China Largest Manufacturer factory sales Calcium Propionate CAS 4075-81-4 CAS NO.4075-81-4

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Calcium Propionate Basic information Description Food preservative Preparation Mechanism of Action Uses Regulatory Amount Product Name: Calcium Propionate Synonyms: bioban-c;calciumpropanoate;CALCIUM PROPIONATECALCIUM PROPIONATECALCIUM PROPIONATECALCIUM PROPIONATE;Propanoicacid,calciumsalt;propionatedecalcium;PROPIONIC ACID HEMICALCIUM SALT;PROPIONIC ACID CALCIUM SALT;CALCIUM PROPIONATE CAS: 4075-81-4 MF: C3H8CaO2 MW: 116.17 EINECS: 223-795-8 Product Categories: Food & Flavor Additives;Ca (Calcium) Compounds;INORGANIC & ORGANIC CHEMICALS;Classes of Metal Compounds;Typical Metal Compounds;Food additives;Food additive Mol File: 4075-81-4.mol   Calcium Propionate Chemical Properties Melting point  300 °C storage temp.  Store below +30°C. solubility  water: soluble1g/10 mL, clear, colorless form  Crystals or Crystalline Powder color  White PH 9.2 (200g/l, H2O, 20℃)(IUCLID) Water Solubility  1 g/10 mL Merck  14,1698 BRN  3698682 Stability: Stable. Hygroscopic. Incompatible with strong oxidizing agents. InChIKey BCZXFFBUYPCTSJ-UHFFFAOYSA-L CAS DataBase Reference 4075-81-4(CAS DataBase Reference) EPA Substance Registry System Calcium propionate (4075-81-4)   Safety Information Risk Statements  36/37/38 Safety Statements  24/25 WGK Germany  2 RTECS  UE8450000 TSCA  Yes HS Code  29155000 Hazardous Substances Data 4075-81-4(Hazardous Substances Data) MSDS Information Provider Language Calcium propionate English SigmaAldrich English ACROS English   Calcium Propionate Usage And Synthesis Description Calcium propionate, also known as calcium salt and propanoic acid is a white powder that has a faint smell. The compound is stable at room temperature. It is hygroscopic and incompatible with strong oxidizing agents. It has a melting point of 300oC and a pH value of 7 to 9. It is slightly soluble in alcohol and fully soluble in water. Calcium Propionate as the newer food antifungal agent, is the calcium salt of propanoic acid which is a antifungal agent. It appears as white crystalline or powder, odorless or having slight specific odor of propionic acid, stable under light and heat , hygroscopic, soluble in water while aqueous solution is alkaline, slightly soluble in methanol and ethanol, not soluble in benzene and acetone. It is deliquescent in moist air and loses crystal water when heated to 120 ℃ .It changes phase at 200~210 ℃ and decomposes to calcium carbonate at 330~340 ℃ . Under acidic conditions, it generates free propanoic acid which is weaker than sorbic acid while stronger than acetic acid, and has an antibacterial effect on Aspergillus niger and gas bacillus rather than yeast . Calcium Propionate is a normal intermediate product of animal metabolism and is safe eaten by animals. It has a broad antibacterial activity to mold bacteria and yeast bacteria, inhibiting the propagation of microorganisms, preventing feed molding, which can be used as a fungicide on food and feed and a preservative for bread and pastries. As a feed additive ,it can effectively prevent feed molding and prolong shelf life of feed . If combined with other inorganic complexes, it can also improve the appetite of livestock, increase milk production in cows, and its dosage is less than 0.3% of the combined feed (use propionic acid to count). Food preservative Calcium Propionate is an acid-type food preservative, with its inhibitory effected by the environmental pH .When PH5.0 minimum inhibitory concentration is 0.01%, PH6.5 is 0.5%. In the acidic medium ,it has a strong inhibitory effect on the various types of fungi, aerobic bacillus or gram-negative bacilli . It has a specific effect on preventing the production of Aflatoxin streptozotocin, but has little effect on the yeast. In the food industry, it is mainly used in vinegar, soy sauce, bread, cakes and soy products,whose maximum usage (use propionic acid to count, the same below)is 2.5g/kg; while the largest usage in the wet dough products is 0.25g/kg . Also ,it can be used for feed antifungal agent. It is used for breads, pastries and cheese preservatives and feed fungicide. Calcium Propionate as a food preservative, calcium propionate is mainly used for bread, because sodium propionate keeps pH of bread rising, delays the fermentation of the dough; sodium propionate is more widely used for cake, because the pastry gets bulky by using leavening agent, there is no problem about yeast development caused by tincrease in the pH . As a feed preservative, sodium propionate is better than calcium propionate. But Calcium Propionate is more stable than sodium propionate. In food industry , except uses for bread, pastries, cheese, Calcium Propionate can also be used for preventing soy sauce from getting moldy which inhibits the refermentation . In medicine, Calcium Propionate can be made into powders, solutions and ointments to treat skin disease caused by parasitic fungi. Ointment (liquid) contains 12.3% sodium propionate, while a powder contains15% Calcium Propionate. Preparation Calcium propionate is produced by reacting calcium hydroxide with propionic acid. Mechanism of Action Calcium propionate suppresses mold and bacteria growth on bread and cakes, but does not inhibit yeast. However, its addition to bread does not interfere with the fermentation of yeast. Calcium ion affects the chemical leaving action, therefore is not usually utilized in cake. Since it can enrich bread and rolls, it is normally used in their production. Uses In Food During dough preparation, calcium propionate is added with other ingredients as a preservative and nutritional supplement in food production such as bread, processed meat, other baked goods, dairy products, and whey.  Calcium propionate is mostly effective below pH 5.5, which is relatively equal to the pH required in the dough preparation to effectively control mold. Calcium propionate can assist in lowering the levels of sodium in bread.  Calcium propionate can be used as an browning agent in processed vegetables and fruits.  Other chemicals that can be used as alternatives to calcium propionate is sodium propionate.  In Beverage Calcium propionate is used in preventing the growth of microorganisms in beverages.  In Pharmaceuticals Calcium propionate powder is utilized as an anti-microbial agent.it is also used in retarding mold in key aloe vera holistic therapy for treating numerous infections. Large concentrations of aloe vera liquid that is normally added to feel pellets cannot be made without using calcium propionate to inhibit mold growth on the product.  In Agriculture Calcium propionate is used as a food supplement and in preventing milk fever in cows. The compound can also be used in poultry feed, animal feed, for instance cattle and dog food. It is also used as a pesticide.  In Cosmetics  Calcium propionate E282 inhibit or prevent bacterial growth, therefore protect cosmetic products from spoilage. The material is also used in controlling the pH of personal care and cosmetic products. Industrial Uses Calcium propionate is used in paint and coating additives. It is also used as plating and surface treating agents.  In Photography  Calcium propionate is used in making photo chemicals and photographic supplies.  Regulatory Amount FAO/WHO (1984): Processed cheese 3000mg/kg (alone or in combination with propionic acid, sorbic acid and its salts ). Japan (use propionic acid to count): 2.5g/kg ( the product 3.15g).It is mainly used for bread and pastry. 1.0g calcium salt (monohydrate) equals 0.790g propanoic acid ). The excess of amount will prevent the growth of yeast in the bread, which damages the flavor. It can be used to prevent growth of Aspergillus niger (Asp.Niger), aerobic spore-forming bacteria (B.Subtilis) . USDA, 9CFR, §318.7 (2000): flour products, 0.32% (use wheat flour amount to count, alone or together with the amount of sodium propionate). USDA§381.147 (1994): The new pie dough 3% (use wheat flour amount to count). Calcium salt is generally used in bread while sodium salt is used in West Point .Alkalinity resulting from the use of sodium causes the delaying of the dough fermentation but use of calcium can strengthen the role of calcium. If calcium salt is used in West Point, then it can react to the sodium bicarbonate in the leavening agent, producing insoluble calcium carbonate, which reduces the amount of CO2 generated,so sodium salt is mainly used . Description Calcium propanoate or calcium propionate has the formula Ca(C2H5COO)2. It is the calcium salt of propanoic acid. Chemical Properties white powder(s) or monoclinic crystal(s); uses: mold-retardant additive for bread, tobacco, pharmaceuticals, antifungal agent [HAW93] Uses Calcium Propionate is the salt of propionic acid which functions as a preservative. it is effective against mold, has limited activity against bacteria, and no activity against yeast. it is soluble in water with a solubility of 49 g/100 ml of water at 0°c and insoluble in alcohol. it is less soluble than sodium propionate. its optimum effectiveness is up to ph 5.0 and it has reduced action above ph 6.0. it is used in bakery products, breads, and pizza crust to protect against mold and “rope.” it is also used in cold-pack cheese food and pie fillings. typical usage level is 0.2–0.3% and 0.1–0.4% based on flour weight. Uses As a food additive, it is listed as E number 282 in the Codex Alimentarius. Calcium propanoate is used as a preservative in a wide variety of products, including but not limited to bread, other baked goods, processed meat, whey, and other dairy products. In agriculture, it is used, amongst other things, to prevent milk fever in cows and as a feed supplement Propanoates prevent microbes from producing the energy they need, like benzoates do. However, unlike benzoates, propanoates do not require an acidic environment. Calcium propanoate is used in bakery products as a mold inhibitor, typically at 0.1- 0.4 % (though animal feed may contain up to 1 % ) . When propanoic acid is infused directly into rodents' brains, it produces reversible behavior changes (e.g. hyperactivity, dystonia, social impairment, perseveration ) and brain changes (e.g. innate neuroinflammation, glutathione depletion) that may be used as a model of human autism in rats. According to the Pesticide Action Network North America, calcium propionate is slightly toxic . This rating is not uncommon for food products; vitamin C is also rated by the same standards as being slightly toxic . Calcium propanoate can be used as a fungicide on fruit. Uses Calcium propionate is the most widely used antimycotic in breadmaking. It is often utilized at about 0.2%, flour basis; higher concentrations lead to flavor problems and begin to inhibit yeast fermentation. General Description Calcium propionate is generally used as a food preservative in bread. It has also been reported to reduce milk fever in dairy cows. Safety Profile Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes. Purification Methods Crystallise this antifungal salt from water (2mL/g) by partial evaporation in a desiccator. [Beilstein 2 H 238, 2 II 218, 2 III 516.]   Calcium Propionate Preparation Products And Raw materials Raw materials Calcium carbonate-->Calcium hydroxide-->Propionic acid-->Propionitrile-->Propionamide Preparation Products D-(+)-Pantothenic acid calcium salt

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Calcium Propionate Basic information Description Food preservative Preparation Mechanism of Action Uses Regulatory Amount Product Name: Calcium Propionate Synonyms: bioban-c;calciumpropanoate;CALCIUM PROPIONATECALCIUM PROPIONATECALCIUM PROPIONATECALCIUM PROPIONATE;Propanoicacid,calciumsalt;propionatedecalcium;PROPIONIC ACID HEMICALCIUM SALT;PROPIONIC ACID CALCIUM SALT;CALCIUM PROPIONATE CAS: 4075-81-4 MF: C3H8CaO2 MW: 116.17 EINECS: 223-795-8 Product Categories: Food & Flavor Additives;Ca (Calcium) Compounds;INORGANIC & ORGANIC CHEMICALS;Classes of Metal Compounds;Typical Metal Compounds;Food additives;Food additive Mol File: 4075-81-4.mol   Calcium Propionate Chemical Properties Melting point  300 °C storage temp.  Store below +30°C. solubility  water: soluble1g/10 mL, clear, colorless form  Crystals or Crystalline Powder color  White PH 9.2 (200g/l, H2O, 20℃)(IUCLID) Water Solubility  1 g/10 mL Merck  14,1698 BRN  3698682 Stability: Stable. Hygroscopic. Incompatible with strong oxidizing agents. InChIKey BCZXFFBUYPCTSJ-UHFFFAOYSA-L CAS DataBase Reference 4075-81-4(CAS DataBase Reference) EPA Substance Registry System Calcium propionate (4075-81-4)   Safety Information Risk Statements  36/37/38 Safety Statements  24/25 WGK Germany  2 RTECS  UE8450000 TSCA  Yes HS Code  29155000 Hazardous Substances Data 4075-81-4(Hazardous Substances Data) MSDS Information Provider Language Calcium propionate English SigmaAldrich English ACROS English   Calcium Propionate Usage And Synthesis Description Calcium propionate, also known as calcium salt and propanoic acid is a white powder that has a faint smell. The compound is stable at room temperature. It is hygroscopic and incompatible with strong oxidizing agents. It has a melting point of 300oC and a pH value of 7 to 9. It is slightly soluble in alcohol and fully soluble in water. Calcium Propionate as the newer food antifungal agent, is the calcium salt of propanoic acid which is a antifungal agent. It appears as white crystalline or powder, odorless or having slight specific odor of propionic acid, stable under light and heat , hygroscopic, soluble in water while aqueous solution is alkaline, slightly soluble in methanol and ethanol, not soluble in benzene and acetone. It is deliquescent in moist air and loses crystal water when heated to 120 ℃ .It changes phase at 200~210 ℃ and decomposes to calcium carbonate at 330~340 ℃ . Under acidic conditions, it generates free propanoic acid which is weaker than sorbic acid while stronger than acetic acid, and has an antibacterial effect on Aspergillus niger and gas bacillus rather than yeast . Calcium Propionate is a normal intermediate product of animal metabolism and is safe eaten by animals. It has a broad antibacterial activity to mold bacteria and yeast bacteria, inhibiting the propagation of microorganisms, preventing feed molding, which can be used as a fungicide on food and feed and a preservative for bread and pastries. As a feed additive ,it can effectively prevent feed molding and prolong shelf life of feed . If combined with other inorganic complexes, it can also improve the appetite of livestock, increase milk production in cows, and its dosage is less than 0.3% of the combined feed (use propionic acid to count). Food preservative Calcium Propionate is an acid-type food preservative, with its inhibitory effected by the environmental pH .When PH5.0 minimum inhibitory concentration is 0.01%, PH6.5 is 0.5%. In the acidic medium ,it has a strong inhibitory effect on the various types of fungi, aerobic bacillus or gram-negative bacilli . It has a specific effect on preventing the production of Aflatoxin streptozotocin, but has little effect on the yeast. In the food industry, it is mainly used in vinegar, soy sauce, bread, cakes and soy products,whose maximum usage (use propionic acid to count, the same below)is 2.5g/kg; while the largest usage in the wet dough products is 0.25g/kg . Also ,it can be used for feed antifungal agent. It is used for breads, pastries and cheese preservatives and feed fungicide. Calcium Propionate as a food preservative, calcium propionate is mainly used for bread, because sodium propionate keeps pH of bread rising, delays the fermentation of the dough; sodium propionate is more widely used for cake, because the pastry gets bulky by using leavening agent, there is no problem about yeast development caused by tincrease in the pH . As a feed preservative, sodium propionate is better than calcium propionate. But Calcium Propionate is more stable than sodium propionate. In food industry , except uses for bread, pastries, cheese, Calcium Propionate can also be used for preventing soy sauce from getting moldy which inhibits the refermentation . In medicine, Calcium Propionate can be made into powders, solutions and ointments to treat skin disease caused by parasitic fungi. Ointment (liquid) contains 12.3% sodium propionate, while a powder contains15% Calcium Propionate. Preparation Calcium propionate is produced by reacting calcium hydroxide with propionic acid. Mechanism of Action Calcium propionate suppresses mold and bacteria growth on bread and cakes, but does not inhibit yeast. However, its addition to bread does not interfere with the fermentation of yeast. Calcium ion affects the chemical leaving action, therefore is not usually utilized in cake. Since it can enrich bread and rolls, it is normally used in their production. Uses In Food During dough preparation, calcium propionate is added with other ingredients as a preservative and nutritional supplement in food production such as bread, processed meat, other baked goods, dairy products, and whey.  Calcium propionate is mostly effective below pH 5.5, which is relatively equal to the pH required in the dough preparation to effectively control mold. Calcium propionate can assist in lowering the levels of sodium in bread.  Calcium propionate can be used as an browning agent in processed vegetables and fruits.  Other chemicals that can be used as alternatives to calcium propionate is sodium propionate.  In Beverage Calcium propionate is used in preventing the growth of microorganisms in beverages.  In Pharmaceuticals Calcium propionate powder is utilized as an anti-microbial agent.it is also used in retarding mold in key aloe vera holistic therapy for treating numerous infections. Large concentrations of aloe vera liquid that is normally added to feel pellets cannot be made without using calcium propionate to inhibit mold growth on the product.  In Agriculture Calcium propionate is used as a food supplement and in preventing milk fever in cows. The compound can also be used in poultry feed, animal feed, for instance cattle and dog food. It is also used as a pesticide.  In Cosmetics  Calcium propionate E282 inhibit or prevent bacterial growth, therefore protect cosmetic products from spoilage. The material is also used in controlling the pH of personal care and cosmetic products. Industrial Uses Calcium propionate is used in paint and coating additives. It is also used as plating and surface treating agents.  In Photography  Calcium propionate is used in making photo chemicals and photographic supplies.  Regulatory Amount FAO/WHO (1984): Processed cheese 3000mg/kg (alone or in combination with propionic acid, sorbic acid and its salts ). Japan (use propionic acid to count): 2.5g/kg ( the product 3.15g).It is mainly used for bread and pastry. 1.0g calcium salt (monohydrate) equals 0.790g propanoic acid ). The excess of amount will prevent the growth of yeast in the bread, which damages the flavor. It can be used to prevent growth of Aspergillus niger (Asp.Niger), aerobic spore-forming bacteria (B.Subtilis) . USDA, 9CFR, §318.7 (2000): flour products, 0.32% (use wheat flour amount to count, alone or together with the amount of sodium propionate). USDA§381.147 (1994): The new pie dough 3% (use wheat flour amount to count). Calcium salt is generally used in bread while sodium salt is used in West Point .Alkalinity resulting from the use of sodium causes the delaying of the dough fermentation but use of calcium can strengthen the role of calcium. If calcium salt is used in West Point, then it can react to the sodium bicarbonate in the leavening agent, producing insoluble calcium carbonate, which reduces the amount of CO2 generated,so sodium salt is mainly used . Description Calcium propanoate or calcium propionate has the formula Ca(C2H5COO)2. It is the calcium salt of propanoic acid. Chemical Properties white powder(s) or monoclinic crystal(s); uses: mold-retardant additive for bread, tobacco, pharmaceuticals, antifungal agent [HAW93] Uses Calcium Propionate is the salt of propionic acid which functions as a preservative. it is effective against mold, has limited activity against bacteria, and no activity against yeast. it is soluble in water with a solubility of 49 g/100 ml of water at 0°c and insoluble in alcohol. it is less soluble than sodium propionate. its optimum effectiveness is up to ph 5.0 and it has reduced action above ph 6.0. it is used in bakery products, breads, and pizza crust to protect against mold and “rope.” it is also used in cold-pack cheese food and pie fillings. typical usage level is 0.2–0.3% and 0.1–0.4% based on flour weight. Uses As a food additive, it is listed as E number 282 in the Codex Alimentarius. Calcium propanoate is used as a preservative in a wide variety of products, including but not limited to bread, other baked goods, processed meat, whey, and other dairy products. In agriculture, it is used, amongst other things, to prevent milk fever in cows and as a feed supplement Propanoates prevent microbes from producing the energy they need, like benzoates do. However, unlike benzoates, propanoates do not require an acidic environment. Calcium propanoate is used in bakery products as a mold inhibitor, typically at 0.1- 0.4 % (though animal feed may contain up to 1 % ) . When propanoic acid is infused directly into rodents' brains, it produces reversible behavior changes (e.g. hyperactivity, dystonia, social impairment, perseveration ) and brain changes (e.g. innate neuroinflammation, glutathione depletion) that may be used as a model of human autism in rats. According to the Pesticide Action Network North America, calcium propionate is slightly toxic . This rating is not uncommon for food products; vitamin C is also rated by the same standards as being slightly toxic . Calcium propanoate can be used as a fungicide on fruit. Uses Calcium propionate is the most widely used antimycotic in breadmaking. It is often utilized at about 0.2%, flour basis; higher concentrations lead to flavor problems and begin to inhibit yeast fermentation. General Description Calcium propionate is generally used as a food preservative in bread. It has also been reported to reduce milk fever in dairy cows. Safety Profile Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes. Purification Methods Crystallise this antifungal salt from water (2mL/g) by partial evaporation in a desiccator. [Beilstein 2 H 238, 2 II 218, 2 III 516.]   Calcium Propionate Preparation Products And Raw materials Raw materials Calcium carbonate-->Calcium hydroxide-->Propionic acid-->Propionitrile-->Propionamide Preparation Products D-(+)-Pantothenic acid calcium salt