China Manufacturer factory sales Polyhexamethylene biguanidine hydrochloride(PHMB) CAS 32289-58-0 CAS NO.32289-58-0

                                PRODUCT DETAILS       

Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Basic information Description Application Safety Product Name: Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Synonyms: PHMB(20%);Polyhexamethyl;PHMB;Biguanide PHMB;Polyhexamethylene biguanidine hydrochloride,~20% in water;PHMB 98%, 20% solution (Polyhexamethylene biguanide hydrochloride);20% solution;98% powder CAS: 32289-58-0 MF: C10H23N5 MW: 213.32312 EINECS: 1308068-626-2 Product Categories: Disinfectants;PHM;Fungicide series;Antibacterial agent;CHEMICAL;Biocide;Industrial/Fine Chemicals;Polymers;Intermediates & Fine Chemicals;Pharmaceuticals;Water treatment;intermediate Mol File: 32289-58-0.mol   Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Chemical Properties storage temp.  Inert atmosphere,Room Temperature solubility  Water CAS DataBase Reference 32289-58-0(CAS DataBase Reference) EPA Substance Registry System Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride (32289-58-0)   Safety Information Hazardous Substances Data 32289-58-0(Hazardous Substances Data) MSDS Information   Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Usage And Synthesis Description PHMB is best known for its broad-spectrum antimicrobial and antifungal activity. It is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY). PHMB is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.  Application Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae). Safety On the 20th of April 2018, the european commission decided to ban preservative uses of PHMB PT9 (Fibre, leather, rubber and polymerised materials preservatives). It’s still allowed for uses as disinfectants PT2 (Disinfectants and algaecides not intended for direct application to humans or animals). Furthermore, PHMB has been declared as a candidate for substitution by the ECHA. Chemical Properties Colorless to pale yellow solution Uses Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes. Uses Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes Biological Activity Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.   Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Preparation Products And Raw materials

                                                                         About US 

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

                                                                       Group profiles

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse 

                                                       Product information

Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Basic information Description Application Safety Product Name: Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Synonyms: PHMB(20%);Polyhexamethyl;PHMB;Biguanide PHMB;Polyhexamethylene biguanidine hydrochloride,~20% in water;PHMB 98%, 20% solution (Polyhexamethylene biguanide hydrochloride);20% solution;98% powder CAS: 32289-58-0 MF: C10H23N5 MW: 213.32312 EINECS: 1308068-626-2 Product Categories: Disinfectants;PHM;Fungicide series;Antibacterial agent;CHEMICAL;Biocide;Industrial/Fine Chemicals;Polymers;Intermediates & Fine Chemicals;Pharmaceuticals;Water treatment;intermediate Mol File: 32289-58-0.mol   Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Chemical Properties storage temp.  Inert atmosphere,Room Temperature solubility  Water CAS DataBase Reference 32289-58-0(CAS DataBase Reference) EPA Substance Registry System Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride (32289-58-0)   Safety Information Hazardous Substances Data 32289-58-0(Hazardous Substances Data) MSDS Information   Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Usage And Synthesis Description PHMB is best known for its broad-spectrum antimicrobial and antifungal activity. It is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY). PHMB is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.  Application Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae). Safety On the 20th of April 2018, the european commission decided to ban preservative uses of PHMB PT9 (Fibre, leather, rubber and polymerised materials preservatives). It’s still allowed for uses as disinfectants PT2 (Disinfectants and algaecides not intended for direct application to humans or animals). Furthermore, PHMB has been declared as a candidate for substitution by the ECHA. Chemical Properties Colorless to pale yellow solution Uses Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes. Uses Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes Biological Activity Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.   Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride Preparation Products And Raw materials