China Largest Manufacturer factory sales Isovanillin CAS 621-59-0 CAS NO.621-59-0

                                PRODUCT DETAILS       

Isovanillin Basic information Product Name: Isovanillin Synonyms: ISOVANILIN;ISOVANILLIN;3-HYDROXY-4-ANISALDEHYDE;3-HYDROXY-4-METHOXYBENZALDEHYDE;3-HYDROXYANISALDEHYDE;3-HYDROXY-P-ANISALDEHYDE;AKOS B022473;AKOS BBS-00003278 CAS: 621-59-0 MF: C8H8O3 MW: 152.15 EINECS: 210-694-9 Product Categories: Aromatics;FINE Chemical & INTERMEDIATES;Aromatic Aldehydes & Derivatives (substituted);BenzaldehydeDerivative;Benzaldehyde;Matrix Substances for MALDI-MS;Aldehydes;Analytical Reagents;Analytical/Chromatography;Building Blocks;C8;Carbonyl Compounds;Chemical Synthesis;Mass Spectrometry;Mass Spectrometry (MS);Matrices for MALDI Analysis;Organic Building Blocks;Proteomics;Spectroscopy;Piperidines ,Piperazines ,Homopiperidines;API Mol File: 621-59-0.mol   Isovanillin Chemical Properties Melting point  113-116 °C Boiling point  179 °C15 mm Hg(lit.) density  1.20 refractive index  1.4945 (estimate) Fp  179°C/15mm storage temp.  Keep in dark place,Sealed in dry,Room Temperature solubility  Soluble in acetone and methanol. pka pK1:8.889 (25°C) form  crystalline color  faintly brown Sensitive  Air Sensitive BRN  1073021 InChIKey JVTZFYYHCGSXJV-UHFFFAOYSA-N CAS DataBase Reference 621-59-0(CAS DataBase Reference) NIST Chemistry Reference Benzaldehyde, 3-hydroxy-4-methoxy-(621-59-0) EPA Substance Registry System Benzaldehyde, 3-hydroxy-4-methoxy- (621-59-0)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36/37-36 WGK Germany  3 RTECS  CU6540000 Hazard Note  Irritant TSCA  Yes HS Code  29124900 MSDS Information Provider Language Isovanillin English SigmaAldrich English ACROS English ALFA English   Isovanillin Usage And Synthesis Chemical Properties Light Tan Cyrstalline Solid Uses 3-Hydroxy-4-methoxybenzaldehyde was used as starting reagent during the two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 and glycitein synthesis. Application Isovanillin is a kind of fragrance and isomer of vanillin. it has unique properties than vanillin, its fragrance can change with the change of ambient temperature, so it is especially suitable for special cosmetics and some special fragrance industries. Isovanillin is a selective inhibitor of aldehyde oxidase. It is not a substrate of that enzyme, and is metabolized by aldehyde dehydrogenase into isovanillic acid, which could make it a candidate drug for use in alcohol aversion therapy. Preparation Synthesis of isovanillin: 4-Hydroxybenzaldehyde is used as raw material, firstly react with bromine to obtain 3-bromo-4-hydroxybenzaldehyde, then react with methyl iodide to obtain 3-bromo-4-methoxybenzaldehyde, and then hydrolyzed under the action of sodium hydroxide and cuprous chloride to produce isovanillin. The yield was 64.1%. Synthesis Reference(s) The Journal of Organic Chemistry, 45, p. 1596, 1980 DOI: 10.1021/jo01297a010 General Description 3-Hydroxy-4-methoxybenzaldehyde on condensation with furan-2-carboxylic acid hydrazide and thiophene-2-carboxylic acid hydrazide yields Schiff-bases. It undergoes condensation reaction with1-azabicyclo[2.2.2]octan-3-one to give (Z)-2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one. Purification Methods Crystallise isovaniline from H2O or *C6H6. The oxime has m 147o. [Beilstein 8 IV 1764.]   Isovanillin Preparation Products And Raw materials Raw materials Dimethyl sulfate-->Vanillin Preparation Products 2-Chloroveratraldehyde-->3-CYCLOPENTYLOXY-4-METHOXYBENZALDEHYDE-->Tetrahydrocurcumin-->COMBRETASTATIN A-4-->6-HYDROXY-7-METHOXYCOUMARIN-->3-HYDROXY-4-METHOXYPHENETHYLAMINE HYDROCHLORIDE-->Fenoldopam-->5-BROMOPROTOCATECHUALDEHYDE-->(R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine-->3-(3-morpholinylpropoxy)-4-methoxybenzonitrile-->2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE-->S- (+)-Rolipram-->4-METHOXY-3-HYDROXYACETOPHENONE-->oxidopamine-->2-METHOXY-5-METHYLPHENOL Tag:Isovanillin(621-59-0) Related Product Information

                                                                         About US 

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

                                                                       Group profiles

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse 

                                                       Product information

Isovanillin Basic information Product Name: Isovanillin Synonyms: ISOVANILIN;ISOVANILLIN;3-HYDROXY-4-ANISALDEHYDE;3-HYDROXY-4-METHOXYBENZALDEHYDE;3-HYDROXYANISALDEHYDE;3-HYDROXY-P-ANISALDEHYDE;AKOS B022473;AKOS BBS-00003278 CAS: 621-59-0 MF: C8H8O3 MW: 152.15 EINECS: 210-694-9 Product Categories: Aromatics;FINE Chemical & INTERMEDIATES;Aromatic Aldehydes & Derivatives (substituted);BenzaldehydeDerivative;Benzaldehyde;Matrix Substances for MALDI-MS;Aldehydes;Analytical Reagents;Analytical/Chromatography;Building Blocks;C8;Carbonyl Compounds;Chemical Synthesis;Mass Spectrometry;Mass Spectrometry (MS);Matrices for MALDI Analysis;Organic Building Blocks;Proteomics;Spectroscopy;Piperidines ,Piperazines ,Homopiperidines;API Mol File: 621-59-0.mol   Isovanillin Chemical Properties Melting point  113-116 °C Boiling point  179 °C15 mm Hg(lit.) density  1.20 refractive index  1.4945 (estimate) Fp  179°C/15mm storage temp.  Keep in dark place,Sealed in dry,Room Temperature solubility  Soluble in acetone and methanol. pka pK1:8.889 (25°C) form  crystalline color  faintly brown Sensitive  Air Sensitive BRN  1073021 InChIKey JVTZFYYHCGSXJV-UHFFFAOYSA-N CAS DataBase Reference 621-59-0(CAS DataBase Reference) NIST Chemistry Reference Benzaldehyde, 3-hydroxy-4-methoxy-(621-59-0) EPA Substance Registry System Benzaldehyde, 3-hydroxy-4-methoxy- (621-59-0)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36/37-36 WGK Germany  3 RTECS  CU6540000 Hazard Note  Irritant TSCA  Yes HS Code  29124900 MSDS Information Provider Language Isovanillin English SigmaAldrich English ACROS English ALFA English   Isovanillin Usage And Synthesis Chemical Properties Light Tan Cyrstalline Solid Uses 3-Hydroxy-4-methoxybenzaldehyde was used as starting reagent during the two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 and glycitein synthesis. Application Isovanillin is a kind of fragrance and isomer of vanillin. it has unique properties than vanillin, its fragrance can change with the change of ambient temperature, so it is especially suitable for special cosmetics and some special fragrance industries. Isovanillin is a selective inhibitor of aldehyde oxidase. It is not a substrate of that enzyme, and is metabolized by aldehyde dehydrogenase into isovanillic acid, which could make it a candidate drug for use in alcohol aversion therapy. Preparation Synthesis of isovanillin: 4-Hydroxybenzaldehyde is used as raw material, firstly react with bromine to obtain 3-bromo-4-hydroxybenzaldehyde, then react with methyl iodide to obtain 3-bromo-4-methoxybenzaldehyde, and then hydrolyzed under the action of sodium hydroxide and cuprous chloride to produce isovanillin. The yield was 64.1%. Synthesis Reference(s) The Journal of Organic Chemistry, 45, p. 1596, 1980 DOI: 10.1021/jo01297a010 General Description 3-Hydroxy-4-methoxybenzaldehyde on condensation with furan-2-carboxylic acid hydrazide and thiophene-2-carboxylic acid hydrazide yields Schiff-bases. It undergoes condensation reaction with1-azabicyclo[2.2.2]octan-3-one to give (Z)-2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one. Purification Methods Crystallise isovaniline from H2O or *C6H6. The oxime has m 147o. [Beilstein 8 IV 1764.]   Isovanillin Preparation Products And Raw materials Raw materials Dimethyl sulfate-->Vanillin Preparation Products 2-Chloroveratraldehyde-->3-CYCLOPENTYLOXY-4-METHOXYBENZALDEHYDE-->Tetrahydrocurcumin-->COMBRETASTATIN A-4-->6-HYDROXY-7-METHOXYCOUMARIN-->3-HYDROXY-4-METHOXYPHENETHYLAMINE HYDROCHLORIDE-->Fenoldopam-->5-BROMOPROTOCATECHUALDEHYDE-->(R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine-->3-(3-morpholinylpropoxy)-4-methoxybenzonitrile-->2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE-->S- (+)-Rolipram-->4-METHOXY-3-HYDROXYACETOPHENONE-->oxidopamine-->2-METHOXY-5-METHYLPHENOL Tag:Isovanillin(621-59-0) Related Product Information