China Largest Manufacturer factory sales L-ASPARTIC ACID CAS 56-84-8 CAS NO.56-84-8

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L-Aspartic acid Basic information Chemical Properties Uses Production Product Name: L-Aspartic acid Synonyms: L-Aspartic acidUSP, 98.5-101.5% (Titration: anhydrous basis);(s)-butanedioicaci;alpha-Aminosuccinic acid;Asparagic acid;asparagicacid;Asparaginic acid;asparaginicacid;asparaginsaeure CAS: 56-84-8 MF: C4H7NO4 MW: 133.1 EINECS: 200-291-6 Product Categories: amino;aspartic acid;amino acid;bio-chemical;chemicals;food additive;Food & Feed ADDITIVES;Aspartic acid [Asp, D];Amino Acids and Derivatives;food additives;food flavor;organic acids;pharmaceutical intermediate;sweetener;chiral;alpha-Amino Acids;Amino Acids;Biochemistry;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;Nutritional Supplements;L-Amino Acids;Amino Acids;Glutamate receptor Mol File: 56-84-8.mol   L-Aspartic acid Chemical Properties Melting point  >300 °C (dec.)(lit.) alpha  25 º (c=8, 6N HCl) Boiling point  245.59°C (rough estimate) density  1.66 FEMA  3656 | L-ASPARTIC ACID refractive index  1.4540 (estimate) storage temp.  Store below +30°C. solubility  H2O: 5 mg/mL form  powder pka 1.99(at 25℃) color  White PH 2.5-3.5 (4g/l, H2O, 20℃) Odor acid taste optical activity [α]20/D +24.7±1°, c = 5% in 5 M HCl Water Solubility  5 g/L (25 ºC) λmax λ: 260 nm Amax: 0.20 λ: 280 nm Amax: 0.10 JECFA Number 1429 Merck  14,840 BRN  1723530 Stability: Stable. Combustible. Incompatible with strong oxidising agents. InChIKey CKLJMWTZIZZHCS-REOHCLBHSA-N CAS DataBase Reference 56-84-8(CAS DataBase Reference) NIST Chemistry Reference Aspartic acid(56-84-8) EPA Substance Registry System Aspartic acid (56-84-8)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36-36/37/38-20/21/22 Safety Statements  26-24/25-22-36 WGK Germany  2 RTECS  CI9098500 F  10 TSCA  Yes HazardClass  IRRITANT HS Code  29224995 Hazardous Substances Data 56-84-8(Hazardous Substances Data) Toxicity LD50 intraperitoneal in mouse: 6gm/kg MSDS Information Provider Language L-Aminosuccinic acid English ACROS English SigmaAldrich English ALFA English   L-Aspartic acid Usage And Synthesis Chemical Properties The product is white crystal or crystalline powder, slightly sour in taste. Soluble in boiling water, slightly soluble in water at 25℃(0.5%), freely soluble in dilute acid and sodium hydroxide solution and insoluble in ethanol and ethyl ether. It decomposes when heated to 270 ℃. Its isoelectric point is 2.77 and its specific rotation is associated with the soluble solvent. It is dextral in the acid solution and water solution, but levorotary in the alkali solution. [α]25D+5.05 (C=0.5-2.0 g/ml, H2O). Combined with HNO2, alcohol or acyl chloride, it can produce L- malic acid, ester and amide respectively. It is the ingredient of unripe sugarcane and beet molasses. Uses It is used as an electrolyte supplement for aminophenol transfusion, inorganic ion supplement (K+, Ca+, etc.) and fatigue restorer. Potassium magnesium aspartate injection or oral solution can be used for arrhythmia, premature beat, tachycardia, hypokalemia, hypomagnesemia, heart failure, myocardial infarction, angina pectoris, hepatitis, cirrhosis and other diseases caused by cardiac glycoside poisoning. Due to its low toxicity, this product cannot be injected without dilution, and the patients with renal insufficiency and atrioventricular conduction block should use it with caution. Production L- aspartic acid is mainly produced by enzymatic method. L- aspartase acts on the fumaric acid and ammonia, that is, which generates L- aspartic acid. Strain Culturing: Eschrichia coli Asl.881 was cultured. The common meat juice medium is agarslantculture-medium. The vase medium comprises corn steep liquor 7.5%, fumaric acid 2.0% and MgSO4 7H2O 0.02%. Adjust the pH value of solution to 6.0 with ammonia water, then put 50-100ml culture medium into 500ml cone bottle after boiling and filtering. Take the fresh cultivated seeds on the slope or in the liquid, inoculate culture medium in shake flask, shake overnight at 37℃, adjust pH to 5.0 with 1mol/L HCl after enlarging culture step by step to 1000-2000L, cool it to room temperature after keeping 45℃ for 1h, centrifuge in rotary supercentrifuge and collect the thallus including aspartase. Immobilize aspartase: Make a bioreactor to take out 20kg E.Coli wet cell, suspend it in the culture supernatant after centrifugation in 80L (or 80L saline), keep it at 40℃ and then add 90L 12% gelatin solution and 1.0% glutaraldehyde solution, which should be held 40℃.  Stir well, set aside to cool down and solidify, soak in 0.25% glutaraldehyde solution, hold 5℃ after an overnight, cut into small pieces ( 3-5 mm3) , soak in 0.25% glutaraldehyde solution at 5℃ for a night, take it out and elut with water, drain to obtain immobilized E.Coli containing aspartase and load it into filled bioreactor in reserve. Conversion: The solution of 1 mol/L of ammonium fumarate (including 1mmol/L MgCl2, pH8.5) substrate, which keeps 37℃, flows through a bioreactor at a constant speed (SV) continuously in the case of controlling the maximum conversion rate over 95% and then the conversion solution is obtained. Roughhew and refine:  Add 1 mol/L of HCl into the conversion solution gradually to adjust pH valkue to 2.8, place at 5℃ overnight for crystallizing, filter to prepare crystallization, drain after water washing, drying at 105℃ to obtain L- aspartic acid crude. Use dilute ammonia to recrystallize, dissolve into 15% solution (pH5.0) with ammonia, add 1% activated carbon, stir and fade for 1h when heat to 70℃, filter immediately to remove slag, cool the filtrate, hold 5℃ overnight for crystallizing, filter to get crystallization and obtain the L-Aspartic acid finished products after vacuum drying at 85℃. Description L-Aspartic acid is the L-form of the aspartic acid. It is one of the 20 amino acids that used in the protein synthesis. It is the non-essential amino acids for humans as it can be synthesized in vivo. It is important in the synthesis of other amino acids and some nucleotides, and is a metabolite in the citric acid and urea cycles. In animals, it may be used as a neurotransmitter. It can be chemically synthesize from the diethyl sodium phthalimidomalonate. Currently, almost all the aspartic acids are manufactured in China. Its application include being used as low calorie sweetener (as the part of the aspartame), scale and corrosion inhibitor, and in resins. One of its growing applications is for the manufacturing of biodegradable superabsorbent polymer, polyaspartic acid. It can also be used in fertilizer industry to improve water retention and nitrogen uptake. Chemical Properties Colorless crystals. Soluble in water; insoluble in alcohol and ether. Optically active. dl-aspartic acid. Chemical Properties Aspartic acid (abbreviated as Asp or D) is an α-amino acid with the chemical formula HOOCCH(NH2 )CH2COOH. The carboxylate anion, salt, or ester of aspartic acid is known as aspartate. The Lisomer of aspartate is one of the 20 proteinogenic amino acids, i.e., the building blocks of proteins. Its codons are GAU and GAC. Aspartic acid is, together with glutamic acid, classified as an acidic amino acid with a pKa of 3.9, however in a peptide the pKa is highly dependent on the local environment. A pKa as high as 14 is not at all uncommon. Aspartate is pervasive in biosynthesis. As with all amino acids, the presence of acid protons depends on the residue's local chemical environment and the pH of the solution. Chemical Properties Apartic acid is an aliphatic monoaminodicarboxylic acid (amino acid) and is a well-known constituent of protein. It has a slight acid taste Occurrence Dietary sources Aspartic acid is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans. Aspartic acid is found in : Animal sources : luncheon meats, sausage meat, wild game Vegetable sources: sprouting seeds, oat flakes, avocado, asparagus , young sugarcane, and molasses from sugar beets. Chemical synthesis Racemic aspartic acid can be synthesized from diethyl sodium phthalimido malonate, (C6H4(CO)2NC(CO2Et)2). The major disadvantage of the above technique is that equimolar amounts of each enantiomer are made. Using biotechnology it is now possible to use immobilized enzymes to create just one type of enantiomer owing to their stereo specificity. Aspartic acid is made synthetically using ammonium fumarate and aspartase from E.coli, E.coli usually breaks down the aspartic acid as a nitrogen source but using excess amounts of ammonium fumarate a reversal of the enzyme's job is possible, and so aspartic acid is made to very high yields, 98.7 mM from 1 M. History Aspartic acid was first discovered in 1827 by Plisson, derived from asparagine, which had been isolated from asparagus juice in 1806, by boiling with a base. Uses L-Aspartic acid is used as a component of parenteral and enteral nutrition and as a pharmaceutical ingredient. it is used for cell culture and in manufacturing processes. It is widely utilized for mineral supplementation in the salt form. Uses L-aspartic acid is used as a dietary supplement, it can be blended with minerals to make compounds like potassium aspartate, copper aspartate, manganese aspartate, magnesium aspartate, zinc aspartate and more. Increasing the absorption, and hence utilization potentials, of these minerals via the addition of aspartate induces certain health benefits. Many athletes use L-aspartic acid-based mineral supplements orally to enhance their performance capacities. Aspartic acid and glutamic acid play important roles as general acids in enzyme active centers, as well as in maintaining the solubility and ionic character of proteins. It can help promote a robust metabolism, and is sometimes used to treat fatigue and depression. Aspartic acid is used as a component of parenteral and enteral nutrition. In pharmaceutical agents aspartic acid is used as an ammoniac detoxicating agent, hepar function accelerator and fatigue refresher. Uses l-aspartic acid is an amino acid used as a skin-conditioning agent. Definition ChEBI: The L-enantiomer of aspartic acid. Aroma threshold values Detection: 300 ppb General Description To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement. Hazard Low toxicity. Biological Activity Endogenous NMDA receptor agonist. Biochem/physiol Actions Principal neurotransmitter for fast synaptic excitation. Safety Profile Low toxicity by intraperitoneal route. When heated to decomposition emits toxic fumes of NOx. Chemical Synthesis Enzymatically, aspartic acid is reversibly synthesized by a transamination reaction between oxaloacetic acid and glutamic acid in the presence of pyridoxal phosphate. Chemical Synthesis Aspartate is non - essential in mammals, being produced from oxaloacetate by transamination. It can also be generated from ornithine and citrulline in the urea cycle. In plants and microorganisms, aspartate is the precursor to several amino acids, including four that are essential for humans: methionine, threonine, isoleucine, and lysine. The conversion of aspartate to these other amino acids begins with reduction of aspartate to its "semi aldehyde," O2CCH(NH2)CH2CHO. Asparagine is derived from aspartate via trans amidation : -O2CCH(NH2)CH2CO2 - + G C (O)NH3+ O2CCH(NH2)CH2CONH3+ + GC(O)O (where GC(O)NH2 and GC(O)OH are glutamine and glutamic acid, respectively). Forms and nomenclature There are two forms or enantiomers of aspartic acid. The name "aspartic acid" can refer to either enantiomer or a mixture of two. Of these two forms, only one, "L - aspartic acid", is directly incorporated into proteins. The biological roles of its counterpart, "Daspartic acid" are more limited. Where enzymatic synthesis will produce one or the other, most chemical syntheses will produce both forms, "DL-aspartic acid," known as a racemic mixture. Other biochemical roles Aspartate is also a metabolite in the urea cycle and participates in gluconeogenesis. It carries reducing equivalents in the malateaspartate shuttle, which utilizes the ready inter conversion of aspartate and oxaloacetate, which is the oxidized (dehydrogenated) derivative of malic acid. Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases. In addition, aspartic acid acts as hydrogen acceptor in a chain of ATP synthase.   L-Aspartic acid Preparation Products And Raw materials Raw materials Sulfuric acid-->Ammonium hydroxide-->Ammonia-->Activated carbon-->Calcium hydroxide-->Α-PROTEIN-->Fumaric acid-->Maleic acid-->Succinic acid-->Gelatin-->Chloroacetamide-->DL-Aspartic acid-->Glutaraldehyde-->L-ASPARTIC ACID-->Aminoacylase Preparation Products L-Alanine-->DL-Aspartic acid-->(S)-3-(Boc-amino)pyrrolidine-->Aspartame-->L-Asparagine-->N-FMOC-L-aspartic acid 4-t-butyl ester-->Sodium L-aspartate-->D-Alaninamide, L-.alpha.-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-, hydrate (2:5)-->L-Lysine-L-aspartate-->Magnesium dihydrogen di-L-aspartate-->N-Cbz-L-Aspartic acid 4-benzyl ester-->Calcium L-aspartate-->3-oxopropanoic acid

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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L-Aspartic acid Basic information Chemical Properties Uses Production Product Name: L-Aspartic acid Synonyms: L-Aspartic acidUSP, 98.5-101.5% (Titration: anhydrous basis);(s)-butanedioicaci;alpha-Aminosuccinic acid;Asparagic acid;asparagicacid;Asparaginic acid;asparaginicacid;asparaginsaeure CAS: 56-84-8 MF: C4H7NO4 MW: 133.1 EINECS: 200-291-6 Product Categories: amino;aspartic acid;amino acid;bio-chemical;chemicals;food additive;Food & Feed ADDITIVES;Aspartic acid [Asp, D];Amino Acids and Derivatives;food additives;food flavor;organic acids;pharmaceutical intermediate;sweetener;chiral;alpha-Amino Acids;Amino Acids;Biochemistry;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;Nutritional Supplements;L-Amino Acids;Amino Acids;Glutamate receptor Mol File: 56-84-8.mol   L-Aspartic acid Chemical Properties Melting point  >300 °C (dec.)(lit.) alpha  25 º (c=8, 6N HCl) Boiling point  245.59°C (rough estimate) density  1.66 FEMA  3656 | L-ASPARTIC ACID refractive index  1.4540 (estimate) storage temp.  Store below +30°C. solubility  H2O: 5 mg/mL form  powder pka 1.99(at 25℃) color  White PH 2.5-3.5 (4g/l, H2O, 20℃) Odor acid taste optical activity [α]20/D +24.7±1°, c = 5% in 5 M HCl Water Solubility  5 g/L (25 ºC) λmax λ: 260 nm Amax: 0.20 λ: 280 nm Amax: 0.10 JECFA Number 1429 Merck  14,840 BRN  1723530 Stability: Stable. Combustible. Incompatible with strong oxidising agents. InChIKey CKLJMWTZIZZHCS-REOHCLBHSA-N CAS DataBase Reference 56-84-8(CAS DataBase Reference) NIST Chemistry Reference Aspartic acid(56-84-8) EPA Substance Registry System Aspartic acid (56-84-8)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36-36/37/38-20/21/22 Safety Statements  26-24/25-22-36 WGK Germany  2 RTECS  CI9098500 F  10 TSCA  Yes HazardClass  IRRITANT HS Code  29224995 Hazardous Substances Data 56-84-8(Hazardous Substances Data) Toxicity LD50 intraperitoneal in mouse: 6gm/kg MSDS Information Provider Language L-Aminosuccinic acid English ACROS English SigmaAldrich English ALFA English   L-Aspartic acid Usage And Synthesis Chemical Properties The product is white crystal or crystalline powder, slightly sour in taste. Soluble in boiling water, slightly soluble in water at 25℃(0.5%), freely soluble in dilute acid and sodium hydroxide solution and insoluble in ethanol and ethyl ether. It decomposes when heated to 270 ℃. Its isoelectric point is 2.77 and its specific rotation is associated with the soluble solvent. It is dextral in the acid solution and water solution, but levorotary in the alkali solution. [α]25D+5.05 (C=0.5-2.0 g/ml, H2O). Combined with HNO2, alcohol or acyl chloride, it can produce L- malic acid, ester and amide respectively. It is the ingredient of unripe sugarcane and beet molasses. Uses It is used as an electrolyte supplement for aminophenol transfusion, inorganic ion supplement (K+, Ca+, etc.) and fatigue restorer. Potassium magnesium aspartate injection or oral solution can be used for arrhythmia, premature beat, tachycardia, hypokalemia, hypomagnesemia, heart failure, myocardial infarction, angina pectoris, hepatitis, cirrhosis and other diseases caused by cardiac glycoside poisoning. Due to its low toxicity, this product cannot be injected without dilution, and the patients with renal insufficiency and atrioventricular conduction block should use it with caution. Production L- aspartic acid is mainly produced by enzymatic method. L- aspartase acts on the fumaric acid and ammonia, that is, which generates L- aspartic acid. Strain Culturing: Eschrichia coli Asl.881 was cultured. The common meat juice medium is agarslantculture-medium. The vase medium comprises corn steep liquor 7.5%, fumaric acid 2.0% and MgSO4 7H2O 0.02%. Adjust the pH value of solution to 6.0 with ammonia water, then put 50-100ml culture medium into 500ml cone bottle after boiling and filtering. Take the fresh cultivated seeds on the slope or in the liquid, inoculate culture medium in shake flask, shake overnight at 37℃, adjust pH to 5.0 with 1mol/L HCl after enlarging culture step by step to 1000-2000L, cool it to room temperature after keeping 45℃ for 1h, centrifuge in rotary supercentrifuge and collect the thallus including aspartase. Immobilize aspartase: Make a bioreactor to take out 20kg E.Coli wet cell, suspend it in the culture supernatant after centrifugation in 80L (or 80L saline), keep it at 40℃ and then add 90L 12% gelatin solution and 1.0% glutaraldehyde solution, which should be held 40℃.  Stir well, set aside to cool down and solidify, soak in 0.25% glutaraldehyde solution, hold 5℃ after an overnight, cut into small pieces ( 3-5 mm3) , soak in 0.25% glutaraldehyde solution at 5℃ for a night, take it out and elut with water, drain to obtain immobilized E.Coli containing aspartase and load it into filled bioreactor in reserve. Conversion: The solution of 1 mol/L of ammonium fumarate (including 1mmol/L MgCl2, pH8.5) substrate, which keeps 37℃, flows through a bioreactor at a constant speed (SV) continuously in the case of controlling the maximum conversion rate over 95% and then the conversion solution is obtained. Roughhew and refine:  Add 1 mol/L of HCl into the conversion solution gradually to adjust pH valkue to 2.8, place at 5℃ overnight for crystallizing, filter to prepare crystallization, drain after water washing, drying at 105℃ to obtain L- aspartic acid crude. Use dilute ammonia to recrystallize, dissolve into 15% solution (pH5.0) with ammonia, add 1% activated carbon, stir and fade for 1h when heat to 70℃, filter immediately to remove slag, cool the filtrate, hold 5℃ overnight for crystallizing, filter to get crystallization and obtain the L-Aspartic acid finished products after vacuum drying at 85℃. Description L-Aspartic acid is the L-form of the aspartic acid. It is one of the 20 amino acids that used in the protein synthesis. It is the non-essential amino acids for humans as it can be synthesized in vivo. It is important in the synthesis of other amino acids and some nucleotides, and is a metabolite in the citric acid and urea cycles. In animals, it may be used as a neurotransmitter. It can be chemically synthesize from the diethyl sodium phthalimidomalonate. Currently, almost all the aspartic acids are manufactured in China. Its application include being used as low calorie sweetener (as the part of the aspartame), scale and corrosion inhibitor, and in resins. One of its growing applications is for the manufacturing of biodegradable superabsorbent polymer, polyaspartic acid. It can also be used in fertilizer industry to improve water retention and nitrogen uptake. Chemical Properties Colorless crystals. Soluble in water; insoluble in alcohol and ether. Optically active. dl-aspartic acid. Chemical Properties Aspartic acid (abbreviated as Asp or D) is an α-amino acid with the chemical formula HOOCCH(NH2 )CH2COOH. The carboxylate anion, salt, or ester of aspartic acid is known as aspartate. The Lisomer of aspartate is one of the 20 proteinogenic amino acids, i.e., the building blocks of proteins. Its codons are GAU and GAC. Aspartic acid is, together with glutamic acid, classified as an acidic amino acid with a pKa of 3.9, however in a peptide the pKa is highly dependent on the local environment. A pKa as high as 14 is not at all uncommon. Aspartate is pervasive in biosynthesis. As with all amino acids, the presence of acid protons depends on the residue's local chemical environment and the pH of the solution. Chemical Properties Apartic acid is an aliphatic monoaminodicarboxylic acid (amino acid) and is a well-known constituent of protein. It has a slight acid taste Occurrence Dietary sources Aspartic acid is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans. Aspartic acid is found in : Animal sources : luncheon meats, sausage meat, wild game Vegetable sources: sprouting seeds, oat flakes, avocado, asparagus , young sugarcane, and molasses from sugar beets. Chemical synthesis Racemic aspartic acid can be synthesized from diethyl sodium phthalimido malonate, (C6H4(CO)2NC(CO2Et)2). The major disadvantage of the above technique is that equimolar amounts of each enantiomer are made. Using biotechnology it is now possible to use immobilized enzymes to create just one type of enantiomer owing to their stereo specificity. Aspartic acid is made synthetically using ammonium fumarate and aspartase from E.coli, E.coli usually breaks down the aspartic acid as a nitrogen source but using excess amounts of ammonium fumarate a reversal of the enzyme's job is possible, and so aspartic acid is made to very high yields, 98.7 mM from 1 M. History Aspartic acid was first discovered in 1827 by Plisson, derived from asparagine, which had been isolated from asparagus juice in 1806, by boiling with a base. Uses L-Aspartic acid is used as a component of parenteral and enteral nutrition and as a pharmaceutical ingredient. it is used for cell culture and in manufacturing processes. It is widely utilized for mineral supplementation in the salt form. Uses L-aspartic acid is used as a dietary supplement, it can be blended with minerals to make compounds like potassium aspartate, copper aspartate, manganese aspartate, magnesium aspartate, zinc aspartate and more. Increasing the absorption, and hence utilization potentials, of these minerals via the addition of aspartate induces certain health benefits. Many athletes use L-aspartic acid-based mineral supplements orally to enhance their performance capacities. Aspartic acid and glutamic acid play important roles as general acids in enzyme active centers, as well as in maintaining the solubility and ionic character of proteins. It can help promote a robust metabolism, and is sometimes used to treat fatigue and depression. Aspartic acid is used as a component of parenteral and enteral nutrition. In pharmaceutical agents aspartic acid is used as an ammoniac detoxicating agent, hepar function accelerator and fatigue refresher. Uses l-aspartic acid is an amino acid used as a skin-conditioning agent. Definition ChEBI: The L-enantiomer of aspartic acid. Aroma threshold values Detection: 300 ppb General Description To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement. Hazard Low toxicity. Biological Activity Endogenous NMDA receptor agonist. Biochem/physiol Actions Principal neurotransmitter for fast synaptic excitation. Safety Profile Low toxicity by intraperitoneal route. When heated to decomposition emits toxic fumes of NOx. Chemical Synthesis Enzymatically, aspartic acid is reversibly synthesized by a transamination reaction between oxaloacetic acid and glutamic acid in the presence of pyridoxal phosphate. Chemical Synthesis Aspartate is non - essential in mammals, being produced from oxaloacetate by transamination. It can also be generated from ornithine and citrulline in the urea cycle. In plants and microorganisms, aspartate is the precursor to several amino acids, including four that are essential for humans: methionine, threonine, isoleucine, and lysine. The conversion of aspartate to these other amino acids begins with reduction of aspartate to its "semi aldehyde," O2CCH(NH2)CH2CHO. Asparagine is derived from aspartate via trans amidation : -O2CCH(NH2)CH2CO2 - + G C (O)NH3+ O2CCH(NH2)CH2CONH3+ + GC(O)O (where GC(O)NH2 and GC(O)OH are glutamine and glutamic acid, respectively). Forms and nomenclature There are two forms or enantiomers of aspartic acid. The name "aspartic acid" can refer to either enantiomer or a mixture of two. Of these two forms, only one, "L - aspartic acid", is directly incorporated into proteins. The biological roles of its counterpart, "Daspartic acid" are more limited. Where enzymatic synthesis will produce one or the other, most chemical syntheses will produce both forms, "DL-aspartic acid," known as a racemic mixture. Other biochemical roles Aspartate is also a metabolite in the urea cycle and participates in gluconeogenesis. It carries reducing equivalents in the malateaspartate shuttle, which utilizes the ready inter conversion of aspartate and oxaloacetate, which is the oxidized (dehydrogenated) derivative of malic acid. Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases. In addition, aspartic acid acts as hydrogen acceptor in a chain of ATP synthase.   L-Aspartic acid Preparation Products And Raw materials Raw materials Sulfuric acid-->Ammonium hydroxide-->Ammonia-->Activated carbon-->Calcium hydroxide-->Α-PROTEIN-->Fumaric acid-->Maleic acid-->Succinic acid-->Gelatin-->Chloroacetamide-->DL-Aspartic acid-->Glutaraldehyde-->L-ASPARTIC ACID-->Aminoacylase Preparation Products L-Alanine-->DL-Aspartic acid-->(S)-3-(Boc-amino)pyrrolidine-->Aspartame-->L-Asparagine-->N-FMOC-L-aspartic acid 4-t-butyl ester-->Sodium L-aspartate-->D-Alaninamide, L-.alpha.-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-, hydrate (2:5)-->L-Lysine-L-aspartate-->Magnesium dihydrogen di-L-aspartate-->N-Cbz-L-Aspartic acid 4-benzyl ester-->Calcium L-aspartate-->3-oxopropanoic acid