China Biggest Manufacturer factory sales L-Phenylalanine CAS 63-91-2 CAS NO.63-91-2

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L-Phenylalanine Basic information Description References Product Name: L-Phenylalanine Synonyms: L-beta-Phenylalanine 99 %;(S)-(-)-PHENYLALANINE FOR SYNTHESIS;L-Alanine, phenyl-;L-AminobenzenepropanoicAcid;L-Antibiotic FN 1636;l-beta-phenyl-alpha-alanin;L-Phenylalanin;L-α-Amino-β-phenyl-propionsαure CAS: 63-91-2 MF: C9H11NO2 MW: 165.19 EINECS: 200-568-1 Product Categories: Amino Acids;Amino Acids & Derivatives;Amino ACIDS SERIES;Amino Acids 13C, 2H, 15N;Nutritional Supplements;L-Amino Acids;Food and Feed Additive;API intermediates;Phenylalanine [Phe, F];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;amino Mol File: 63-91-2.mol   L-Phenylalanine Chemical Properties Melting point  270-275 °C (dec.)(lit.) alpha  -34.1 º (c=2, water, dry basis) Boiling point  293.03°C (rough estimate) density  1.29 vapor pressure  <1 Pa (25 °C) FEMA  3585 | L-PHENYLALANINE refractive index  -34 ° (C=2, H2O) storage temp.  Store below +30°C. solubility  H2O: 0.1 M at 20 °C, clear, colorless form  powder pka 2.2(at 25℃) color  White to off-white PH 5.0-7.0 (25℃, 0.1M in H2O) optical activity [α]25/D -34.2°, c = 2 in H2O (dried basis) Water Solubility  1-5 g/100 mL at 25 ºC JECFA Number 1428 Merck  14,7271 BRN  1910408 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey COLNVLDHVKWLRT-QMMMGPOBSA-N CAS DataBase Reference 63-91-2(CAS DataBase Reference) NIST Chemistry Reference L-Phenylalanine(63-91-2) EPA Substance Registry System L-Phenylalanine (63-91-2)   Safety Information Hazard Codes  C Risk Statements  36/37/38-34 Safety Statements  22-24/25-37/39-45-36/37/39-27-26 WGK Germany  3 RTECS  AY7535000 F  10 TSCA  Yes HS Code  29224995 Hazardous Substances Data 63-91-2(Hazardous Substances Data) MSDS Information Provider Language L-Phenylalanine English ACROS English SigmaAldrich English ALFA English   L-Phenylalanine Usage And Synthesis Description Phenylalanie is an essential amino acid and it is the precursor of the amino acid tyrosine. The body cannot make phenylalanie but it needs phenylalanie to produce proteins. Thus, human needs to obtain phenylalanie from food. 3 forms of phenylalanie are found in the nature: D-phenylalanine, L-phenylalanine, and DL-phenylalanine. Among these three forms, L-phenylalanine is the natural form found in most foods that containing proteins, including beef, poultry, pork, fish, milk, yogurt, eggs, cheeses, soy products, and certain nuts and seeds. The form of phenylalanine determines its application. It is suggested that L-phenylalanine can strengthen the effect of UVA radiation for people with vitiligo, in which L-phenylalanine may lead to darkening or repigmentation of the white patches, particularly on the face. The neurotransmitters L-phenylalanine affects help reduce hunger, improve memory, lessen the symptoms of ADHD and Parkinson's disease, and ease chronic pain, according to the UMMC research. Thus, L-phenylalanine is used in the manufacture of food and drink products and sold as a nutritional supplement for its reputed analgesic and antidepressant effects. L-phenylalanine is also suggested as an intermediate for anti-cancer drugs. A few small studies showed promise using L-Phenylalanine to manage alcohol withdrawal and ease PMS symptoms. It is also used in artificial sweeteners such as aspartame. References [1] # [2] Xueqin Song , Philip L. Lorenzi , Christopher P. Landowski , Balvinder S. Vig , John M. Hilfinger , Gordon L. Amidon (2005) Amino Acid Ester Prodrugs of the Anticancer Agent Gemcitabine: Synthesis, Bioconversion, Metabolic Bioevasion, and hPEPT1-Mediated Transport, 2, 157-167. Chemical Properties L-Phenylalanine has no odor and a slight bitter taste. It melts with decomposition at about 283°C. The pH of a 1 in 100 solution is between 5.4 and 6.0. FEMA notes this chemical is used in cocoa substitute only. Chemical Properties White crystalline powder Occurrence Reported found in white bread, macaroni, egg noodles, corn flakes, corn grits, oatmeal, wheat bran, wheat flakes, shredded wheat, barley, brown rice, rye flour, whole grain wheat flour, buttermilk, blue cheese, cheddar cheese, cottage cheese, cream cheese, parmesan cheese, bacon, cured ham, frankfurters, pork sausage, canned red kidney beans, canned sweet corn, canned peas, canned lima beans, canned potatoes, canned asparagus, canned snap beans, canned beets, beef, lamb, fresh ham, veal round, beef liver, chicken, chicken liver, turkey and other natural sources. Uses phenylalanine is a conditioning agent with greater application in hair care than in skin care preparations. It is also used in suntan products. Uses L-Phenylalanine is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further conv erted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame. Uses L-phenylalanine is an amino acid used as a skin-conditioning agent. It has greater use in hair care than in skin care products. Definition ChEBI: The L-enantiomer of phenylalanine. Preparation From PTS-negative Escherichia coli bioengineered strains. Synthesis Reference(s) Canadian Journal of Chemistry, 29, p. 427, 1951 DOI: 10.1139/v51-051 The Journal of Organic Chemistry, 30, p. 3414, 1965 DOI: 10.1021/jo01021a035 Tetrahedron Letters, 26, p. 2449, 1985 DOI: 10.1016/S0040-4039(00)94850-0 General Description Odorless white crystalline powder. Slightly bitter taste. pH (1% aqueous solution) 5.4 to 6. Air & Water Reactions Water soluble. Aqueous solutions are weak acids. Reactivity Profile L-Phenylalanine may be light sensitive. Act as weak acids in solution. Health Hazard ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Phenylalanine emits toxic fumes of nitrogen oxides. Fire Hazard Flash point data for L-Phenylalanine are not available; however, L-Phenylalanine is probably combustible. Biochem/physiol Actions L-Phenylalanine is an essential amino acid. It is significantly involved in the synthesis of neurotransmitters such as dopamine, epinephrine, norepinephrine, l-DOPA (Dihydroxyphenylalanine), melanin and thyroxine. L-Phenylalanine metabolism also results in phenylethylamine, that brings about effect of a stimulant in the brain and enhances mood. Safety Profile Mildly toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Purification Methods Likely impurities are leucine, valine, methionine and tyrosine. Crystallise L-phenylalanine from water by adding 4volumes of EtOH. Dry it in vacuo over P2O5. Also crystallise it from saturated refluxing aqueous solutions at neutral pH, or 1:1 (v/v) EtOH/water solution, or conc HCl. It sublimes at 176-184o/0.3mm with 98.7% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2156-2175 1961, Beilstein 14 IV 1552.]   L-Phenylalanine Preparation Products And Raw materials Raw materials Α-PROTEIN-->L-Leucine-->3,4-DIAMINOQUINOLINE-->Soy bean Isoflavone Isoflavone 10-40%-->Phenylacetaldehyde-->L(+)-Arginine-->Boc-D-Tyr-OH-->Cinnamic acid-->DL-Phenylalanine-->1,4-Dibromobenzene-->Phenprobamate-->N-Acetylglycine-->N-CARBOBENZOXY-DL-LEUCINE-->L-ACYLASE-->L-Phenylalanine, N-[(1R)-1-phenylethyl]--->Benzenepropanoic acid, a-hydrazino-, (S)--->methyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-phenylpropanoate Preparation Products DL-Tryptophan-->DL-Phenylalanine-->Aspartame-->H-TYR-GLY-GLY-PHE-MET-OH-->N-(tert-Butoxycarbonyl)-L-phenylalanine-->BOC-D-Phenylalanine

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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L-Phenylalanine Basic information Description References Product Name: L-Phenylalanine Synonyms: L-beta-Phenylalanine 99 %;(S)-(-)-PHENYLALANINE FOR SYNTHESIS;L-Alanine, phenyl-;L-AminobenzenepropanoicAcid;L-Antibiotic FN 1636;l-beta-phenyl-alpha-alanin;L-Phenylalanin;L-α-Amino-β-phenyl-propionsαure CAS: 63-91-2 MF: C9H11NO2 MW: 165.19 EINECS: 200-568-1 Product Categories: Amino Acids;Amino Acids & Derivatives;Amino ACIDS SERIES;Amino Acids 13C, 2H, 15N;Nutritional Supplements;L-Amino Acids;Food and Feed Additive;API intermediates;Phenylalanine [Phe, F];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;amino Mol File: 63-91-2.mol   L-Phenylalanine Chemical Properties Melting point  270-275 °C (dec.)(lit.) alpha  -34.1 º (c=2, water, dry basis) Boiling point  293.03°C (rough estimate) density  1.29 vapor pressure  <1 Pa (25 °C) FEMA  3585 | L-PHENYLALANINE refractive index  -34 ° (C=2, H2O) storage temp.  Store below +30°C. solubility  H2O: 0.1 M at 20 °C, clear, colorless form  powder pka 2.2(at 25℃) color  White to off-white PH 5.0-7.0 (25℃, 0.1M in H2O) optical activity [α]25/D -34.2°, c = 2 in H2O (dried basis) Water Solubility  1-5 g/100 mL at 25 ºC JECFA Number 1428 Merck  14,7271 BRN  1910408 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey COLNVLDHVKWLRT-QMMMGPOBSA-N CAS DataBase Reference 63-91-2(CAS DataBase Reference) NIST Chemistry Reference L-Phenylalanine(63-91-2) EPA Substance Registry System L-Phenylalanine (63-91-2)   Safety Information Hazard Codes  C Risk Statements  36/37/38-34 Safety Statements  22-24/25-37/39-45-36/37/39-27-26 WGK Germany  3 RTECS  AY7535000 F  10 TSCA  Yes HS Code  29224995 Hazardous Substances Data 63-91-2(Hazardous Substances Data) MSDS Information Provider Language L-Phenylalanine English ACROS English SigmaAldrich English ALFA English   L-Phenylalanine Usage And Synthesis Description Phenylalanie is an essential amino acid and it is the precursor of the amino acid tyrosine. The body cannot make phenylalanie but it needs phenylalanie to produce proteins. Thus, human needs to obtain phenylalanie from food. 3 forms of phenylalanie are found in the nature: D-phenylalanine, L-phenylalanine, and DL-phenylalanine. Among these three forms, L-phenylalanine is the natural form found in most foods that containing proteins, including beef, poultry, pork, fish, milk, yogurt, eggs, cheeses, soy products, and certain nuts and seeds. The form of phenylalanine determines its application. It is suggested that L-phenylalanine can strengthen the effect of UVA radiation for people with vitiligo, in which L-phenylalanine may lead to darkening or repigmentation of the white patches, particularly on the face. The neurotransmitters L-phenylalanine affects help reduce hunger, improve memory, lessen the symptoms of ADHD and Parkinson's disease, and ease chronic pain, according to the UMMC research. Thus, L-phenylalanine is used in the manufacture of food and drink products and sold as a nutritional supplement for its reputed analgesic and antidepressant effects. L-phenylalanine is also suggested as an intermediate for anti-cancer drugs. A few small studies showed promise using L-Phenylalanine to manage alcohol withdrawal and ease PMS symptoms. It is also used in artificial sweeteners such as aspartame. References [1] # [2] Xueqin Song , Philip L. Lorenzi , Christopher P. Landowski , Balvinder S. Vig , John M. Hilfinger , Gordon L. Amidon (2005) Amino Acid Ester Prodrugs of the Anticancer Agent Gemcitabine: Synthesis, Bioconversion, Metabolic Bioevasion, and hPEPT1-Mediated Transport, 2, 157-167. Chemical Properties L-Phenylalanine has no odor and a slight bitter taste. It melts with decomposition at about 283°C. The pH of a 1 in 100 solution is between 5.4 and 6.0. FEMA notes this chemical is used in cocoa substitute only. Chemical Properties White crystalline powder Occurrence Reported found in white bread, macaroni, egg noodles, corn flakes, corn grits, oatmeal, wheat bran, wheat flakes, shredded wheat, barley, brown rice, rye flour, whole grain wheat flour, buttermilk, blue cheese, cheddar cheese, cottage cheese, cream cheese, parmesan cheese, bacon, cured ham, frankfurters, pork sausage, canned red kidney beans, canned sweet corn, canned peas, canned lima beans, canned potatoes, canned asparagus, canned snap beans, canned beets, beef, lamb, fresh ham, veal round, beef liver, chicken, chicken liver, turkey and other natural sources. Uses phenylalanine is a conditioning agent with greater application in hair care than in skin care preparations. It is also used in suntan products. Uses L-Phenylalanine is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further conv erted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame. Uses L-phenylalanine is an amino acid used as a skin-conditioning agent. It has greater use in hair care than in skin care products. Definition ChEBI: The L-enantiomer of phenylalanine. Preparation From PTS-negative Escherichia coli bioengineered strains. Synthesis Reference(s) Canadian Journal of Chemistry, 29, p. 427, 1951 DOI: 10.1139/v51-051 The Journal of Organic Chemistry, 30, p. 3414, 1965 DOI: 10.1021/jo01021a035 Tetrahedron Letters, 26, p. 2449, 1985 DOI: 10.1016/S0040-4039(00)94850-0 General Description Odorless white crystalline powder. Slightly bitter taste. pH (1% aqueous solution) 5.4 to 6. Air & Water Reactions Water soluble. Aqueous solutions are weak acids. Reactivity Profile L-Phenylalanine may be light sensitive. Act as weak acids in solution. Health Hazard ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Phenylalanine emits toxic fumes of nitrogen oxides. Fire Hazard Flash point data for L-Phenylalanine are not available; however, L-Phenylalanine is probably combustible. Biochem/physiol Actions L-Phenylalanine is an essential amino acid. It is significantly involved in the synthesis of neurotransmitters such as dopamine, epinephrine, norepinephrine, l-DOPA (Dihydroxyphenylalanine), melanin and thyroxine. L-Phenylalanine metabolism also results in phenylethylamine, that brings about effect of a stimulant in the brain and enhances mood. Safety Profile Mildly toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Purification Methods Likely impurities are leucine, valine, methionine and tyrosine. Crystallise L-phenylalanine from water by adding 4volumes of EtOH. Dry it in vacuo over P2O5. Also crystallise it from saturated refluxing aqueous solutions at neutral pH, or 1:1 (v/v) EtOH/water solution, or conc HCl. It sublimes at 176-184o/0.3mm with 98.7% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2156-2175 1961, Beilstein 14 IV 1552.]   L-Phenylalanine Preparation Products And Raw materials Raw materials Α-PROTEIN-->L-Leucine-->3,4-DIAMINOQUINOLINE-->Soy bean Isoflavone Isoflavone 10-40%-->Phenylacetaldehyde-->L(+)-Arginine-->Boc-D-Tyr-OH-->Cinnamic acid-->DL-Phenylalanine-->1,4-Dibromobenzene-->Phenprobamate-->N-Acetylglycine-->N-CARBOBENZOXY-DL-LEUCINE-->L-ACYLASE-->L-Phenylalanine, N-[(1R)-1-phenylethyl]--->Benzenepropanoic acid, a-hydrazino-, (S)--->methyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-phenylpropanoate Preparation Products DL-Tryptophan-->DL-Phenylalanine-->Aspartame-->H-TYR-GLY-GLY-PHE-MET-OH-->N-(tert-Butoxycarbonyl)-L-phenylalanine-->BOC-D-Phenylalanine