China Biggest Factory manufacturer supply Ascorbyl Palmitate CAS NO.137-66-6

                                    Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse 

                                                       Product information

Ascorbyl Palmitate Basic information Product Name: Ascorbyl Palmitate Synonyms: PALMITOYL L-ASCORBIC ACID;6-O-Palmitoyl ascorbate;Palmitoyl ascorbate;Ascorbyl Palmitate (2 g);Ascorbyl Palmitate (2 g) (AS);ASCORBYL PALMITATE(ASCORBIC ACID-6-PALMITATE)(P);Ascorbyl palMitate / 6-PalMitoylascorbic acid;VitaMin C Oil Soluble /L-Ascorbyl PalMitate CAS: 137-66-6 MF: C22H38O7 MW: 414.53 EINECS: 205-305-4 Product Categories: Vitamin Ingredients;Vitamins and derivatives;Food & Feed ADDITIVES;Biochemistry;Sugar Acids;Food Additives;Sugars;Vitamin Derivatives;Vitamins;Vitamin series;EMPROVE;Inhibitors Mol File: 137-66-6.mol   Ascorbyl Palmitate Chemical Properties Melting point  115-118 °C(lit.) alpha  +21～+26°(20℃/D, c=2, C2H5OH) Boiling point  512.7±50.0 °C(Predicted) density  1.150±0.06 g/cm3(Predicted) refractive index  22.5 ° (C=1, EtOH) storage temp.  2-8°C solubility  Slightly soluble in ethyl alcohol. pka 3.96±0.10(Predicted) form  neat color  White to Pale Gray optical activity [α]20/D +23±1°, c = 1% in ethanol BRN  96552 InChIKey QAQJMLQRFWZOBN-UWJYYQICSA-N CAS DataBase Reference 137-66-6(CAS DataBase Reference) EPA Substance Registry System Ascorbyl palmitate (137-66-6)   Safety Information Hazard Codes  Xn Risk Statements  20/21/22-36/37/38 Safety Statements  26-36-24/25 WGK Germany  1 RTECS  CI7671040 TSCA  Yes HS Code  2936 27 00 Hazardous Substances Data 137-66-6(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: > 5000 mg/kg MSDS Information Provider Language SigmaAldrich English ALFA English   Ascorbyl Palmitate Usage And Synthesis Description Ascorbyl palmitate is a lipophilic derivative of ascorbic acid (Item No. 14656) with antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays. Ascorbyl palmitate (0.01%) reduces the rate of autoxidation of soybean, safflower, sunflower, peanut, and corn oil. It inhibits increases in epidermal ornithine decarboxylase activity and DNA synthesis induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice in a concentration-dependent manner when applied topically. Ascorbyl palmitate (0.8 and 4 μmol per 200 μl of acetone, applied topically) reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse skin two-stage model of tumor formation initiated and promoted by 7,12-dimethylbenz[a]anthracene (DMBA) and TPA, respectively. Formulations containing ascorbyl palmitate have been used as antioxidants and preservatives in foods, pharmaceuticals, and cosmetics. Chemical Properties Light yellow powder Chemical Properties Ascorbyl palmitate is a practically odorless, white to yellowish powder. Uses Ascorbyl Palmitate is an ester formed from ascorbic acid (A786990) and palmitic acid (P144500) creating a fat soluble form of vitamin C. Ascorbyl Palmitate is also used as an antioxidant food additiv e. Uses ascorbyl palmitate is used as a preservative and an anti-oxidant in cosmetic creams and lotions to prevent rancidity. Ascorbyl palmitate facilitates the incorporation of ingredients such as vitamins A, C, and D into cosmetic formulations. It has no known toxicity. Uses Ascorbyl Palmitate is an antioxidant formed by combining ascor- bic acid with palmitic acid. ascorbic acid is not fat soluble but ascor- byl palmitate is, thus combining them produces a fat-soluble antioxidant. it exists as a white or yellowish white powder of citric- like odor. it is used as a preservative for natural oils, edible oils, col- ors, and other substances. it acts synergistically with alpha-tocopherol in oils/fats. it is used in peanut oil at a maximum level of 200 mg/kg individually or in combination. Definition A white or yellowish-white powder having a citrus-like odor. Mp 116–117C; soluble in alcohol and in animal and vegetable oils; slightly soluble in water. Production Methods Ascorbyl palmitate is prepared synthetically by the reaction of ascorbic acid with sulfuric acid followed by reesterification with palmitic acid. General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Ascorbyl Palmitate is a lipophilic ascorbic acid derivative, used as an antioxidant in both food and cosmetics industries. Pharmaceutical Applications Ascorbyl palmitate is primarily used either alone or in combination with alpha tocopherol as a stabilizer for oils in oral pharmaceutical formulations and food products; generally 0.05% w/v is used. It may also be used in oral and topical preparations as an antioxidant for drugs unstable to oxygen. The combination of ascorbyl palmitate with alpha tocopherol shows marked synergism, which increases the effect of the components and allows the amount used to be reduced. The solubility of ascorbyl palmitate in alcohol permits it to be used in nonaqueous and aqueous systems and emulsions. Biochem/physiol Actions 6-O-Palmitoyl-L-ascorbic acid possesses metastasis inhibitory and anti-tumor activity. Ascorbyl palmitate exhibits antioxidant activity by protecting the cell membranes from oxidative damage. Safety Profile When heated to decomposition it emits acrid smoke and irritating fumes. Safety Ascorbyl palmitate is used in oral pharmaceutical formulations and food products, and is generally regarded as an essentially nontoxic and nonirritant material. The WHO has set an estimated acceptable daily intake for ascorbyl palmitate at up to 1.25 mg/kg bodyweight. LD50 (mouse, oral): 25 g/kg LD50 (rat, oral): 10 g/kg storage Ascorbyl palmitate is stable in the dry state, but is gradually oxidized and becomes discolored when exposed to light and high humidity. In an unopened container, stored in a cool place, it has a shelf life of at least 12 months. During processing, temperatures greater than 658℃ should be avoided. The bulk material should be stored in an airtight container at 8–158℃, protected from light. Incompatibilities Incompatibilities are known with oxidizing agents; e.g. in solution oxidation is catalyzed by trace metal ions such as Cu2+ and Fe3+. Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, rectal, topical preparations). Included in nonparenteral medicines licensed in the UK.   Ascorbyl Palmitate Preparation Products And Raw materials Raw materials Thionyl chloride-->Palmitic acid-->L(+)-Ascorbic acid-->Palmitoyl chloride-->L-Ascorbic acid, 5,6-O-(1-methylethylidene)-2,3-bis-O-(phenylmethyl)--->L-Ascorbic acid, 2,3-bis-O-(phenylmethyl)--->Palmitic acid ethyl ester-->PALMITIC ACID VINYL ESTER-->(+)-5,6-O-Isopropylidene-L-ascorbic acid-->Palmitic anhydride Tag:Ascorbyl Palmitate(137-66-6) Related Product Information