China Largest Manufacturer factory sales 4-Hydroxyphenylacetic acid CAS 156-38-7 CAS NO.156-38-7

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4-Hydroxyphenylacetic acid Basic information Description Referrence Product Name: 4-Hydroxyphenylacetic acid Synonyms: (p-hydroxyphenyl)-aceticaci;4-carboxymethylphenol;4-Hydroxybenzeneacetic acid;4-Hydroxyphenylacetic acid Vetec(TM) reagent grade, 98%;Arbidol Impurity F HCl;Levothyroxine Sodium Impurity d;NSC 27460;Acetic acid, (p-hydroxyphenyl)- CAS: 156-38-7 MF: C8H8O3 MW: 152.15 EINECS: 205-851-3 Product Categories: C8Fluorescent Probes, Labels, Particles and Stains;Other Fluorescent Labels;Aromatic Phenylacetic Acids and Derivatives;Carbonyl Compounds;Carboxylic Acids;Fluorescent Labels;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;pharmaceutical;alcohol| carboxylic acid;1 Mol File: 156-38-7.mol   4-Hydroxyphenylacetic acid Chemical Properties Melting point  148-151 °C(lit.) Boiling point  234.6°C (rough estimate) density  1.2143 (rough estimate) refractive index  1.4945 (estimate) storage temp.  Inert atmosphere,Room Temperature solubility  50g/l pka 4.50±0.10(Predicted) form  Crystalline Powder color  White to cream or light tan PH 2.0-2.4 (30g/l, H2O, 20℃) Water Solubility  Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water. BRN  1448766 InChIKey XQXPVVBIMDBYFF-UHFFFAOYSA-N CAS DataBase Reference 156-38-7(CAS DataBase Reference) NIST Chemistry Reference Benzeneacetic acid, 4-hydroxy-(156-38-7) EPA Substance Registry System Benzeneacetic acid, 4-hydroxy- (156-38-7)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-24/25 WGK Germany  3 RTECS  AI2680000 Hazard Note  Irritant TSCA  Yes HS Code  29182990 MSDS Information Provider Language 4-Hydroxyphenylacetic acid English ACROS English SigmaAldrich English ALFA English   4-Hydroxyphenylacetic acid Usage And Synthesis Description 4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid. Referrence Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84. Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115.  Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825. Chemical Properties 4-Hydroxyphenylacetic acid is a white to cream or light tan crystalline powder. sublimation. Insoluble in cold water, soluble in hot water, ether, ethanol, ethyl acetate. In the case of ferric chloride, it is a purple-green precipitate. It is used as a pharmaceutical raw material for the synthesis of cephalosporin antibiotics, antipyretic analgesics. Uses A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development. Uses It is used as a reagent in the acylation of phenols and amines. It is also used for fluorometric determination of oxidative enzymes. Preparation 4-Hydroxyphenylacetic acid is synthesized by diazotization and hydrolysis of 4-aminophenylacetic acid. 4-aminophenylacetic acid and alkali solution are prepared into sodium salt, and then sulfuric acid is added. Cool to 0°C, control the temperature at 0-5°C, and add sodium nitrate solution dropwise, and the reaction is completed for 0.5h. The obtained diazonium was added dropwise to dilute sulfuric acid at 90-95°C for about 1 hour, and the reaction was continued for 1 hour. The reaction solution was decolorized and filtered, cooled and extracted with ethyl acetate, and the extract was recovered with ethyl acetate to obtain 4-Hydroxyphenylacetic acid. The yield is about 85%. Definition ChEBI: 4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It derives from an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate. Purification Methods Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]   4-Hydroxyphenylacetic acid Preparation Products And Raw materials Raw materials Phenol-->Glyoxal-->Glyoxylic acid-->4-Aminophenylacetic acid-->BENZYL 2-(4-(BENZYLOXY)PHENYL)ACETATE-->4-Iodophenylacetic acid-->4-Hydroxyphenethyl alcohol-->Methyl 4-chlorophenylacetate-->4-Hydroxybenzyl cyanide-->4-Methoxyphenylacetic acid-->2-hydroxy-1-(4-hydroxyphenyl)ethanone-->3,4-Dihydroxyphenylacetic acid-->4-Hydroxystyrene Preparation Products 2-[3-(2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate-->Cefprozil hydrate-->4-Hydroxyphenylacetamide-->4-METHOXYPHENYLACETYL CHLORIDE-->Camostat-->Isobutylparaben-->P-TOLYL-ACETYL CHLORIDE-->Ethyl 4-hydroxyphenylacetate-->Methyl 4-hydroxyphenylacetate-->Bufexamac

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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4-Hydroxyphenylacetic acid Basic information Description Referrence Product Name: 4-Hydroxyphenylacetic acid Synonyms: (p-hydroxyphenyl)-aceticaci;4-carboxymethylphenol;4-Hydroxybenzeneacetic acid;4-Hydroxyphenylacetic acid Vetec(TM) reagent grade, 98%;Arbidol Impurity F HCl;Levothyroxine Sodium Impurity d;NSC 27460;Acetic acid, (p-hydroxyphenyl)- CAS: 156-38-7 MF: C8H8O3 MW: 152.15 EINECS: 205-851-3 Product Categories: C8Fluorescent Probes, Labels, Particles and Stains;Other Fluorescent Labels;Aromatic Phenylacetic Acids and Derivatives;Carbonyl Compounds;Carboxylic Acids;Fluorescent Labels;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;pharmaceutical;alcohol| carboxylic acid;1 Mol File: 156-38-7.mol   4-Hydroxyphenylacetic acid Chemical Properties Melting point  148-151 °C(lit.) Boiling point  234.6°C (rough estimate) density  1.2143 (rough estimate) refractive index  1.4945 (estimate) storage temp.  Inert atmosphere,Room Temperature solubility  50g/l pka 4.50±0.10(Predicted) form  Crystalline Powder color  White to cream or light tan PH 2.0-2.4 (30g/l, H2O, 20℃) Water Solubility  Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water. BRN  1448766 InChIKey XQXPVVBIMDBYFF-UHFFFAOYSA-N CAS DataBase Reference 156-38-7(CAS DataBase Reference) NIST Chemistry Reference Benzeneacetic acid, 4-hydroxy-(156-38-7) EPA Substance Registry System Benzeneacetic acid, 4-hydroxy- (156-38-7)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-24/25 WGK Germany  3 RTECS  AI2680000 Hazard Note  Irritant TSCA  Yes HS Code  29182990 MSDS Information Provider Language 4-Hydroxyphenylacetic acid English ACROS English SigmaAldrich English ALFA English   4-Hydroxyphenylacetic acid Usage And Synthesis Description 4-Hydroxyphenylacetic acid is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxyphenylacetic acid. Referrence Liu, Zhongyang, et al. "4-Hydroxyphenylacetic Acid Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84. Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115.  Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825. Chemical Properties 4-Hydroxyphenylacetic acid is a white to cream or light tan crystalline powder. sublimation. Insoluble in cold water, soluble in hot water, ether, ethanol, ethyl acetate. In the case of ferric chloride, it is a purple-green precipitate. It is used as a pharmaceutical raw material for the synthesis of cephalosporin antibiotics, antipyretic analgesics. Uses A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development. Uses It is used as a reagent in the acylation of phenols and amines. It is also used for fluorometric determination of oxidative enzymes. Preparation 4-Hydroxyphenylacetic acid is synthesized by diazotization and hydrolysis of 4-aminophenylacetic acid. 4-aminophenylacetic acid and alkali solution are prepared into sodium salt, and then sulfuric acid is added. Cool to 0°C, control the temperature at 0-5°C, and add sodium nitrate solution dropwise, and the reaction is completed for 0.5h. The obtained diazonium was added dropwise to dilute sulfuric acid at 90-95°C for about 1 hour, and the reaction was continued for 1 hour. The reaction solution was decolorized and filtered, cooled and extracted with ethyl acetate, and the extract was recovered with ethyl acetate to obtain 4-Hydroxyphenylacetic acid. The yield is about 85%. Definition ChEBI: 4-hydroxyphenylacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. It has a role as a plant metabolite, a fungal metabolite, a human metabolite and a mouse metabolite. It is a monocarboxylic acid and a member of phenols. It derives from an acetic acid. It is a conjugate acid of a 4-hydroxyphenylacetate. Purification Methods Crystallise the acid from water or Et2O/pet ether. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.]   4-Hydroxyphenylacetic acid Preparation Products And Raw materials Raw materials Phenol-->Glyoxal-->Glyoxylic acid-->4-Aminophenylacetic acid-->BENZYL 2-(4-(BENZYLOXY)PHENYL)ACETATE-->4-Iodophenylacetic acid-->4-Hydroxyphenethyl alcohol-->Methyl 4-chlorophenylacetate-->4-Hydroxybenzyl cyanide-->4-Methoxyphenylacetic acid-->2-hydroxy-1-(4-hydroxyphenyl)ethanone-->3,4-Dihydroxyphenylacetic acid-->4-Hydroxystyrene Preparation Products 2-[3-(2H-Benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate-->Cefprozil hydrate-->4-Hydroxyphenylacetamide-->4-METHOXYPHENYLACETYL CHLORIDE-->Camostat-->Isobutylparaben-->P-TOLYL-ACETYL CHLORIDE-->Ethyl 4-hydroxyphenylacetate-->Methyl 4-hydroxyphenylacetate-->Bufexamac