China Largest Manufacturer factory sales (S)-(+)-2-Amino-3-methyl-1-butanol CAS 2026-48-4 CAS NO.2026-48-4

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(S)-(+)-2-Amino-3-methyl-1-butanol Basic information Product Name: (S)-(+)-2-Amino-3-methyl-1-butanol Synonyms: L-VALINAL;(+)-L-VALINOL;L-(+)-VALINOL;L-VALINOL;L-2-AMINO-3-METHYL-1-BUTANOL;l-2-amino-3-methylbutan-1-ol;H-VALINOL;H-VAL-OL CAS: 2026-48-4 MF: C5H13NO MW: 103.16 EINECS: 217-975-5 Product Categories: Pharmaceutical Intermediates;Amines;blocks;Amino Acid Derivatives;Valine [Val, V];Amino Alcohols (Chiral);Amino Alcohols;Asymmetric Synthesis;Chiral Building Blocks;Synthetic Organic Chemistry;Chiral Compound;Amino alcohols Mol File: 2026-48-4.mol   (S)-(+)-2-Amino-3-methyl-1-butanol Chemical Properties Melting point  30-34 °C Boiling point  81 °C8 mm Hg(lit.) alpha  16 º (c=10,EtOH) density  0.926 g/mL at 25 °C(lit.) refractive index  n20/D 1.4548(lit.) Fp  196 °F storage temp.  Store at +2°C to +8°C. solubility  DMSO (Slightly), Methanol (Slightly) pka 12.82±0.10(Predicted) form  Liquid After Melting color  Clear slightly yellow optical activity [α]25/D +10°, c = 10 in H2O Water Solubility  Soluble in water. Sensitive  Air Sensitive BRN  1719137 InChIKey NWYYWIJOWOLJNR-RXMQYKEDSA-N CAS DataBase Reference 2026-48-4(CAS DataBase Reference) NIST Chemistry Reference (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)   Safety Information Hazard Codes  Xi Risk Statements  36-36/37/38 Safety Statements  26-24/25-36 WGK Germany  3 F  10-23 HazardClass  IRRITANT HS Code  29221980 MSDS Information Provider Language L-(+)-Valinol English ACROS English SigmaAldrich English ALFA English   (S)-(+)-2-Amino-3-methyl-1-butanol Usage And Synthesis Chemical Properties white to light yellow crystal powde Uses L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer. Uses (S)-(+)-2-Amino-3-methyl-1-butanol can be used to prepare: Imines and oxazolines by reacting with aldehydes and nitriles, respectively. Chiral oxazoline derived multidentate ligands containing cyclophosphazene moiety. Purification Methods Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]   (S)-(+)-2-Amino-3-methyl-1-butanol Preparation Products And Raw materials Preparation Products (4S 4'S)-(-)-2 2'-(3-PENTYLIDENE)BIS(4-&-->(S)-4,5-DIHYDRO-2-(2-((S)-4,5-DIHYDRO-4-ISOPROPYLOXAZOL-2-YL)PROPAN-2-YL)-4-ISOPROPYLOXAZOLE-->(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone-->(S,S)-2,6-BIS(4-ISOPROPYL-2-OXAZOLIN-2-YL)PYRIDINE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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(S)-(+)-2-Amino-3-methyl-1-butanol Basic information Product Name: (S)-(+)-2-Amino-3-methyl-1-butanol Synonyms: L-VALINAL;(+)-L-VALINOL;L-(+)-VALINOL;L-VALINOL;L-2-AMINO-3-METHYL-1-BUTANOL;l-2-amino-3-methylbutan-1-ol;H-VALINOL;H-VAL-OL CAS: 2026-48-4 MF: C5H13NO MW: 103.16 EINECS: 217-975-5 Product Categories: Pharmaceutical Intermediates;Amines;blocks;Amino Acid Derivatives;Valine [Val, V];Amino Alcohols (Chiral);Amino Alcohols;Asymmetric Synthesis;Chiral Building Blocks;Synthetic Organic Chemistry;Chiral Compound;Amino alcohols Mol File: 2026-48-4.mol   (S)-(+)-2-Amino-3-methyl-1-butanol Chemical Properties Melting point  30-34 °C Boiling point  81 °C8 mm Hg(lit.) alpha  16 º (c=10,EtOH) density  0.926 g/mL at 25 °C(lit.) refractive index  n20/D 1.4548(lit.) Fp  196 °F storage temp.  Store at +2°C to +8°C. solubility  DMSO (Slightly), Methanol (Slightly) pka 12.82±0.10(Predicted) form  Liquid After Melting color  Clear slightly yellow optical activity [α]25/D +10°, c = 10 in H2O Water Solubility  Soluble in water. Sensitive  Air Sensitive BRN  1719137 InChIKey NWYYWIJOWOLJNR-RXMQYKEDSA-N CAS DataBase Reference 2026-48-4(CAS DataBase Reference) NIST Chemistry Reference (S)-(+)-2-Amino-3-methyl-1-butanol(2026-48-4)   Safety Information Hazard Codes  Xi Risk Statements  36-36/37/38 Safety Statements  26-24/25-36 WGK Germany  3 F  10-23 HazardClass  IRRITANT HS Code  29221980 MSDS Information Provider Language L-(+)-Valinol English ACROS English SigmaAldrich English ALFA English   (S)-(+)-2-Amino-3-methyl-1-butanol Usage And Synthesis Chemical Properties white to light yellow crystal powde Uses L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer. Uses (S)-(+)-2-Amino-3-methyl-1-butanol can be used to prepare: Imines and oxazolines by reacting with aldehydes and nitriles, respectively. Chiral oxazoline derived multidentate ligands containing cyclophosphazene moiety. Purification Methods Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]   (S)-(+)-2-Amino-3-methyl-1-butanol Preparation Products And Raw materials Preparation Products (4S 4'S)-(-)-2 2'-(3-PENTYLIDENE)BIS(4-&-->(S)-4,5-DIHYDRO-2-(2-((S)-4,5-DIHYDRO-4-ISOPROPYLOXAZOL-2-YL)PROPAN-2-YL)-4-ISOPROPYLOXAZOLE-->(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone-->(S,S)-2,6-BIS(4-ISOPROPYL-2-OXAZOLIN-2-YL)PYRIDINE