China Largest Manufacturer factory sales Sulfachloropyridazine CAS 80-32-0 CAS NO.80-32-0

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SULFACHLOROPYRIDAZINE Basic information Description Brand Name(s) in US Reference Product Name: SULFACHLOROPYRIDAZINE Synonyms: N’-(6-Chloro-3-pyridazinyl)sulfanilamide;Soxilyn;Sulphachlorpyridazine;VetisullideNefrosul;AKOS B014357;Nefrosul (TN);Prinz;Sulfachlorpyridazine (USP) CAS: 80-32-0 MF: C10H9ClN4O2S MW: 284.72 EINECS: 201-269-9 Product Categories: pharmaceutical;Inhibitors;Amines;Aromatics;Sulfur & Selenium Compounds;VETISULID Mol File: 80-32-0.mol   SULFACHLOROPYRIDAZINE Chemical Properties Melting point  186-187℃ Boiling point  559.7±60.0 °C(Predicted) density  1.588 refractive index  1.6300 (estimate) storage temp.  Keep in dark place,Inert atmosphere,2-8°C solubility  0.5 M NaOH: soluble50mg/mL pka pKa 6.10 (Uncertain) form  powder color  off-white to light yellow BRN  261558 EPA Substance Registry System Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)- (80-32-0)   Safety Information Hazard Codes  Xi Risk Statements  43 Safety Statements  36/37 WGK Germany  3 HazardClass  IRRITANT HS Code  2935909550 MSDS Information Provider Language SigmaAldrich English   SULFACHLOROPYRIDAZINE Usage And Synthesis Description It is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood. Specifically, due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.1 Moreover, this substance can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.2 In addition, this compound can act as an eco-friendly inhibitor for corrosion of mild steel in H2SO4 solution.3 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.4 Brand Name(s) in US Vetisulid Reference Stolar, M. E., Synergistic antibacterial composition US Patent 4470978 1984. Gerhard Lukas; Atasoy, K., Aqueous liquid formulations for control of bacterial and protozoal diseases US Patent 4423043 1983. Omar A. Hazazi; Ahmed Fawzy; Awad, M. I., Sulfachloropyridazine as an Eco-Friendly Inhibitor for Corrosion of Mild Steel in H2SO4 Solution Chemical Science Review and Letters 2015, 4, 67-79. M. Nakano; M.N. Narimatsu; Portugal, M. A. S. C., Use of sulfachloropyridazine associated to tripelennamine hydrochloride as anti-stress agent in poultry after vaccinations. Biologico 1977. Originator Sonilyn,Mallinckrodt Inc.,US,1962 Uses Antibacterial compound. Uses Sulfachloropyridazine is an antibacterial compound.This compound is a contaminant of emerging concern (CECs). Definition ChEBI: A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine. Manufacturing Process 1.9 parts of 3,6-dichloropyridazine, 3.4 parts of sulfanilamide, 2.7 parts of potassium carbonate and 1 part of sodium chloride were ground together. The solid mixture was heated with stirring and as the dichloropyridazine and sulfanilamide melted, the mixture became a slurry. When the bath temperature had reached 140°C a sudden evolution of carbon dioxide occurred which lasted about 5 minutes, after which the mixture set in fine granules. When no more carbon dioxide was evolved, heating was stopped and the reaction mixture was heated with sufficient water to dissolve it and the solution allowed to cool. Unreacted sulfanilamide was collected by filtration. Excess dichloropyridazine was removed from the filtrate by extraction with a water immiscible organic solvent such as ether. The basic solution was chilled and poured into one-half volume of 1:3 acetic acid. Sufficient hydrochloric acid was added to bring the mixture to pH 4. The crude 3-sulfanilamido-6-chloropyridazine which precipitated was purified by solution in 6 parts of 1:100 ammonium hydroxide, charcoal treatment and precipitation by pouring of the filtrate into dilute acetic acid. Brand name Nefrosul (3M Pharmaceuticals); Sonilyn,(Carter-Wallace); Vetisulid [Veterinary] (Fort Dodge Animal Health). Therapeutic Function Antibacterial   SULFACHLOROPYRIDAZINE Preparation Products And Raw materials Raw materials Maleic anhydride-->Sulfanilamide-->3,6-Dichloropyridazine-->Maleic hydrazide Preparation Products N1-(6-ethoxypyridazin-3-yl)sulphanilamide

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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SULFACHLOROPYRIDAZINE Basic information Description Brand Name(s) in US Reference Product Name: SULFACHLOROPYRIDAZINE Synonyms: N’-(6-Chloro-3-pyridazinyl)sulfanilamide;Soxilyn;Sulphachlorpyridazine;VetisullideNefrosul;AKOS B014357;Nefrosul (TN);Prinz;Sulfachlorpyridazine (USP) CAS: 80-32-0 MF: C10H9ClN4O2S MW: 284.72 EINECS: 201-269-9 Product Categories: pharmaceutical;Inhibitors;Amines;Aromatics;Sulfur & Selenium Compounds;VETISULID Mol File: 80-32-0.mol   SULFACHLOROPYRIDAZINE Chemical Properties Melting point  186-187℃ Boiling point  559.7±60.0 °C(Predicted) density  1.588 refractive index  1.6300 (estimate) storage temp.  Keep in dark place,Inert atmosphere,2-8°C solubility  0.5 M NaOH: soluble50mg/mL pka pKa 6.10 (Uncertain) form  powder color  off-white to light yellow BRN  261558 EPA Substance Registry System Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)- (80-32-0)   Safety Information Hazard Codes  Xi Risk Statements  43 Safety Statements  36/37 WGK Germany  3 HazardClass  IRRITANT HS Code  2935909550 MSDS Information Provider Language SigmaAldrich English   SULFACHLOROPYRIDAZINE Usage And Synthesis Description It is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood. Specifically, due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.1 Moreover, this substance can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.2 In addition, this compound can act as an eco-friendly inhibitor for corrosion of mild steel in H2SO4 solution.3 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.4 Brand Name(s) in US Vetisulid Reference Stolar, M. E., Synergistic antibacterial composition US Patent 4470978 1984. Gerhard Lukas; Atasoy, K., Aqueous liquid formulations for control of bacterial and protozoal diseases US Patent 4423043 1983. Omar A. Hazazi; Ahmed Fawzy; Awad, M. I., Sulfachloropyridazine as an Eco-Friendly Inhibitor for Corrosion of Mild Steel in H2SO4 Solution Chemical Science Review and Letters 2015, 4, 67-79. M. Nakano; M.N. Narimatsu; Portugal, M. A. S. C., Use of sulfachloropyridazine associated to tripelennamine hydrochloride as anti-stress agent in poultry after vaccinations. Biologico 1977. Originator Sonilyn,Mallinckrodt Inc.,US,1962 Uses Antibacterial compound. Uses Sulfachloropyridazine is an antibacterial compound.This compound is a contaminant of emerging concern (CECs). Definition ChEBI: A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine. Manufacturing Process 1.9 parts of 3,6-dichloropyridazine, 3.4 parts of sulfanilamide, 2.7 parts of potassium carbonate and 1 part of sodium chloride were ground together. The solid mixture was heated with stirring and as the dichloropyridazine and sulfanilamide melted, the mixture became a slurry. When the bath temperature had reached 140°C a sudden evolution of carbon dioxide occurred which lasted about 5 minutes, after which the mixture set in fine granules. When no more carbon dioxide was evolved, heating was stopped and the reaction mixture was heated with sufficient water to dissolve it and the solution allowed to cool. Unreacted sulfanilamide was collected by filtration. Excess dichloropyridazine was removed from the filtrate by extraction with a water immiscible organic solvent such as ether. The basic solution was chilled and poured into one-half volume of 1:3 acetic acid. Sufficient hydrochloric acid was added to bring the mixture to pH 4. The crude 3-sulfanilamido-6-chloropyridazine which precipitated was purified by solution in 6 parts of 1:100 ammonium hydroxide, charcoal treatment and precipitation by pouring of the filtrate into dilute acetic acid. Brand name Nefrosul (3M Pharmaceuticals); Sonilyn,(Carter-Wallace); Vetisulid [Veterinary] (Fort Dodge Animal Health). Therapeutic Function Antibacterial   SULFACHLOROPYRIDAZINE Preparation Products And Raw materials Raw materials Maleic anhydride-->Sulfanilamide-->3,6-Dichloropyridazine-->Maleic hydrazide Preparation Products N1-(6-ethoxypyridazin-3-yl)sulphanilamide