China Biggest Factory manufacturer supply Vitamin A Acetate CAS NO.127-47-9

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Retinyl acetate Basic information Description Reference Product Name: Retinyl acetate Synonyms: RETINYL ACETATE;RETINOL ACETATE;RETINOL ACETATE ALL TRANS;RETINOL ACETATE, WATER SOLUBLE;VITAMIN A ACETATE, ALL TRANS;VITAMIN A ACETATE 1500;VITAMIN A ACETATE;TRANS-RETINOL ACETATE CAS: 127-47-9 MF: C22H32O2 MW: 328.49 EINECS: 204-844-2 Product Categories: Vitamin series;Retinoids;Vitamins and derivatives;Vitamin Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors Mol File: 127-47-9.mol   Retinyl acetate Chemical Properties Melting point  57-58 °C Boiling point  406.22°C (rough estimate) density  1.0474 (rough estimate) refractive index  1.547-1.555 Fp  14℃ storage temp.  2-8°C solubility  absolute ethanol: 25 mg/mL form  solid or viscous liquid color  Yellow powder Odor Amine like Water Solubility  soluble Sensitive  Light & Air Sensitive & Hygroscopic Merck  14,10013 BRN  1915439 Stability: Hygroscopic, Light Sensitive InChIKey QGNJRVVDBSJHIZ-QHLGVNSISA-N CAS DataBase Reference 127-47-9(CAS DataBase Reference) NIST Chemistry Reference Retinol, acetate(127-47-9) EPA Substance Registry System Retinol acetate (127-47-9)   Safety Information Hazard Codes  Xn,Xi,T,F Risk Statements  38-63-36/37/38-53-61-11 Safety Statements  36/37-45-37/39-26-53-16 RIDADR  UN1170 - class 3 - PG 2 - Ethanol WGK Germany  2 RTECS  VH6825000 F  1-8-10 TSCA  Yes HS Code  29362100 Toxicity LD50 (10 day) orally in mice: 4100 mg/kg (Kamm) MSDS Information Provider Language all-trans Vitamin A acetate English ACROS English SigmaAldrich English ALFA English   Retinyl acetate Usage And Synthesis Description Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent. Reference Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5 Chemical Properties Crystalline Uses vitamin precursor Uses Essential micronutrient Uses Retinyl acetate has been used: a control diet to study its effect at different developmental periods in fish larvae to study its inhibitory effects on Mycobacterium avium subspecies paratuberculosis (MAP) strains as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk General Description Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase. Biochem/physiol Actions Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property. Safety Profile Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A. Purification Methods The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]   Retinyl acetate Preparation Products And Raw materials Preparation Products 9-CIS-RETINAL

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Retinyl acetate Basic information Description Reference Product Name: Retinyl acetate Synonyms: RETINYL ACETATE;RETINOL ACETATE;RETINOL ACETATE ALL TRANS;RETINOL ACETATE, WATER SOLUBLE;VITAMIN A ACETATE, ALL TRANS;VITAMIN A ACETATE 1500;VITAMIN A ACETATE;TRANS-RETINOL ACETATE CAS: 127-47-9 MF: C22H32O2 MW: 328.49 EINECS: 204-844-2 Product Categories: Vitamin series;Retinoids;Vitamins and derivatives;Vitamin Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors Mol File: 127-47-9.mol   Retinyl acetate Chemical Properties Melting point  57-58 °C Boiling point  406.22°C (rough estimate) density  1.0474 (rough estimate) refractive index  1.547-1.555 Fp  14℃ storage temp.  2-8°C solubility  absolute ethanol: 25 mg/mL form  solid or viscous liquid color  Yellow powder Odor Amine like Water Solubility  soluble Sensitive  Light & Air Sensitive & Hygroscopic Merck  14,10013 BRN  1915439 Stability: Hygroscopic, Light Sensitive InChIKey QGNJRVVDBSJHIZ-QHLGVNSISA-N CAS DataBase Reference 127-47-9(CAS DataBase Reference) NIST Chemistry Reference Retinol, acetate(127-47-9) EPA Substance Registry System Retinol acetate (127-47-9)   Safety Information Hazard Codes  Xn,Xi,T,F Risk Statements  38-63-36/37/38-53-61-11 Safety Statements  36/37-45-37/39-26-53-16 RIDADR  UN1170 - class 3 - PG 2 - Ethanol WGK Germany  2 RTECS  VH6825000 F  1-8-10 TSCA  Yes HS Code  29362100 Toxicity LD50 (10 day) orally in mice: 4100 mg/kg (Kamm) MSDS Information Provider Language all-trans Vitamin A acetate English ACROS English SigmaAldrich English ALFA English   Retinyl acetate Usage And Synthesis Description Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent. Reference Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5 Chemical Properties Crystalline Uses vitamin precursor Uses Essential micronutrient Uses Retinyl acetate has been used: a control diet to study its effect at different developmental periods in fish larvae to study its inhibitory effects on Mycobacterium avium subspecies paratuberculosis (MAP) strains as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk General Description Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase. Biochem/physiol Actions Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property. Safety Profile Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A. Purification Methods The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]   Retinyl acetate Preparation Products And Raw materials Preparation Products 9-CIS-RETINAL