China Biggest Manufacturer factory sales Sodium Salicylate CAS 54-21-7 CAS NO.54-21-7

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Sodium salicylate Basic information Product Name: Sodium salicylate Synonyms: Sdium salicylate;Sodium Salicylate 2-Hydroxybenzoic acid monosodium salt Sodium o-hydroxybenzoate;Sodium salicylate BP98;SODIUM SALICYLATE R. G., REAG. PH. EUR.;SODIUM SALICYLATE, REAGENTPLUS TM, >= 99.5%;SODIUM SALICYLATE, PH EUR;SODIUM SALICYLATE, REAGENTPLUS, >=99%;SodiumSalicylatePurified CAS: 54-21-7 MF: C7H5NaO3 MW: 160.1 EINECS: 200-198-0 Product Categories: API;IDOCYL;Pharmaceutical intermediate Mol File: 54-21-7.mol   Sodium salicylate Chemical Properties Melting point  >300 °C (lit.) density  0.32 g/cm3 (20℃) storage temp.  Store at +15°C to +25°C. solubility  1000g/l form  Crystals or Crystalline Powder color  White PH 6.5 (100g/l, H2O, 20℃) Water Solubility  1000 g/L (20 ºC) Sensitive  Light Sensitive Merck  14,8332 BRN  3732792 Stability: Stable. Incompatible with mineral acids, metallic salts, iodine. May be light-sensitive. InChIKey ABBQHOQBGMUPJH-UHFFFAOYSA-M CAS DataBase Reference 54-21-7(CAS DataBase Reference) EPA Substance Registry System Sodium salicylate (54-21-7)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-41-36/37/38-36 Safety Statements  26-36 WGK Germany  1 RTECS  VO5075000 F  8 Autoignition Temperature >250 °C TSCA  Yes HS Code  29182100 Toxicity LD50 i.p. in rats: 780 mg/kg (Goldenthal) MSDS Information Provider Language 2-Hydroxybenzoic acid sodium salt English SigmaAldrich English ACROS English ALFA English   Sodium salicylate Usage And Synthesis Description Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux. Chemical Properties Sodium salicylate, HOC6H4COONa, is a shiny, white powder with sweetish taste and mild aromatic aroma that is soluble in water,glycerol, and alcohol.Used in medicine and as a preservative. Chemical Properties Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19. Uses keratolytic Uses In manufacture of aspirin, methyl salicylate, and other salicylates. Coupling agent for azo dyes. Has been used as food preservative. Uses It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non - steroidal anti - inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultra violet radiation and electrons. Definition A salt or ester of salicylic acid. Brand name Alysine (Marion Merrell Dow). General Description Sodium salicylate may be prepared by the reaction, in aqueoussolution, by adding equal molar ratio of salicylic acidand sodium bicarbonate; evaporating to dryness yields thewhite salt. In solution, particularly in the presence of sodiumbicarbonate, the salt will darken on standing. This is the saltof choice for salicylate medication and usually is administeredwith sodium bicarbonate to lessen gastric distress, or itis administered in enteric coated tablets. However, the useof sodium bicarbonate is ill advised, because it decreases theplasma levels of salicylate and increases the excretion offree salicylate in the urine. Sodium salicylate, even though not as potent as aspirinfor pain relief, also has less GI irritation and is useful for patientswho are hypersensitive to aspirin. Biochem/physiol Actions Cell permeable: yes Safety Profile Experimental poison by subcutaneous route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by multiple and unspecified routes: toxic psychosis, excitement, respiratory stimulation, nausea or vomiting, and sweating. Experimental reproductive effects. Mutation data reported. A powerful irritant which affects the central nervous system. Incompatible with ferric salts, mineral acids, iodme, lead acetate, silver nitrate, sodium phosphate powder. When heated to decomposition it emits toxic fumes of Na2O.   Sodium salicylate Preparation Products And Raw materials Raw materials Sodium dithionite-->Salicylic acid-->Ethylenediaminetetraacetic acid Preparation Products Salicylic acid-->Benzyl salicylate-->3,6-DICHLORO-2-HYDROXY BENZOIC ACID-->Mordant Yellow 1-->2-Hydroxyethyl salicylate-->Mordant Orange 1-->Choline salicylate-->2,6-DI-O-METHYL-BETA-CYCLODEXTRIN-->2-Chlorobenzotrichloride

                                Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

Sodium salicylate Basic information Product Name: Sodium salicylate Synonyms: Sdium salicylate;Sodium Salicylate 2-Hydroxybenzoic acid monosodium salt Sodium o-hydroxybenzoate;Sodium salicylate BP98;SODIUM SALICYLATE R. G., REAG. PH. EUR.;SODIUM SALICYLATE, REAGENTPLUS TM, >= 99.5%;SODIUM SALICYLATE, PH EUR;SODIUM SALICYLATE, REAGENTPLUS, >=99%;SodiumSalicylatePurified CAS: 54-21-7 MF: C7H5NaO3 MW: 160.1 EINECS: 200-198-0 Product Categories: API;IDOCYL;Pharmaceutical intermediate Mol File: 54-21-7.mol   Sodium salicylate Chemical Properties Melting point  >300 °C (lit.) density  0.32 g/cm3 (20℃) storage temp.  Store at +15°C to +25°C. solubility  1000g/l form  Crystals or Crystalline Powder color  White PH 6.5 (100g/l, H2O, 20℃) Water Solubility  1000 g/L (20 ºC) Sensitive  Light Sensitive Merck  14,8332 BRN  3732792 Stability: Stable. Incompatible with mineral acids, metallic salts, iodine. May be light-sensitive. InChIKey ABBQHOQBGMUPJH-UHFFFAOYSA-M CAS DataBase Reference 54-21-7(CAS DataBase Reference) EPA Substance Registry System Sodium salicylate (54-21-7)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-41-36/37/38-36 Safety Statements  26-36 WGK Germany  1 RTECS  VO5075000 F  8 Autoignition Temperature >250 °C TSCA  Yes HS Code  29182100 Toxicity LD50 i.p. in rats: 780 mg/kg (Goldenthal) MSDS Information Provider Language 2-Hydroxybenzoic acid sodium salt English SigmaAldrich English ACROS English ALFA English   Sodium salicylate Usage And Synthesis Description Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux. Chemical Properties Sodium salicylate, HOC6H4COONa, is a shiny, white powder with sweetish taste and mild aromatic aroma that is soluble in water,glycerol, and alcohol.Used in medicine and as a preservative. Chemical Properties Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19. Uses keratolytic Uses In manufacture of aspirin, methyl salicylate, and other salicylates. Coupling agent for azo dyes. Has been used as food preservative. Uses It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non - steroidal anti - inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultra violet radiation and electrons. Definition A salt or ester of salicylic acid. Brand name Alysine (Marion Merrell Dow). General Description Sodium salicylate may be prepared by the reaction, in aqueoussolution, by adding equal molar ratio of salicylic acidand sodium bicarbonate; evaporating to dryness yields thewhite salt. In solution, particularly in the presence of sodiumbicarbonate, the salt will darken on standing. This is the saltof choice for salicylate medication and usually is administeredwith sodium bicarbonate to lessen gastric distress, or itis administered in enteric coated tablets. However, the useof sodium bicarbonate is ill advised, because it decreases theplasma levels of salicylate and increases the excretion offree salicylate in the urine. Sodium salicylate, even though not as potent as aspirinfor pain relief, also has less GI irritation and is useful for patientswho are hypersensitive to aspirin. Biochem/physiol Actions Cell permeable: yes Safety Profile Experimental poison by subcutaneous route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by multiple and unspecified routes: toxic psychosis, excitement, respiratory stimulation, nausea or vomiting, and sweating. Experimental reproductive effects. Mutation data reported. A powerful irritant which affects the central nervous system. Incompatible with ferric salts, mineral acids, iodme, lead acetate, silver nitrate, sodium phosphate powder. When heated to decomposition it emits toxic fumes of Na2O.   Sodium salicylate Preparation Products And Raw materials Raw materials Sodium dithionite-->Salicylic acid-->Ethylenediaminetetraacetic acid Preparation Products Salicylic acid-->Benzyl salicylate-->3,6-DICHLORO-2-HYDROXY BENZOIC ACID-->Mordant Yellow 1-->2-Hydroxyethyl salicylate-->Mordant Orange 1-->Choline salicylate-->2,6-DI-O-METHYL-BETA-CYCLODEXTRIN-->2-Chlorobenzotrichloride