China Largest Manufacturer factory sales Histamine Dinydrochloride CAS 56-92-8 CAS NO.56-92-8

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Histamine dihydrochloride Basic information Product Name: Histamine dihydrochloride Synonyms: TIMTEC-BB SBB003722;2-[4-IMIDAZOYL]-ETHYLAMINE DIHYDROCHLORIDE;2-(1H-IMIDAZOL-4-YL)-ETHYLAMINE 2HCL;2-(1H-IMIDAZOL-4-YL)ETHYLAMINE DIHYDROCHLORIDE;1H-IMIDAZOLE-4-ETHANAMINE DIHYDROCHLORIDE;2-imidazol-4-ylethylamine dihydrochloride;HISTAMINE DICHLORHYDRATE;Histamine-alpha,alpha, d4 HCl)2 CAS: 56-92-8 MF: C5H11Cl2N3 MW: 184.07 EINECS: 200-298-4 Product Categories: Pyrimidines;amino;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;Imidazoles & Benzimidazoles;Heterocyclic Compounds;Histidine [His, H];Amino acid salt;Imidazoles & Benzimidazoles Mol File: 56-92-8.mol   Histamine dihydrochloride Chemical Properties Melting point  249-252 °C(lit.) storage temp.  2-8°C solubility  H2O: 0.1 g/mL, clear, colorless form  powder color  white to off-white Water Solubility  SOLUBLE Merck  14,4719 BRN  3624116 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey PPZMYIBUHIPZOS-UHFFFAOYSA-N CAS DataBase Reference 56-92-8(CAS DataBase Reference) EPA Substance Registry System 1H-Imidazole-4-ethanamine, dihydrochloride (56-92-8)   Safety Information Hazard Codes  Xn,Xi Risk Statements  36/37/38-42/43-42-22 Safety Statements  22-26-36/37/39-45-37-36/37 RIDADR  3335 WGK Germany  2 RTECS  MS1575000 F  1-8-9 Hazard Note  Irritant TSCA  Yes HazardClass  IRRITANT HS Code  29332900 MSDS Information Provider Language 2-(4-Imidazolyl)ethylamine dihydrochloride English ACROS English SigmaAldrich English ALFA English   Histamine dihydrochloride Usage And Synthesis Chemical Properties white powder Uses Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. Uses Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist. Uses Histamine dihydrochloride has been used: as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP) to determine its level in fish using HPLC (high performance liquid chromatography) to assess the tracheal response to antigens in guinea-pigs General Description Histamine Dihydrochloride is a derivative of histamine, which is implicated in tumor cell apoptosis and prevents the relapse of acute myeloid leukemia in patients. It prevents the formation of ROS (reactive oxygen species) and inhibits the activation of T cells and natural killer cells. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biological Activity Endogenous agonist at histamine receptors (H 1-4 ). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo . Biochem/physiol Actions Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. Purification Methods The dihydrochloride crystallises from aqueous EtOH. The phosphate (2H3PO4) [51-74-1] has m 132-133o (from H2O). [Beilstein 25 III/IV 2049.]   Histamine dihydrochloride Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Histamine dihydrochloride Basic information Product Name: Histamine dihydrochloride Synonyms: TIMTEC-BB SBB003722;2-[4-IMIDAZOYL]-ETHYLAMINE DIHYDROCHLORIDE;2-(1H-IMIDAZOL-4-YL)-ETHYLAMINE 2HCL;2-(1H-IMIDAZOL-4-YL)ETHYLAMINE DIHYDROCHLORIDE;1H-IMIDAZOLE-4-ETHANAMINE DIHYDROCHLORIDE;2-imidazol-4-ylethylamine dihydrochloride;HISTAMINE DICHLORHYDRATE;Histamine-alpha,alpha, d4 HCl)2 CAS: 56-92-8 MF: C5H11Cl2N3 MW: 184.07 EINECS: 200-298-4 Product Categories: Pyrimidines;amino;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;Imidazoles & Benzimidazoles;Heterocyclic Compounds;Histidine [His, H];Amino acid salt;Imidazoles & Benzimidazoles Mol File: 56-92-8.mol   Histamine dihydrochloride Chemical Properties Melting point  249-252 °C(lit.) storage temp.  2-8°C solubility  H2O: 0.1 g/mL, clear, colorless form  powder color  white to off-white Water Solubility  SOLUBLE Merck  14,4719 BRN  3624116 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey PPZMYIBUHIPZOS-UHFFFAOYSA-N CAS DataBase Reference 56-92-8(CAS DataBase Reference) EPA Substance Registry System 1H-Imidazole-4-ethanamine, dihydrochloride (56-92-8)   Safety Information Hazard Codes  Xn,Xi Risk Statements  36/37/38-42/43-42-22 Safety Statements  22-26-36/37/39-45-37-36/37 RIDADR  3335 WGK Germany  2 RTECS  MS1575000 F  1-8-9 Hazard Note  Irritant TSCA  Yes HazardClass  IRRITANT HS Code  29332900 MSDS Information Provider Language 2-(4-Imidazolyl)ethylamine dihydrochloride English ACROS English SigmaAldrich English ALFA English   Histamine dihydrochloride Usage And Synthesis Chemical Properties white powder Uses Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. Uses Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist. Uses Histamine dihydrochloride has been used: as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP) to determine its level in fish using HPLC (high performance liquid chromatography) to assess the tracheal response to antigens in guinea-pigs General Description Histamine Dihydrochloride is a derivative of histamine, which is implicated in tumor cell apoptosis and prevents the relapse of acute myeloid leukemia in patients. It prevents the formation of ROS (reactive oxygen species) and inhibits the activation of T cells and natural killer cells. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biological Activity Endogenous agonist at histamine receptors (H 1-4 ). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo . Biochem/physiol Actions Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. Purification Methods The dihydrochloride crystallises from aqueous EtOH. The phosphate (2H3PO4) [51-74-1] has m 132-133o (from H2O). [Beilstein 25 III/IV 2049.]   Histamine dihydrochloride Preparation Products And Raw materials