China Largest Manufacturer factory sales L-Tetrahydrofolic Acid CAS 135-16-0 CAS NO.135-16-0

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L-Tetrahydrofolic Acid Basic information Product Name: L-Tetrahydrofolic Acid Synonyms: L-5,6,7,8-Tetrahydrofolic acid;Tetrahydropteroylglutaamic acid;(6S)-Tetrahydrofolic acid;(6S)-Thfa;C00101;Tetrahydrofolic acid,5,6,7,8-Tetrahydropteroyl-L-glutamic acid, THF;L-Tetrahydrofolic Acid, synthesized on receipt of order. 95% MiniMuM purity when shipped.;(-)-L-5,6,7,8-Tetrahydrofolic acid CAS: 135-16-0 MF: C19H23N7O6 MW: 445.43 EINECS: 205-181-1 Product Categories: co-factor;Intermediates & Fine Chemicals;Chiral Reagents;Pharmaceuticals Mol File: 135-16-0.mol   L-Tetrahydrofolic Acid Chemical Properties Melting point  >162°C (dec.) Boiling point  555.12°C (rough estimate) density  1.4216 (rough estimate) refractive index  1.6800 (estimate) storage temp.  -20°C solubility  Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) pka 3.51±0.10(Predicted) form  powder color  off-white to tan BRN  9238187 Stability: We have observed that this material decomposes steadily over time. Use immediately upon receipt.   Safety Information WGK Germany  3 RTECS  MA0600800 F  3-8-10 MSDS Information Provider Language SigmaAldrich English   L-Tetrahydrofolic Acid Usage And Synthesis Chemical Properties Light Tan Solid Uses L-Tetrahydrofolic Acid is a folic acid derivative and coenzyme involved in the metabolism of amino and nucleic acids. We have observed that this material decomposes steadily over time. Use immediately upon receipt. Uses Asa folic acid derivative and coenzyme, L-Tetrahydrofolic Acid can be involved in the metabolism of amino and nucleic acids. Uses Tetrahydrofolic acid has been used to determine the inhibitory effect of tetrahydrofolate on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). A recent use of tetrahydrofolate (THF) is for studying the activation of riboswitches. Definition ChEBI: A derivative of folic acid in which the pteridine ring is fully reduced; it is the parent compound of a variety of coenzymes that serve as carriers of one-carbon groups in metabolic reactions. Biochem/physiol Actions Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids Purification Methods Very high quality material is now available commercially, and it should be a white powder. It can be dried over P2O5 in a vacuum desiccator and stored in weighed aliquots in sealed ampoules. It is stable at room temperature in sealed ampoules for many months and for much more extended periods at -10o. When moist, it is extremely sensitive to air whereby it oxidises to the yellow 7,8-dihydro derivative. In solution it turns yellow in colour as it oxidises, and then particularly in the presence of acids it turns dark reddish brown in colour. Hence aqueous solutions should be frozen immediately when not in use. It is always advisable to add 2-mercaptoethanol (if it does not interfere with the procedure for which it is used) which stabilises it by depleting the solution of O2. The sulfate salt is more stable but is much less soluble. The best way to prepare standard solutions of this acid is to dissolve it in the desired buffer and estimate the concentration by UV absorption in pH 7 buffer at 297nm ( 22,000 M-1cm-1). If a sample is suspect, it is not advisable to purify it because it is likely to deteriorate further as “dry box” conditions are necessary. Either a new sample is purchased or one is freshly prepared from folic acid. It has the above pKa values. [Hafeti et al. Biochemical Preparations 7 89 1960, UV: Mathews & Huennekens J Biol Chem 235 3304 1960, Osborn & Huennekens J Biol Chem 233 969 1958, O'Dell et al. J Am Chem Soc 69 250 1947, Blakley Biochem J 6 5 331 1957, Asahi Yakugaku Zasshi (J Pharm Soc Jpn) 79 1548 1959, Beilstein 26 III/IV 3879.]   L-Tetrahydrofolic Acid Preparation Products And Raw materials Raw materials DIHYDROFOLIC ACID-->Folic acid Preparation Products 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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L-Tetrahydrofolic Acid Basic information Product Name: L-Tetrahydrofolic Acid Synonyms: L-5,6,7,8-Tetrahydrofolic acid;Tetrahydropteroylglutaamic acid;(6S)-Tetrahydrofolic acid;(6S)-Thfa;C00101;Tetrahydrofolic acid,5,6,7,8-Tetrahydropteroyl-L-glutamic acid, THF;L-Tetrahydrofolic Acid, synthesized on receipt of order. 95% MiniMuM purity when shipped.;(-)-L-5,6,7,8-Tetrahydrofolic acid CAS: 135-16-0 MF: C19H23N7O6 MW: 445.43 EINECS: 205-181-1 Product Categories: co-factor;Intermediates & Fine Chemicals;Chiral Reagents;Pharmaceuticals Mol File: 135-16-0.mol   L-Tetrahydrofolic Acid Chemical Properties Melting point  >162°C (dec.) Boiling point  555.12°C (rough estimate) density  1.4216 (rough estimate) refractive index  1.6800 (estimate) storage temp.  -20°C solubility  Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) pka 3.51±0.10(Predicted) form  powder color  off-white to tan BRN  9238187 Stability: We have observed that this material decomposes steadily over time. Use immediately upon receipt.   Safety Information WGK Germany  3 RTECS  MA0600800 F  3-8-10 MSDS Information Provider Language SigmaAldrich English   L-Tetrahydrofolic Acid Usage And Synthesis Chemical Properties Light Tan Solid Uses L-Tetrahydrofolic Acid is a folic acid derivative and coenzyme involved in the metabolism of amino and nucleic acids. We have observed that this material decomposes steadily over time. Use immediately upon receipt. Uses Asa folic acid derivative and coenzyme, L-Tetrahydrofolic Acid can be involved in the metabolism of amino and nucleic acids. Uses Tetrahydrofolic acid has been used to determine the inhibitory effect of tetrahydrofolate on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). A recent use of tetrahydrofolate (THF) is for studying the activation of riboswitches. Definition ChEBI: A derivative of folic acid in which the pteridine ring is fully reduced; it is the parent compound of a variety of coenzymes that serve as carriers of one-carbon groups in metabolic reactions. Biochem/physiol Actions Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids Purification Methods Very high quality material is now available commercially, and it should be a white powder. It can be dried over P2O5 in a vacuum desiccator and stored in weighed aliquots in sealed ampoules. It is stable at room temperature in sealed ampoules for many months and for much more extended periods at -10o. When moist, it is extremely sensitive to air whereby it oxidises to the yellow 7,8-dihydro derivative. In solution it turns yellow in colour as it oxidises, and then particularly in the presence of acids it turns dark reddish brown in colour. Hence aqueous solutions should be frozen immediately when not in use. It is always advisable to add 2-mercaptoethanol (if it does not interfere with the procedure for which it is used) which stabilises it by depleting the solution of O2. The sulfate salt is more stable but is much less soluble. The best way to prepare standard solutions of this acid is to dissolve it in the desired buffer and estimate the concentration by UV absorption in pH 7 buffer at 297nm ( 22,000 M-1cm-1). If a sample is suspect, it is not advisable to purify it because it is likely to deteriorate further as “dry box” conditions are necessary. Either a new sample is purchased or one is freshly prepared from folic acid. It has the above pKa values. [Hafeti et al. Biochemical Preparations 7 89 1960, UV: Mathews & Huennekens J Biol Chem 235 3304 1960, Osborn & Huennekens J Biol Chem 233 969 1958, O'Dell et al. J Am Chem Soc 69 250 1947, Blakley Biochem J 6 5 331 1957, Asahi Yakugaku Zasshi (J Pharm Soc Jpn) 79 1548 1959, Beilstein 26 III/IV 3879.]   L-Tetrahydrofolic Acid Preparation Products And Raw materials Raw materials DIHYDROFOLIC ACID-->Folic acid Preparation Products 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid