China Largest Factory Manufacturer sales Ginkgolic Acid CAS 22910-60-7 CAS NO.22910-60-7

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Ginkgolic acid Basic information Product Name: Ginkgolic acid Synonyms: C-17:1;GINKGOLIC ACID;ROMANICARDIC ACID;Ginkgolic;C10794;6-[(8Z)-Pentadecenyl]-salicylic acid, Ginkgolic acid I;2-Hydroxy-6-[(8Z)-8-pentadecenyl]benzoic acid;2-Hydroxy-6-[(Z)-8-pentadecenyl]benzoic acid CAS: 22910-60-7 MF: C22H34O3 MW: 346.5 EINECS:   Product Categories: Miscellaneous Natural Products Mol File: 22910-60-7.mol   Ginkgolic acid Chemical Properties Melting point  45～48℃ storage temp.  2-8°C solubility  Chloroform (Slightly), Methanol (Slightly) Boiling point  221-223 °C(Press: 4 Torr) density  0.9148 g/cm3 pKa 3.08±0.30(Predicted) form  White solid color  White to Off-White InChIKey YXHVCZZLWZYHSA-FPLPWBNLSA-N CAS DataBase Reference 22910-60-7(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-26 WGK Germany  3 HS Code  29182900 MSDS Information   Ginkgolic acid Usage And Synthesis Description Ginkgolic acid is slightly toxic and is an allergen; for this reason, some sources suggest using only the standardized extract, which is standardized to the flavonoids and minimizes ginkgolic acid content. Ginkgolic acid is active against the tubercle bacillus. Elsewhere, leaf extracts are used in peripheral arterial circulation problems like arteriosclerotic angiopathy, post-thrombotic syndrome, diabetic vasoconstriction with gangrene and angina, intermittent claudication，Raynaud's disease. Extracts are inhaled for ear, nose, and throat ailments like bronchitis and chronic rhinitis. Extracts of the leaves and fruit of Ginkgo plants have long been used in traditional medicine and have multiple potential therapeutic applications, including ameliorating dementia. However, ginkgolic acids, 2-hydroxy-6-alkylbenzoic acids related to anacardic acids, may be deleterious components in these extracts. Ginkgolic acid C15:1 is a 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position. It inhibits SUMOylation in vitro (IC50 = 3 μM) and in cells without affecting protein ubiquitination. Ginkgolic acid C15:1 directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate. Ginkgolic acid C15:1 also suppresses the development of pancreatic cancer xenografts in mice. Uses Ginkgolic acid C15:1 may be used as a reference standard in the quantitative determination of alkylphenols like ginkgolic acids in Ginkgolic extract using high performance liquid chromatography coupled with mass spectrometry(HPLC-MS). Ginkgolic acid C15:1 may be used as an analytical reference standard for the quantification of the analyte in Ginkgo biloba plant extracts, and dietary supplements using chromatography techniques. Definition ChEBI:Ginkgoic acid is a hydroxybenzoic acid. It derives from a salicylic acid. General Description Ginkgolic acid C15:1 is an alkylphenol belonging to the class of ginkgolic acids isolated from Ginkgo biloba leaves. It also shows strong allergenic properties, with carcinogenic and mutagenic activity. Biochem/physiol Actions Cell permeable: yes   Ginkgolic acid Preparation Products And Raw materials Raw materials Benzoic acid, 2-(chloromethyl)-6-methoxy-, ethyl ester-->2-(7-Bromoheptyloxy)tetrahydro-2H-pyran-->Heptanal,7-[(tetrahydro-2H-pyran-2-yl)oxy]--->5-HYDROXY-2,2-DIMETHYL-4H-BENZO[D][1,3]DIOXIN-4-ONE-->Methanesulfonic acid, 1,1,1-trifluoro-, 2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-5-yl ester-->1,7-Heptanediol-->1-Heptanol, 7-[(tetrahydro-2H-pyran-2-yl)oxy]--->2,6-Dihydroxybenzoic acid

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Ginkgolic acid Basic information Product Name: Ginkgolic acid Synonyms: C-17:1;GINKGOLIC ACID;ROMANICARDIC ACID;Ginkgolic;C10794;6-[(8Z)-Pentadecenyl]-salicylic acid, Ginkgolic acid I;2-Hydroxy-6-[(8Z)-8-pentadecenyl]benzoic acid;2-Hydroxy-6-[(Z)-8-pentadecenyl]benzoic acid CAS: 22910-60-7 MF: C22H34O3 MW: 346.5 EINECS:   Product Categories: Miscellaneous Natural Products Mol File: 22910-60-7.mol   Ginkgolic acid Chemical Properties Melting point  45～48℃ storage temp.  2-8°C solubility  Chloroform (Slightly), Methanol (Slightly) Boiling point  221-223 °C(Press: 4 Torr) density  0.9148 g/cm3 pKa 3.08±0.30(Predicted) form  White solid color  White to Off-White InChIKey YXHVCZZLWZYHSA-FPLPWBNLSA-N CAS DataBase Reference 22910-60-7(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-26 WGK Germany  3 HS Code  29182900 MSDS Information   Ginkgolic acid Usage And Synthesis Description Ginkgolic acid is slightly toxic and is an allergen; for this reason, some sources suggest using only the standardized extract, which is standardized to the flavonoids and minimizes ginkgolic acid content. Ginkgolic acid is active against the tubercle bacillus. Elsewhere, leaf extracts are used in peripheral arterial circulation problems like arteriosclerotic angiopathy, post-thrombotic syndrome, diabetic vasoconstriction with gangrene and angina, intermittent claudication，Raynaud's disease. Extracts are inhaled for ear, nose, and throat ailments like bronchitis and chronic rhinitis. Extracts of the leaves and fruit of Ginkgo plants have long been used in traditional medicine and have multiple potential therapeutic applications, including ameliorating dementia. However, ginkgolic acids, 2-hydroxy-6-alkylbenzoic acids related to anacardic acids, may be deleterious components in these extracts. Ginkgolic acid C15:1 is a 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position. It inhibits SUMOylation in vitro (IC50 = 3 μM) and in cells without affecting protein ubiquitination. Ginkgolic acid C15:1 directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate. Ginkgolic acid C15:1 also suppresses the development of pancreatic cancer xenografts in mice. Uses Ginkgolic acid C15:1 may be used as a reference standard in the quantitative determination of alkylphenols like ginkgolic acids in Ginkgolic extract using high performance liquid chromatography coupled with mass spectrometry(HPLC-MS). Ginkgolic acid C15:1 may be used as an analytical reference standard for the quantification of the analyte in Ginkgo biloba plant extracts, and dietary supplements using chromatography techniques. Definition ChEBI:Ginkgoic acid is a hydroxybenzoic acid. It derives from a salicylic acid. General Description Ginkgolic acid C15:1 is an alkylphenol belonging to the class of ginkgolic acids isolated from Ginkgo biloba leaves. It also shows strong allergenic properties, with carcinogenic and mutagenic activity. Biochem/physiol Actions Cell permeable: yes   Ginkgolic acid Preparation Products And Raw materials Raw materials Benzoic acid, 2-(chloromethyl)-6-methoxy-, ethyl ester-->2-(7-Bromoheptyloxy)tetrahydro-2H-pyran-->Heptanal,7-[(tetrahydro-2H-pyran-2-yl)oxy]--->5-HYDROXY-2,2-DIMETHYL-4H-BENZO[D][1,3]DIOXIN-4-ONE-->Methanesulfonic acid, 1,1,1-trifluoro-, 2,2-dimethyl-4-oxo-4H-1,3-benzodioxin-5-yl ester-->1,7-Heptanediol-->1-Heptanol, 7-[(tetrahydro-2H-pyran-2-yl)oxy]--->2,6-Dihydroxybenzoic acid