China Largest Manufacturer factory sales Ethyl maltol CAS 4940-11-8 CAS NO.4940-11-8

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Ethyl maltol Basic information Product Name: Ethyl maltol Synonyms: 6-ETHYL-3-HYDROXY-2-METHYL-4H-PYRAN-4-ONE;3-HYDROXY-2-ETHYL-4-PYRONE;Ethylmaltol (Subject To Patent Free);3-Hydroxy-2-ethyl-4-pyrone,ethyl maltol;ETHYL MALTOL 99+% FCC;ETHYLMALTOL FCCIV;PYRAN-4-ONE,3-HYDROXY-2-METHYL-,2-ETHYLESTER;2-Ethyl-3-hydroxy-4H-pyran-4-one, Ethyl maltol CAS: 4940-11-8 MF: C7H8O3 MW: 140.14 EINECS: 225-582-5 Product Categories: Food Additives;Food & Flavor Additives;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Pyrans;Food and Feed Additive;Food & Feed ADDITIVES;VX:15689727968 Mol File: 4940-11-8.mol   Ethyl maltol Chemical Properties Melting point  85-95 °C (lit.) Boiling point  196.62°C (rough estimate) density  1.1624 (rough estimate) FEMA  3487 | ETHYL MALTOL refractive index  1.4850 (estimate) storage temp.  2-8°C solubility  Chloroform (Slightly), Methanol (Slightly) pka 8.38±0.10(Predicted) form  neat color  White to Pale Yellow JECFA Number 1481 Merck  14,3824 CAS DataBase Reference 4940-11-8(CAS DataBase Reference) NIST Chemistry Reference 4H-pyran-4-one, 2-ethyl-3-hydroxy-(4940-11-8) EPA Substance Registry System 4H-Pyran-4-one, 2-ethyl-3-hydroxy- (4940-11-8)   Safety Information Hazard Codes  Xn Risk Statements  22 Safety Statements  36 WGK Germany  3 RTECS  UQ0840000 HS Code  29329990 Toxicity LD50 orally in male mice, male rats, female rats, chicks (mg/kg): 780, 1150, 1200, 1270 (Gralla) MSDS Information Provider Language SigmaAldrich English   Ethyl maltol Usage And Synthesis Chemical Properties White crystalline solid with characteristic, very sweet, caramel-like odor and taste. In dilute solution it possesses a sweet, fruitlike flavor and odor. Chemical Properties It forms white crystals (mp 90–91°C) with very sweet caramel-like odor, four to six times more potent than maltol. Several syntheses have been developed for its preparation. In a one-pot process, for example, -ethylfurfuryl alcohol is treated with halogen to give 4-halo- 6-hydroxy-2-ethyl-2H-pyran-3(6H)-one, which need not be isolated and can be converted to ethylmaltol by aqueous hydrolysis Chemical Properties Ethyl maltol has a very sweet, fruit-like odor of immense tenacity and sweet, fruity taste with initial bitter-tart flavor; rapid loss of flavor per se. It is four to six times more potent than maltol. Occurrence Has apparently not been reported to occur in nature. History In 1891, Bernhardi first discovered synthesis, and its derivatives are used for therapeutic purposes and can be prepared in industrial experiments. As war ammunition, it was first used by France in fortress warfare, and was prepared before the war. In October 1914, the French used it as a gas grenade, planned for the fortress battle. On January 7, 1915, it was actually used in the forest of Argonnen on the western front of France. Uses Ethyl Maltol is an extract from medicinal plants such as P. Incarnata and can be used as an anticonvulsant, acting as a depressant, and on motor activity. Uses Ethyl Maltol is a flavoring agent that is a white, crystalline powder. it has a unique odor and a sweet taste that resembles fruit. the melt- ing point is 90°c. it is sparingly soluble in water and propylene gly- col and soluble in alcohol and chloroform. it is obtained by chemical synthesis. Uses Flavor and fragrance enhancer in foods, especially baked goods, beverages, and synthetic berry and citrus flavorings; minimizes undesirable flavors in tobacco products, cough syrup, vitamins, cosmetics, and saccharin-containing products. Preparation Several syntheses have been developed for its preparation. In a one-pot process, for example, -ethylfurfuryl alcohol is treated with halogen to give 4-halo- 6-hydroxy-2-ethyl-2H-pyran-3(6H)-one, which need not be isolated and can be converted to ethylmaltol by aqueous hydrolysis. Production Methods Unlike maltol, ethyl maltol does not occur naturally. It may be prepared by treating a-ethylfurfuryl alcohol with a halogen to produce 4-halo-6-hydroxy-2-ethyl-2H-pyran-3(6H)-one, which is converted to ethyl maltol by hydrolysis. Preparation Fermentation method. Kojic acid is obtained from starch fermentation, and then ethyl maltol is obtained by etherification, oxidation, debenzylation, decarboxylation, hydroxylation and reduction. Pyrofuroic acid method. A solution of pyrofuroic acid and acetic acid at a temperature of 90°C was added dropwise to the ether solution of diacetyl peroxide within 1~2h, and then the mixture was raised to 2h within 2h. 110 ° C, so that the 2-position of pyrofuroic acid can be directly alkylated to obtain ethyl maltol. furfuryl alcohol method. Furfuryl alcohol is chlorinated in methanol aqueous solution by introducing chlorine gas to generate 4-chloro-3-hydroxy-4H-ketone, and then heated and hydrolyzed to obtain pyrofuroic acid; under alkaline conditions, pyrofuroic acid is condensed with acetaldehyde to obtain hydroxyethyl Pyrofuroic acid, which is reduced to ethyl maltol with zinc powder in hydrochloric acid. Furfural method. Furfural reacts with ethylmagnesium bromide to obtain ethylfurfuryl alcohol (α-furan alkanol), which is then oxidized by chlorine gas in methanol aqueous solution at 0°C, and then heated to 100°C for hydrolysis to obtain ethyl maltol. Taste threshold values Taste characteristics at 70 ppm: sweet, burnt cotton, sugar candy-like with jamy, strawberry notes. General Description Ethyl maltol is a synthetic homologue of maltol, often found as flavor enhancers and it contributes to the fragrance of commercials products such as cereals, breads, malt beverages, coffee, soybeans and chocolate milk. Pharmaceutical Applications Ethyl maltol is used in pharmaceutical formulations and food products as a flavoring agent or flavor enhancer in applications similar to maltol. It has a flavor and odor 4–6 times as intense asmaltol. Ethyl maltol is used in oral syrups at concentrations of about 0.004% w/v and also at low levels in perfumery. Safety Profile Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Safety In animal feeding studies, ethyl maltol has been shown to be well tolerated with no adverse toxic, reproductive, or embryogenic effects. It has been reported that while the acute toxicity of ethyl maltol, in animal studies, is slightly greater than maltol, with repeated dosing the opposite is true. The WHO has set an acceptable daily intake for ethyl maltol at up to 2 mg/kg bodyweight. LD50 (chicken, oral): 1.27 g/kg LD50 (rat, oral): 1.15 g/kg LD50 (mouse, oral): 0.78 g/kg LD50 (mouse, SC): 0.91 g/kg Chemical Synthesis From kojic acid Metabolism When orally administered, ethyl maltol was rapidly and extensively absorbed. Elimination was also extensive and rapid, involving conjugation as the glucuronide and ethereal sulphate, and excretion in the urine to the extent of 65-70% within 24 hr. Rate studies after iv dosage indicated that the bulk (86%) of the recovered conjugates was excreted within 6 hr (Rennhard, 1971). storage Solutions may be stored in glass or plastic containers. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (oral syrup).   Ethyl maltol Preparation Products And Raw materials Raw materials Diethyl ether-->Ammonium chloride-->Chlorine-->Benzyl chloride-->Manganese dioxide-->Bromoethane-->Sodium chlorate-->CHLOROETHANE-->Furfural-->Furfuryl alcohol-->2-Furoic acid-->CARAMEL-->Benzyl ether-->Kojic acid-->Pyromeconic acid

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Ethyl maltol Basic information Product Name: Ethyl maltol Synonyms: 6-ETHYL-3-HYDROXY-2-METHYL-4H-PYRAN-4-ONE;3-HYDROXY-2-ETHYL-4-PYRONE;Ethylmaltol (Subject To Patent Free);3-Hydroxy-2-ethyl-4-pyrone,ethyl maltol;ETHYL MALTOL 99+% FCC;ETHYLMALTOL FCCIV;PYRAN-4-ONE,3-HYDROXY-2-METHYL-,2-ETHYLESTER;2-Ethyl-3-hydroxy-4H-pyran-4-one, Ethyl maltol CAS: 4940-11-8 MF: C7H8O3 MW: 140.14 EINECS: 225-582-5 Product Categories: Food Additives;Food & Flavor Additives;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Pyrans;Food and Feed Additive;Food & Feed ADDITIVES;VX:15689727968 Mol File: 4940-11-8.mol   Ethyl maltol Chemical Properties Melting point  85-95 °C (lit.) Boiling point  196.62°C (rough estimate) density  1.1624 (rough estimate) FEMA  3487 | ETHYL MALTOL refractive index  1.4850 (estimate) storage temp.  2-8°C solubility  Chloroform (Slightly), Methanol (Slightly) pka 8.38±0.10(Predicted) form  neat color  White to Pale Yellow JECFA Number 1481 Merck  14,3824 CAS DataBase Reference 4940-11-8(CAS DataBase Reference) NIST Chemistry Reference 4H-pyran-4-one, 2-ethyl-3-hydroxy-(4940-11-8) EPA Substance Registry System 4H-Pyran-4-one, 2-ethyl-3-hydroxy- (4940-11-8)   Safety Information Hazard Codes  Xn Risk Statements  22 Safety Statements  36 WGK Germany  3 RTECS  UQ0840000 HS Code  29329990 Toxicity LD50 orally in male mice, male rats, female rats, chicks (mg/kg): 780, 1150, 1200, 1270 (Gralla) MSDS Information Provider Language SigmaAldrich English   Ethyl maltol Usage And Synthesis Chemical Properties White crystalline solid with characteristic, very sweet, caramel-like odor and taste. In dilute solution it possesses a sweet, fruitlike flavor and odor. Chemical Properties It forms white crystals (mp 90–91°C) with very sweet caramel-like odor, four to six times more potent than maltol. Several syntheses have been developed for its preparation. In a one-pot process, for example, -ethylfurfuryl alcohol is treated with halogen to give 4-halo- 6-hydroxy-2-ethyl-2H-pyran-3(6H)-one, which need not be isolated and can be converted to ethylmaltol by aqueous hydrolysis Chemical Properties Ethyl maltol has a very sweet, fruit-like odor of immense tenacity and sweet, fruity taste with initial bitter-tart flavor; rapid loss of flavor per se. It is four to six times more potent than maltol. Occurrence Has apparently not been reported to occur in nature. History In 1891, Bernhardi first discovered synthesis, and its derivatives are used for therapeutic purposes and can be prepared in industrial experiments. As war ammunition, it was first used by France in fortress warfare, and was prepared before the war. In October 1914, the French used it as a gas grenade, planned for the fortress battle. On January 7, 1915, it was actually used in the forest of Argonnen on the western front of France. Uses Ethyl Maltol is an extract from medicinal plants such as P. Incarnata and can be used as an anticonvulsant, acting as a depressant, and on motor activity. Uses Ethyl Maltol is a flavoring agent that is a white, crystalline powder. it has a unique odor and a sweet taste that resembles fruit. the melt- ing point is 90°c. it is sparingly soluble in water and propylene gly- col and soluble in alcohol and chloroform. it is obtained by chemical synthesis. Uses Flavor and fragrance enhancer in foods, especially baked goods, beverages, and synthetic berry and citrus flavorings; minimizes undesirable flavors in tobacco products, cough syrup, vitamins, cosmetics, and saccharin-containing products. Preparation Several syntheses have been developed for its preparation. In a one-pot process, for example, -ethylfurfuryl alcohol is treated with halogen to give 4-halo- 6-hydroxy-2-ethyl-2H-pyran-3(6H)-one, which need not be isolated and can be converted to ethylmaltol by aqueous hydrolysis. Production Methods Unlike maltol, ethyl maltol does not occur naturally. It may be prepared by treating a-ethylfurfuryl alcohol with a halogen to produce 4-halo-6-hydroxy-2-ethyl-2H-pyran-3(6H)-one, which is converted to ethyl maltol by hydrolysis. Preparation Fermentation method. Kojic acid is obtained from starch fermentation, and then ethyl maltol is obtained by etherification, oxidation, debenzylation, decarboxylation, hydroxylation and reduction. Pyrofuroic acid method. A solution of pyrofuroic acid and acetic acid at a temperature of 90°C was added dropwise to the ether solution of diacetyl peroxide within 1~2h, and then the mixture was raised to 2h within 2h. 110 ° C, so that the 2-position of pyrofuroic acid can be directly alkylated to obtain ethyl maltol. furfuryl alcohol method. Furfuryl alcohol is chlorinated in methanol aqueous solution by introducing chlorine gas to generate 4-chloro-3-hydroxy-4H-ketone, and then heated and hydrolyzed to obtain pyrofuroic acid; under alkaline conditions, pyrofuroic acid is condensed with acetaldehyde to obtain hydroxyethyl Pyrofuroic acid, which is reduced to ethyl maltol with zinc powder in hydrochloric acid. Furfural method. Furfural reacts with ethylmagnesium bromide to obtain ethylfurfuryl alcohol (α-furan alkanol), which is then oxidized by chlorine gas in methanol aqueous solution at 0°C, and then heated to 100°C for hydrolysis to obtain ethyl maltol. Taste threshold values Taste characteristics at 70 ppm: sweet, burnt cotton, sugar candy-like with jamy, strawberry notes. General Description Ethyl maltol is a synthetic homologue of maltol, often found as flavor enhancers and it contributes to the fragrance of commercials products such as cereals, breads, malt beverages, coffee, soybeans and chocolate milk. Pharmaceutical Applications Ethyl maltol is used in pharmaceutical formulations and food products as a flavoring agent or flavor enhancer in applications similar to maltol. It has a flavor and odor 4–6 times as intense asmaltol. Ethyl maltol is used in oral syrups at concentrations of about 0.004% w/v and also at low levels in perfumery. Safety Profile Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Safety In animal feeding studies, ethyl maltol has been shown to be well tolerated with no adverse toxic, reproductive, or embryogenic effects. It has been reported that while the acute toxicity of ethyl maltol, in animal studies, is slightly greater than maltol, with repeated dosing the opposite is true. The WHO has set an acceptable daily intake for ethyl maltol at up to 2 mg/kg bodyweight. LD50 (chicken, oral): 1.27 g/kg LD50 (rat, oral): 1.15 g/kg LD50 (mouse, oral): 0.78 g/kg LD50 (mouse, SC): 0.91 g/kg Chemical Synthesis From kojic acid Metabolism When orally administered, ethyl maltol was rapidly and extensively absorbed. Elimination was also extensive and rapid, involving conjugation as the glucuronide and ethereal sulphate, and excretion in the urine to the extent of 65-70% within 24 hr. Rate studies after iv dosage indicated that the bulk (86%) of the recovered conjugates was excreted within 6 hr (Rennhard, 1971). storage Solutions may be stored in glass or plastic containers. The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (oral syrup).   Ethyl maltol Preparation Products And Raw materials Raw materials Diethyl ether-->Ammonium chloride-->Chlorine-->Benzyl chloride-->Manganese dioxide-->Bromoethane-->Sodium chlorate-->CHLOROETHANE-->Furfural-->Furfuryl alcohol-->2-Furoic acid-->CARAMEL-->Benzyl ether-->Kojic acid-->Pyromeconic acid