China Largest Manufacturer factory sales L-Glutamine CAS 56-85-9 CAS NO.56-85-9

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L-Glutamine Basic information Description References Product Name: L-Glutamine Synonyms: 2,5-Diamino-5-oxpentanoicacid;LEVOGLUTAMIDE;L(+)-GLUTAMINE;L-GLUTAMINE;L(+)-GLUTAMIC ACID-5-AMIDE;L-GLUTAMIC ACID 5-AMIDE;L-GLUTAMIC ACID AMIDE;L-GLN CAS: 56-85-9 MF: C5H10N2O3 MW: 146.14 EINECS: 200-292-1 Product Categories: Inhibitors;Other APIs;Glutamine [Gln, Q];Amino Acids and Derivatives;alpha-Amino Acids;amino;Amino ACIDS SERIES;Food & Feed ADDITIVES;Amino Acids;Amino Acid Derivatives;Food & Flavor Additives;API's;Aliphatics;Amino Acids & Derivatives;Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids;Hybridoma Media SupplementsCardiac Stem Cell Biology;Supplements&Reagents;Cardiac Stem Cell Expansion and Differentiation;Conditioned Media, Media Supplements and ReagentsSerum-free Media;Hybridoma Platform;Hybridoma Reagents;Reagents and Supplements;amino acid;amino acid series Mol File: 56-85-9.mol   L-Glutamine Chemical Properties Melting point  185 °C (dec.) (lit.) alpha  32.25 º (c=10, 2 N HCl) Boiling point  265.74°C (rough estimate) density  1.47 g/cm3 (20℃) FEMA  3684 | L-GLUTAMINE refractive index  6.8 ° (C=4, H2O) Fp  185°C storage temp.  Store below +30°C. solubility  H2O: 25 mg/mL pka 2.17(at 25℃) form  solution color  White PH 5.0-6.0 (25℃, 0.1M in H2O) optical activity [α]20/D +33.0±1°, c = 5% in 5 M HCl Water Solubility  Soluble in water, dimethyl sulfoxide and ethanol. Insoluble in methanol, ether, benzene, acetone, ethyl acetate and chloroform. λmax λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01 Decomposition  185 ºC JECFA Number 1430 Merck  14,4471 BRN  1723797 Stability: Stability Moisture and light sensitive. Incompatible with moisture, strong oxidizing agents. InChIKey ZDXPYRJPNDTMRX-VKHMYHEASA-N CAS DataBase Reference 56-85-9(CAS DataBase Reference) NIST Chemistry Reference L-Glutamine(56-85-9) EPA Substance Registry System L-Glutamine (56-85-9)   Safety Information Hazard Codes  Xi Risk Statements  36-36/37/38 Safety Statements  26-24/25-36/37/39-27 WGK Germany  2 RTECS  MA2275100 TSCA  Yes HS Code  29241900 Hazardous Substances Data 56-85-9(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 7500 mg/kg MSDS Information Provider Language 2-Aminoglutaramic acid English ACROS English SigmaAldrich English ALFA English   L-Glutamine Usage And Synthesis Description L-glutamine (chemical formula: C5H10N2O3) is an alpha-amino acid that is one of the 20 amino acids consisting proteins. L-glutamine is a non-essential amino acids and is also the most abundant amino acids in human bodies. It is involved in many important biological processes. For example, it is a building block for the protein synthesis as one key amino acid; it is used in the biosynthesis of urea and purines for nucleic acid synthesis; it is a substrate for the biosynthesis of neurotransmitters; it is also an important sources of cellular energy generation. L-glutamine provides many benefits to the body such as improving gastrointestinal health, aiding the treatment of ulcer and leaky gut, promoting muscle growth, improving diabetes and blood sugar as well as aiding in the treatment of cancer. References # # # Description Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders.Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500–900 μmol / l . Chemical Properties White crystalline powder Chemical Properties White, odorless crystals or crystalline powder having a slightly sweet taste. It is soluble in water and practically insoluble in alcohol and in ether. Its solutions are acid to litmus. It melts with decomposition at about 185°C. Chemical Properties L-glutamine is odorless, but has a slightly sweet taste L-glutamine performs a major role in DNA synthesis and sup- ports the immune system by means of glutathione synthesis. Occurrence Occurrences in nature Glutamine is the most abundant naturally occurring, nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier.In the body, it is found circulating in the blood, as well as stored in the skeletal muscles. It becomes conditionally essential (requiring intake from food or supplements) in states of illness or injury.Dietary sources Dietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. Small amounts of free L-glutamine are also found in vegetable juices. Aiding gastrointestinal functionGlutamine-enriched diets have been linked with maintenance of gut barrier function and cell differentiation, suggesting glutamine may help to protect the lining of the gastrointestinal tract or mucosa. People who have inflammatory bowel disease (ulcerative colitis and Crohn' s disease) may not have enough glutamine, but two clinical trials found taking glutamine supplements did not improve symptoms of Crohn' s disease. Uses L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use. Uses L-Glutamine is one of the 20 amino acids encoded by the standard genetic code. Its codons are CAA and CAG. Glutamine is a substance naturally produced in the body to help regulate cell growth and function. There may also be man-made versions of these subs Uses amine protecting agent Definition ChEBI: An optically active form of glutamine having L-configuration. Preparation By isolation from sugar beet juice. Brand name Nutrestore (Nutritional Restart). Biological Functions Glutamine plays a role in a variety of biochemical functions, including : Protein synthesis, as any other of the 20 proteinogenic amino acids Regulation of acid-base balance in the kidney by producing ammonium Cellular energy, as a source, next to glucose Nitrogen donation for many anabolic processes, including the synthesis of purines Carbon donation , as a source , refilling the citric acid cycle Nontoxic transporter of ammonia in the blood circulation. Synthesis Reference(s) Tetrahedron: Asymmetry, 17, p. 245, 2006 DOI: 10.1016/j.tetasy.2005.12.023 Journal of the Chemical Society, p. 3315, 1949 DOI: 10.1039/JR9490003315 General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-glutamine is the most abundant amino acid in the body. It is essential for the synthesis of L-asparagine. It also helps in muscle growth through protein synthesis and increased growth hormone levels. Biochem/physiol Actions L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use. Safety Profile Mddly toxic by ingestion. Human systemic effects: euphoria. When heated to decomposition it emits toxic fumes of NOx. Veterinary Drugs and Treatments Glutamine has been used as a GI protectant and in an attempt to enhance GI healing in conditions where GI epithelium is damaged (Parvo enteritis, chemotherapy, etc.). A study that evaluated the efficacy of glutamine supplementation in cats with methotrexate-induced enteritis found no difference between cats supplemented with glutamine and those that were not. (Marks, Cook et al. 1999) Purification Methods Likely impurities are glutamic acid, ammonium pyroglutamate, tyrosine, asparagine, isoglutamine, arginine. Crystallise it from water or aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1929-1925 1961, Beilstein 4 IV 3038.] Producing and consuming organs Producers Glutamine is synthesized by the enzyme glutamine synthetase from glutamate and ammonia. The most relevant glutamine-producing tissue is the muscle mass, accounting for about 90% of all glutamine synthesized. Glutamine is also released, in small amounts, by the lung and the brain. Although the liver is capable of relevant glutamine synthesis, its role in glutamine metabolism is more regulatory than producing, since the liver takes up large amounts of glutamine derived from the gut. Consumers The most eager consumers of glutamine are the cells of intestines, the kidney cells for the acid - base balance, activated immune cells, and many cancer cells. In respect to the last point mentioned, different glutamine analogues, such as DON, Azaserine or Acivicin, are tested as anticancer drugs. Examples for the usage of glutamine In catabolic states of injury and illness, glutamine becomes conditionally essential (requiring intake from food or supplements). Glutamine has been studied extensively over the past 10–15 years, and has been shown to be useful in treatment of injuries, trauma, burns, and treatment - related side effects of cancer, as well as in wound healing for postoperative patients. Glutamine is also marketed as a supplement used for muscle growth in weight lifting , body building, endurance, and other sports. Evidence indicates glutamine, when orally loaded, may increase plasma HGH levels by stimulating the anterior pituitary gland. In biological research, L-glutamine is commonly added to the media in cell culture. However, the high level of glutamine in the culture media may inhibit other amino acid transport activities.   L-Glutamine Preparation Products And Raw materials Raw materials Carbon disulfide-->L-Glutamic acid-->Metaclazepam-->L-Glutamic acid 5-methyl ester-->Octanoic hydrazide-->Carbodithioic acid Preparation Products (2S)-2-amino-3-(5-bromo-1H-indol-3-yl)propanoic acid-->5-Methyl-L-tryptophan-->N-Acetyl-L-glutamine-->5-amino-2,5-dioxo-pentanoic acid-->H-GAMMA-GLU-VAL-OH-->N-Carbobenzyloxy-L-glutamine-->Carbamic acid, (2,6-dioxo-3-piperidinyl)-, phenylmethyl ester (9CI)-->3-AMINO-PIPERIDINE-2,6-DIONE-->AMINO ACID HYDROXAMATES L-GLUTAMIC ACID GAMMA-MONOHYDROXAMATE Tag:L-Glutamine(56-85-9) Related Product Information

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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L-Glutamine Basic information Description References Product Name: L-Glutamine Synonyms: 2,5-Diamino-5-oxpentanoicacid;LEVOGLUTAMIDE;L(+)-GLUTAMINE;L-GLUTAMINE;L(+)-GLUTAMIC ACID-5-AMIDE;L-GLUTAMIC ACID 5-AMIDE;L-GLUTAMIC ACID AMIDE;L-GLN CAS: 56-85-9 MF: C5H10N2O3 MW: 146.14 EINECS: 200-292-1 Product Categories: Inhibitors;Other APIs;Glutamine [Gln, Q];Amino Acids and Derivatives;alpha-Amino Acids;amino;Amino ACIDS SERIES;Food & Feed ADDITIVES;Amino Acids;Amino Acid Derivatives;Food & Flavor Additives;API's;Aliphatics;Amino Acids & Derivatives;Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids;Hybridoma Media SupplementsCardiac Stem Cell Biology;Supplements&Reagents;Cardiac Stem Cell Expansion and Differentiation;Conditioned Media, Media Supplements and ReagentsSerum-free Media;Hybridoma Platform;Hybridoma Reagents;Reagents and Supplements;amino acid;amino acid series Mol File: 56-85-9.mol   L-Glutamine Chemical Properties Melting point  185 °C (dec.) (lit.) alpha  32.25 º (c=10, 2 N HCl) Boiling point  265.74°C (rough estimate) density  1.47 g/cm3 (20℃) FEMA  3684 | L-GLUTAMINE refractive index  6.8 ° (C=4, H2O) Fp  185°C storage temp.  Store below +30°C. solubility  H2O: 25 mg/mL pka 2.17(at 25℃) form  solution color  White PH 5.0-6.0 (25℃, 0.1M in H2O) optical activity [α]20/D +33.0±1°, c = 5% in 5 M HCl Water Solubility  Soluble in water, dimethyl sulfoxide and ethanol. Insoluble in methanol, ether, benzene, acetone, ethyl acetate and chloroform. λmax λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01 Decomposition  185 ºC JECFA Number 1430 Merck  14,4471 BRN  1723797 Stability: Stability Moisture and light sensitive. Incompatible with moisture, strong oxidizing agents. InChIKey ZDXPYRJPNDTMRX-VKHMYHEASA-N CAS DataBase Reference 56-85-9(CAS DataBase Reference) NIST Chemistry Reference L-Glutamine(56-85-9) EPA Substance Registry System L-Glutamine (56-85-9)   Safety Information Hazard Codes  Xi Risk Statements  36-36/37/38 Safety Statements  26-24/25-36/37/39-27 WGK Germany  2 RTECS  MA2275100 TSCA  Yes HS Code  29241900 Hazardous Substances Data 56-85-9(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 7500 mg/kg MSDS Information Provider Language 2-Aminoglutaramic acid English ACROS English SigmaAldrich English ALFA English   L-Glutamine Usage And Synthesis Description L-glutamine (chemical formula: C5H10N2O3) is an alpha-amino acid that is one of the 20 amino acids consisting proteins. L-glutamine is a non-essential amino acids and is also the most abundant amino acids in human bodies. It is involved in many important biological processes. For example, it is a building block for the protein synthesis as one key amino acid; it is used in the biosynthesis of urea and purines for nucleic acid synthesis; it is a substrate for the biosynthesis of neurotransmitters; it is also an important sources of cellular energy generation. L-glutamine provides many benefits to the body such as improving gastrointestinal health, aiding the treatment of ulcer and leaky gut, promoting muscle growth, improving diabetes and blood sugar as well as aiding in the treatment of cancer. References # # # Description Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders.Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500–900 μmol / l . Chemical Properties White crystalline powder Chemical Properties White, odorless crystals or crystalline powder having a slightly sweet taste. It is soluble in water and practically insoluble in alcohol and in ether. Its solutions are acid to litmus. It melts with decomposition at about 185°C. Chemical Properties L-glutamine is odorless, but has a slightly sweet taste L-glutamine performs a major role in DNA synthesis and sup- ports the immune system by means of glutathione synthesis. Occurrence Occurrences in nature Glutamine is the most abundant naturally occurring, nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier.In the body, it is found circulating in the blood, as well as stored in the skeletal muscles. It becomes conditionally essential (requiring intake from food or supplements) in states of illness or injury.Dietary sources Dietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. Small amounts of free L-glutamine are also found in vegetable juices. Aiding gastrointestinal functionGlutamine-enriched diets have been linked with maintenance of gut barrier function and cell differentiation, suggesting glutamine may help to protect the lining of the gastrointestinal tract or mucosa. People who have inflammatory bowel disease (ulcerative colitis and Crohn' s disease) may not have enough glutamine, but two clinical trials found taking glutamine supplements did not improve symptoms of Crohn' s disease. Uses L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use. Uses L-Glutamine is one of the 20 amino acids encoded by the standard genetic code. Its codons are CAA and CAG. Glutamine is a substance naturally produced in the body to help regulate cell growth and function. There may also be man-made versions of these subs Uses amine protecting agent Definition ChEBI: An optically active form of glutamine having L-configuration. Preparation By isolation from sugar beet juice. Brand name Nutrestore (Nutritional Restart). Biological Functions Glutamine plays a role in a variety of biochemical functions, including : Protein synthesis, as any other of the 20 proteinogenic amino acids Regulation of acid-base balance in the kidney by producing ammonium Cellular energy, as a source, next to glucose Nitrogen donation for many anabolic processes, including the synthesis of purines Carbon donation , as a source , refilling the citric acid cycle Nontoxic transporter of ammonia in the blood circulation. Synthesis Reference(s) Tetrahedron: Asymmetry, 17, p. 245, 2006 DOI: 10.1016/j.tetasy.2005.12.023 Journal of the Chemical Society, p. 3315, 1949 DOI: 10.1039/JR9490003315 General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-glutamine is the most abundant amino acid in the body. It is essential for the synthesis of L-asparagine. It also helps in muscle growth through protein synthesis and increased growth hormone levels. Biochem/physiol Actions L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use. Safety Profile Mddly toxic by ingestion. Human systemic effects: euphoria. When heated to decomposition it emits toxic fumes of NOx. Veterinary Drugs and Treatments Glutamine has been used as a GI protectant and in an attempt to enhance GI healing in conditions where GI epithelium is damaged (Parvo enteritis, chemotherapy, etc.). A study that evaluated the efficacy of glutamine supplementation in cats with methotrexate-induced enteritis found no difference between cats supplemented with glutamine and those that were not. (Marks, Cook et al. 1999) Purification Methods Likely impurities are glutamic acid, ammonium pyroglutamate, tyrosine, asparagine, isoglutamine, arginine. Crystallise it from water or aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1929-1925 1961, Beilstein 4 IV 3038.] Producing and consuming organs Producers Glutamine is synthesized by the enzyme glutamine synthetase from glutamate and ammonia. The most relevant glutamine-producing tissue is the muscle mass, accounting for about 90% of all glutamine synthesized. Glutamine is also released, in small amounts, by the lung and the brain. Although the liver is capable of relevant glutamine synthesis, its role in glutamine metabolism is more regulatory than producing, since the liver takes up large amounts of glutamine derived from the gut. Consumers The most eager consumers of glutamine are the cells of intestines, the kidney cells for the acid - base balance, activated immune cells, and many cancer cells. In respect to the last point mentioned, different glutamine analogues, such as DON, Azaserine or Acivicin, are tested as anticancer drugs. Examples for the usage of glutamine In catabolic states of injury and illness, glutamine becomes conditionally essential (requiring intake from food or supplements). Glutamine has been studied extensively over the past 10–15 years, and has been shown to be useful in treatment of injuries, trauma, burns, and treatment - related side effects of cancer, as well as in wound healing for postoperative patients. Glutamine is also marketed as a supplement used for muscle growth in weight lifting , body building, endurance, and other sports. Evidence indicates glutamine, when orally loaded, may increase plasma HGH levels by stimulating the anterior pituitary gland. In biological research, L-glutamine is commonly added to the media in cell culture. However, the high level of glutamine in the culture media may inhibit other amino acid transport activities.   L-Glutamine Preparation Products And Raw materials Raw materials Carbon disulfide-->L-Glutamic acid-->Metaclazepam-->L-Glutamic acid 5-methyl ester-->Octanoic hydrazide-->Carbodithioic acid Preparation Products (2S)-2-amino-3-(5-bromo-1H-indol-3-yl)propanoic acid-->5-Methyl-L-tryptophan-->N-Acetyl-L-glutamine-->5-amino-2,5-dioxo-pentanoic acid-->H-GAMMA-GLU-VAL-OH-->N-Carbobenzyloxy-L-glutamine-->Carbamic acid, (2,6-dioxo-3-piperidinyl)-, phenylmethyl ester (9CI)-->3-AMINO-PIPERIDINE-2,6-DIONE-->AMINO ACID HYDROXAMATES L-GLUTAMIC ACID GAMMA-MONOHYDROXAMATE Tag:L-Glutamine(56-85-9) Related Product Information