O-β-D-Galactopyranosyl-D-gluconic acid;LACTOBIONIC ACID FREE ACID;LACTOBIONIC ACID 97%;4-[β-D-Galactosido]-D-gluconic acid;Lactobionic Acid (mixture of Acid form and Lactone form);D-Gluconic acid, 4-O-.beta.-D-galactopyranosyl- CAS: 96-82-2 MF: C12H22O12 MW: 358.3 EINECS: 202-538-3 Product Categories: Biochemistry;Disaccharides;Sugar Acids;Sugars Mol File: 96-82-2.mol   Lactobionic acid Chemical Properties Melting point  113-118 °C(lit.) alpha  22.8 º (c=10, H2O) Boiling point  410.75°C (rough estimate) density  1.4662 (rough estimate) refractive index  26 ° (C=8.8, H2O) storage temp.  Inert atmosphere,Room Temperature solubility  10 g/100 mL pka 3.28±0.35(Predicted) form  Powder color  White to Off-white optical activity [α]20/D +25°, c = 10 in H2O Water Solubility  10 g/100 mL Merck  5342 BRN  95054 CAS DataBase Reference 96-82-2(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  24/25-36-26 WGK Germany  1 HS Code  29400000 MSDS Information Provider Language Lactobionic acid English ACROS English SigmaAldrich English   Lactobionic acid Usage And Synthesis Description Lactobionic acid (C12H22O12) is a disaccharide obtained from the oxidation of lactose. Chemically, Lactobionic acid is made up of a galactose moiety that is bonded to a gluconic acid molecule through an ether-like bond. The compound can be dehydrated to a lactone. Lactobionic acid is widely used in the chemical, food and pharmaceutical industries due to its chelating, emulsifying, humectant and chelating properties. Lactobionic acid and its constituent salts are essential as food additives due to excellent solubility, good taste, and health-promoting aspects. The compound may also be essential in the synthesis of targetable and biocompatible drug delivery systems. Properties Lactobionic acid has a molecular weight of 358.296 g/mol and a monoisotopic mass of 358.111 g/mol, which is also its exact mass. The compound has a heavy atom count of 24. Lactobionic acid has a melting point of 113-118°C and a boiling point of about 410.75°C. It is a white to off-white powder with a solubility of 10 g/100 mL in water and a density of about 1.4662. It is also slightly soluble in anhydrous methanol and ethanol. Lactobionic acid is hygroscopic, and it has a good water retention potential hence its applicability to cosmetic products. The compound and its constituent mineral salts (Ca, Na, and K lactobionate) are produced commercially for medical and industrial applications and in some cases for research purposes. Preparation The selective transformation of lactose into Lactobionic acid entails the oxidation of the radical aldehyde category of glucose on the lactose molecule to the carboxylic classification. The production of Lactobionic acid entails various processes which may include enzymatic synthesis, microbial production, biocatalytic oxidation, electrochemical oxidation and heterogeneous catalytic oxidation. Extraction and Purification To enhance the productive capacity of Lactobionic acid, the enzymatic reaction can be cut off after several hours of activity and the unchanged substrates can be re-injected into the cycle after the elimination of useful products. The effective process of separation is through liquid chromatography particularly because the recovered species are pure. Exposing the solution made of lactobionate ions through a sequence of ion-transfer resins produces a pure solution of Lactobionic acid with minimal amounts of calcium ions. Different techniques such as crystallization, evaporation, electrodialysis and ethanol precipitation can be employed to obtain Lactobionic acid. Physiological & Commercial Applications Lactobionic acid is an essential compound based on its chelating properties and its ability to form complex bonds with Ca, Fe, Cu, and Mn. Its incorporation into food additives can stimulate mineral absorption and Ca2+ in the intestines hence enhancing one’s health. Lactobionic acid is unaffected by digestive enzymes hence it is a valuable ingredient in the preparation of functional foods. It is poorly absorbed into the linings of the intestines hence it can also be a Bifidus booster molecule for functional beverages and foods. It enhances the healing process of wounds hence it is valuable in oral, skin, nail, hair and vaginal mucosa care. As an antioxidant, Lactobionic acid acts by suppressing the synthesis of hydroxyl radicals due to its iron chelating ability. As a food additive, Lactobionic acid functions as an acidifier in products containing fermented milk, an aging suppressor for bread, an antioxidant, and as a gelling or stabilizing medium in desserts. In cosmetics, Lactobionic acid is applied as an active ingredient in regenerative and antiaging skin-care products based on its therapeutic properties. Its metal chelation potential suppresses the degeneration potential of metalloproteinase enzymes, which decreases the appearance of aging wrinkles. In the chemical industry, Lactobionic acid is an active ingredient (sugar-based surfactant) in biodegradable detergents. It may also be used in drug delivery systems, nanoparticle diagnosis and tissue engineering. Chemical Properties White to off-white crystalline powder Uses Lactobionic acid is mainly used in preservation solutions for organ transplantation. It is used to produce erythromycine lactobionate. Uses food additive Uses Arginine metabolite in bovine brain; clonidine-displacing substance activity Uses An inhibitor of matrix metalloproteinases Definition ChEBI: A disaccharide formed between beta-D-galactose and D-gluconic acid. Biotechnological Production Currently, lactobionic acid is produced by chemical synthesis using refined lactose as feedstock. This process is expensive due to the energy demand. Alternatively, Acidic Organic Compounds in Beverage, Food, and Feed Production 111 enzymatic processes have been suggested. For example, lactose could be reacted to lactobionic acid using an enzymatic system with co-factor regeneration. First, lactose is converted to lactobionolactone by a cellobiose dehydrogenase. This reaction requires an electron acceptor, which is regenerated by a laccase reducing oxygen to water. Finally, lactobionolactone spontaneously hydrolyzes to lactobionic acid. Moreover, microbial production of lactobionic acid has been described. In a fed-batch cultivation of Burkolderia cepacia growing in a complex medium (lactose, salts, peptone, and yeast extract), a final titer of 400 g.L-1, a yield of approximately 1.0 g of lactobionic acid per gram of lactose, and a productivity of 1.67 g.L-1.h-1 have been achieved. Another promising strategy for an inexpensive biotechnological process is the utilization of cheap raw materials. For example, lactobionic acid could be obtained from concentrated cheese whey by fermentation with Pseudomonas taetrolens. In a fed-batch process, a product concentration of 164 g.L-1 with a productivity of 2.05 g.L-1.h-1 and a yield of 0.82 g of lactobionic acid per gram of lactose have been observed. Furthermore, whole-cell biocatalysis using permeabilized Zymonmonas mobilis cells and an equimolar mixture of lactose and fructose has been tested. In a batch process, a maximum lactobionic acid concentration of 268 g.L-1 and a conversion rate of 72 % within 24 h have been measured. The productivity of lactobionic acid was 11.2 g.L-1.h-1 . Clinical Use Erythromycin lactobionate is a salt with enhanced water solubility that is used for injections. Purification Methods Crystallise lactobionic acid from water by addition of EtOH. [NMR: Taga et al. Bull Chem Soc Jpn 51 2278 1978, Beilstein 17 III/IV 3392, 17/7 V 436.]   Lactobionic acid Preparation Products And Raw materials Preparation Products 6-methoxy-alpha-methylnaphthalen-1-acetaldehyde Tag:Lactobionic acid(96-82-2) Related Product Information