China Biggest Factory manufacturer supply 4-Methoxyacetophenone CAS NO.100-06-1

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Product Name:	4'-Methoxyacetophenone
Synonyms:	4'-Methoxyacetophenone≥ 99% (GC);4'-Methoxyacetophenone p-Acetanisole 4-Methoxyacetophenone;Para Methoxyl Acetophenone;ACETANISOLE 98+% FCC;4-Methoxyacetophenone,>99%;Epenone;P-METHOXY ACETOPLENONE;PARA-METHOXYACETONPHENONE
CAS:	100-06-1
MF:	C9H10O2
MW:	150.17
EINECS:	202-815-9
Product Categories:	Azetidines;Acetophenones (Building Blocks for Liquid Crystals);FINE Chemical & INTERMEDIATES;Aromatic Acetophenones & Derivatives (substituted);Building Blocks for Liquid Crystals;Functional Materials;Acetophenone Series;100-06-1
Mol File:	100-06-1.mol

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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4'-Methoxyacetophenone Basic information Identification Description Regulatory Status Usage Natural occurrence Product Name: 4'-Methoxyacetophenone Synonyms: 4'-Methoxyacetophenone≥ 99% (GC);4'-Methoxyacetophenone p-Acetanisole 4-Methoxyacetophenone;Para Methoxyl Acetophenone;ACETANISOLE 98+% FCC;4-Methoxyacetophenone,>99%;Epenone;P-METHOXY ACETOPLENONE;PARA-METHOXYACETONPHENONE CAS: 100-06-1 MF: C9H10O2 MW: 150.17 EINECS: 202-815-9 Product Categories: Azetidines;Acetophenones (Building Blocks for Liquid Crystals);FINE Chemical & INTERMEDIATES;Aromatic Acetophenones & Derivatives (substituted);Building Blocks for Liquid Crystals;Functional Materials;Acetophenone Series;100-06-1 Mol File: 100-06-1.mol   4'-Methoxyacetophenone Chemical Properties Melting point  36-38 °C (lit.) Boiling point  152-154 °C/26 mmHg (lit.) density  1.08 FEMA  2005 | ACETANISOLE refractive index  1.5470 (estimate) Fp  >230 °F storage temp.  Keep in dark place,Sealed in dry,Room Temperature solubility  H2O: soluble2.474g/L at 20°C form  Crystals or Crystalline Powder color  White Water Solubility  insoluble Sensitive  Light Sensitive JECFA Number 810 BRN  742313 InChIKey NTPLXRHDUXRPNE-UHFFFAOYSA-N CAS DataBase Reference 100-06-1(CAS DataBase Reference) NIST Chemistry Reference Acetophenone, 4'-methoxy-(100-06-1) EPA Substance Registry System 4'-Methoxyacetophenone (100-06-1)   Safety Information Hazard Codes  Xn Risk Statements  22-38-36/38-20/21/22 Safety Statements  37-37/39-26-36 WGK Germany  2 RTECS  AM9240000 TSCA  Yes HS Code  29145000 Hazardous Substances Data 100-06-1(Hazardous Substances Data) toxicity The acute oral LD50 value in rats was reported as 1.72 g/kg (1.47-1.97 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1973). MSDS Information Provider Language 4'-Methoxyacetophenone English SigmaAldrich English ACROS English ALFA English   4'-Methoxyacetophenone Usage And Synthesis Identification CAS.No.:  100-06-1  FL.No.:  7.038 FEMA.No.:  2005 NAS.No.:  2005 CoE.No.:  570 EINECS.No.:  202-815-9  JECFA.No.:  810 Description Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors. Regulatory Status CoE: Approved. Bev.: 10 ppm; Food: 20 ppm FDA: 21 CFR 172.515 FDA (other): n/a JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2001). Usage Reported uses (ppm): (FEMA, 1994) Food Category  Usual  Max.  Alcoholic.beverages  0.0001 0.0001 Baked.goods  1.5 2 Chewing.gum  110 110 Frozen.dairy  1 2 Gelatins,.puddings  0.2 0.2 Hard.candy  278.3 335 Meat.products  100 100 Nonalcoholic.beverages  7.8 150 Soft.candy  2.1 31 Natural occurrence Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.). Chemical Properties WHITE CRYSTALS OR CRYSTALLINE POWDER Chemical Properties 4-Methoxyacetophenone occurs in anise oil. It forms white crystals (mp 38°C) with a sweet odor, reminiscent of hawthorn. 4-Methoxyacetophenone is prepared by Friedel–Crafts acetylation of anisole. A modern process uses -zeolites as Friedel–Crafts catalysts in combination with a continuous flow technology. 4-Methoxyacetophenone is used in soap perfumes Chemical Properties Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors Occurrence Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.). Uses 4'-Methoxyacetophenone is used as a component of perfumes and as chemical intermediate in the manufacture of pharmaceuticals, resins, flavouring agents. And also used to study ruthenium catalyzed step growth copolymerization of 4 -methoxyacetophenone with α,ω-dienes to yield copolymers. Uses 4'-Methoxyacetophenone is a solid, pale yellow flavoring agent with a hawthornlike odor. It is soluble in most fixed oils and propylene glycol, and it is insoluble in glycerin and mineral oil. It is obtained by chemical synthesis. This flavoring substance or its adjuvant may be safely used in food in the minimum quantity required to produce its intended flavor. It can be used alone or in combination with other flavoring substances or adjuvants. It is also termed p-methoxyacetophenone. Uses Perfumery (for floral odors), flavoring. Definition ChEBI: A member of the class of acetophenones that is acetophenone substituted by a methoxy group at position 4. Preparation From anisole and acetyl chloride in the presence of aluminum chloride and carbon disulfide; from anisole and acetic acid in the presence of boron trifluoride. Taste threshold values Taste characteristics at 10 ppm: sweet, anisic, fruity, cherry with powdery vanilla nuances. Synthesis Reference(s) The Journal of Organic Chemistry, 46, p. 5414, 1981 DOI: 10.1021/jo00339a036 Synthetic Communications, 26, p. 291, 1996 DOI: 10.1080/00397919608003617 Tetrahedron Letters, 35, p. 9471, 1994 DOI: 10.1016/S0040-4039(00)78574-1 General Description 4′-Methoxyacetophenone undergoes biocatalytic enantioselective reduction using immobilized Rhodotorula sp. AS2.2241 cells to yield (S)-1-(4-methoxyphenyl) ethanol in a hydrophilic ionic liquid-containing co-solvent system. Safety Profile Moderately toxic by ingestion. Human systemic effects by inhalation: pulse rate increase without fall in blood pressure and blood pressure elevation. A skin irritant. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES. Purification Methods Crystallise the ketone from diethyl ether/pet ether. [Beilstein 8 IV 340.]   4'-Methoxyacetophenone Preparation Products And Raw materials Raw materials Aluminum chloride-->Acetyl chloride-->Ferric chloride-->Aluminium chloride hexahydrate-->Anisole-->Bentonite,calcium base Preparation Products 5-AMINO-3-(4-METHOXYPHENYL)ISOXAZOLE 9&-->2-Bromo-4'-methoxyacetophenone-->4-(1,2,3-THIADIAZOL-4-YL)PHENOL-->4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOLE-->5-(4-METHOXY-PHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE-->3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOHYDRAZIDE-->3-(4-Methoxyphenyl)-1H-pyrazole-5-carboxamide ,97%-->4-Nitroanisole-->ETHYL 2-AMINO-4-(4-METHOXYPHENYL)-3-THIOPHENECARBOXYLATE-->2-(4-bromophenyl)-1,3,4-oxadiazole-->5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID-->4-HYDROXYBENZOYLACETIC ACID METHYL ESTER-->CHLOROTRIANISENE-->2-(4-HYDROXYPHENYL)PROPIONIC ACID-->5-(4-METHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER-->4-Methoxyphenylacetic acid-->METHYL 4-METHOXYPHENYLACETATE-->ETHYL 4-METHOXYBENZOYLACETATE-->2-(4-METHOXY-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID-->Quinazoline