Hot Sales!!!!!!!!!+China Biggest Manufacturer supply Pterostilbene CAS NO.537-42-8

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Pterostilbene Basic information Product Name: Pterostilbene Synonyms: AKOS 236-80;3,5-DIMETHOXY-4'-HYDROXYSTILBENE;3',5'-DIMETHOXY-4-STILBENOL;4-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]PHENOL;PTEROSTILBENE;PTEROCARPUS MARSUPIUM;TRANS-3,5-DIMETHOXY-4'-HYDROXYSTILBENE;(E)-3,5-Dimethoxy-4'-hydroxystilbene CAS: 537-42-8 MF: C16H16O3 MW: 256.3 EINECS: 611-041-4 Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Health supplements;Herb extract;Inhibitors Mol File: 537-42-8.mol   Pterostilbene Chemical Properties Melting point  89-92 ºC Boiling point  420.4±35.0 °C(Predicted) density  1.169±0.06 g/cm3(Predicted) storage temp.  2-8°C solubility  DMSO: >20mg/mL pka 9.96±0.26(Predicted) form  solid color  White or off-white λmax 321nm(MeOH)(lit.) Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.   Safety Information Hazard Codes  Xi,N Risk Statements  41-51/53 Safety Statements  26-39-61 RIDADR  3077 WGK Germany  3 HazardClass  IRRITANT PackingGroup  Ⅲ HS Code  29095000 MSDS Information   Pterostilbene Usage And Synthesis Description Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a naturally derived compound found primarily in blueberries and Pterocarpus marsupium (PM) heartwood. Pterostilbene is structurally similar to resveratrol, a compound found in red wine that has comparable antioxidant, anti-inflammatory, and anticarcinogenic properties; however, pterostilbene exhibits increased bioavailability due to the presence of two methoxy groups which cause it to exhibit increased lipophilic and oral absorption. In plants, it serves a defensive phytoalexin role. Chemical Properties Pterostilbene is a white to off-white solid and It is a stilbenoid chemically similar to resveratrol and is found in grapes, wine and berries (Rimando et al. 2004). Pterostilbene is generated by plants in response to microbial infestation or exposure to ultraviolet light (Langcake 1981). Pterostilbene is closely related structurally to resveratrol (a naturally occurring dimethylether analogue of resveratrol) and shows many of the same characteristics, as well as its own unique therapeutic potential (Rimando et al. 2002). Occurrence Pterostilbene is found in almonds,various Vaccinium berries (including blueberries), grape leaves and vines,and Pterocarpus marsupium heartwood. Uses Pterostilbene has been used: to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells) to study its effects on the cytotoxicity of 2-chloroethyl ethyl sulphide (CEES) in human epidermoid carcinoma cells (A-431) through MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide)viability assay Definition ChEBI: Pterostilbene is a stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'. It has a role as an antioxidant, an antineoplastic agent, a neurotransmitter, a plant metabolite, an apoptosis inducer, a neuroprotective agent, an anti-inflammatory agent, a radical scavenger and a hypoglycemic agent. It is a stilbenol, a member of methoxybenzenes and a diether. It derives from a hydride of a trans-stilbene. benefits Pterostilbene is a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Pterostilbene is known to have many pharmacological benefits for the prevention and treatment of a wide variety of diseases, including ( cancer (McCormack and McFadden 2012), dyslipidaemia (Rimando et al. 2005), diabetes (Amarnath Satheesh and Pari 2006), cardiovascular degeneration (Amarnath Satheesh and Pari 2008) and pain (Hougee et al. 2005). Antioxidant and antiinfamatory effects of pterostilbene are also demonstrated (Roupe et al. 2006, PereCko et al. 2010, Hsu et al. 2013). Pterostilbene possesses strong, dose-dependent antioxidant effects (Rimando et al. 2002, Amorati et al.2004). The antioxidant activity of pterostilbene was first demonstrated in vitro by its inhibition of methyl linoleate oxidation (Roupe et al. 2006). It inhibits the production of hydroxyl radicals (Perecko et al. 2010). In terms of the antiinfamatory effect of pterostilbene, Hsu et al. (2013) demonstrated that pterostilbene downregulates inflammatory TNF-0, IL-6, cyclooxygenase-2, inducible nitric oxide synthase, IL-1β, monocyte chemotactic protein-l, C-reactive protein and plasminogen activator inhibitor-1 expression by inhibiting the activation of NF-KB. General Description A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox (Cat. No. 64847). Moderately inhibits COX-1 & COX-2 activities (IC50 = 19.8 μM & 83.9 μM, respectively) and induces apoptosis in HL60 cells (IC50 = 70 μM). Also prevents DMBA-induced pre-neoplastic lesions (ED50 = 4.8 μM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin. Biochem/physiol Actions Cell permeable: yes References 1) Siedlecka-Kroplewska et al. (2013), Pterostilbene induces accumulation of autophagic vacuoles followed by cell death in HL60 human leukemia cells; J. Physiol. Pharmacol., 64 545 2) Acharya et al. (2013), Protective effect of Pterostilbene against free radical mediated oxidative damage; BMC Complement. Altern. Med., 13 238 3) McCormack et al. (2012), Pterostilbene ameliorates tumor necrosis factor alpha-induced pancreatitis in vitro; Infect. J. Surg. Res., 178 28 4) Lin et al. (2012), Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells; J. Agric. Food Chem., 60 6399   Pterostilbene Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Product Name:	Pterostilbene
Synonyms:	AKOS 236-80;3,5-DIMETHOXY-4'-HYDROXYSTILBENE;3',5'-DIMETHOXY-4-STILBENOL;4-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]PHENOL;PTEROSTILBENE;PTEROCARPUS MARSUPIUM;TRANS-3,5-DIMETHOXY-4'-HYDROXYSTILBENE;(E)-3,5-Dimethoxy-4'-hydroxystilbene
CAS:	537-42-8
MF:	C16H16O3
MW:	256.3
EINECS:	611-041-4
Product Categories:	chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Health supplements;Herb extract;Inhibitors
Mol File:	537-42-8.mol