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Factory supply EGCG(Epigallocatechin Gallate) CAS 989-51-5 CAS NO.989-51-5
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- Min.Order: 50 Kilogram
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- Product Details
Keywords
- EGCG
- Epigallocatechin Gallate
- 989-51-5
Quick Details
- ProName: Factory supply EGCG(Epigallocatechin G...
- CasNo: 989-51-5
- Molecular Formula: China Biggest factory manufacturer sup...
- Appearance: white powder
- Application: (-)-Epigallocatechin Gallate is a tumo...
- DeliveryTime: 3-5 days
- PackAge: 25KG/Drum
- Port: Shanghai Guangzhou Qingdao Shenzhen
- ProductionCapacity: 50 Metric Ton/Month
- Purity: 99%
- Storage: 2-8°C
- Transportation: By air /Sea/ coruier
- LimitNum: 50 Kilogram
- Plant of Origin: Cranberry and Mulberry
- Testing Method: HPLC
- Product Ecification: 99%
- Heavy Metal: 10PPM
- Voluntary Standards: QS
- Color: white
- Melting point: ≥350?°C
- Boiling point: 363.24°C (rough estimate)
- density: 1.667
- solubility: 1 M NaOH: 10 mg/mL, dark green
- Water Solubility: <0.1 g/100 mL at 21 oC
- Stability: Stable. Combustible. Incompatible with...
Superiority
| (-)-Epigallocatechin gallate Basic information |
| Product Name: | (-)-Epigallocatechin gallate |
| Synonyms: | TEA CATECHIN;(-)-Epigallocatechin-3-O-gallate (20 mg);EGCG, (-)-Epigallocatechin gallate/Green Tea EGCG90;EGCG, (-)-Epigallocatechin gallate/Green Tea Extract;(-)-CIS-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3 ,5,7-TRIOL 3-GALLATE (-)-CIS-3,3',4',5,5',7-HEXAHYDROXY-FLAVANE-3-GALLATE;Epigallocatechin-3-Monogallate;L-Epigallocatechin Gallate;(-)-Epigallocatechin Gallate-d6 |
| CAS: | 989-51-5 |
| MF: | C22H18O11 |
| MW: | 458.37 |
| EINECS: | 479-560-7 |
| Product Categories: | Aromatics;Heterocycles;Standard extract;Natural Plant Extract;Inhibitors;Amyloid beta-peptide and related;Pharmaceutical Raw Materials;Catechins & Tannins;All Inhibitors;Antioxidant;Biochemistry;Flavonoids;chemical reagent;pharmaceutical intermediate;ProteasomeInhibitors;Plant extracts;Herb extract;Inhibitor;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 989-51-5.mol |
| (-)-Epigallocatechin gallate Chemical Properties |
| Melting point | 222-224°C |
| alpha | D -185 ±2°(ethanol) |
| refractive index | -175.5 ° (C=1, EtOH) |
| storage temp. | 2-8°C |
| solubility | H2O: ≥5mg/mL, clear |
| Boiling point | 909.1±65.0 °C(Predicted) |
| density | 1.90±0.1 g/cm3(Predicted) |
| form | neat |
| pKa | 7.75±0.25(Predicted) |
| Water Solubility | Soluble in ethanol, dimethyl formamide, water. |
| Merck | 14,3526 |
| Stability: | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | WMBWREPUVVBILR-WIYYLYMNSA-N |
| CAS DataBase Reference | 989-51-5(CAS DataBase Reference) |
| Safety Information |
| Safety Statements | 24/25 |
| WGK Germany | 2 |
| RTECS | KB5200000 |
| F | 10-23 |
| HS Code | 29339900 |
| Toxicity | LD50 oral in mouse: 2170mg/kg |
| MSDS Information |
| Provider | Language |
|---|---|
| EGCG | English |
| SigmaAldrich | English |
| (-)-Epigallocatechin gallate Usage And Synthesis |
| Uses | (-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of amaloid-ß and amaloid plaques in mice. This compound has neuroprotective properties. |
| Chemical Properties | solid |
| Uses | telomerase inhibitor |
| Uses | An inhibitor of Bcl-2 and NOS2 |
| Uses | A tumor-inhibiting constituent of green tea. Alters the cleavage of amyloid precursor protein, decreasing production of amaloid- and amaloid plaques in mice |
| Uses | (-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of amaloid- and amaloid plaques in mice. This compound has neuroprotective properties. |
| General Description |
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Hazard | Moderately toxic by ingestion. |
| Biochem/physiol Actions | (-)-Epigallocatechin gallate (EGCG), an antioxidant polyphenol flavonoid exerts anti-tumor properties by inhibiting telomerase and DNA methyltransferase activity. EGCG inhibits the expression of matrix metalloproteinase-2 (MMP-2), MMP-9 and reduces the invasiveness. EGCG blocks the activation of epidermal growth factor (EGF) receptors and human epidermal growth factor receptor-2 (HER-2). EGCG increases bone mineral density and reduces bone resorption. EGCG inhibits osteoclastogenesis by inhibiting receptor activator of nuclear factor κ-B ligand (RANKL) induced nuclear factor κ B (NF-κB) transcriptional activity. EGCG reduces skeletal muscle atrophy. EGCG has anti-aging property and increases myogenic differentiation. EGCG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
| Anticancer Research | EGCG and EGC are the active polyphenol compounds found in green tea, found toinhibit p-glycoprotein transport activities in Chinese hamster ovary (p-gp+) cells.EGCG facilitates the retraction of MDR phenotype by reducing cellular drug effluxwhen given in combination with vinblastine or doxorubicin. Hesperetin, quercetin,daidzein, silymarin, naringenin, and resveratrol also inhibit the MRP1, MRP4, andMRP5 (Kawasaki et al. 2008). Curcumin increases the cellular accumulation ofanticancer agents like cisplatin, tamoxifen, daunorubicin, vincristine, anddoxorubicin and thereby effectively sensitizes the drug-resistant cancer cells. Areduction in MDR1B expression in L1210/Adr cells (mouse leukemic MDR cells)by curcumin is mediated by PI3K, Akt, and NF-κB pathways. It also inhibits theABCG2 transporter activity. In addition curcumin facilitates the accumulation ofmitoxantrone and doxorubicin in ABCG2-expressing HEK cells and hence reversesMDR (Kawasaki et al. 2008; Dandawate et al. 2013). |
| Anticancer Research | EGCG is an ester of gallic acid and epigallocatechin and is a catechin compound(Murakami et al. 1996). It is found most abundantly in green tea. It can be used to treat brain, prostate, cervical, and bladder cancers (Wang et al. 2012). It suppressesthe ornithine decarboxylase action, an enzyme that leads to rapid proliferation andfurthermore circumvents apoptosis (Singh et al. 2016a). It suppresses nuclear factor(NF-κB) activation and expression of Bcl-2 (B-cell lymphoma 2) as well as COX-2(cyclooxygenase-2) in prostate cancer cells and causes induction of apoptosis. Ithamper the matrix metallopeptidase-9 (MMP-9) activation in bladder and lungcancer cells and suppresses the synthesis of VGEF (vascular endothelial growthfactor) in head and neck cancers. It prevents ERK (extracellular signal-regulatedkinase) phosphorylation and MMP-2 and MMP-9 activation and suppresses ERK,c-Jun N-terminal kinase (JNK), and MMP-9 expressions in gastric carcinoma cells(Singh et al. 2016a). It is binding and inhibits the antiapoptotic protein Bcl-xL,interferes with EGFR (epidermal growth factor receptor) signaling, and inhibitshepatocyte growth factor-induced cell proliferation and MAPK (mitogen-activatedprotein kinase), CDK (cyclin-dependent kinase), and cell signaling linked to growthfactors (Wang et al. 2012; Du et al. 2012). Green tea constitutes the rich amount of EGCG which aids in cancer chemoprevention(Fujiki et al. 1998). EGCG improved the impacts of ginseng compoundin the restraint of colon tumor cell development, showing that green tea could bea successful synergist with an anticancer agent for malignancy chemoprevention.It obstructs the PDGF-initiated proliferation and migration of rodent pancreaticstellate cells (Masamune et al. 2005). The soluble and plasma membrane-integratedEGCG straightforwardly communicates with PDGF-BB and in this wayputs off precise receptor binding promoting the inhibitory impacts of EGCG onplatelet-derivedgrowth factor-incited cell signaling and mitogens (Weber et al.2004). |
Details
| (-)-Epigallocatechin gallate Usage And Synthesis |
| Uses | (-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of amaloid-ß and amaloid plaques in mice. This compound has neuroprotective properties. |
| Chemical Properties | solid |
| Uses | telomerase inhibitor |
| Uses | An inhibitor of Bcl-2 and NOS2 |
| Uses | A tumor-inhibiting constituent of green tea. Alters the cleavage of amyloid precursor protein, decreasing production of amaloid- and amaloid plaques in mice |
| Uses | (-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of amaloid- and amaloid plaques in mice. This compound has neuroprotective properties. |
| General Description |
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Hazard | Moderately toxic by ingestion. |
| Biochem/physiol Actions | (-)-Epigallocatechin gallate (EGCG), an antioxidant polyphenol flavonoid exerts anti-tumor properties by inhibiting telomerase and DNA methyltransferase activity. EGCG inhibits the expression of matrix metalloproteinase-2 (MMP-2), MMP-9 and reduces the invasiveness. EGCG blocks the activation of epidermal growth factor (EGF) receptors and human epidermal growth factor receptor-2 (HER-2). EGCG increases bone mineral density and reduces bone resorption. EGCG inhibits osteoclastogenesis by inhibiting receptor activator of nuclear factor κ-B ligand (RANKL) induced nuclear factor κ B (NF-κB) transcriptional activity. EGCG reduces skeletal muscle atrophy. EGCG has anti-aging property and increases myogenic differentiation. EGCG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
| Anticancer Research | EGCG and EGC are the active polyphenol compounds found in green tea, found toinhibit p-glycoprotein transport activities in Chinese hamster ovary (p-gp+) cells.EGCG facilitates the retraction of MDR phenotype by reducing cellular drug effluxwhen given in combination with vinblastine or doxorubicin. Hesperetin, quercetin,daidzein, silymarin, naringenin, and resveratrol also inhibit the MRP1, MRP4, andMRP5 (Kawasaki et al. 2008). Curcumin increases the cellular accumulation ofanticancer agents like cisplatin, tamoxifen, daunorubicin, vincristine, anddoxorubicin and thereby effectively sensitizes the drug-resistant cancer cells. Areduction in MDR1B expression in L1210/Adr cells (mouse leukemic MDR cells)by curcumin is mediated by PI3K, Akt, and NF-κB pathways. It also inhibits theABCG2 transporter activity. In addition curcumin facilitates the accumulation ofmitoxantrone and doxorubicin in ABCG2-expressing HEK cells and hence reversesMDR (Kawasaki et al. 2008; Dandawate et al. 2013). |
| Anticancer Research | EGCG is an ester of gallic acid and epigallocatechin and is a catechin compound(Murakami et al. 1996). It is found most abundantly in green tea. It can be used to treat brain, prostate, cervical, and bladder cancers (Wang et al. 2012). It suppressesthe ornithine decarboxylase action, an enzyme that leads to rapid proliferation andfurthermore circumvents apoptosis (Singh et al. 2016a). It suppresses nuclear factor(NF-κB) activation and expression of Bcl-2 (B-cell lymphoma 2) as well as COX-2(cyclooxygenase-2) in prostate cancer cells and causes induction of apoptosis. Ithamper the matrix metallopeptidase-9 (MMP-9) activation in bladder and lungcancer cells and suppresses the synthesis of VGEF (vascular endothelial growthfactor) in head and neck cancers. It prevents ERK (extracellular signal-regulatedkinase) phosphorylation and MMP-2 and MMP-9 activation and suppresses ERK,c-Jun N-terminal kinase (JNK), and MMP-9 expressions in gastric carcinoma cells(Singh et al. 2016a). It is binding and inhibits the antiapoptotic protein Bcl-xL,interferes with EGFR (epidermal growth factor receptor) signaling, and inhibitshepatocyte growth factor-induced cell proliferation and MAPK (mitogen-activatedprotein kinase), CDK (cyclin-dependent kinase), and cell signaling linked to growthfactors (Wang et al. 2012; Du et al. 2012). Green tea constitutes the rich amount of EGCG which aids in cancer chemoprevention(Fujiki et al. 1998). EGCG improved the impacts of ginseng compoundin the restraint of colon tumor cell development, showing that green tea could bea successful synergist with an anticancer agent for malignancy chemoprevention.It obstructs the PDGF-initiated proliferation and migration of rodent pancreaticstellate cells (Masamune et al. 2005). The soluble and plasma membrane-integratedEGCG straightforwardly communicates with PDGF-BB and in this wayputs off precise receptor binding promoting the inhibitory impacts of EGCG onplatelet-derivedgrowth factor-incited cell signaling and mitogens (Weber et al.2004). |