China Largest Manufacturer factory sales p-Toluenesulfonamide CAS 70-55-3 CAS NO.70-55-3

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p-Toluenesulfonamide Basic information Role and purpose Uses Production methods Product Name: p-Toluenesulfonamide Synonyms: Tosylamide;Uniplex 173;4-TOLUENESULFONIC ACID AMIDE;4-TOLUENESULFONAMIDE;4-METHYLBENZENESULFONAMIDE;P-TOLUENESULFONAMIDE;P-TOLUENESULFONYLAMIDE;P-TOLUENESULPHONAMIDE CAS: 70-55-3 MF: C7H9NO2S MW: 171.22 EINECS: 200-741-1 Product Categories: Organic Building Blocks;Sulfonamides/Sulfinamides;FINE Chemical & INTERMEDIATES;Sulfur Compounds;Bioactive Small Molecules;Building Blocks;SULFONAMIDE;Cell Biology;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;T;pharmaceutical intermediate;Isoquinolines ,Quinolines ,Quinaldines Mol File: 70-55-3.mol   p-Toluenesulfonamide Chemical Properties Melting point  134-137 °C (lit.) Boiling point  221 °C (10 mmHg) density  1.2495 (rough estimate) vapor density  5.9 (vs air) refractive index  1.6100 (estimate) Fp  202 °C storage temp.  Store below +30°C. solubility  DMSO: soluble pka 10.20±0.10(Predicted) form  Crystalline Powder color  White Odor Odorless Water Solubility  0.32 g/100 mL (25 º C) BRN  472689 CAS DataBase Reference 70-55-3(CAS DataBase Reference) NIST Chemistry Reference 4-Methylbenzenesulfonamide(70-55-3) EPA Substance Registry System p-Toluenesulfonamide (70-55-3)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36-20/21/22 Safety Statements  26-36 WGK Germany  1 RTECS  XT5075000 TSCA  Yes PackingGroup  III HS Code  29350090 Hazardous Substances Data 70-55-3(Hazardous Substances Data) MSDS Information Provider Language 4-Methylbenzenesulfonamide English SigmaAldrich English ACROS English ALFA English   p-Toluenesulfonamide Usage And Synthesis Role and purpose P-toluene sulfonamide is a kind of excellent solid plasticizer used for thermoset plastic. It is suitable for being applied to phenolic resin, melamine resin, urea-formaldehyde resins and polyamide resins. Combination with a small amount can improve workability and make the solidification be uniform, and thus endowing the products with a good gloss. However, P-toluene sulfonamide has no softening effect as the liquid plasticizer, and is incompatible with polyvinyl chloride and vinyl chloride copolymer and is partially compatible with cellulose acetate, cellulose acetate butyrate and cellulose nitrate. p-Toluene sulfonamide has a low toxicity. It has been approved by the US Food and Drug Administration for being applied into adhesives as food packaging materials. p-Toluene sulfonamide is briefly called TSH and is commonly used for nickel plating. It can improve the coating structure by the adsorption on the electrode so that it has some degree of surface glossing effect; it is generally not strictly limited for the added amount of brighteners lax; moreover it also has very light effects on the coating characteristics. However, it can only give semi-bright coatings, and the surface gloss is related to the polishing quality of the matrix before plating. Currently, the brightener agents of nickel plating used is mostly some kinds of organic compounds. And the used amount of these organic compound, although are very little, but with a significant effect. In addition to brightening the coating, it can also largely determine the mechanical properties and chemical properties of the coating. But it must be realized that, since the bright nickel plating solution has been added to the organic brightener, it naturally makes the nickel plating layer contain a relative big amount of organic sulfur and other impurities, thus inevitably enlarging the internal stress, so its mechanical properties is a bitter lower than the conventional nickel-plate, and is prone to crack layer when the plating gets stress; its antirust ability is also worse than the dark nickel. Thus, a single layer of bright nickel is unable to improve the corrosion resistance and mechanical properties of the nickel layer; it must need to form a bi-layer and multilayer nickel or chromium to form a multilayer combination of decorative protective coatings. When toluene sulfonamide is heated to 105 °C, it will be decomposed and there will be nitrogen released (gas evolution 130 mL/g); p-toluene sulfonamide foaming agents can give a fine foaming with small product shrinkage. It also has a high tear strength and good stability. Thereby, it has a wide range of applications. The above information is edited by the chemicalbook of Dai xiongfeng. Uses 1. It is used in the manufacture of dyes, synthetic resins, paints, disinfectants and wood processing brightener. 2. It is used for the manufacture of plasticizers, disinfectants; it can also be used for the production of synthetic resins, paints, and fluorescent dyes. 3. It can be used as primary brightener in the bright nickel plating. It is sued for bright nickel plating for multilayer to obtain uniform bright coating. It has a commonly used amount of 0.2~0.3 g/L. 4. It can be used as plasticizers, also used for synthesis of organics, resins and saccharin. Production methods It is obtained by the reaction between toluenesulfonyl chloride and ammonia. First, add part of HN3 water into the reaction pot, stirring for adding p-toluenesulfonyl chloride with the temperature rising naturally to above 50 °C; after the temperature has dropped, add the remaining ammonia and have reaction for 0.5 h at 85~90 °C. Stop the reaction when the pH reaches 8 to 9. Cool to 20 °C, filter, and wash the filter cake with water to obtain the crude. Then further go through bleaching via activated carbon, alkali dissolution, acid precipitation, rejection filter, drying to get products. Chemical Properties White leaflets. Soluble in alcohol; very slightly soluble inwater.Combustible. Uses p-Toluenesulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. Uses 4-Tolylsulfonamide is a carbonic anhydrase inhibitor used the synthesis of antiglaucoma and anticancer drugs. Uses Used in the manufacture of plasticizer, disinfectant, fungicide, fungicides, wood brightener. Also can be used in the production of synthetic resin, the coating, the fluorescent dye, pharmaceutical, etc. Definition ChEBI: A sulfonamide that is benzenesulfonamide bearing a methyl group at position 4. Synthesis Reference(s) The Journal of Organic Chemistry, 47, p. 4327, 1982 DOI: 10.1021/jo00143a031 Synthetic Communications, 20, p. 293, 1990 DOI: 10.1080/00397919008052297 Synthesis, p. 1031, 1986 DOI: 10.1055/s-1986-31862 General Description p-Toluenesulfonamide undergoes FeCl3-catalyzed direct substitution reaction with benzylic and allylic alcohols.It is employed as nucleophile in tetrabutylammonium fluoride (TBAF) catalyzed vinyl aziridine opening reaction. Purification Methods Crystallise the amide from hot water, then from EtOH or Et2O/pet ether. [Beilstein 11 H 104, 11 IV 376.]   p-Toluenesulfonamide Preparation Products And Raw materials Raw materials Ammonia-->Tosyl chloride-->Carbon-->Terephthaloyl chloride Preparation Products 3-ISOPROPENYL-ALPHA,ALPHA-DIMETHYLBENZYL ISOCYANATE-->isoindoline-5-carboxylic acid-->METHYL ISOINDOLINE-5-CARBOXYLATE-->4-bromoisoindoline-->5-BROMOISOINDOLINE-->Ketoconazole-->DIMINAZENE ACETURATE-->Acid Red 92-->NORMEPERIDINE-->Gliclazide-->4-Nitrobenzonitrile-->Isobutylamine-->Probenecid-->Carzenide-->5-Methyl-1H-benzotriazole-->Disperse Red 86-->DICHLORAMINE T-->4-Methylphenylsulfonylurea-->6-amino-10,12-dichloronaphth[2,3-c]acridine-5,8,14(13H)-trione-->Disperse Red 11

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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p-Toluenesulfonamide Basic information Role and purpose Uses Production methods Product Name: p-Toluenesulfonamide Synonyms: Tosylamide;Uniplex 173;4-TOLUENESULFONIC ACID AMIDE;4-TOLUENESULFONAMIDE;4-METHYLBENZENESULFONAMIDE;P-TOLUENESULFONAMIDE;P-TOLUENESULFONYLAMIDE;P-TOLUENESULPHONAMIDE CAS: 70-55-3 MF: C7H9NO2S MW: 171.22 EINECS: 200-741-1 Product Categories: Organic Building Blocks;Sulfonamides/Sulfinamides;FINE Chemical & INTERMEDIATES;Sulfur Compounds;Bioactive Small Molecules;Building Blocks;SULFONAMIDE;Cell Biology;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;T;pharmaceutical intermediate;Isoquinolines ,Quinolines ,Quinaldines Mol File: 70-55-3.mol   p-Toluenesulfonamide Chemical Properties Melting point  134-137 °C (lit.) Boiling point  221 °C (10 mmHg) density  1.2495 (rough estimate) vapor density  5.9 (vs air) refractive index  1.6100 (estimate) Fp  202 °C storage temp.  Store below +30°C. solubility  DMSO: soluble pka 10.20±0.10(Predicted) form  Crystalline Powder color  White Odor Odorless Water Solubility  0.32 g/100 mL (25 º C) BRN  472689 CAS DataBase Reference 70-55-3(CAS DataBase Reference) NIST Chemistry Reference 4-Methylbenzenesulfonamide(70-55-3) EPA Substance Registry System p-Toluenesulfonamide (70-55-3)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36-20/21/22 Safety Statements  26-36 WGK Germany  1 RTECS  XT5075000 TSCA  Yes PackingGroup  III HS Code  29350090 Hazardous Substances Data 70-55-3(Hazardous Substances Data) MSDS Information Provider Language 4-Methylbenzenesulfonamide English SigmaAldrich English ACROS English ALFA English   p-Toluenesulfonamide Usage And Synthesis Role and purpose P-toluene sulfonamide is a kind of excellent solid plasticizer used for thermoset plastic. It is suitable for being applied to phenolic resin, melamine resin, urea-formaldehyde resins and polyamide resins. Combination with a small amount can improve workability and make the solidification be uniform, and thus endowing the products with a good gloss. However, P-toluene sulfonamide has no softening effect as the liquid plasticizer, and is incompatible with polyvinyl chloride and vinyl chloride copolymer and is partially compatible with cellulose acetate, cellulose acetate butyrate and cellulose nitrate. p-Toluene sulfonamide has a low toxicity. It has been approved by the US Food and Drug Administration for being applied into adhesives as food packaging materials. p-Toluene sulfonamide is briefly called TSH and is commonly used for nickel plating. It can improve the coating structure by the adsorption on the electrode so that it has some degree of surface glossing effect; it is generally not strictly limited for the added amount of brighteners lax; moreover it also has very light effects on the coating characteristics. However, it can only give semi-bright coatings, and the surface gloss is related to the polishing quality of the matrix before plating. Currently, the brightener agents of nickel plating used is mostly some kinds of organic compounds. And the used amount of these organic compound, although are very little, but with a significant effect. In addition to brightening the coating, it can also largely determine the mechanical properties and chemical properties of the coating. But it must be realized that, since the bright nickel plating solution has been added to the organic brightener, it naturally makes the nickel plating layer contain a relative big amount of organic sulfur and other impurities, thus inevitably enlarging the internal stress, so its mechanical properties is a bitter lower than the conventional nickel-plate, and is prone to crack layer when the plating gets stress; its antirust ability is also worse than the dark nickel. Thus, a single layer of bright nickel is unable to improve the corrosion resistance and mechanical properties of the nickel layer; it must need to form a bi-layer and multilayer nickel or chromium to form a multilayer combination of decorative protective coatings. When toluene sulfonamide is heated to 105 °C, it will be decomposed and there will be nitrogen released (gas evolution 130 mL/g); p-toluene sulfonamide foaming agents can give a fine foaming with small product shrinkage. It also has a high tear strength and good stability. Thereby, it has a wide range of applications. The above information is edited by the chemicalbook of Dai xiongfeng. Uses 1. It is used in the manufacture of dyes, synthetic resins, paints, disinfectants and wood processing brightener. 2. It is used for the manufacture of plasticizers, disinfectants; it can also be used for the production of synthetic resins, paints, and fluorescent dyes. 3. It can be used as primary brightener in the bright nickel plating. It is sued for bright nickel plating for multilayer to obtain uniform bright coating. It has a commonly used amount of 0.2~0.3 g/L. 4. It can be used as plasticizers, also used for synthesis of organics, resins and saccharin. Production methods It is obtained by the reaction between toluenesulfonyl chloride and ammonia. First, add part of HN3 water into the reaction pot, stirring for adding p-toluenesulfonyl chloride with the temperature rising naturally to above 50 °C; after the temperature has dropped, add the remaining ammonia and have reaction for 0.5 h at 85~90 °C. Stop the reaction when the pH reaches 8 to 9. Cool to 20 °C, filter, and wash the filter cake with water to obtain the crude. Then further go through bleaching via activated carbon, alkali dissolution, acid precipitation, rejection filter, drying to get products. Chemical Properties White leaflets. Soluble in alcohol; very slightly soluble inwater.Combustible. Uses p-Toluenesulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. Uses 4-Tolylsulfonamide is a carbonic anhydrase inhibitor used the synthesis of antiglaucoma and anticancer drugs. Uses Used in the manufacture of plasticizer, disinfectant, fungicide, fungicides, wood brightener. Also can be used in the production of synthetic resin, the coating, the fluorescent dye, pharmaceutical, etc. Definition ChEBI: A sulfonamide that is benzenesulfonamide bearing a methyl group at position 4. Synthesis Reference(s) The Journal of Organic Chemistry, 47, p. 4327, 1982 DOI: 10.1021/jo00143a031 Synthetic Communications, 20, p. 293, 1990 DOI: 10.1080/00397919008052297 Synthesis, p. 1031, 1986 DOI: 10.1055/s-1986-31862 General Description p-Toluenesulfonamide undergoes FeCl3-catalyzed direct substitution reaction with benzylic and allylic alcohols.It is employed as nucleophile in tetrabutylammonium fluoride (TBAF) catalyzed vinyl aziridine opening reaction. Purification Methods Crystallise the amide from hot water, then from EtOH or Et2O/pet ether. [Beilstein 11 H 104, 11 IV 376.]   p-Toluenesulfonamide Preparation Products And Raw materials Raw materials Ammonia-->Tosyl chloride-->Carbon-->Terephthaloyl chloride Preparation Products 3-ISOPROPENYL-ALPHA,ALPHA-DIMETHYLBENZYL ISOCYANATE-->isoindoline-5-carboxylic acid-->METHYL ISOINDOLINE-5-CARBOXYLATE-->4-bromoisoindoline-->5-BROMOISOINDOLINE-->Ketoconazole-->DIMINAZENE ACETURATE-->Acid Red 92-->NORMEPERIDINE-->Gliclazide-->4-Nitrobenzonitrile-->Isobutylamine-->Probenecid-->Carzenide-->5-Methyl-1H-benzotriazole-->Disperse Red 86-->DICHLORAMINE T-->4-Methylphenylsulfonylurea-->6-amino-10,12-dichloronaphth[2,3-c]acridine-5,8,14(13H)-trione-->Disperse Red 11