China Largest Manufacturer factory sales 4-Hydroxycinnamic Acid CAS 501-98-4 CAS NO.501-98-4

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p-Coumaric acid Basic information Product Name: p-Coumaric acid Synonyms: (e)-3-(4-hydroxyphenyl)-2-propenoicacid;trans-p-hydroxycinnamicacid;TRANS-P-COUMARIC ACID;TRANS-P-CUMARIC ACID;TRANS-4-COUMARIC ACID;TRANS-4-HYDROXYCINNAMIC ACID;AKOS BAR-2479;AKOS 221-47 CAS: 501-98-4 MF: C9H8O3 MW: 164.16 EINECS: 610-511-6 Product Categories: Antioxidant;Auxins;Aromatic Cinnamic Acids, Esters and Derivatives;Biochemistry;Plant Growth Regulators;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;501-98-4 Mol File: 501-98-4.mol   p-Coumaric acid Chemical Properties Melting point  214 °C (dec.)(lit.) Boiling point  231.61°C (rough estimate) density  1.1403 (rough estimate) refractive index  1.4500 (estimate) storage temp.  Keep in dark place,Sealed in dry,Room Temperature solubility  ethanol: soluble50mg/mL pka 4.65±0.10(Predicted) form  Powder color  Off-white to beige or greenish Water Solubility  soluble Merck  14,2560 BRN  2207383 InChIKey NGSWKAQJJWESNS-ZZXKWVIFSA-N CAS DataBase Reference 501-98-4(CAS DataBase Reference) NIST Chemistry Reference p-Hydroxycinnamic acid(501-98-4) EPA Substance Registry System 2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)- (501-98-4)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  2 RTECS  GD9095000 HS Code  29163990 MSDS Information Provider Language 4-Hydroxycinnamic acid English ACROS English SigmaAldrich English ALFA English   p-Coumaric acid Usage And Synthesis Chemical Properties Off-white to beige or greenish powder Uses trans-p-Coumaric Acid is the E-isomer of p-Coumaric Acid (C755365), a hydroxy derivative of Cinnamic Acid with antioxidant properties. p-Coumaric acid is a is a major component of lignocellulose. Stud ies suggest that p-Coumaric Acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines. Uses trans-4-Hydroxycinnamic acid is used as a hydroxycinnamic acid with antioxidant properties. p-Coumaric acid is an aromatic phytochemical for proteomics research. Application p-Coumaric acid has been used as a component of chemiluminescent substrate for protein detection in western blotting. Definition ChEBI: The trans-isomer of 4-coumaric acid. 4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate. Biochem/physiol Actions p-Coumaric acid is mainly a plant metabolite which exhibits antioxidant and anti-inflammatory properties. It also shows bactericidal activity by damaging bacterial cell membrane and by interacting with bacterial DNA. In western blot, p-coumaric is also used as an enhancer in chemiluminescent substrate. Hydroxycinnamic acid found in many fruits and vegetables. Purification Methods Crystallise p-coumaric acid from H2O (charcoal). It forms needles from concentrated aqueous solutions as the anhydrous acid, but from hot dilute solutions the monohydrate acid separates on slow cooling. The acid (33g) has been crystallised from 2.5L of H2O (1.5g charcoal) yielding 28.4g of recrystallised acid, m 207o. It is insoluble in *C6H6 or pet ether. The UV in 95% EtOH has max 223 and 286nm ( 14,450 and 19000 M-1cm-1). [UV Wheeler & Covarrubias J Org Chem 28 2015 1963, Corti Helv Chim Acta 32 681 1949, Beilstein 10 IV 1005.]   p-Coumaric acid Preparation Products And Raw materials Raw materials Ethyl acetate-->Potassium hydroxide-->Phenol-->4-Hydroxycoumarin-->2-Hexanone-->O-ACETYLSALICYLOYL CHLORIDE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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p-Coumaric acid Basic information Product Name: p-Coumaric acid Synonyms: (e)-3-(4-hydroxyphenyl)-2-propenoicacid;trans-p-hydroxycinnamicacid;TRANS-P-COUMARIC ACID;TRANS-P-CUMARIC ACID;TRANS-4-COUMARIC ACID;TRANS-4-HYDROXYCINNAMIC ACID;AKOS BAR-2479;AKOS 221-47 CAS: 501-98-4 MF: C9H8O3 MW: 164.16 EINECS: 610-511-6 Product Categories: Antioxidant;Auxins;Aromatic Cinnamic Acids, Esters and Derivatives;Biochemistry;Plant Growth Regulators;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;501-98-4 Mol File: 501-98-4.mol   p-Coumaric acid Chemical Properties Melting point  214 °C (dec.)(lit.) Boiling point  231.61°C (rough estimate) density  1.1403 (rough estimate) refractive index  1.4500 (estimate) storage temp.  Keep in dark place,Sealed in dry,Room Temperature solubility  ethanol: soluble50mg/mL pka 4.65±0.10(Predicted) form  Powder color  Off-white to beige or greenish Water Solubility  soluble Merck  14,2560 BRN  2207383 InChIKey NGSWKAQJJWESNS-ZZXKWVIFSA-N CAS DataBase Reference 501-98-4(CAS DataBase Reference) NIST Chemistry Reference p-Hydroxycinnamic acid(501-98-4) EPA Substance Registry System 2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)- (501-98-4)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  2 RTECS  GD9095000 HS Code  29163990 MSDS Information Provider Language 4-Hydroxycinnamic acid English ACROS English SigmaAldrich English ALFA English   p-Coumaric acid Usage And Synthesis Chemical Properties Off-white to beige or greenish powder Uses trans-p-Coumaric Acid is the E-isomer of p-Coumaric Acid (C755365), a hydroxy derivative of Cinnamic Acid with antioxidant properties. p-Coumaric acid is a is a major component of lignocellulose. Stud ies suggest that p-Coumaric Acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines. Uses trans-4-Hydroxycinnamic acid is used as a hydroxycinnamic acid with antioxidant properties. p-Coumaric acid is an aromatic phytochemical for proteomics research. Application p-Coumaric acid has been used as a component of chemiluminescent substrate for protein detection in western blotting. Definition ChEBI: The trans-isomer of 4-coumaric acid. 4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate. Biochem/physiol Actions p-Coumaric acid is mainly a plant metabolite which exhibits antioxidant and anti-inflammatory properties. It also shows bactericidal activity by damaging bacterial cell membrane and by interacting with bacterial DNA. In western blot, p-coumaric is also used as an enhancer in chemiluminescent substrate. Hydroxycinnamic acid found in many fruits and vegetables. Purification Methods Crystallise p-coumaric acid from H2O (charcoal). It forms needles from concentrated aqueous solutions as the anhydrous acid, but from hot dilute solutions the monohydrate acid separates on slow cooling. The acid (33g) has been crystallised from 2.5L of H2O (1.5g charcoal) yielding 28.4g of recrystallised acid, m 207o. It is insoluble in *C6H6 or pet ether. The UV in 95% EtOH has max 223 and 286nm ( 14,450 and 19000 M-1cm-1). [UV Wheeler & Covarrubias J Org Chem 28 2015 1963, Corti Helv Chim Acta 32 681 1949, Beilstein 10 IV 1005.]   p-Coumaric acid Preparation Products And Raw materials Raw materials Ethyl acetate-->Potassium hydroxide-->Phenol-->4-Hydroxycoumarin-->2-Hexanone-->O-ACETYLSALICYLOYL CHLORIDE