China Biggest Factory manufacturer supply Hydroxycobalamin Sulfate CAS NO.13870-90-1

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Hydroxycobalamin Sulfate Basic information Product Name: Hydroxycobalamin Sulfate Synonyms: DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6-;DMBC COENZYME;COENZYME B12;COBAMAMIDE;COBAMAMIDE/DIBENCOZIDE;COBAMIDE;5'-deoxyadenosylcobalamin;5'-DEOXYADENOSYLCOBALAMINE CAS: 13870-90-1 MF: C72H100CoN18O17P MW: 1579.58 EINECS: 237-627-6 Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;PHARMACEUTICALS Mol File: 13870-90-1.mol   5'-Deoxyadenosylcobalamin Chemical Properties storage temp.  -20°C solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) form  Solid pka 3.5(at 25℃) color  Red to Very Dark Red Water Solubility  26g/L(24 ºC) Merck  13,2476 BRN  4122932 Stability: Hygroscopic   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-36-26 WGK Germany  3 RTECS  GG3800000 F  8 HS Code  2936260000 Toxicity LD50 oral in guinea pig: 5gm/kg MSDS Information Provider Language SigmaAldrich English   5'-Deoxyadenosylcobalamin Usage And Synthesis Originator Actimide,Tobishi Uses emulsifying agent Uses Coenzyme B12 has been used as a supplement for culturing plasmid variants in in vivo assay of yvrC-lacZ fusions. Definition ChEBI: A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12. Manufacturing Process Isopropylidine adenosine was converted to the p-toluene sulphonyl (tosyl) ester by reaction with tosyl chlorine solution, following the method of Clark et al. (1951) [J. Chem. Soc. 2952]. Because of its tendency to cyclization, the reagent was used directly it was ready. A reaction flask with separating funnels was set up in such a way that the whole system could be evacuated and filled with pure nitrogen two or three times, to eliminate all oxygen, and reagents could then be added when desired, in the closed system. The flask contained 700.0 mg hydroxocobalamin in 20 ml of water, one funnel 200.0 mg sodium borohydride in 10 ml of water, and another the crude isopropylidine adenosine tosyl ester made from 500 mg isopropylidine adenosine dissolved in 10 ml of 50% aqueous methanol. On adding the borohydride to the vitamin, the color changed instantly from red to brown, then slowly to a greenish black. After 15 min the isopropylidine adenosine tosyl ester was added, and the colour slowly changed to a red-brown. After 45 min at room temperature air was admitted and the mixture was shaken to reoxidise any remaining reduced vitamin B12. The alkaline solution was neutralized with dilute hydrochloric acid and extracted with phenol carbon tetrachloride 3:1 in small portions till the aqueous layer was nearly colorless. The combined extracts were washed with water, mixed with about ten parts of carbon tetrachloride-acetone 10:1 and shaken with small portions of water till all red color was removed. The product was purified by chromatography on columns of DEAE (diethyl aminoethyl) cellulose (3 x 1) followed by CM (carboxymethyl) cellulose (6 x 1), developed with water. Nearly all the color washed quickly through DEAE cellulose. The effluent and washes were applied to the CM cellulose column, which was further developed with water. Elution was continued as long as this fraction continued to emerge, in a total of 850 ml. One half of this fraction (425 ml) was concentrated to a few ml under reduced pressure; it crystallized slowly after adding acetone to slight turbidity. So cobamamide was obtained. Therapeutic Function Anabolic, Analgesic General Description Vitamin B12 cobalamin refers to a group of chemically-related cobalt containing molecules. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Agricultural Uses Cobamide enzyme is the cobalt complex formed between the cobalt-porphyrin ring structure and the nucleotide in vitamin B12 co-enzyme. Biochem/physiol Actions Vitamin B12 cobalamin is involved in DNA synthesis and fatty acid synthesis. It also plays a vital role as a coenzyme in the conversion of mitochondrial methylmalonyl co-enzyme A to succinyl co-enzyme A.   5'-Deoxyadenosylcobalamin Preparation Products And Raw materials Raw materials Sodium cyanide-->Chlortetracycline-->Hydrochloric acid

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Hydroxycobalamin Sulfate Product Name: Hydroxycobalamin Sulfate Synonyms: DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6-;DMBC COENZYME;COENZYME B12;COBAMAMIDE;COBAMAMIDE/DIBENCOZIDE;COBAMIDE;5'-deoxyadenosylcobalamin;5'-DEOXYADENOSYLCOBALAMINE CAS: 13870-90-1 MF: C72H100CoN18O17P MW: 1579.58 EINECS: 237-627-6 Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;PHARMACEUTICALS Mol File: 13870-90-1.mol   5'-Deoxyadenosylcobalamin Chemical Properties storage temp.  -20°C solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) form  Solid pka 3.5(at 25℃) color  Red to Very Dark Red Water Solubility  26g/L(24 ºC) Merck  13,2476 BRN  4122932 Stability: Hygroscopic   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-36-26 WGK Germany  3 RTECS  GG3800000 F  8 HS Code  2936260000 Toxicity LD50 oral in guinea pig: 5gm/kg MSDS Information Provider Language SigmaAldrich English   5'-Deoxyadenosylcobalamin Usage And Synthesis Originator Actimide,Tobishi Uses emulsifying agent Uses Coenzyme B12 has been used as a supplement for culturing plasmid variants in in vivo assay of yvrC-lacZ fusions. Definition ChEBI: A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12. Manufacturing Process Isopropylidine adenosine was converted to the p-toluene sulphonyl (tosyl) ester by reaction with tosyl chlorine solution, following the method of Clark et al. (1951) [J. Chem. Soc. 2952]. Because of its tendency to cyclization, the reagent was used directly it was ready. A reaction flask with separating funnels was set up in such a way that the whole system could be evacuated and filled with pure nitrogen two or three times, to eliminate all oxygen, and reagents could then be added when desired, in the closed system. The flask contained 700.0 mg hydroxocobalamin in 20 ml of water, one funnel 200.0 mg sodium borohydride in 10 ml of water, and another the crude isopropylidine adenosine tosyl ester made from 500 mg isopropylidine adenosine dissolved in 10 ml of 50% aqueous methanol. On adding the borohydride to the vitamin, the color changed instantly from red to brown, then slowly to a greenish black. After 15 min the isopropylidine adenosine tosyl ester was added, and the colour slowly changed to a red-brown. After 45 min at room temperature air was admitted and the mixture was shaken to reoxidise any remaining reduced vitamin B12. The alkaline solution was neutralized with dilute hydrochloric acid and extracted with phenol carbon tetrachloride 3:1 in small portions till the aqueous layer was nearly colorless. The combined extracts were washed with water, mixed with about ten parts of carbon tetrachloride-acetone 10:1 and shaken with small portions of water till all red color was removed. The product was purified by chromatography on columns of DEAE (diethyl aminoethyl) cellulose (3 x 1) followed by CM (carboxymethyl) cellulose (6 x 1), developed with water. Nearly all the color washed quickly through DEAE cellulose. The effluent and washes were applied to the CM cellulose column, which was further developed with water. Elution was continued as long as this fraction continued to emerge, in a total of 850 ml. One half of this fraction (425 ml) was concentrated to a few ml under reduced pressure; it crystallized slowly after adding acetone to slight turbidity. So cobamamide was obtained. Therapeutic Function Anabolic, Analgesic General Description Vitamin B12 cobalamin refers to a group of chemically-related cobalt containing molecules. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Agricultural Uses Cobamide enzyme is the cobalt complex formed between the cobalt-porphyrin ring structure and the nucleotide in vitamin B12 co-enzyme. Biochem/physiol Actions Vitamin B12 cobalamin is involved in DNA synthesis and fatty acid synthesis. It also plays a vital role as a coenzyme in the conversion of mitochondrial methylmalonyl co-enzyme A to succinyl co-enzyme A.   5'-Deoxyadenosylcobalamin Preparation Products And Raw materials Raw materials Sodium cyanide-->Chlortetracycline-->Hydrochloric acid