China Largest Manufacturer factory sales Lactose CAS 63-42-3 CAS NO.63-42-3

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Lactose Basic information Product Name: Lactose Synonyms: Aletobiose;Galactinum;lactose,anhydrous;Osmolactan;Saccharum lactin;saccharumlactin;LACTOBIOSE;D-Lactose Anhydrous CAS: 63-42-3 MF: C12H22O11 MW: 342.3 EINECS: 200-559-2 Product Categories: medicine excipents;Inhibitors;Dextrins、Sugar & Carbohydrates;Imidazoles Mol File: 63-42-3.mol   Lactose Chemical Properties Melting point  222.8°C Boiling point  397.76°C (rough estimate) density  1.5300 refractive index  1.5376 (estimate) storage temp.  2-8°C solubility  Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent). pka 12.39±0.20(Predicted) form  Powder color  White to Off-white Water Solubility  5-10 g/100 mL at 20 ºC BRN  93796 Stability: Stable. Incompatible with strong oxidizing agents. CAS DataBase Reference 63-42-3(CAS DataBase Reference) NIST Chemistry Reference D-Glucose, 4-o-«beta»-D-galactopyranosyl-(63-42-3) EPA Substance Registry System Lactose (63-42-3)   Safety Information Safety Statements  24/25 WGK Germany  2 RTECS  OD9625000 TSCA  Yes HS Code  17021100 Hazardous Substances Data 63-42-3(Hazardous Substances Data) MSDS Information Provider Language 4-(beta-D-Galactosido)-D-glucose English SigmaAldrich English   Lactose Usage And Synthesis Chemical Properties white crystals or powder Chemical Properties Anhydrous lactose occurs as white to off-white crystalline particles or powder. Several different brands of anhydrous lactose are commercially available which contain anhydrous b-lactose and anhydrous a-lactose. Anhydrous lactose typically contains 70–80% anhydrous b-lactose and 20–30% anhydrous a-lactose. Uses A disaccharide sugar present in milk. Uses Lactose is a disaccharide carbohydrate that occurs in mammalian milk except that of the whale and the hippopotamus. it is princi- pally obtained as a cows’ milk derivative. it is also termed milk sugar and it is a reducing sugar consisting of glucose and galactose. its most common commercial form is alpha-monohydrate, with the beta-anhydride form available to a lesser extent. all forms in solution will equilibrate to a beta:alpha ratio of 62.25:37.75 at 0°c. it is about one-sixth as sweet as sugar and is less soluble. it functions as a flow agent, humectant, crystallization control agent, and sweetener. it is used in baked goods for flavor, browning, and tenderizing and in dry mixes as an anticaking agent. Uses D-Lactose is used for the culture of lactic acid metabolizing bacteria, lactic acid bacteria. D-Lactose is used to identify and characterized galectins. Definition A sugar found in milk. It is a disaccharide composed of glucose and galactose units. Production Methods There are two anhydrous forms of lactose: a-lactose and b-lactose. The temperature of crystallization influences the ratio of a- and blactose. The anhydrous forms that are commercially available may exhibit hygroscopicity at high relative humidities. Anhydrous lactose is produced by roller drying a solution of lactose above 93.5°C. The resulting product is then milled and sieved. Two anhydrous a-lactoses can be prepared using special drying techniques: one is unstable and hygroscopic; the other exhibits good compaction properties. However, these materials are not commercially available. General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Air & Water Reactions Water soluble. Reactivity Profile Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. Health Hazard ACUTE/CHRONIC HAZARDS: Lactose should be considered toxic. Pharmaceutical Applications Anhydrous lactose is widely used in direct compression tableting applications, and as a tablet and capsule filler and binder. Anhydrous lactose can be used with moisture-sensitive drugs due to its low moisture content. It may also be used in intravenous injections. Safety Lactose is widely used in pharmaceutical formulations as a diluent and filler-binder in oral capsule and tablet formulations. It may also be used in intravenous injections. Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the intestinal enzyme lactase, and is associated with oral ingestion of amounts well over those found in solid dosage forms. storage Mold growth may occur under humid conditions (80% RH and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. At 80°C and 80% RH, tablets containing anhydrous lactose have been shown to expand 1.2 times after one day. Lactose anhydrous should be stored in a well-closed container in a cool, dry place. Purification Methods -Lactose crystallises from water below 93.5o as the hydrate which can be dried at 80o/14mm. [Horst Recl Trav Chim, Pays-Bas 72 878 1953, Beilst 17 III/IV 3066.] Incompatibilities Lactose anhydrous is incompatible with strong oxidizers. When mixtures containing a hydrophobic leukotriene antagonist and anhydrous lactose or lactose monohydrate were stored for six weeks at 40°C and 75% RH, the mixture containing anhydrous lactose showed greater moisture uptake and drug degradation. Studies have also shown that in blends of roxifiban acetate (DMP-754) and lactose anhydrous, the presence of lactose anhydrous accelerated the hydrolysis of the ester and amidine groups. Lactose anhydrous is a reducing sugar with the potential to interact with primary and secondary amines (Maillard reaction) when stored under conditions of high humidity for extended periods. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV: powder for injection solution; IV and sublingual preparations; oral: capsules and tablets; powder for inhalation; vaginal). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   Lactose Preparation Products And Raw materials Raw materials Α-PROTEIN-->Whey-->MILK Preparation Products CARAMEL-->Whey-->Abamectin-->L-carnitine-->Pepsin-->Whey saIts-->Lactulose-->Whev’redliced lactose-->thyroid powder-->LACTITOL

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Lactose Basic information Product Name: Lactose Synonyms: Aletobiose;Galactinum;lactose,anhydrous;Osmolactan;Saccharum lactin;saccharumlactin;LACTOBIOSE;D-Lactose Anhydrous CAS: 63-42-3 MF: C12H22O11 MW: 342.3 EINECS: 200-559-2 Product Categories: medicine excipents;Inhibitors;Dextrins、Sugar & Carbohydrates;Imidazoles Mol File: 63-42-3.mol   Lactose Chemical Properties Melting point  222.8°C Boiling point  397.76°C (rough estimate) density  1.5300 refractive index  1.5376 (estimate) storage temp.  2-8°C solubility  Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent). pka 12.39±0.20(Predicted) form  Powder color  White to Off-white Water Solubility  5-10 g/100 mL at 20 ºC BRN  93796 Stability: Stable. Incompatible with strong oxidizing agents. CAS DataBase Reference 63-42-3(CAS DataBase Reference) NIST Chemistry Reference D-Glucose, 4-o-«beta»-D-galactopyranosyl-(63-42-3) EPA Substance Registry System Lactose (63-42-3)   Safety Information Safety Statements  24/25 WGK Germany  2 RTECS  OD9625000 TSCA  Yes HS Code  17021100 Hazardous Substances Data 63-42-3(Hazardous Substances Data) MSDS Information Provider Language 4-(beta-D-Galactosido)-D-glucose English SigmaAldrich English   Lactose Usage And Synthesis Chemical Properties white crystals or powder Chemical Properties Anhydrous lactose occurs as white to off-white crystalline particles or powder. Several different brands of anhydrous lactose are commercially available which contain anhydrous b-lactose and anhydrous a-lactose. Anhydrous lactose typically contains 70–80% anhydrous b-lactose and 20–30% anhydrous a-lactose. Uses A disaccharide sugar present in milk. Uses Lactose is a disaccharide carbohydrate that occurs in mammalian milk except that of the whale and the hippopotamus. it is princi- pally obtained as a cows’ milk derivative. it is also termed milk sugar and it is a reducing sugar consisting of glucose and galactose. its most common commercial form is alpha-monohydrate, with the beta-anhydride form available to a lesser extent. all forms in solution will equilibrate to a beta:alpha ratio of 62.25:37.75 at 0°c. it is about one-sixth as sweet as sugar and is less soluble. it functions as a flow agent, humectant, crystallization control agent, and sweetener. it is used in baked goods for flavor, browning, and tenderizing and in dry mixes as an anticaking agent. Uses D-Lactose is used for the culture of lactic acid metabolizing bacteria, lactic acid bacteria. D-Lactose is used to identify and characterized galectins. Definition A sugar found in milk. It is a disaccharide composed of glucose and galactose units. Production Methods There are two anhydrous forms of lactose: a-lactose and b-lactose. The temperature of crystallization influences the ratio of a- and blactose. The anhydrous forms that are commercially available may exhibit hygroscopicity at high relative humidities. Anhydrous lactose is produced by roller drying a solution of lactose above 93.5°C. The resulting product is then milled and sieved. Two anhydrous a-lactoses can be prepared using special drying techniques: one is unstable and hygroscopic; the other exhibits good compaction properties. However, these materials are not commercially available. General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Air & Water Reactions Water soluble. Reactivity Profile Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. Health Hazard ACUTE/CHRONIC HAZARDS: Lactose should be considered toxic. Pharmaceutical Applications Anhydrous lactose is widely used in direct compression tableting applications, and as a tablet and capsule filler and binder. Anhydrous lactose can be used with moisture-sensitive drugs due to its low moisture content. It may also be used in intravenous injections. Safety Lactose is widely used in pharmaceutical formulations as a diluent and filler-binder in oral capsule and tablet formulations. It may also be used in intravenous injections. Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the intestinal enzyme lactase, and is associated with oral ingestion of amounts well over those found in solid dosage forms. storage Mold growth may occur under humid conditions (80% RH and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. At 80°C and 80% RH, tablets containing anhydrous lactose have been shown to expand 1.2 times after one day. Lactose anhydrous should be stored in a well-closed container in a cool, dry place. Purification Methods -Lactose crystallises from water below 93.5o as the hydrate which can be dried at 80o/14mm. [Horst Recl Trav Chim, Pays-Bas 72 878 1953, Beilst 17 III/IV 3066.] Incompatibilities Lactose anhydrous is incompatible with strong oxidizers. When mixtures containing a hydrophobic leukotriene antagonist and anhydrous lactose or lactose monohydrate were stored for six weeks at 40°C and 75% RH, the mixture containing anhydrous lactose showed greater moisture uptake and drug degradation. Studies have also shown that in blends of roxifiban acetate (DMP-754) and lactose anhydrous, the presence of lactose anhydrous accelerated the hydrolysis of the ester and amidine groups. Lactose anhydrous is a reducing sugar with the potential to interact with primary and secondary amines (Maillard reaction) when stored under conditions of high humidity for extended periods. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV: powder for injection solution; IV and sublingual preparations; oral: capsules and tablets; powder for inhalation; vaginal). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   Lactose Preparation Products And Raw materials Raw materials Α-PROTEIN-->Whey-->MILK Preparation Products CARAMEL-->Whey-->Abamectin-->L-carnitine-->Pepsin-->Whey saIts-->Lactulose-->Whev’redliced lactose-->thyroid powder-->LACTITOL