China Largest Manufacturer factory sales Pyridoxamine Dihydrochloride CAS 524-36-7 CAS NO.524-36-7

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Pyridoxamine dihydrochloride Basic information Product Name: Pyridoxamine dihydrochloride Synonyms: PYRIDOXAMINE HCL;Pyridoxamine Dihydrochloride Monohydrate;2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine dihydrochloride;Dyridoxamine hydrochloride;Pyridoxamine·2hydrochloride;vitamin B6dihydrochloride;Pyridoxamine dihydrochloride,4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride;Pyridoxamine dihydro CAS: 524-36-7 MF: C8H14Cl2N2O2 MW: 241.11 EINECS: 208-357-6 Product Categories: Isolabel;Vitamins and derivatives;Aromatics Compounds;Aromatics;Bases & Related Reagents;Nucleotides;Pyridinium Compounds Mol File: 524-36-7.mol   Pyridoxamine dihydrochloride Chemical Properties Melting point  224-226 °C (dec.)(lit.) density  1.4025 (rough estimate) refractive index  1.6100 (estimate) storage temp.  Inert atmosphere,Store in freezer, under -20°C solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly) form  Powder or Solid pka pKa 3.31(H2O t = 25 I = 0.1)(Approximate) color  White to off-white to pale brown Water Solubility  Soluble in DMSO, water, or methanol /n Merck  7980 BRN  3632748 CAS DataBase Reference 524-36-7(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  2 RTECS  UV1230000 HazardClass  IRRITANT HS Code  29333990 MSDS Information Provider Language Pyridoxamine dihydrochloride English SigmaAldrich English   Pyridoxamine dihydrochloride Usage And Synthesis Description Pyridoxamine dihydrochloride is a salt of pyridoxamine, which belongs to the family of vitamin B6 compounds. Pyridoxamine occurs naturally in animal-based food products. Its deficiency in humans potentially causes sideroblastic anemia, weakness, insomnia, and neurological disorders. It has been reported to have been effective against diabetic nephropathy. Use in mammalian cell culture as an alternative to pyridoxine or pyridoxal. Vitamin B6 is a required component of cell culture media. Historically, media have been supplemented with vitamin B6 in the aldehyde form, pyridoxal. While this is a biologically active form of vitamin B6, it is unstable in liquid media. When cells are able to utilize either pyridoxine and/or pyridoxamine, they are preferred supplement versus pyridoxal. A number of classical media are now offered with a choice between pyridoxal and pyridoxine as the vitamin A source. # context=product Chemical Properties White crystalline powder Uses Pyridoxamine dihydrochloride blocks pathogenic oxidative pathways in the progression of diabetic nephropathy. Pyridoxamine dihydrochloride, a derivative of vitaminB6 and potent inhibitor of AGE formation has been shown slowDKD progression, but only in patients with relatively preservedkidney function (i.e., baseline SCr 1.3 to 1.9 mg/dL). Pyridoxamine dihydrochloride (Pyridorin, NephroGenex) inhibits formation of advanced glycation end products and scavenges reactive oxygen species and toxic carbonyls. Whether these effects translate into kidney protection is unknown, although a year-long study of the effects of pyridoxamine dihydrochlo-ride in patients with type 2 diabetes and proteinuria failed to show a difference in kidney function decline with pyri-doxamine dihydrochloride in daily doses of 300 or 600 mg versus placebo treatment. Uses Pyridoxamine Dihydrochloride (cas# 524-36-7) is a compound useful in organic synthesis. Definition ChEBI: A hydrochloride obtained by combining pyridoxamine with two molar equivalents of hydrochloric acid. Used for treatment of diabetic nephropathy. Preparation The invention relates to a preparation method of pyridoxamine dihydrochloride, belonging to the technical field of the preparation of water soluble vitamins. The preparation method comprises the following steps: preparing pyridoxal oxime: taking pyridoxine hydrochloride as initial raw material and water as a reaction medium, adding activated manganese dioxide and concentrated sulfuric acid to generate pyridoxal by the reaction, and then reacting with anhydrous sodium acetate and hydroxylamine hydrochloride to obtain pyridoxal oxime; preparing pyridoxamine dihydrochloride: firstly enabling pyridoxal oxime to react with acetic acid and zinc to obtain acetic acid solution containing pyridoxamine, then decompressing the solution and reclaiming the acetic acid to obtain slurry concentrate, decompressing and reclaiming the acetic acid again to obtain pyridoxamine water solution, regulating the pH value to be alkaline so as to separate pyridoxamine out, adding water and hydrochloric acid after vacuum filteration, decoloring and filtering to obtain filtrate, decompressing and concentrating the filtrate until white solids are separated out, adding solvent and stirring, and finally crystallizing at the lower temperature, filtering and drying to obtain the pyridoxamine dihydrochloride. The invention has the advantages that the prepared pyridoxamine dihydrochloride has high total mol yield and purity, and the preparation method is reduced. # Purification Methods The amine salt is crystallised from hot MeOH. The free base crystallises from EtOH with m 193-193.5o [Harris et al. J Biol Chem 154 315 1944, J Am Chem Soc 66 2088 1944]. [Beilstein 22 IV 6064, 22/12 V 324.]   Pyridoxamine dihydrochloride Preparation Products And Raw materials Raw materials Manganese dioxide-->Pyridoxine hydrochloride Preparation Products Pyridoxal phosphate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Pyridoxamine dihydrochloride Basic information Product Name: Pyridoxamine dihydrochloride Synonyms: PYRIDOXAMINE HCL;Pyridoxamine Dihydrochloride Monohydrate;2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine dihydrochloride;Dyridoxamine hydrochloride;Pyridoxamine·2hydrochloride;vitamin B6dihydrochloride;Pyridoxamine dihydrochloride,4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride;Pyridoxamine dihydro CAS: 524-36-7 MF: C8H14Cl2N2O2 MW: 241.11 EINECS: 208-357-6 Product Categories: Isolabel;Vitamins and derivatives;Aromatics Compounds;Aromatics;Bases & Related Reagents;Nucleotides;Pyridinium Compounds Mol File: 524-36-7.mol   Pyridoxamine dihydrochloride Chemical Properties Melting point  224-226 °C (dec.)(lit.) density  1.4025 (rough estimate) refractive index  1.6100 (estimate) storage temp.  Inert atmosphere,Store in freezer, under -20°C solubility  DMSO (Slightly), Methanol (Slightly), Water (Slightly) form  Powder or Solid pka pKa 3.31(H2O t = 25 I = 0.1)(Approximate) color  White to off-white to pale brown Water Solubility  Soluble in DMSO, water, or methanol /n Merck  7980 BRN  3632748 CAS DataBase Reference 524-36-7(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  2 RTECS  UV1230000 HazardClass  IRRITANT HS Code  29333990 MSDS Information Provider Language Pyridoxamine dihydrochloride English SigmaAldrich English   Pyridoxamine dihydrochloride Usage And Synthesis Description Pyridoxamine dihydrochloride is a salt of pyridoxamine, which belongs to the family of vitamin B6 compounds. Pyridoxamine occurs naturally in animal-based food products. Its deficiency in humans potentially causes sideroblastic anemia, weakness, insomnia, and neurological disorders. It has been reported to have been effective against diabetic nephropathy. Use in mammalian cell culture as an alternative to pyridoxine or pyridoxal. Vitamin B6 is a required component of cell culture media. Historically, media have been supplemented with vitamin B6 in the aldehyde form, pyridoxal. While this is a biologically active form of vitamin B6, it is unstable in liquid media. When cells are able to utilize either pyridoxine and/or pyridoxamine, they are preferred supplement versus pyridoxal. A number of classical media are now offered with a choice between pyridoxal and pyridoxine as the vitamin A source. # context=product Chemical Properties White crystalline powder Uses Pyridoxamine dihydrochloride blocks pathogenic oxidative pathways in the progression of diabetic nephropathy. Pyridoxamine dihydrochloride, a derivative of vitaminB6 and potent inhibitor of AGE formation has been shown slowDKD progression, but only in patients with relatively preservedkidney function (i.e., baseline SCr 1.3 to 1.9 mg/dL). Pyridoxamine dihydrochloride (Pyridorin, NephroGenex) inhibits formation of advanced glycation end products and scavenges reactive oxygen species and toxic carbonyls. Whether these effects translate into kidney protection is unknown, although a year-long study of the effects of pyridoxamine dihydrochlo-ride in patients with type 2 diabetes and proteinuria failed to show a difference in kidney function decline with pyri-doxamine dihydrochloride in daily doses of 300 or 600 mg versus placebo treatment. Uses Pyridoxamine Dihydrochloride (cas# 524-36-7) is a compound useful in organic synthesis. Definition ChEBI: A hydrochloride obtained by combining pyridoxamine with two molar equivalents of hydrochloric acid. Used for treatment of diabetic nephropathy. Preparation The invention relates to a preparation method of pyridoxamine dihydrochloride, belonging to the technical field of the preparation of water soluble vitamins. The preparation method comprises the following steps: preparing pyridoxal oxime: taking pyridoxine hydrochloride as initial raw material and water as a reaction medium, adding activated manganese dioxide and concentrated sulfuric acid to generate pyridoxal by the reaction, and then reacting with anhydrous sodium acetate and hydroxylamine hydrochloride to obtain pyridoxal oxime; preparing pyridoxamine dihydrochloride: firstly enabling pyridoxal oxime to react with acetic acid and zinc to obtain acetic acid solution containing pyridoxamine, then decompressing the solution and reclaiming the acetic acid to obtain slurry concentrate, decompressing and reclaiming the acetic acid again to obtain pyridoxamine water solution, regulating the pH value to be alkaline so as to separate pyridoxamine out, adding water and hydrochloric acid after vacuum filteration, decoloring and filtering to obtain filtrate, decompressing and concentrating the filtrate until white solids are separated out, adding solvent and stirring, and finally crystallizing at the lower temperature, filtering and drying to obtain the pyridoxamine dihydrochloride. The invention has the advantages that the prepared pyridoxamine dihydrochloride has high total mol yield and purity, and the preparation method is reduced. # Purification Methods The amine salt is crystallised from hot MeOH. The free base crystallises from EtOH with m 193-193.5o [Harris et al. J Biol Chem 154 315 1944, J Am Chem Soc 66 2088 1944]. [Beilstein 22 IV 6064, 22/12 V 324.]   Pyridoxamine dihydrochloride Preparation Products And Raw materials Raw materials Manganese dioxide-->Pyridoxine hydrochloride Preparation Products Pyridoxal phosphate