China Largest Manufacturer factory sales Butylparaben CAS 94-26-8 CAS NO.94-26-8

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Product Name:	Butylparaben
Synonyms:	Methylparaben Impurity 3（Butylparaben）;2-butyl-4-hydroxybenzoic acid;BUTYL 4-HYDROXYBENZOATE;BUTYL CHEMOSEPT;BUTYL P-HYDROXYBENZOATE;BUTYLPARABEN;butyl parabens;BUTYL PARASEPT
CAS:	94-26-8
MF:	C11H14O3
MW:	194.23
EINECS:	202-318-7
Product Categories:	Aromatics;Pharmaceutical Raw Materials;API;94-26-8
Mol File:	94-26-8.mol

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Butylparaben Basic information Chemical properties Production method Uses Toxicity Content analysis Usage limit Hazards & Safety Information Product Name: Butylparaben Synonyms: Methylparaben Impurity 3（Butylparaben）;2-butyl-4-hydroxybenzoic acid;BUTYL 4-HYDROXYBENZOATE;BUTYL CHEMOSEPT;BUTYL P-HYDROXYBENZOATE;BUTYLPARABEN;butyl parabens;BUTYL PARASEPT CAS: 94-26-8 MF: C11H14O3 MW: 194.23 EINECS: 202-318-7 Product Categories: Aromatics;Pharmaceutical Raw Materials;API;94-26-8 Mol File: 94-26-8.mol   Butylparaben Chemical Properties Melting point  67-70 °C(lit.) Boiling point  156-157 °C3.5 mm Hg(lit.) density  1.28 FEMA  2203 | BUTYL P-HYDROXY BENZOATE refractive index  1.5115 (estimate) Fp  181℃ storage temp.  2-8°C solubility  Soluble in DMSO, ethyl acetate, methanol. form  Crystalline Powder pka pKa 8.5 (Uncertain) color  White to almost white Water Solubility  <0.1 g/100 mL at 17 ºC JECFA Number 870 Merck  14,1584 BRN  1103741 Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong alkalies. InChIKey QFOHBWFCKVYLES-UHFFFAOYSA-N CAS DataBase Reference 94-26-8(CAS DataBase Reference) NIST Chemistry Reference P-hydroxybenzoic acid, n-butyl ester(94-26-8) EPA Substance Registry System Butylparaben (94-26-8)   Safety Information Risk Statements  36/37/38 Safety Statements  22-24/25-37/39-26 WGK Germany  2 RTECS  DH1980000 TSCA  Yes HS Code  29182900 Hazardous Substances Data 94-26-8(Hazardous Substances Data) MSDS Information Provider Language 4-(Butoxycarbonyl)phenol English SigmaAldrich English ACROS English ALFA English   Butylparaben Usage And Synthesis Chemical properties Butylparaben appears as white crystal powder, having slightly special odor. It is slightly soluble in water, being soluble in alcohol, ether and chloroform. Production method Butylparaben is derived from the esterification between p-hydroxybenzoic acid and butanol. Butanol and p-hydroxybenzoic acid are heated together for being dissolved, slowly added dropwise of sulfuric acid, continue the refluxing for 8h. After cooling, add 4% sodium carbonate solution, separate the water layer, steam out the butanol, let it cool, filter to obtain the crude product, and then carry out ethanol recrystallization (solubility in ethanol: 200g/100ml). Take sulfuric acid as a catalyst; derive it from the reaction between p-hydroxybenzoic acid and butanol. Uses Butylparaben is used as a preservative in some foods, cosmetics, and drug formulations. It has been added to solutions such as commercially prepared low-ionic strength saline (LISS) solutions and beer to retard microbial growth (Judd et al., 1982; Raducan et al., 1994). Parabens in general are most active against molds and yeasts and, to a lesser extent, bacteria. In comparison to other parabens, butylparaben appears to be the best antifungal agent (HSDB, 2003). Toxicity ADI is subject to postponed decision (FAO/WHO, 2001). LD50: 16.0 g/kg (mouse, subcutaneous injection). Mice subjecting to short-term toxicity test have gotten inhibited weight increase. There have been reports regarding to the acute dermatitis for human beings. In the p-hydroxybenzoic acid esters, this product gives the best anti-corrosion effect, but also the largest toxicity. Content analysis 2g (accurate to 0.1mg) was taken and dried in silica gel for 5h before being transferred to the flask. Add 40 mL of 1mol/L of sodium hydroxide, flush flasks with water. Cover the surface of the dish and apply a small fire to boil 1h before cooling. Add 5 drops of bromothymol blue solution (TS-56), titrate the excess sodium hydroxide with 1 mol/L sulfuric acid, and make the color of the solution consistent with the buffer containing the same indicator (pH 6.5). Carry out a blank test at the same time and make the necessary calibration. 1ml/L sodium hydroxide per milliliter corresponds to the 194.2 mg of this product (C11H14O3). Usage limit Japan (1998, calculated on p-hydroxybenzoic acid; the data in parentheses is the amount converted into equivalent amount of this product, g/ kg), soy sauce 0.25 g/L (0.35 g/L), vinegar 0.1 g/L (0.14 g/L); Soft drinks and syrup: 0.1 (0.14); fruit sauce: 0.2 (0.28); fruits and vegetables 0.012 (0.016). Hazards & Safety Information Category :Toxic substances Toxic classification: poisoning Acute toxicity:  Oral-mouse LD50: 13200 mg/kg; celiac-mouse LD50: 230 mg/kg Stimulation Data:  Skin-Guinea Pig 5%/48 hours Mild Flammability and Hazardous characteristics:  Thermal decomposition; pungent irritation Smoke Storage and transportation characteristics:  Treasury: ventilated, low temperature and dry Fire extinguishing agent:  water, dry powder, foam, carbon dioxide Description Butylparaben is an antimicrobial agent used in pharmaceutical suspensions. It is act by inhibiting DNA, RNA, and enzymes (eg, ATPase and phosphotransferase) synthesis. Butylparaben may be used alone or with other parabens, chiefly methylparaben and/or propylparaben, in medications. It is common in many liquid and solid (gel cap) OTC products such as Tylenol, Drixoral, Maalox, and Mylanta. Unfortunately, butylparaben concentrations were seldom identified for OTC or prescription products. No attempt was made to identify butylparaben-containing dietary supplements. Chemical Properties Butylparaben occurs as colorless crystals or a white, crystalline, odorless or almost odorless, tasteless powder. Uses preservative in many creams, lotions, ointments and other cosmetics, foods (salad dressings, mayonnaise, spiced sauces, mustard, frozen dairy products, baked products), pharmaceutical preparations and dentifrices. It is active against molds, fungi and yeasts, but less active against bacteria. ICU. Definition ChEBI: Butylparaben is an organic molecular entity. It is a Standardized Chemical Allergen. The physiologic effect of butylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. Preparation Butyl paraben is prepared by esterifying p-hydroxybenzoic acid with butyl alcohol in the presence of an acid catalyst, such as sulfuric acid, and an excess of the specific alcohol. Production Methods Butylparaben is prepared by esterification of p-hydroxybenzoic acid with n-butanol. General Description Odorless white crystals or crystalline powder. Tasteless, but numbs the tongue. Aqueous solutions slightly acidic to litmus. Air & Water Reactions Insoluble in water. Reactivity Profile Butylparaben is incompatible with strong oxidizing agents and strong caustics. Fire Hazard Flash point data for Butylparaben are not available; however, Butylparaben is probably combustible. Pharmaceutical Applications Butylparaben is widely used as an antimicrobial preservative in cosmetics and pharmaceutical formulations. It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics, it is the fourth most frequently used preservative. As a group, the parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used in formulations. However, this may raise the pH of poorly buffered formulations. See Methylparaben for further information. Contact allergens This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin. Safety Butylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics and oral and topical pharmaceutical formulations. Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions generally appearing as contact dematitis. Immediate reactions with urticaria and bronchospasm have occurred rarely. See Methylparaben for further information. LD50 (mouse, IP): 0.23 g/kg LD50 (mouse, oral): 13.2 g/kg storage Aqueous butylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature). Incompatibilities The antimicrobial activity of butylparaben is considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of butylparaben by plastics has not been reported but appears probable given the behavior of other parabens. Some pigments, e.g. ultramarine blue and yellow iron oxide, absorb butylparaben and thus reduce its preservative properties. Butylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids. Regulatory Status Butylparaben is regulated by the U.S. Environmental Protection Agency (EPA) under the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). In 1998 its pesticide registration status was listed as "cancelled" (U.S. EPA, 2003). Included in the FDA Inactive Ingredients Database (injections; oral capsules, solutions, suspensions, syrups and tablets; rectal, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.   Butylparaben Preparation Products And Raw materials Raw materials Sulfuric acid-->1-Butanol-->tert-Butanol-->4-Hydroxybenzoic acid Preparation Products 3-Amino-4-hydroxybenzoic acid-->4-(MethoxyMethoxy)benzoicacid