China Biggest Manufacturer factory sales Hesperitin CAS 520-33-2 CAS NO.520-33-2

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Hesperetin Basic information Product Name: Hesperetin Synonyms: 4'-METHOXY-3',5,7-TRIHYDROXYFLAVANONE;(+/-)-3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE;3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE;3',5,7-TRIHYDROXY-4-METHOXYFLAVANONE;2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE;5,7,3'-TRIHYDROXY-4'-METHOXYFLAVANONE;HESPERETINE;(+/-)-HESPERETIN CAS: 520-33-2 MF: C16H14O6 MW: 302.28 EINECS: 208-290-2 Product Categories: natural product;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Biochemistry;Flavonoids;Natural Plant Extract;Inhibitors;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;CITRIMORE;Flavanones Mol File: 520-33-2.mol   Hesperetin Chemical Properties Melting point  230-232°C Boiling point  363.32°C (rough estimate) density  1.2514 (rough estimate) refractive index  -4 ° (C=1.8, EtOH) storage temp.  Inert atmosphere,Room Temperature solubility  DMSO (Slightly), Methanol (Slightly) form  Solid pka 7.49±0.40(Predicted) color  White to Pale Yellow Water Solubility  Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml). Merck  14,4670 BRN  309850 InChIKey AIONOLUJZLIMTK-AWEZNQCLSA-N CAS DataBase Reference 520-33-2(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36/37/39-27-37 WGK Germany  3 HS Code  29329990 MSDS Information Provider Language SigmaAldrich English ALFA English   Hesperetin Usage And Synthesis Description Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation. Chemical Properties Beige to Light Brown Crystalline Solid Uses The aglucon of Hesperidin (H281185), a flavanone found in citrus fruits. Uses antiallergic Uses (±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage. Definition ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-). Purification Methods Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]   Hesperetin Preparation Products And Raw materials Preparation Products BETA-PHENYLPROPIOPHENONE-->Neosperidin dihydrochalcone

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Hesperetin Basic information Product Name: Hesperetin Synonyms: 4'-METHOXY-3',5,7-TRIHYDROXYFLAVANONE;(+/-)-3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE;3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE;3',5,7-TRIHYDROXY-4-METHOXYFLAVANONE;2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE;5,7,3'-TRIHYDROXY-4'-METHOXYFLAVANONE;HESPERETINE;(+/-)-HESPERETIN CAS: 520-33-2 MF: C16H14O6 MW: 302.28 EINECS: 208-290-2 Product Categories: natural product;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Biochemistry;Flavonoids;Natural Plant Extract;Inhibitors;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;CITRIMORE;Flavanones Mol File: 520-33-2.mol   Hesperetin Chemical Properties Melting point  230-232°C Boiling point  363.32°C (rough estimate) density  1.2514 (rough estimate) refractive index  -4 ° (C=1.8, EtOH) storage temp.  Inert atmosphere,Room Temperature solubility  DMSO (Slightly), Methanol (Slightly) form  Solid pka 7.49±0.40(Predicted) color  White to Pale Yellow Water Solubility  Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml). Merck  14,4670 BRN  309850 InChIKey AIONOLUJZLIMTK-AWEZNQCLSA-N CAS DataBase Reference 520-33-2(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36/37/39-27-37 WGK Germany  3 HS Code  29329990 MSDS Information Provider Language SigmaAldrich English ALFA English   Hesperetin Usage And Synthesis Description Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation. Chemical Properties Beige to Light Brown Crystalline Solid Uses The aglucon of Hesperidin (H281185), a flavanone found in citrus fruits. Uses antiallergic Uses (±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage. Definition ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-). Purification Methods Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]   Hesperetin Preparation Products And Raw materials Preparation Products BETA-PHENYLPROPIOPHENONE-->Neosperidin dihydrochalcone