China Biggest Factory manufacturer supply L-VALINE CAS NO.72-18-4

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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L-Valine Basic information Amino acids Content Analysis Chemical property Uses Product Name: L-Valine Synonyms: (S)-alpha-Aminoisovaleric acid, (L)-2-Amino-3-methylbutanoic acid;Valine (V) Solution, 100ppm;L-VALINE (13C5, 99%);L-Valine Vetec(TM) reagent grade, >=98%;(s)-2-amino-3-methylbutanoicacid;(S)-2-Amino-3-methylbutansαure;(s)-2-amino-3-methylbutyricacid;(s)-alpha-amino-beta-methylbutyricacid CAS: 72-18-4 MF: C5H11NO2 MW: 117.15 EINECS: 200-773-6 Product Categories: amino;alpha-Amino Acids;Amino Acid Derivatives;Biochemistry;Nutritional Supplements;Amino Acids;Amino Acids;Valine [Val, V];Amino Acids and Derivatives Mol File: 72-18-4.mol   L-Valine Chemical Properties Melting point  295-300 °C (subl.) (lit.) alpha  28 º (c=8, 6N HCl) Boiling point  213.6±23.0 °C(Predicted) density  1.23 refractive index  28 ° (C=8, HCl) storage temp.  2-8°C solubility  H2O: 25 mg/mL pka 2.29(at 25℃) form  powder color  White PH 5.5-6.5 (100g/l, H2O, 20℃) optical activity [α]20/D +27.0±0.5°, c = 5% in 5 M HCl Water Solubility  85 g/L (20 ºC) λmax λ: 260 nm Amax: 0.15 λ: 280 nm Amax: 0.1 Merck  14,9909 BRN  1721136 InChIKey KZSNJWFQEVHDMF-BYPYZUCNSA-N CAS DataBase Reference 72-18-4(CAS DataBase Reference) NIST Chemistry Reference Valine(72-18-4) EPA Substance Registry System L-Valine (72-18-4)   Safety Information Hazard Codes  Xn Risk Statements  40 Safety Statements  24/25-36-22 WGK Germany  3 RTECS  YV9361000 TSCA  Yes HS Code  29224995 Hazardous Substances Data 72-18-4(Hazardous Substances Data) Toxicity LD50 intraperitoneal in rat: 5390mg/kg MSDS Information Provider Language 2-Aminoisovaleric acid English SigmaAldrich English ACROS English ALFA English   L-Valine Usage And Synthesis Amino acids L-Valine is a kind of branched-chain amino acids (BCAA). Animal cannot synthesize it by itself. It must be obtained from the diet to meet their nutritional needs. Therefore L-valine belongs to the essential amino acids. Amino acids are the basic structural unit of protein synthesis, and the predecessor of other amines that metabolism needs. They are indispensable materials in our life. At present, it is known that there are 20 to 30 amino acids. Some of them can be synthesized in the human body, which are known as non-essential amino acids. And some, called essential amino acids, cannot be synthesized in the human body that should be supplemented from the outside. Mammal cells need twelve essential amino acids: L-arginine, L-cystine, L-histidine, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L-valine. These amino acids are all laevoisomer, and some non-essential amino acids of dextroisomer may have inhibitory effect on cultured cells. L-amino acids can easier to be absorbed than D-amino acids. And the absorption of D, L-methionine has no difference. There is competition between the body transport of amino acids. The transporting of an amino acid can be suppressed by the presence of another amino acid. For example, L-valine and L-methionine can inhibit the absorption of L-leucine. Excessive lysine in dietary can inhibit the absorption of arginine. High concentration (100mM) of L-valine has no effect on the absorption of L-methionine. Because it can be transported through another route. Content Analysis About 200mg sample is accurately weighed, dissolved in 3ml formic acid and 50ml glacial acetic acid. Add 2 drops of crystal violet test solution (TS-74), then use 0.1mol/L perchloric acid to titrate the solution to green or blue disappear entirely. Each Ml0.1mol/L perchloric acid is equivalent to 11.72mg L-valine (C5H11NO2). Chemical property White crystal or crystalline powder, odorless, bitter taste. Soluble in water, solubility in water of 8.85% at 25℃. Almost insoluble in ethanol, ether, acetone. melting point(decomposition point) 315℃, isoelectric point 5.96, [α]25D+28.3 (C = 1-2g/ml, in 5mol/L HCl). Uses Amino acids drugs, nutritional supplements. It can be used as the main component of aminophenol transfusion and synthesize aminophenol. L-Valine is one of the three branched-chain amino acids. It is essential amino acid. It can be used to treat liver failure and central nervous system dysfunction. L-Valine is essential amino acid. The requirement for men is 10mg/(kg·d). Physiological effects of the L-form is 2 times of the D-type. L-Valine deficiency can cause neurological disorders, blastocolysis, loss of weight, anemia and the like. As nutritional supplements, it can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion. Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor. L-Valine is the essential amino acid. It can be used as one of pharmaceutical composition of amino acid infusion to synthesize drugs. It also can be used as food additives. Nutritional supplements. It can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion.Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor. L-Valine can be used for biochemical research, the preparation of tissue culture media. It also used as amino acids nutritional drugs in medicine. Description Valine (abbreviated as Val or V) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. L-Valine is one of 20 proteinogenic amino acids. Its codons are GUU, GUC, GUA, and GUG. This essential amino acid is classified as nonpolar. Human dietary sources are any proteinaceous foods such as meats, dairy products, soy products, beans and legumes. Along with leucine and isoleucine, valine is a branched-chain amino acid. It is named after the plant valerian. In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. Because valine is hydrophobic, the hemoglobin is prone to abnormal aggregation. Chemical Properties White or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol. Uses L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grai ns, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects. Uses valine is an amino acid used as a skin-conditioning and odor-masking agent. It is more commonly used in hair care preparations than in skin care. Uses L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects. Definition ChEBI: The L-enantiomer of valine. Biosynthesis Valine is an essential amino acid, hence it must be ingested, usually as a component of proteins. It is synthesized in plants via several steps starting from pyruvic acid. The initial part of the pathway also leads to leucine. The intermediate α-ketoisovalerate undergoes reductive amination with glutamate. Enzymes involved in this biosynthesis include : Acetolactate synthase Acetohydroxy acid isomeroreductase Dihydroxyacid dehydratase Valine aminotransferase. Synthesis Reference(s) Tetrahedron Letters, 22, p. 2411, 1981 DOI: 10.1016/S0040-4039(01)82922-1 Chemical and Pharmaceutical Bulletin, 23, p. 167, 1975 DOI: 10.1248/cpb.23.167 General Description Valine is an essential amino acid, involved in the biosynthesis of glutamine and alanine. Valine being a branched-chain amino acid (BCAA), maintains a balance among the BCAAs. L-Valine serves as an energy fuel. Biochem/physiol Actions Valine is an essential amino acid, involved in the biosynthesis of glutamine and alanine. Valine being a branched-chain amino acid (BCAA) maintains a balance among the BCAAs. L-Valine serves as an energy fuel. Long term deficiency of L-Valine leads to growth failure, organ damage and loss of muscle mass. Safety Profile Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Chemical Synthesis Racemic valine can be synthesized by bromination of isovaleric acid followed by amination of the α-bromo derivative HO2CCH2CH(CH3)2 + Br2 → HO2CCHBrCH(CH3)2 + HBr HO2CCHBrCH(CH3)2 + 2 NH3 → HO2CCH(NH2)CH(CH3)2 + NH4Br . Purification Methods Crystallise L-valine from water by addition of EtOH. It sublimes at 178-188o/0.03mm with 99.3% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Perrin J Chm Soc 3125 1958, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2368-23771961, Beilstein 4 IV 2659.] Nomenclature According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons.   L-Valine Preparation Products And Raw materials Raw materials Urea-->D(+)-Glucose-->2-Methyl-1-propanol-->Isobutyraldehyde-->HYDROGEN CYANIDE-->L-Glutamic acid-->Ammonium carbonate-->Isobutyronitrile-->Hydantoin-->DL-Valine-->Valine-->L-Serine-->L-Isoleucine Preparation Products (S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID-->N-Boc-L-valine-->FMOC-L-Valine-->L-Valine, N-(2-deoxy-D-glucos-2-yl)- (9CI)-->Boc-N-methyl-L-valine