China Largest Manufacturer factory sales 1,2,4-Triazole CAS 288-88-0 CAS NO.288-88-0

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1,2,4-Triazole Basic information Product Name: 1,2,4-Triazole Synonyms: TA-4;PYRRODIAZOLE;TRIAZOLE;TRIAZOLE(1,2,4-);1H-1,2,4-TRIAZOLE;1-HYDRO-1,2,4-TRIAZOLE;1,2,4-1H-TRIAZOLE;4H-1,2,4-triazole CAS: 288-88-0 MF: C2H3N3 MW: 69.07 EINECS: 206-022-9 Product Categories: Water treatment;Isolabel;Building Blocks;Heterocyclic Building Blocks;Triazoles;Piperidines ,Piperazines ,Homopiperidines;Pyrazoles & Triazoles;Heterocyclic Compounds;Alpha sort;Environmental Standards;MetabolitesPesticides&Metabolites;Pesticides&Metabolites;Q-ZAlphabetic;TP - TZ;Cefoperazone;Biochemistry;Condensation & Active Esterification;Condensing Agents (DNA / RNA Synthesis);Nucleosides, Nucleotides & Related Reagents;Protecting Agents, Phosphorylating Agents & Condensing Agents;Synthetic Organic Chemistry;Pyrazoles & Triazoles;288-88-0 Mol File: 288-88-0.mol   1,2,4-Triazole Chemical Properties Melting point  119-121 °C (lit.) Boiling point  260 °C (lit.) density  1.15 g/cm3 (130℃) refractive index  1.4854 (estimate) Fp  140 °C storage temp.  Store below +30°C. solubility  547g/l pka 2.27(at 20℃) form  Crystalline Powder and Flakes color  White PH 8 (10g/l, H2O, 20℃) Water Solubility  1250 g/L (20 ºC) Merck  14,9605 BRN  104767 InChIKey NSPMIYGKQJPBQR-UHFFFAOYSA-N CAS DataBase Reference 288-88-0(CAS DataBase Reference) NIST Chemistry Reference 1H-1,2,4-Triazole(288-88-0) EPA Substance Registry System 1,2,4-Triazole (288-88-0)   Safety Information Hazard Codes  Xn,Xi,C Risk Statements  22-36-63-34 Safety Statements  36/37-45-36/37/39-27-26 WGK Germany  2 RTECS  XZ3806000 Hazard Note  Irritant TSCA  Yes HS Code  29339990 Hazardous Substances Data 288-88-0(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 1650 mg/kg LD50 dermal Rabbit 3129 - 4200 mg/kg MSDS Information Provider Language 1,2,4-1H-Triazole English ACROS English SigmaAldrich English ALFA English   1,2,4-Triazole Usage And Synthesis Chemical Properties white crystalline powder and flakes Uses 1,2,4-Triazole is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Uses 1,2,4-Triazole is used in the production of pesticides, pharmaceuticals (fluconazole), dyes and rubber additives, and also in the photoconductor of replication system. Intermediate of antifungal fluconazole. Uses 1,2,4-triazole and its derivatives are important structural moieties of many pharmaceutical drugs. Triazoles can also act as ligands to form coordination complexes with transition metal ions. Due to their electron-deficient nature, they exhibit excellent electron-transport and hole-blocking properties, making them promising organic materials in material science applications. Definition A heterocyclic organic compound with a five-membered ring containing two carbon atoms and three nitrogen atoms. There are two isomers. Definition 1,2,4-triazole is a chemical substance with molecular formula C2H3N3, molecular weight 69.07 and CAS No. 288-88-0. Colorless acicular crystal, soluble in water and ethanol. 1H-1,2,4-triazole is a 1,2,4-triazole. It is a tautomer of a 3H-1,2,4-triazole and a 4H-1,2,4-triazole. Triazole is an aromatic five membered heterocyclic compound. Its unique structure is conducive to the formation of a variety of non covalent bonds and is easy to promote the binding of proteins, enzymes and receptors, thus showing a wide range of biological pharmacological activities, such as anticancer, antispasmodic, antibacterial, anti HIV. In particular, 1,2,3-triazole has strong thermal stability and acid-base stability, and is not sensitive to redox, hydrolysis and enzymatic degradation. It is often used as a pharmacodynamic group in drug synthesis. Chemical Synthesis Alkyl bromide and sodium azide were used as raw materials to prepare organic azides, and a series of 1,2,3-triazole small molecules were prepared by click chemistry. The structures of the six products were characterized by 1H NMR, 13C NMR and IR. the products were expected targets. Furthermore, the effect of different substituent structure on the reaction was discussed. Especially the introduction of drug molecule ethisterone, which is expected to provide a certain experimental basis for the application of triazole and its derivatives in biomedicine and other fields. As shown in the figure, alkyl bromide and sodium azide were used as raw materials, N, N-dimethylformamide was used as solvent, and reacted at room temperature for 20 hours under the protection of nitrogen. After the reaction, the solvent was extracted, dried, filtered and spin evaporated to obtain alkyl azide compound 1.Put a certain proportion of alkyl azide 1 and alkynyl compound 2 into a round bottom flask, copper powder and copper acetate as catalysts, acetonitrile as solvent, and react at room temperature for 4 hours under the protection of nitrogen. After that, extract, dry, filter and spin the solvent, and purify by thin chromatography to obtain triazole compound 3. Purification Methods Crystallise 1,2,4-triazole from EtOH, H2O, EtOAc (m 120.5-121o), or EtOH/*C6H6. The hydrochloride has m 170o, and the picrate has m 163-164o (from H2O or CHCl3). [Barszcz et al. J Chem Soc, Dalton Trans 2025 1986]. [Beilstein 26 H 13, 26 II 6, 26 III/IV 35.]   1,2,4-Triazole Preparation Products And Raw materials Raw materials Ammonia-->Hydrazinium hydroxide solution-->Formic acid-->Hydrazine hydrate-->4-Chlorobenzaldehyde-->Ammonium formate-->Methyl formate-->1,2-Diformylhydrazine-->Flutriafol-->1H-1,2,4-Triazole, 1-chloro- Preparation Products Fluconazole-->Paclobutrazol-->1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE-->Anastrozole-->Propiconazole-->1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE-->Bitertanol-->Triapenthenol-->BASIC RED 46-->1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE-->3,5-DIBROMO-1H-1,2,4-TRIAZOLE-->3-[(2,4-dihydro-2,4-dimethyl-3H-1,2,4-triazol-3-ylidene)hydrazono]-1-methyl-2-phenyl-3H-indolium chloride-->Basic Red 22

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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1,2,4-Triazole Basic information Product Name: 1,2,4-Triazole Synonyms: TA-4;PYRRODIAZOLE;TRIAZOLE;TRIAZOLE(1,2,4-);1H-1,2,4-TRIAZOLE;1-HYDRO-1,2,4-TRIAZOLE;1,2,4-1H-TRIAZOLE;4H-1,2,4-triazole CAS: 288-88-0 MF: C2H3N3 MW: 69.07 EINECS: 206-022-9 Product Categories: Water treatment;Isolabel;Building Blocks;Heterocyclic Building Blocks;Triazoles;Piperidines ,Piperazines ,Homopiperidines;Pyrazoles & Triazoles;Heterocyclic Compounds;Alpha sort;Environmental Standards;MetabolitesPesticides&Metabolites;Pesticides&Metabolites;Q-ZAlphabetic;TP - TZ;Cefoperazone;Biochemistry;Condensation & Active Esterification;Condensing Agents (DNA / RNA Synthesis);Nucleosides, Nucleotides & Related Reagents;Protecting Agents, Phosphorylating Agents & Condensing Agents;Synthetic Organic Chemistry;Pyrazoles & Triazoles;288-88-0 Mol File: 288-88-0.mol   1,2,4-Triazole Chemical Properties Melting point  119-121 °C (lit.) Boiling point  260 °C (lit.) density  1.15 g/cm3 (130℃) refractive index  1.4854 (estimate) Fp  140 °C storage temp.  Store below +30°C. solubility  547g/l pka 2.27(at 20℃) form  Crystalline Powder and Flakes color  White PH 8 (10g/l, H2O, 20℃) Water Solubility  1250 g/L (20 ºC) Merck  14,9605 BRN  104767 InChIKey NSPMIYGKQJPBQR-UHFFFAOYSA-N CAS DataBase Reference 288-88-0(CAS DataBase Reference) NIST Chemistry Reference 1H-1,2,4-Triazole(288-88-0) EPA Substance Registry System 1,2,4-Triazole (288-88-0)   Safety Information Hazard Codes  Xn,Xi,C Risk Statements  22-36-63-34 Safety Statements  36/37-45-36/37/39-27-26 WGK Germany  2 RTECS  XZ3806000 Hazard Note  Irritant TSCA  Yes HS Code  29339990 Hazardous Substances Data 288-88-0(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 1650 mg/kg LD50 dermal Rabbit 3129 - 4200 mg/kg MSDS Information Provider Language 1,2,4-1H-Triazole English ACROS English SigmaAldrich English ALFA English   1,2,4-Triazole Usage And Synthesis Chemical Properties white crystalline powder and flakes Uses 1,2,4-Triazole is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959. Uses 1,2,4-Triazole is used in the production of pesticides, pharmaceuticals (fluconazole), dyes and rubber additives, and also in the photoconductor of replication system. Intermediate of antifungal fluconazole. Uses 1,2,4-triazole and its derivatives are important structural moieties of many pharmaceutical drugs. Triazoles can also act as ligands to form coordination complexes with transition metal ions. Due to their electron-deficient nature, they exhibit excellent electron-transport and hole-blocking properties, making them promising organic materials in material science applications. Definition A heterocyclic organic compound with a five-membered ring containing two carbon atoms and three nitrogen atoms. There are two isomers. Definition 1,2,4-triazole is a chemical substance with molecular formula C2H3N3, molecular weight 69.07 and CAS No. 288-88-0. Colorless acicular crystal, soluble in water and ethanol. 1H-1,2,4-triazole is a 1,2,4-triazole. It is a tautomer of a 3H-1,2,4-triazole and a 4H-1,2,4-triazole. Triazole is an aromatic five membered heterocyclic compound. Its unique structure is conducive to the formation of a variety of non covalent bonds and is easy to promote the binding of proteins, enzymes and receptors, thus showing a wide range of biological pharmacological activities, such as anticancer, antispasmodic, antibacterial, anti HIV. In particular, 1,2,3-triazole has strong thermal stability and acid-base stability, and is not sensitive to redox, hydrolysis and enzymatic degradation. It is often used as a pharmacodynamic group in drug synthesis. Chemical Synthesis Alkyl bromide and sodium azide were used as raw materials to prepare organic azides, and a series of 1,2,3-triazole small molecules were prepared by click chemistry. The structures of the six products were characterized by 1H NMR, 13C NMR and IR. the products were expected targets. Furthermore, the effect of different substituent structure on the reaction was discussed. Especially the introduction of drug molecule ethisterone, which is expected to provide a certain experimental basis for the application of triazole and its derivatives in biomedicine and other fields. As shown in the figure, alkyl bromide and sodium azide were used as raw materials, N, N-dimethylformamide was used as solvent, and reacted at room temperature for 20 hours under the protection of nitrogen. After the reaction, the solvent was extracted, dried, filtered and spin evaporated to obtain alkyl azide compound 1.Put a certain proportion of alkyl azide 1 and alkynyl compound 2 into a round bottom flask, copper powder and copper acetate as catalysts, acetonitrile as solvent, and react at room temperature for 4 hours under the protection of nitrogen. After that, extract, dry, filter and spin the solvent, and purify by thin chromatography to obtain triazole compound 3. Purification Methods Crystallise 1,2,4-triazole from EtOH, H2O, EtOAc (m 120.5-121o), or EtOH/*C6H6. The hydrochloride has m 170o, and the picrate has m 163-164o (from H2O or CHCl3). [Barszcz et al. J Chem Soc, Dalton Trans 2025 1986]. [Beilstein 26 H 13, 26 II 6, 26 III/IV 35.]   1,2,4-Triazole Preparation Products And Raw materials Raw materials Ammonia-->Hydrazinium hydroxide solution-->Formic acid-->Hydrazine hydrate-->4-Chlorobenzaldehyde-->Ammonium formate-->Methyl formate-->1,2-Diformylhydrazine-->Flutriafol-->1H-1,2,4-Triazole, 1-chloro- Preparation Products Fluconazole-->Paclobutrazol-->1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE-->Anastrozole-->Propiconazole-->1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE-->Bitertanol-->Triapenthenol-->BASIC RED 46-->1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE-->3,5-DIBROMO-1H-1,2,4-TRIAZOLE-->3-[(2,4-dihydro-2,4-dimethyl-3H-1,2,4-triazol-3-ylidene)hydrazono]-1-methyl-2-phenyl-3H-indolium chloride-->Basic Red 22