China Largest Factory Manufacturer sales beta-Cyclodextrin methyl ethers CAS 128446-36-6 CAS NO.128446-36-6

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beta-Cyclodextrin methyl ethers Basic information Product Name: beta-Cyclodextrin methyl ethers Synonyms: .beta.-cyclodextrin,methylethers;METHYL-BETA-CYCLODEXTRIN;MBC;BETA-W7 M1.8;BETA-CYD;(Mixture of several Methylated);Methyl-beta-cyclodextrin ;Methyl-beta-cyclodextrin (mixture of several Methylated) CAS: 128446-36-6 MF: C54H94O35 MW: 1303.3 EINECS: 1308068-626-2 Product Categories: Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Dextrins、Sugar & Carbohydrates;Chelation/Complexation Compounds;Synthetic Reagents;Carbohydrates;Carbohydrates A to;Carbohydrates M-OSynthetic Reagents;CyclodextrinsBiochemicals and Reagents;Polysaccharide;Cell Signaling and Neuroscience;CyclodextrinsCell Culture;CyclodextrinsSynthetic Reagents;Lipids and Lipid Carriers;Reagents and Supplements;Signal Transduction Research Tools Mol File: 128446-36-6.mol   beta-Cyclodextrin methyl ethers Chemical Properties Melting point  180-182 °C(lit.) alpha  +159°(25℃, c=1, H2O) Fp  187 °C storage temp.  room temp solubility  H2O: soluble50mg/mL form  powder color  White to off-white optical activity [α]25/D +159°, c = 1 in H2O Water Solubility  Soluble in water InChIKey YZOUYRAONFXZSI-SBHWVFSVSA-N EPA Substance Registry System .beta.-Cyclodextrin, methyl ethers (128446-36-6)   Safety Information Safety Statements  22-24/25 WGK Germany  3 TSCA  Yes HS Code  35051000 MSDS Information Provider Language SigmaAldrich English   beta-Cyclodextrin methyl ethers Usage And Synthesis Description Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin (Item No. 23387). Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy. Chemical Properties White powder Uses substrate for laminarinase and other glucanases Uses Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts. Uses Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry. General Description Methyl-β-cyclodextrin is a small cyclic heptasaccharide. Biochem/physiol Actions Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.   beta-Cyclodextrin methyl ethers Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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beta-Cyclodextrin methyl ethers Basic information Product Name: beta-Cyclodextrin methyl ethers Synonyms: .beta.-cyclodextrin,methylethers;METHYL-BETA-CYCLODEXTRIN;MBC;BETA-W7 M1.8;BETA-CYD;(Mixture of several Methylated);Methyl-beta-cyclodextrin ;Methyl-beta-cyclodextrin (mixture of several Methylated) CAS: 128446-36-6 MF: C54H94O35 MW: 1303.3 EINECS: 1308068-626-2 Product Categories: Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Dextrins、Sugar & Carbohydrates;Chelation/Complexation Compounds;Synthetic Reagents;Carbohydrates;Carbohydrates A to;Carbohydrates M-OSynthetic Reagents;CyclodextrinsBiochemicals and Reagents;Polysaccharide;Cell Signaling and Neuroscience;CyclodextrinsCell Culture;CyclodextrinsSynthetic Reagents;Lipids and Lipid Carriers;Reagents and Supplements;Signal Transduction Research Tools Mol File: 128446-36-6.mol   beta-Cyclodextrin methyl ethers Chemical Properties Melting point  180-182 °C(lit.) alpha  +159°(25℃, c=1, H2O) Fp  187 °C storage temp.  room temp solubility  H2O: soluble50mg/mL form  powder color  White to off-white optical activity [α]25/D +159°, c = 1 in H2O Water Solubility  Soluble in water InChIKey YZOUYRAONFXZSI-SBHWVFSVSA-N EPA Substance Registry System .beta.-Cyclodextrin, methyl ethers (128446-36-6)   Safety Information Safety Statements  22-24/25 WGK Germany  3 TSCA  Yes HS Code  35051000 MSDS Information Provider Language SigmaAldrich English   beta-Cyclodextrin methyl ethers Usage And Synthesis Description Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin (Item No. 23387). Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy. Chemical Properties White powder Uses substrate for laminarinase and other glucanases Uses Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts. Uses Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry. General Description Methyl-β-cyclodextrin is a small cyclic heptasaccharide. Biochem/physiol Actions Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.   beta-Cyclodextrin methyl ethers Preparation Products And Raw materials