China Largest Manufacturer factory Supply Isonicotinic acid CAS 55-22-1 CAS NO.55-22-1

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Isonicotinic acid Basic information Product Name: Isonicotinic acid Synonyms: 4-PYRIDINECARBOXYLIC ACID FOR SYNTHESIS;Isonicotinic aci;66 kDa neurofilament protein;ANTI-INA (ALPHA INTERNEXIN) (CENTER) antibody produced in rabbit;NEF5;Neurofilament 5;Pyridine-4-carboxylic acid, 4-Carboxypyridine;Isonicotinic acid, CP,98% CAS: 55-22-1 MF: C6H5NO2 MW: 123.11 EINECS: 200-228-2 Product Categories: Building Blocks;C6;Nitrogen cyclic compounds;API's;Chemical Synthesis;Heterocyclic Building Blocks;Pyridine;API intermediates;Heterocycles;Pyridines;carboxylic acid Mol File: 55-22-1.mol   Isonicotinic acid Chemical Properties Melting point  ≥300 °C (lit.) Boiling point  260 °C (15 mmHg) density  1,47g/cm refractive index  1.5423 (estimate) Fp  260°C/15mm storage temp.  no restrictions. solubility  6g/l pka 4.96(at 25℃) form  powder color  yellow to tan PH 3-4 (6g/l, H2O, 20℃)(saturated solution) Water Solubility  5.2 g/L (20 ºC) Merck  14,5187 BRN  109599 InChIKey TWBYWOBDOCUKOW-UHFFFAOYSA-N CAS DataBase Reference 55-22-1(CAS DataBase Reference) NIST Chemistry Reference Isonicotinic acid(55-22-1) EPA Substance Registry System Isonicotinic acid (55-22-1)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  2 RTECS  NS1103000 TSCA  Yes HS Code  29333999 Toxicity LD50 orally in Rabbit: 5000 mg/kg MSDS Information Provider Language Isonicotinic acid English ACROS English SigmaAldrich English ALFA English   Isonicotinic acid Usage And Synthesis Chemical Properties isonicotinic acid is also known as pyridine-4-carboxylic acid. white to light yellow crystal powder or white needle crystals. odorless, sublimable. molecular weight 123.11. melting point 319°C . slightly soluble in cold water, soluble in hot water, insoluble in alcohol, benzene and ether. isonicotinic acid is an amphoteric compound that is soluble in both acids and bases. soluble in hot water and ethanol, slightly soluble in cold water and ether. stable to heat and oxidation. Uses Isonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. The chronic toxicity of isonicotinic acid is slightly higher than that of isonicotinic acid hydrazide ( INH ) . Isonicotinic acid is a moderately basic compound (based on its pKa). Isonicotinic acid is an organic compound with a carboxyl group on a pyridine ring. The carboxyl group for isonicotinic acid is on the 4-position instead of the 3-position for nicotinic acid. It is an isomer of nicotinic acid. Isonicotinic acid is a metabolite of isoniazid. Isonicotinic acid considered to be inactive isomer of nicotinic acid. Isonicotinic acid is a metabolite of pyridine-4-carboxy hydrazide (isonicotinyl hydrazide; isoniazid) a front-line weapon in the battle against tuberculosis. Isonicotinic acid and its derivatives are used in manufacturing pharmaceuticals and agrochemicals. Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines Definition ChEBI: Isonicotinic acid is a pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring. It has a role as a human metabolite and an algal metabolite. It is a conjugate acid of an isonicotinate. Preparation Isonicotinic acid is synthesized by continuous oxidation with 4-methylpyridine as raw material and vanadium pentoxide as catalyst. The purity of the industrial product isonicotinic acid is more than 95%, and the yield of the above method is 70-75%. The consumption of 4-methylpyridine per ton of product is 1070kg. Application Isonicotinic acid (IN) can be used as: An organocatalyst in the one pot four component condensation reaction, to synthesize pyranopyrazoles based heterocyclic compounds. An organic ligand for the preparation of copper(I) halide coordination polymer [CuBr(IN)]n, by hydrothermal method. As a starting material for the synthesis of cation-dimers with potent antimalarial activity. Purification Methods Crystallise the acid repeatedly from water and dry it under vacuum at 110o or sublime it at 260o/15mm (m 319o). [Beilstein 22 III/IV 518, 22/2 V 188.]   Isonicotinic acid Preparation Products And Raw materials Raw materials Vanadium(V) oxide Preparation Products 2-Chloro-4-pyridinecarboxylic acid-->Forchlorfenuron-->4-Amino-2-chloropyridine-->4-ISOCYANATOPYRIDINE-->ISONICOTINOYL CHLORIDE HYDROCHLORIDE-->2-IODO-ISONICOTINIC ACID-->3-BROMO-N-PHENYLPYRIDINE-4-CARBOXAMIDE-->2-SULFANYLISONICOTINIC ACID-->2,5-BIS(4-PYRIDYL)-1,3,4-THIADIAZOLE-->3-Bromoisonicotinic acid-->2-Chloropyridine-4-carbonyl chloride-->4-(Ethylaminomethyl)pyridine-->N-PHENYLISONICOTINAMIDE-->Isoniazid-->4-Pyridylcarbinol-->Isonicotinic acid chloride-->3,4-Pyridinedicarboxylic acid-->Ethyl isonicotinate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Isonicotinic acid Basic information Product Name: Isonicotinic acid Synonyms: 4-PYRIDINECARBOXYLIC ACID FOR SYNTHESIS;Isonicotinic aci;66 kDa neurofilament protein;ANTI-INA (ALPHA INTERNEXIN) (CENTER) antibody produced in rabbit;NEF5;Neurofilament 5;Pyridine-4-carboxylic acid, 4-Carboxypyridine;Isonicotinic acid, CP,98% CAS: 55-22-1 MF: C6H5NO2 MW: 123.11 EINECS: 200-228-2 Product Categories: Building Blocks;C6;Nitrogen cyclic compounds;API's;Chemical Synthesis;Heterocyclic Building Blocks;Pyridine;API intermediates;Heterocycles;Pyridines;carboxylic acid Mol File: 55-22-1.mol   Isonicotinic acid Chemical Properties Melting point  ≥300 °C (lit.) Boiling point  260 °C (15 mmHg) density  1,47g/cm refractive index  1.5423 (estimate) Fp  260°C/15mm storage temp.  no restrictions. solubility  6g/l pka 4.96(at 25℃) form  powder color  yellow to tan PH 3-4 (6g/l, H2O, 20℃)(saturated solution) Water Solubility  5.2 g/L (20 ºC) Merck  14,5187 BRN  109599 InChIKey TWBYWOBDOCUKOW-UHFFFAOYSA-N CAS DataBase Reference 55-22-1(CAS DataBase Reference) NIST Chemistry Reference Isonicotinic acid(55-22-1) EPA Substance Registry System Isonicotinic acid (55-22-1)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  2 RTECS  NS1103000 TSCA  Yes HS Code  29333999 Toxicity LD50 orally in Rabbit: 5000 mg/kg MSDS Information Provider Language Isonicotinic acid English ACROS English SigmaAldrich English ALFA English   Isonicotinic acid Usage And Synthesis Chemical Properties isonicotinic acid is also known as pyridine-4-carboxylic acid. white to light yellow crystal powder or white needle crystals. odorless, sublimable. molecular weight 123.11. melting point 319°C . slightly soluble in cold water, soluble in hot water, insoluble in alcohol, benzene and ether. isonicotinic acid is an amphoteric compound that is soluble in both acids and bases. soluble in hot water and ethanol, slightly soluble in cold water and ether. stable to heat and oxidation. Uses Isonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. The chronic toxicity of isonicotinic acid is slightly higher than that of isonicotinic acid hydrazide ( INH ) . Isonicotinic acid is a moderately basic compound (based on its pKa). Isonicotinic acid is an organic compound with a carboxyl group on a pyridine ring. The carboxyl group for isonicotinic acid is on the 4-position instead of the 3-position for nicotinic acid. It is an isomer of nicotinic acid. Isonicotinic acid is a metabolite of isoniazid. Isonicotinic acid considered to be inactive isomer of nicotinic acid. Isonicotinic acid is a metabolite of pyridine-4-carboxy hydrazide (isonicotinyl hydrazide; isoniazid) a front-line weapon in the battle against tuberculosis. Isonicotinic acid and its derivatives are used in manufacturing pharmaceuticals and agrochemicals. Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines Definition ChEBI: Isonicotinic acid is a pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring. It has a role as a human metabolite and an algal metabolite. It is a conjugate acid of an isonicotinate. Preparation Isonicotinic acid is synthesized by continuous oxidation with 4-methylpyridine as raw material and vanadium pentoxide as catalyst. The purity of the industrial product isonicotinic acid is more than 95%, and the yield of the above method is 70-75%. The consumption of 4-methylpyridine per ton of product is 1070kg. Application Isonicotinic acid (IN) can be used as: An organocatalyst in the one pot four component condensation reaction, to synthesize pyranopyrazoles based heterocyclic compounds. An organic ligand for the preparation of copper(I) halide coordination polymer [CuBr(IN)]n, by hydrothermal method. As a starting material for the synthesis of cation-dimers with potent antimalarial activity. Purification Methods Crystallise the acid repeatedly from water and dry it under vacuum at 110o or sublime it at 260o/15mm (m 319o). [Beilstein 22 III/IV 518, 22/2 V 188.]   Isonicotinic acid Preparation Products And Raw materials Raw materials Vanadium(V) oxide Preparation Products 2-Chloro-4-pyridinecarboxylic acid-->Forchlorfenuron-->4-Amino-2-chloropyridine-->4-ISOCYANATOPYRIDINE-->ISONICOTINOYL CHLORIDE HYDROCHLORIDE-->2-IODO-ISONICOTINIC ACID-->3-BROMO-N-PHENYLPYRIDINE-4-CARBOXAMIDE-->2-SULFANYLISONICOTINIC ACID-->2,5-BIS(4-PYRIDYL)-1,3,4-THIADIAZOLE-->3-Bromoisonicotinic acid-->2-Chloropyridine-4-carbonyl chloride-->4-(Ethylaminomethyl)pyridine-->N-PHENYLISONICOTINAMIDE-->Isoniazid-->4-Pyridylcarbinol-->Isonicotinic acid chloride-->3,4-Pyridinedicarboxylic acid-->Ethyl isonicotinate