China Biggest Factory manufacturer supply Choline Bitartrate CAS NO.87-67-2

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Choline bitartrate Basic information Description Chemical Properties natural source Health Benefits Uses Side effects References Product Name: Choline bitartrate Synonyms: CHOLINE BITARTRATE;CHOLINE BITARTRATE SALT;CHOLINE HYDROGEN TARTRATE;Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with (2R,3R)-2,3-dihydroxybutanedioic acid (1:1);CHOLINE BITARTRATE COATED;CHOLINE BITARTRATE UNCOATED;Cholini Bitatratis;2-Hydroxyethyl-trimethylazanium (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate CAS: 87-67-2 MF: C9H19NO7 MW: 253.25 EINECS: 201-763-4 Product Categories: Food additive and acidulant;Ammonium Polyhalides, etc. (Quaternary);Biochemistry;Quaternary Ammonium Compounds;Vitamin Related Compounds;Vitamins;87-67-2 Mol File: 87-67-2.mol   Choline bitartrate Chemical Properties Melting point  151-153°C alpha  [α]D20 +15～+18° (c=4, H2O) storage temp.  Store at RT. solubility  DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly) form  Solid color  White to Off-White PH 3.0-4.4 (50g/l, H2O, 20°C) Water Solubility  Soluble in alcohol and slightly soluble in water. Sensitive  Hygroscopic InChIKey QWJSAWXRUVVRLH-UHFFFAOYSA-M CAS DataBase Reference 87-67-2(CAS DataBase Reference) EPA Substance Registry System Choline tartrate (1:1) (87-67-2)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  3 TSCA  Yes HS Code  29231000 Hazardous Substances Data 87-67-2(Hazardous Substances Data) MSDS Information Provider Language 2-(Hydroxyethyl)trimethylammonium bitartrate English SigmaAldrich English   Choline bitartrate Usage And Synthesis Description Choline, a quaternary ammonium compound, is similar to the B vitamins.  It can be made in the liver and found in foods such as liver, muscle meats, fish, nuts, beans, peas, spinach, wheat germ, and eggs. Choline is required to make essential membrane phospholipids. It is an important source of labile methyl groups and a precursor for the biosynthesis of the neurotransmitter acetylcholine which is released by nerve cells to send signals to other cells. Choline is an essential nutrient for humans when excess methionine and folate are not available in the diet. It is used to treat liver diseases, including chronic hepatitis and cirrhosis. It is also used to treat depression, memory loss, Alzheimer-type dementias, Huntington's chorea, Tourette's disease, a brain disorder called cerebellar ataxia, certain types of seizures, and a mental condition called schizophrenia. Athletes use choline for bodybuilding and delaying fatigue in endurance sports. Choline is taken by pregnant women to prevent neural tube defects in their babies and is used as a supplement in infant formulas. Other uses include preventing cancer, lowering cholesterol, and controlling asthma. Choline is often linked together with tartaric acid (also known as bitrate) in many brain vitamin supplement formulas to improve its absorption rate into the body’s nervous system and eventually into the brain. A binding of these two brain vitamins together helps to synthesize compounds that are essential for the optimal health of membranes and nerve endings found in cells in the body.  Chemical Properties Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others. Choline Bitartrate (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain. As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. natural source natural source of Choline bitartrate: Egg yolk, peanuts, wheat germ, organ meats and legumes. Health Benefits Health Benefits of Choline Bitartrate: Being a product of vitamin, it can be applied to medicine, healthcare product and food. Choline Bitartrate is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver. Influence muscle contractions, movement, coordination and enhance memory. Involved in higher level brain functions like memory, thought and intellect. Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats. Aid in the treatment of Alzheimer's Disease, manic depression and improve the symptoms of Parkinson's Disease. Recommended Choline Bitartrate dosage is 500 mg to 3000 mg per day. Uses Choline is available as a dietary supplement as choline chloride or choline bitartrate and as lecithin, which usually contains approximately 25 percent phosphatidylcholine or 3 to 4 percent choline by weight. Choline bitartrate and choline chloride are GRAS for use as a nutrient/dietary supplement in animal feed (21 CFR 582.5250, 21 CFR 582.5252). The safety of choline bitartrate and choline chloride as nutritional ingredients has been well established by a GRAS evaluation. Water-soluble choline salts choline chloride and choline bitartrate are very easily added to virtually any processed food or feed product, liquid, tablet or capsule. They have a long history of safe use and a minimal environmental impact in manufacture and use. Choline chloride and choline bitartrate deliver a greater bioavailable cation content (74 and 40%, respectively) than do naturally‐occuring forms (e.g. phosphatidylcholine, soybean meal, etc.), and they exhibit excellent stability and high bioavailability in virtually all applications. Side effects Choline Bitartrate may be a useful dietary supplement for individuals wishing to increase their daily choline intake. Choline and Phosphatidylcholine are well tolerated and extremely non-toxic. Phosphatidylcholine supplementation can worsen depression in some cases. At higher dosages, Phosphatidylcholine may cause reduced appetite, nausea, abdominal bloating, gastrointestinal pain, and diarrhea. Choline at high dosages (i.e. 20 gms) produces a fish odor. Choline bitartrate and Choline chloride are also generally recognized as safe forms of Choline supplementation. Choline is generally regarded as safe and appears to be well-tolerated. High intake of choline may cause low blood pressure, steatorrhea (undigested fat in stool), nausea, vomiting, salivation, diarrhea, constipation, anorexia, dizziness (vertigo), sweating, incomnia and headache. Choline can possibly trigger existing epilepsy. Dosages at the upper limit (UL) intake levels are contraindicated for person suffering from trimethylaminuria, Parkinson's disease, or kidney or liver disease. References [1] # [2] S. H. Zeisel, K. A. Da Costa, P. D. Franklin, E. A. Alexander, J. T. Lamont, N. F. Sheard, A. Beiser (1991) Choline, an essential nutrient for humans, 5, 2093-2098 Chemical Properties White cryst. powder Uses Medicine, dietary supplement, nutrient. Uses Choline Bitartrate is used by nerve cells to manufacture a chemical called acetylcholine, which effectively allows cells to communicate with each other. Choline is also heavily associated with neurological function and can help improve movement, coordination, and myofibril contraction. General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biochem/physiol Actions Acyl group acceptor

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Choline bitartrate Basic information Description Chemical Properties natural source Health Benefits Uses Side effects References Product Name: Choline bitartrate Synonyms: CHOLINE BITARTRATE;CHOLINE BITARTRATE SALT;CHOLINE HYDROGEN TARTRATE;Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with (2R,3R)-2,3-dihydroxybutanedioic acid (1:1);CHOLINE BITARTRATE COATED;CHOLINE BITARTRATE UNCOATED;Cholini Bitatratis;2-Hydroxyethyl-trimethylazanium (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate CAS: 87-67-2 MF: C9H19NO7 MW: 253.25 EINECS: 201-763-4 Product Categories: Food additive and acidulant;Ammonium Polyhalides, etc. (Quaternary);Biochemistry;Quaternary Ammonium Compounds;Vitamin Related Compounds;Vitamins;87-67-2 Mol File: 87-67-2.mol   Choline bitartrate Chemical Properties Melting point  151-153°C alpha  [α]D20 +15～+18° (c=4, H2O) storage temp.  Store at RT. solubility  DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly) form  Solid color  White to Off-White PH 3.0-4.4 (50g/l, H2O, 20°C) Water Solubility  Soluble in alcohol and slightly soluble in water. Sensitive  Hygroscopic InChIKey QWJSAWXRUVVRLH-UHFFFAOYSA-M CAS DataBase Reference 87-67-2(CAS DataBase Reference) EPA Substance Registry System Choline tartrate (1:1) (87-67-2)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  3 TSCA  Yes HS Code  29231000 Hazardous Substances Data 87-67-2(Hazardous Substances Data) MSDS Information Provider Language 2-(Hydroxyethyl)trimethylammonium bitartrate English SigmaAldrich English   Choline bitartrate Usage And Synthesis Description Choline, a quaternary ammonium compound, is similar to the B vitamins.  It can be made in the liver and found in foods such as liver, muscle meats, fish, nuts, beans, peas, spinach, wheat germ, and eggs. Choline is required to make essential membrane phospholipids. It is an important source of labile methyl groups and a precursor for the biosynthesis of the neurotransmitter acetylcholine which is released by nerve cells to send signals to other cells. Choline is an essential nutrient for humans when excess methionine and folate are not available in the diet. It is used to treat liver diseases, including chronic hepatitis and cirrhosis. It is also used to treat depression, memory loss, Alzheimer-type dementias, Huntington's chorea, Tourette's disease, a brain disorder called cerebellar ataxia, certain types of seizures, and a mental condition called schizophrenia. Athletes use choline for bodybuilding and delaying fatigue in endurance sports. Choline is taken by pregnant women to prevent neural tube defects in their babies and is used as a supplement in infant formulas. Other uses include preventing cancer, lowering cholesterol, and controlling asthma. Choline is often linked together with tartaric acid (also known as bitrate) in many brain vitamin supplement formulas to improve its absorption rate into the body’s nervous system and eventually into the brain. A binding of these two brain vitamins together helps to synthesize compounds that are essential for the optimal health of membranes and nerve endings found in cells in the body.  Chemical Properties Choline is available in various forms namely, choline bitartrate, choline citrate,choline chloride and others. Choline Bitartrate (L(+) choline bitartrate) is a colorless or white crystal powder, which is a water-soluble part of the B Vitamin family. The body needs B vitamins to manufacture neurotransmitters, chemicals that control alertness and mood by speeding nerve signals through the brain. As B vitamins are water soluble, they are excreted in the urine and can be quickly depleted from the body. Only a small amount is stored in the body. Because of this, it is important that we take supplements to replenish these important vitamins in our body. Choline bitartrate is an essential nutrient needed by the nervous system to produce acetylcholine. Acetylcholine is a neurotransmitter that facilitates the transmission of impulses between neurons. natural source natural source of Choline bitartrate: Egg yolk, peanuts, wheat germ, organ meats and legumes. Health Benefits Health Benefits of Choline Bitartrate: Being a product of vitamin, it can be applied to medicine, healthcare product and food. Choline Bitartrate is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver. Influence muscle contractions, movement, coordination and enhance memory. Involved in higher level brain functions like memory, thought and intellect. Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats. Aid in the treatment of Alzheimer's Disease, manic depression and improve the symptoms of Parkinson's Disease. Recommended Choline Bitartrate dosage is 500 mg to 3000 mg per day. Uses Choline is available as a dietary supplement as choline chloride or choline bitartrate and as lecithin, which usually contains approximately 25 percent phosphatidylcholine or 3 to 4 percent choline by weight. Choline bitartrate and choline chloride are GRAS for use as a nutrient/dietary supplement in animal feed (21 CFR 582.5250, 21 CFR 582.5252). The safety of choline bitartrate and choline chloride as nutritional ingredients has been well established by a GRAS evaluation. Water-soluble choline salts choline chloride and choline bitartrate are very easily added to virtually any processed food or feed product, liquid, tablet or capsule. They have a long history of safe use and a minimal environmental impact in manufacture and use. Choline chloride and choline bitartrate deliver a greater bioavailable cation content (74 and 40%, respectively) than do naturally‐occuring forms (e.g. phosphatidylcholine, soybean meal, etc.), and they exhibit excellent stability and high bioavailability in virtually all applications. Side effects Choline Bitartrate may be a useful dietary supplement for individuals wishing to increase their daily choline intake. Choline and Phosphatidylcholine are well tolerated and extremely non-toxic. Phosphatidylcholine supplementation can worsen depression in some cases. At higher dosages, Phosphatidylcholine may cause reduced appetite, nausea, abdominal bloating, gastrointestinal pain, and diarrhea. Choline at high dosages (i.e. 20 gms) produces a fish odor. Choline bitartrate and Choline chloride are also generally recognized as safe forms of Choline supplementation. Choline is generally regarded as safe and appears to be well-tolerated. High intake of choline may cause low blood pressure, steatorrhea (undigested fat in stool), nausea, vomiting, salivation, diarrhea, constipation, anorexia, dizziness (vertigo), sweating, incomnia and headache. Choline can possibly trigger existing epilepsy. Dosages at the upper limit (UL) intake levels are contraindicated for person suffering from trimethylaminuria, Parkinson's disease, or kidney or liver disease. References [1] # [2] S. H. Zeisel, K. A. Da Costa, P. D. Franklin, E. A. Alexander, J. T. Lamont, N. F. Sheard, A. Beiser (1991) Choline, an essential nutrient for humans, 5, 2093-2098 Chemical Properties White cryst. powder Uses Medicine, dietary supplement, nutrient. Uses Choline Bitartrate is used by nerve cells to manufacture a chemical called acetylcholine, which effectively allows cells to communicate with each other. Choline is also heavily associated with neurological function and can help improve movement, coordination, and myofibril contraction. General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biochem/physiol Actions Acyl group acceptor