China Biggest Manufacturer factory sales P-METHYLHYDROXYBENZOIC ACID/Anisic Acid CAS 100-09-4 CAS NO.100-09-4

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p-Anisic acid Basic information Product Name: p-Anisic acid Synonyms: PARA-METHOXYBENZOICACID;p-Anissure;4-methoxy-benzoicaci;Anisic acid, para;benzoicacid,4-methoxy-;Draconic acid;draconicacid;Kyselina 4-methoxybenzoova CAS: 100-09-4 MF: C8H8O3 MW: 152.15 EINECS: 202-818-5 Product Categories: carboxylic acid;Organic acids;Absolute Configuration Determination (Exciton Chirality CD Method);Enantiomer Excess & Absolute Configuration Determination;Exciton Chirality CD Method (for Hydroxyl Groups);Analytical Chemistry;Liquid Crystal intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic Acids (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;acid;Pyridines;p-Anisic acid;100-09-4 Mol File: 100-09-4.mol   p-Anisic acid Chemical Properties Melting point  182-185 °C(lit.) Boiling point  275 °C density  1.385 FEMA  3945 | 4-METHOXYBENZOIC ACID refractive index  1.571-1.576 Fp  185 °C storage temp.  Store below +30°C. solubility  H2O: soluble2500 parts pka 4.50(at 25℃) form  Powder color  White to slightly gray-beige PH 3-4 (0.3g/l, H2O, 20℃) Water Solubility  Soluble in water at 20°C 0.3g/L. Soluble in alcohol, ethyl acetate and ether. JECFA Number 883 Merck  14,666 BRN  508910 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey ZEYHEAKUIGZSGI-UHFFFAOYSA-N CAS DataBase Reference 100-09-4(CAS DataBase Reference) NIST Chemistry Reference Benzoic acid, 4-methoxy-(100-09-4) EPA Substance Registry System Benzoic acid, 4-methoxy- (100-09-4)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-22 Safety Statements  26-36-24/25 WGK Germany  1 RTECS  BZ4395000 Autoignition Temperature 185 °C Hazard Note  Irritant TSCA  Yes HS Code  29189090 Toxicity LD50 orally in Rabbit: > 5000 mg/kg MSDS Information Provider Language 4-Methoxybenzoic acid English SigmaAldrich English ACROS English ALFA English   p-Anisic acid Usage And Synthesis Description p-Anisic acid, also known as 4-methoxybenzoic acid or draconic acid, is an organic acid with sweet flavor. It is one of the isomers(m-anisic acid, and o-anisic acid) of anisic acid. The term "anisic acid" often refers to this form specifically. It is a white crystalline solid which is insoluble in water, highly soluble in alcohols and soluble in ether, and ethyl acetate. P-anisic acid is produced through the oxidation of p-cresyl-methyl ether. It is ideal for use as a masking agent and fragrance ingredient in face care, body care, shower products and sun care applications. Chemical Properties 4-Methoxybenzoic acid is a colorless needle crystal at room temperature, soluble in ethanol, ether, chloroform, slightly soluble in hot water, insoluble in cold water. It is used as intermediate of aniracetam, and also used as fragrance and preservative. Uses Intermediates of Liquid Crystals Uses 4-Methoxybenzoic acid is used in oxidation and reduction of cytochrome c in solution through different self-assembled monolayers on gold electrodes using cyclic voltammetry. p-Anisic acid has antiseptic properties. It is also used as an intermediate in the preparation of more complex organic compounds. Definition ChEBI: 4-methoxybenzoic acid is a methoxybenzoic acid substituted with a methoxy group at position C-4. It has a role as a plant metabolite. It derives from a benzoic acid. It is a conjugate acid of a 4-methoxybenzoate. Synthesis Reference(s) Journal of Heterocyclic Chemistry, 25, p. 973, 1988 DOI: 10.1002/jhet.5570250351 Tetrahedron Letters, 34, p. 4603, 1993 DOI: 10.1016/S0040-4039(00)60635-4 General Description 4-Methoxybenzoic acid is the sole source of carbon and energy for growth in the cultures of Nocardia sp. DSM 1069. Safety Profile Poison by subcutaneous route.When heated to decomposition it emits acrid smoke andirritating vapors. Purification Methods Crystallise p-anisic acid from EtOH, water, EtOH/water or toluene. The S-benzylisothiuronium salt has m 189o (from EtOH). [Beilstein 10 II 91, 10 III 280, 10 IV 346.] References [1] Michael Ash (2004) Handbook of Preservatives [2] Asim Kumar Mukhopadhyay (2004) Industrial Chemical Cresols and Downstream Derivatives [3] #   p-Anisic acid Preparation Products And Raw materials Raw materials Ethanol-->Sodium hydroxide-->Hydrochloric acid-->Dimethyl sulfate-->4-Hydroxybenzoic acid Preparation Products 3-Amino-4-methoxybenzoic acid-->4-Methoxybenzoyl chloride-->Aniracetam-->3-Amino-4-methoxybenzanilide-->Zidovudine-->Ethyl 4-methoxybenzoate-->6-Methoxynicotinic acid-->Methyl anisate-->3,5-DICHLORO-4-METHOXYBENZOIC ACID-->(R)-4-METHOXYMANDELIC ACID-->2,4-DIBROMOANISOLE-->Ethyl 4-etoxybenzoate-->2,4,6-TRIBROMOANISOLE-->4-Methoxyphenyl isocyanate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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p-Anisic acid Basic information Product Name: p-Anisic acid Synonyms: PARA-METHOXYBENZOICACID;p-Anissure;4-methoxy-benzoicaci;Anisic acid, para;benzoicacid,4-methoxy-;Draconic acid;draconicacid;Kyselina 4-methoxybenzoova CAS: 100-09-4 MF: C8H8O3 MW: 152.15 EINECS: 202-818-5 Product Categories: carboxylic acid;Organic acids;Absolute Configuration Determination (Exciton Chirality CD Method);Enantiomer Excess & Absolute Configuration Determination;Exciton Chirality CD Method (for Hydroxyl Groups);Analytical Chemistry;Liquid Crystal intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic Acids (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;acid;Pyridines;p-Anisic acid;100-09-4 Mol File: 100-09-4.mol   p-Anisic acid Chemical Properties Melting point  182-185 °C(lit.) Boiling point  275 °C density  1.385 FEMA  3945 | 4-METHOXYBENZOIC ACID refractive index  1.571-1.576 Fp  185 °C storage temp.  Store below +30°C. solubility  H2O: soluble2500 parts pka 4.50(at 25℃) form  Powder color  White to slightly gray-beige PH 3-4 (0.3g/l, H2O, 20℃) Water Solubility  Soluble in water at 20°C 0.3g/L. Soluble in alcohol, ethyl acetate and ether. JECFA Number 883 Merck  14,666 BRN  508910 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey ZEYHEAKUIGZSGI-UHFFFAOYSA-N CAS DataBase Reference 100-09-4(CAS DataBase Reference) NIST Chemistry Reference Benzoic acid, 4-methoxy-(100-09-4) EPA Substance Registry System Benzoic acid, 4-methoxy- (100-09-4)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-22 Safety Statements  26-36-24/25 WGK Germany  1 RTECS  BZ4395000 Autoignition Temperature 185 °C Hazard Note  Irritant TSCA  Yes HS Code  29189090 Toxicity LD50 orally in Rabbit: > 5000 mg/kg MSDS Information Provider Language 4-Methoxybenzoic acid English SigmaAldrich English ACROS English ALFA English   p-Anisic acid Usage And Synthesis Description p-Anisic acid, also known as 4-methoxybenzoic acid or draconic acid, is an organic acid with sweet flavor. It is one of the isomers(m-anisic acid, and o-anisic acid) of anisic acid. The term "anisic acid" often refers to this form specifically. It is a white crystalline solid which is insoluble in water, highly soluble in alcohols and soluble in ether, and ethyl acetate. P-anisic acid is produced through the oxidation of p-cresyl-methyl ether. It is ideal for use as a masking agent and fragrance ingredient in face care, body care, shower products and sun care applications. Chemical Properties 4-Methoxybenzoic acid is a colorless needle crystal at room temperature, soluble in ethanol, ether, chloroform, slightly soluble in hot water, insoluble in cold water. It is used as intermediate of aniracetam, and also used as fragrance and preservative. Uses Intermediates of Liquid Crystals Uses 4-Methoxybenzoic acid is used in oxidation and reduction of cytochrome c in solution through different self-assembled monolayers on gold electrodes using cyclic voltammetry. p-Anisic acid has antiseptic properties. It is also used as an intermediate in the preparation of more complex organic compounds. Definition ChEBI: 4-methoxybenzoic acid is a methoxybenzoic acid substituted with a methoxy group at position C-4. It has a role as a plant metabolite. It derives from a benzoic acid. It is a conjugate acid of a 4-methoxybenzoate. Synthesis Reference(s) Journal of Heterocyclic Chemistry, 25, p. 973, 1988 DOI: 10.1002/jhet.5570250351 Tetrahedron Letters, 34, p. 4603, 1993 DOI: 10.1016/S0040-4039(00)60635-4 General Description 4-Methoxybenzoic acid is the sole source of carbon and energy for growth in the cultures of Nocardia sp. DSM 1069. Safety Profile Poison by subcutaneous route.When heated to decomposition it emits acrid smoke andirritating vapors. Purification Methods Crystallise p-anisic acid from EtOH, water, EtOH/water or toluene. The S-benzylisothiuronium salt has m 189o (from EtOH). [Beilstein 10 II 91, 10 III 280, 10 IV 346.] References [1] Michael Ash (2004) Handbook of Preservatives [2] Asim Kumar Mukhopadhyay (2004) Industrial Chemical Cresols and Downstream Derivatives [3] #   p-Anisic acid Preparation Products And Raw materials Raw materials Ethanol-->Sodium hydroxide-->Hydrochloric acid-->Dimethyl sulfate-->4-Hydroxybenzoic acid Preparation Products 3-Amino-4-methoxybenzoic acid-->4-Methoxybenzoyl chloride-->Aniracetam-->3-Amino-4-methoxybenzanilide-->Zidovudine-->Ethyl 4-methoxybenzoate-->6-Methoxynicotinic acid-->Methyl anisate-->3,5-DICHLORO-4-METHOXYBENZOIC ACID-->(R)-4-METHOXYMANDELIC ACID-->2,4-DIBROMOANISOLE-->Ethyl 4-etoxybenzoate-->2,4,6-TRIBROMOANISOLE-->4-Methoxyphenyl isocyanate