China Manufacturer factory sales Cyanidin-3-O-glucoside CAS 7084-24-4 CAS NO.7084-24-4

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KUROMANIN CHLORIDE Basic information Plant Source Analysis method Pharmacological effects Antioxidant activity Antitumor effects Cytoprotective effects Storage Product Name: KUROMANIN CHLORIDE Synonyms: CHRYSANTHEMIN;CYANIDIN-3-O-GLUCOSIDE CHLORIDE;CYANIDIN-3-GLUCOSIDE;CYANIDIN-3-GLUCOSIDE CHLORIDE;KUROMANIN CHLORIDE;KUROMANINE CHLORIDE;cyanidine3-glucoside;cyanidol3-glucoside CAS: 7084-24-4 MF: C21H21ClO11 MW: 484.84 EINECS: 230-384-7 Product Categories: Anthocyanins;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract Mol File: 7084-24-4.mol   KUROMANIN CHLORIDE Chemical Properties storage temp.  -20°C solubility  Acidic Methanol (Slightly), Water (Slightly) form  neat color  Dark Red to Black Stability: Hygroscopic InChIKey YTMNONATNXDQJF-UBNZBFALSA-N   Safety Information Safety Statements  24/25 WGK Germany  3 RTECS  DK1270000 HS Code  29389090 MSDS Information   KUROMANIN CHLORIDE Usage And Synthesis Plant Source Anthocyanin also called anthocyanidin, is the main color substances in plant flowers and fruit. It is honored as the 7th essential nutrients of the human body after water, protein, fat, carbohydrates, Vitamins and minerals.  Thus, it becomes the most perspective natural pigment. Mulberry anthocyanins has been approved by the Ministry of public health as a kind of food additive and widely used in food and health care products. Cyanidin-3-O-glucoside is one of the main ingredients of mulberry anthocyanins. Black soy bean is a traditional kind of crops in our country.  It has a long food and medical history. Black soybean has been used for enriching the blood, activating the blood and Ufa beauty since the ancient times. Black bean peel, also called black clothes is the dry and mature skin of black soybean which is a kind of leguminous plants.  It is rich in anthocyanins which mainly consist of delphinium and cyaniding. It has lots of healthgiving benefits such as antioxidant activity, Inhibiting mutagenesis, anti-inflammatory, prevention of cancer, anti-aging, etc. It has been a raw material of natural food additives and healthcare food. Until now, only Korean scholar Lee reported 5 kinds of anthocyanins separated from black bean peel as the following: Cyanidin-3-O-glucoside,delphinidin-3-O-glucoside, petunidin-3-O-glucoside, malvidin-3-O-glucoside and Cyanidin. In addition, some research papers reported that Cyanidin-3-O-glucoside is an important ingredient of black bean peel. Anthocyanin, as a kind of flavonoid plant chemicals, occurs ubiquitously in pants. Anthocyanins extracted from food or plants often contain different anthocyanins such as cyaniding, pelargonidin, petunidin, malvidin, etc. Glucoside can also be divided into single, double, three glucoside structures and anthocyanins with different structure have different biological activities. Anthocyanin has many therapeutic effects such as antioxidant, Anti-atherosclerosis, adjusting blood fat, etc. cyanidin-3-O-β-glucoside is one of the main ingredients of Anthocyanin. A new study claims that purple corn anthocyanin can inhibit the body weight growth of high-fat induced mice. But its effective components and the mechanism is not clear. It is speculated that the 7% content of Chrysanthemin in purple corn anthocyanins played a leading role. Analysis method The main Analysis method for Chrysanthemin is high performance liquid chromatography (HPLC). Chromatographic analysis condition is commonly as the following: chromatographic column: Phe nomenex Luna Su C18 (250mm×4.60mm，5μm)； mobile phase: phase A is 0.5 % Phosphoric acid solution，phase B is water-acetonitrile (50: 50，V/ V). gradient elution：0min(18%B),23min(50%B),28min(18%B),33min(18%B),40min(stop)；flow velocity：0.8mL/min；Detection wavelength：520nm；column temperature：30℃. Figure 1 shows the high performance liquid chromatogram (HPLC) figure of cyanidin-3-O-glucoside(Chrysanthemin) in mulberry extracting solution. Pharmacological effects Modern pharmacology study indicated that C3G has many significant medical and health care effects such as antioxidant, anti-tumor, protecting the nervous system, recovering Transient visual impairment, etc. In addition, studies indicated that Chrysanthemin can be used as protective agent for protecting cotton leaves against cotton bollworm. C3G in Black bean peel can reduce the production of reactive oxygen species in 3T3-L1fat cells, thus, Dose dependently improved the resistance of H2O2 or TNF-α induced insulin. At the same time, it can reduce the expression of retinol-binding protein in type II diabetic rats, thus, improve hyperglycemia and insulin sensitivity and the symptoms of diabetes. Antioxidant activity Kuromanin chloride is phytochemical rich in plants and fruits and has remarkable anti-oxidant activity, resulting in it an ideal nutrient for nutritional intervention. The antioxidant activity of kuromanin chloride was evaluated by the DPPH and ABTS assay on GES-1 cells. The results showed that kuromanin chloride possessed obvious antioxidant effects, and also could decrease the ROS level in cells and had negligible effects on the viability of cells. Bulent groups analyzed the antioxidant activity of kuromanin chloride by ferric reducing antioxidant power, indicating that kuromanin chloride was the predominant antioxidant compared with anthocyanin in all blackberry fruits. In addition, by alleviating oxidative stress, strengthening the anti-oxidative system, and chelating with Cd ion, kuromanin chloride has the ability to against Cd-induced damage in various organs such as Cd-induced dysfunction of sex hormones, Cd-induced male reproductive toxicity and spermatogenesis disturbances, and Cd-induced kidney damage. Antitumor effects Kuromanin chloride have been proved that has antitumor effects. Treating PC-3 human prostate cancer cells with kuromanin chloride could induce apoptosis, activate caspase signaling pathway and loss of mitochondrial membrane potential, suggesting the prominent anticarcinogenic activity of kuromanin chloride. Kuromanin chloride also has been shown to inhibit the growth and metastatic potential of melanoma via estrogen receptor beta. These studies suggested that kuromanin chloride is a potential novel therapeutic and preventive approach for tumor. Cytoprotective effects Kuromanin chloride also exhibited cytoprotective effects. For example, experiments showed that kuromanin chloride could against the glucotoxicity?induced apoptosis of pancreatic β?cells, indicating the antidiabetic effects of kuromanin chloride. Moreover, kuromanin chloride also has other potential therapeutic effects, such as rheumatoid arthritis, the cognitive function in older adults with subjective memory impairment, neuroprotective effects, UVA-induced human dermal fibroblast injury by upregulating autophagy, and so on. All these suggested that kuromanin chloride is the potential therapeutic medicine for multiple diseases. Storage It is reported that long time high temperature and light has an obvious destructive effect on Mulberry Anthocyanins.  At room temperature, the degradation rate of mulberry Chrysanthemin increased significantly with the extension of storage time.  In long-term exposure to air, the light might induce the   degradation of Chrysanthemin. The specific reasons need to be further studied.  Therefore, anthocyanin extraction should be carried out in time after picking mulberry fruit. In addition fresh mulberry fruit should be stored in a cool, well-ventilated warehouse. Chemical Properties Purple powder Uses Cyanidol 3-Glucoside is a anthocyanin that is naturally occurring in various fruits, vegetable and plants. Cyanidol 3-Glucoside is known to exhibit high antioxidant capacity and neuroprotective effect s by triggering mobilization of cellular free sialic acid and utilizing it as an additional biological antioxidant in brain neural cells. Uses Cyanidol 3-Glucoside is a anthocyanin that is naturally occurring in various fruits, vegetable and plants. Cyanidol 3-Glucoside is known to exhibit high antioxidant capacity and neuroprotective effects by triggering mobilization of cellular free sialic acid and utilizing it as an additional biological antioxidant in brain neural cells. General Description This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG Biochem/physiol Actions Anthocyanin. Antioxidant. Studied for its neuroprotective property.

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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KUROMANIN CHLORIDE Basic information Plant Source Analysis method Pharmacological effects Antioxidant activity Antitumor effects Cytoprotective effects Storage Product Name: KUROMANIN CHLORIDE Synonyms: CHRYSANTHEMIN;CYANIDIN-3-O-GLUCOSIDE CHLORIDE;CYANIDIN-3-GLUCOSIDE;CYANIDIN-3-GLUCOSIDE CHLORIDE;KUROMANIN CHLORIDE;KUROMANINE CHLORIDE;cyanidine3-glucoside;cyanidol3-glucoside CAS: 7084-24-4 MF: C21H21ClO11 MW: 484.84 EINECS: 230-384-7 Product Categories: Anthocyanins;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract Mol File: 7084-24-4.mol   KUROMANIN CHLORIDE Chemical Properties storage temp.  -20°C solubility  Acidic Methanol (Slightly), Water (Slightly) form  neat color  Dark Red to Black Stability: Hygroscopic InChIKey YTMNONATNXDQJF-UBNZBFALSA-N   Safety Information Safety Statements  24/25 WGK Germany  3 RTECS  DK1270000 HS Code  29389090 MSDS Information   KUROMANIN CHLORIDE Usage And Synthesis Plant Source Anthocyanin also called anthocyanidin, is the main color substances in plant flowers and fruit. It is honored as the 7th essential nutrients of the human body after water, protein, fat, carbohydrates, Vitamins and minerals.  Thus, it becomes the most perspective natural pigment. Mulberry anthocyanins has been approved by the Ministry of public health as a kind of food additive and widely used in food and health care products. Cyanidin-3-O-glucoside is one of the main ingredients of mulberry anthocyanins. Black soy bean is a traditional kind of crops in our country.  It has a long food and medical history. Black soybean has been used for enriching the blood, activating the blood and Ufa beauty since the ancient times. Black bean peel, also called black clothes is the dry and mature skin of black soybean which is a kind of leguminous plants.  It is rich in anthocyanins which mainly consist of delphinium and cyaniding. It has lots of healthgiving benefits such as antioxidant activity, Inhibiting mutagenesis, anti-inflammatory, prevention of cancer, anti-aging, etc. It has been a raw material of natural food additives and healthcare food. Until now, only Korean scholar Lee reported 5 kinds of anthocyanins separated from black bean peel as the following: Cyanidin-3-O-glucoside,delphinidin-3-O-glucoside, petunidin-3-O-glucoside, malvidin-3-O-glucoside and Cyanidin. In addition, some research papers reported that Cyanidin-3-O-glucoside is an important ingredient of black bean peel. Anthocyanin, as a kind of flavonoid plant chemicals, occurs ubiquitously in pants. Anthocyanins extracted from food or plants often contain different anthocyanins such as cyaniding, pelargonidin, petunidin, malvidin, etc. Glucoside can also be divided into single, double, three glucoside structures and anthocyanins with different structure have different biological activities. Anthocyanin has many therapeutic effects such as antioxidant, Anti-atherosclerosis, adjusting blood fat, etc. cyanidin-3-O-β-glucoside is one of the main ingredients of Anthocyanin. A new study claims that purple corn anthocyanin can inhibit the body weight growth of high-fat induced mice. But its effective components and the mechanism is not clear. It is speculated that the 7% content of Chrysanthemin in purple corn anthocyanins played a leading role. Analysis method The main Analysis method for Chrysanthemin is high performance liquid chromatography (HPLC). Chromatographic analysis condition is commonly as the following: chromatographic column: Phe nomenex Luna Su C18 (250mm×4.60mm，5μm)； mobile phase: phase A is 0.5 % Phosphoric acid solution，phase B is water-acetonitrile (50: 50，V/ V). gradient elution：0min(18%B),23min(50%B),28min(18%B),33min(18%B),40min(stop)；flow velocity：0.8mL/min；Detection wavelength：520nm；column temperature：30℃. Figure 1 shows the high performance liquid chromatogram (HPLC) figure of cyanidin-3-O-glucoside(Chrysanthemin) in mulberry extracting solution. Pharmacological effects Modern pharmacology study indicated that C3G has many significant medical and health care effects such as antioxidant, anti-tumor, protecting the nervous system, recovering Transient visual impairment, etc. In addition, studies indicated that Chrysanthemin can be used as protective agent for protecting cotton leaves against cotton bollworm. C3G in Black bean peel can reduce the production of reactive oxygen species in 3T3-L1fat cells, thus, Dose dependently improved the resistance of H2O2 or TNF-α induced insulin. At the same time, it can reduce the expression of retinol-binding protein in type II diabetic rats, thus, improve hyperglycemia and insulin sensitivity and the symptoms of diabetes. Antioxidant activity Kuromanin chloride is phytochemical rich in plants and fruits and has remarkable anti-oxidant activity, resulting in it an ideal nutrient for nutritional intervention. The antioxidant activity of kuromanin chloride was evaluated by the DPPH and ABTS assay on GES-1 cells. The results showed that kuromanin chloride possessed obvious antioxidant effects, and also could decrease the ROS level in cells and had negligible effects on the viability of cells. Bulent groups analyzed the antioxidant activity of kuromanin chloride by ferric reducing antioxidant power, indicating that kuromanin chloride was the predominant antioxidant compared with anthocyanin in all blackberry fruits. In addition, by alleviating oxidative stress, strengthening the anti-oxidative system, and chelating with Cd ion, kuromanin chloride has the ability to against Cd-induced damage in various organs such as Cd-induced dysfunction of sex hormones, Cd-induced male reproductive toxicity and spermatogenesis disturbances, and Cd-induced kidney damage. Antitumor effects Kuromanin chloride have been proved that has antitumor effects. Treating PC-3 human prostate cancer cells with kuromanin chloride could induce apoptosis, activate caspase signaling pathway and loss of mitochondrial membrane potential, suggesting the prominent anticarcinogenic activity of kuromanin chloride. Kuromanin chloride also has been shown to inhibit the growth and metastatic potential of melanoma via estrogen receptor beta. These studies suggested that kuromanin chloride is a potential novel therapeutic and preventive approach for tumor. Cytoprotective effects Kuromanin chloride also exhibited cytoprotective effects. For example, experiments showed that kuromanin chloride could against the glucotoxicity?induced apoptosis of pancreatic β?cells, indicating the antidiabetic effects of kuromanin chloride. Moreover, kuromanin chloride also has other potential therapeutic effects, such as rheumatoid arthritis, the cognitive function in older adults with subjective memory impairment, neuroprotective effects, UVA-induced human dermal fibroblast injury by upregulating autophagy, and so on. All these suggested that kuromanin chloride is the potential therapeutic medicine for multiple diseases. Storage It is reported that long time high temperature and light has an obvious destructive effect on Mulberry Anthocyanins.  At room temperature, the degradation rate of mulberry Chrysanthemin increased significantly with the extension of storage time.  In long-term exposure to air, the light might induce the   degradation of Chrysanthemin. The specific reasons need to be further studied.  Therefore, anthocyanin extraction should be carried out in time after picking mulberry fruit. In addition fresh mulberry fruit should be stored in a cool, well-ventilated warehouse. Chemical Properties Purple powder Uses Cyanidol 3-Glucoside is a anthocyanin that is naturally occurring in various fruits, vegetable and plants. Cyanidol 3-Glucoside is known to exhibit high antioxidant capacity and neuroprotective effect s by triggering mobilization of cellular free sialic acid and utilizing it as an additional biological antioxidant in brain neural cells. Uses Cyanidol 3-Glucoside is a anthocyanin that is naturally occurring in various fruits, vegetable and plants. Cyanidol 3-Glucoside is known to exhibit high antioxidant capacity and neuroprotective effects by triggering mobilization of cellular free sialic acid and utilizing it as an additional biological antioxidant in brain neural cells. General Description This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG Biochem/physiol Actions Anthocyanin. Antioxidant. Studied for its neuroprotective property.