China Manufacturer factory sales Denatonium Benzoate CAS 3734-33-6 CAS NO.3734-33-6

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Denatonium Benzoate Anhydrous Basic information The most bitter compound in the world Chemical structure Uses Product Name: Denatonium Benzoate Anhydrous Synonyms: N,N-DIETHYL-N-[(2,6-DIMETHYLPHENYLCAR-BAMOYL)METHYL]BENZYLAMMONIUM BENZOATE;N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]-N,N-diethyl-benzenemethanaminium benzoate;REJEXIT (R);benzyldiethyl (2,6-xylylcarbamoylmethyl)-ammonium;Bitrex Denatonium Benzoate;Denatoniumbenzoate,96%;Acetylthio-2-Methylpro-Panoyl Chloride;DenatoniumBenzoate,Granular,Usp CAS: 3734-33-6 MF: C28H34N2O3 MW: 446.58 EINECS: 223-095-2 Product Categories: DIMETANE;Miscellaneous Biochemicals;Ammonium Polyhalides, etc. (Quaternary);Quaternary Ammonium Compounds;Pharmaceutical Intermediates Mol File: 3734-33-6.mol   Denatonium Benzoate Anhydrous Chemical Properties Melting point  164-168 °C (lit.) Boiling point  555.91°C (rough estimate) density  1.1256 (rough estimate) refractive index  1.5800 (estimate) Fp  100℃ storage temp.  Inert atmosphere,Room Temperature solubility  methanol: 50 mg/mL, clear, colorless form  Solid color  White to Off-White Merck  14,2891 BRN  8179408 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey VWTINHYPRWEBQY-UHFFFAOYSA-N CAS DataBase Reference 3734-33-6(CAS DataBase Reference) EPA Substance Registry System Denatonium benzoate (3734-33-6)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38-20/21/22 Safety Statements  26-36-37/39 WGK Germany  2 RTECS  BO6650000 TSCA  Yes HS Code  29242995 MSDS Information Provider Language Benzyldiethyl(2,6-xylylcarbamoylmethyl)ammonium benzoate English SigmaAldrich English   Denatonium Benzoate Anhydrous Usage And Synthesis The most bitter compound in the world Denatonium benzoate is now known as the world's most bitter compound. If we set the bitter degree of quinine as datum 1, the degree of bitterness of the product would be 1000. A concentration of 10ppm solution is already too bitter to bear for most people. The vast majority of its applications are related to its bitter flavor. It is an inexpensive and efficient alternative to its counterparts such as strychnine, bitter lignin, quinine, wood song glycosides, saponins grapefruit. Denatonium benzoate is commonly used as aversive agent to prevent people from eating other toxic but tasteless substance. For example, it has been added into industrial alcohol, ethylene glycol or methanol which has similar taste as ordinary wine, antifreeze, paint, toilet cleaners, animals disperse, liquid soaps and shampoos. Moreover, it has been also added into special nail polish agents, to avoid child’s bad habit of biting fingers, as well as being the repellent for expulsing large beasts. However, the effect of Long-term exposure to this substance on human health is still unclear. Chemical structure Denatonium benzoate is a kind of quaternary ammonium salt formed by the combination of the quaternary ammonium cation and inert anion such as benzoic acid or saccharin anion. The structure of its cation form is similar to that of a local anesthetic lidocaine with the only difference being an additional benzyl functional group located on the nitrogen atom of the amino. Uses Flavoring agent. Chemical Properties white crystals Chemical Properties Denatonium benzoate occurs as an odorless, very bitter tasting, white crystalline powder or granules. Uses H1 antihistamine Uses Pharmaceutic aid (alcohol denaturant; flavor). Added to toxic substances as a deterrent to accidental ingestion. Can replace brucine or quassin as denaturant for ethyl alcohol. Uses The bitterest compound knownDenatonium benzoate is used as an alcohol denaturant and flavor in pharmaceuticals. It is also used in antifreeze, nail biting preventions, respirator mask fit-testing, animal repellents, liquid soaps and shampoos. Further, it is used in air care products. It acts as H1 antihistamine. In addition to this, it is used as a disinfectant. Production Methods Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate. Brand name Bitrex (Mac Farlan Smith, Scotland). Pharmaceutical Applications Denatonium benzoate is among the most bitter of substances known and is detectable at concentrations of approximately 10 ppb. In pharmaceutical and other industrial applications it is added to some products as a deterrent to accidental ingestion. It is most commonly used at levels of 5–500 ppm. Denatonium benzoate may also be used to replace brucine or quassin as a denaturant for ethanol. In pharmaceutical formulations, denatonium benzoate has been used as a flavoring agent in placebo tablets, and in a topical formulation it has been used in an anti-nailbiting preparation. Safety Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,therehasbeenasinglereportof contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate. LD50 (rabbit, oral): 0.508g/kg LD50 (rat, oral): 0.584g/kg storage Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light. Incompatibilities Denatonium benzoateis incompatible with strongoxidizing agents. Regulatory Status Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution).   Denatonium Benzoate Anhydrous Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Denatonium Benzoate Anhydrous Basic information The most bitter compound in the world Chemical structure Uses Product Name: Denatonium Benzoate Anhydrous Synonyms: N,N-DIETHYL-N-[(2,6-DIMETHYLPHENYLCAR-BAMOYL)METHYL]BENZYLAMMONIUM BENZOATE;N-[2-[(2,6-Dimethylphenyl)amino]-2-oxoethyl]-N,N-diethyl-benzenemethanaminium benzoate;REJEXIT (R);benzyldiethyl (2,6-xylylcarbamoylmethyl)-ammonium;Bitrex Denatonium Benzoate;Denatoniumbenzoate,96%;Acetylthio-2-Methylpro-Panoyl Chloride;DenatoniumBenzoate,Granular,Usp CAS: 3734-33-6 MF: C28H34N2O3 MW: 446.58 EINECS: 223-095-2 Product Categories: DIMETANE;Miscellaneous Biochemicals;Ammonium Polyhalides, etc. (Quaternary);Quaternary Ammonium Compounds;Pharmaceutical Intermediates Mol File: 3734-33-6.mol   Denatonium Benzoate Anhydrous Chemical Properties Melting point  164-168 °C (lit.) Boiling point  555.91°C (rough estimate) density  1.1256 (rough estimate) refractive index  1.5800 (estimate) Fp  100℃ storage temp.  Inert atmosphere,Room Temperature solubility  methanol: 50 mg/mL, clear, colorless form  Solid color  White to Off-White Merck  14,2891 BRN  8179408 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey VWTINHYPRWEBQY-UHFFFAOYSA-N CAS DataBase Reference 3734-33-6(CAS DataBase Reference) EPA Substance Registry System Denatonium benzoate (3734-33-6)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38-20/21/22 Safety Statements  26-36-37/39 WGK Germany  2 RTECS  BO6650000 TSCA  Yes HS Code  29242995 MSDS Information Provider Language Benzyldiethyl(2,6-xylylcarbamoylmethyl)ammonium benzoate English SigmaAldrich English   Denatonium Benzoate Anhydrous Usage And Synthesis The most bitter compound in the world Denatonium benzoate is now known as the world's most bitter compound. If we set the bitter degree of quinine as datum 1, the degree of bitterness of the product would be 1000. A concentration of 10ppm solution is already too bitter to bear for most people. The vast majority of its applications are related to its bitter flavor. It is an inexpensive and efficient alternative to its counterparts such as strychnine, bitter lignin, quinine, wood song glycosides, saponins grapefruit. Denatonium benzoate is commonly used as aversive agent to prevent people from eating other toxic but tasteless substance. For example, it has been added into industrial alcohol, ethylene glycol or methanol which has similar taste as ordinary wine, antifreeze, paint, toilet cleaners, animals disperse, liquid soaps and shampoos. Moreover, it has been also added into special nail polish agents, to avoid child’s bad habit of biting fingers, as well as being the repellent for expulsing large beasts. However, the effect of Long-term exposure to this substance on human health is still unclear. Chemical structure Denatonium benzoate is a kind of quaternary ammonium salt formed by the combination of the quaternary ammonium cation and inert anion such as benzoic acid or saccharin anion. The structure of its cation form is similar to that of a local anesthetic lidocaine with the only difference being an additional benzyl functional group located on the nitrogen atom of the amino. Uses Flavoring agent. Chemical Properties white crystals Chemical Properties Denatonium benzoate occurs as an odorless, very bitter tasting, white crystalline powder or granules. Uses H1 antihistamine Uses Pharmaceutic aid (alcohol denaturant; flavor). Added to toxic substances as a deterrent to accidental ingestion. Can replace brucine or quassin as denaturant for ethyl alcohol. Uses The bitterest compound knownDenatonium benzoate is used as an alcohol denaturant and flavor in pharmaceuticals. It is also used in antifreeze, nail biting preventions, respirator mask fit-testing, animal repellents, liquid soaps and shampoos. Further, it is used in air care products. It acts as H1 antihistamine. In addition to this, it is used as a disinfectant. Production Methods Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate. Brand name Bitrex (Mac Farlan Smith, Scotland). Pharmaceutical Applications Denatonium benzoate is among the most bitter of substances known and is detectable at concentrations of approximately 10 ppb. In pharmaceutical and other industrial applications it is added to some products as a deterrent to accidental ingestion. It is most commonly used at levels of 5–500 ppm. Denatonium benzoate may also be used to replace brucine or quassin as a denaturant for ethanol. In pharmaceutical formulations, denatonium benzoate has been used as a flavoring agent in placebo tablets, and in a topical formulation it has been used in an anti-nailbiting preparation. Safety Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,therehasbeenasinglereportof contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate. LD50 (rabbit, oral): 0.508g/kg LD50 (rat, oral): 0.584g/kg storage Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light. Incompatibilities Denatonium benzoateis incompatible with strongoxidizing agents. Regulatory Status Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution).   Denatonium Benzoate Anhydrous Preparation Products And Raw materials