(R)-(+)-1,2-Dithiolane-3-pentanoic acid Basic information |
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(R)-(+)-1,2-Dithiolane-3-pentanoic acid Chemical Properties |
Melting point |
48-52 °C(lit.) |
alpha |
D23 +104° (c = 0.88 in benzene) |
Boiling point |
185-195 °C(Press: 0.5 Torr) |
density |
1.218±0.06 g/cm3(Predicted) |
refractive index |
114 ° (C=1, EtOH) |
Fp |
>230 °F |
storage temp. |
-20°C |
solubility |
Acetonitrile (Slightly), Chloroform (Slightly), DMSO |
pka |
5.4(at 25℃) |
optical activity |
[α]20/D +104°, c = 1 in chloroform |
Merck |
14,9326 |
CAS DataBase Reference |
1200-22-2(CAS DataBase Reference) |
Provider |
Language |
SigmaAldrich |
English |
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(R)-(+)-1,2-Dithiolane-3-pentanoic acid Usage And Synthesis |
Chemical Properties |
Yellow Crystalline Solid |
Uses |
A fat-metabolism stimulator |
Uses |
α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS).
It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.
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General Description |
α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms.
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Biochem/physiol Actions |
(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease. |
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(R)-(+)-1,2-Dithiolane-3-pentanoic acid Preparation Products And Raw materials |
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