3,3'-Diindolylmethane Basic information |
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3,3'-Diindolylmethane Chemical Properties |
Melting point |
167 °C |
Boiling point |
230 °C(Press: 0.01 Torr) |
density |
1.271±0.06 g/cm3(Predicted) |
storage temp. |
2-8°C |
solubility |
Chloroform (Sparingly), Methanol (Slightly) |
pka |
16.91±0.30(Predicted) |
form |
Off-white powder. |
CAS DataBase Reference |
1968-05-4(CAS DataBase Reference) |
Hazard Codes |
Xi |
Risk Statements |
36/37/38 |
Safety Statements |
22-24/25-26 |
WGK Germany |
3 |
RTECS |
NM0332000 |
HazardClass |
IRRITANT |
HS Code |
29349990 |
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3,3'-Diindolylmethane Usage And Synthesis |
Chemical Properties |
Solid |
Uses |
apoptosis inducer |
Uses |
An antineoplastic agent that activates Chk 2 and cytochrome p450 |
Uses |
3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells.
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General Description |
3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects.
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Biochem/physiol Actions |
Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system. |
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3,3'-Diindolylmethane Preparation Products And Raw materials |
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