China Largest Manufacturer factory sales 2-Phenylacetamide CAS 103-81-1 for 500MT/Year CAS NO.103-81-1

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2-Phenylacetamide Basic information Product Name: 2-Phenylacetamide Synonyms: PHENYLACETAMIDE;2-PHENYLACETAMIDE;ALPHA-TOLUAMIDE;ALPHA-PHENYLACETAMIDE;2-phenyl-acetamid;Acetamide, 2-phenyl-;alpha-toluimidicacid;Benzeneacetamide CAS: 103-81-1 MF: C8H9NO MW: 135.16 EINECS: 203-147-0 Product Categories: Pharmaceutical intermediates;amine series Mol File: 103-81-1.mol   2-Phenylacetamide Chemical Properties Melting point  156 °C Boiling point  280-290 °C (dec.) density  1.1031 (rough estimate) refractive index  1.5589 (estimate) storage temp.  Refrigerator solubility  Soluble in methanol. pka 16.21±0.40(Predicted) form  Solid color  Plates or leaflets Merck  14,7266 InChIKey LSBDFXRDZJMBSC-UHFFFAOYSA-N CAS DataBase Reference 103-81-1(CAS DataBase Reference) NIST Chemistry Reference Benzeneacetamide(103-81-1) EPA Substance Registry System Benzeneacetamide (103-81-1)   Safety Information Hazard Codes  Xi Risk Statements  22-36 Safety Statements  22-24/25-60-36-26 RTECS  AC7705000 Hazard Note  Irritant TSCA  Yes HazardClass  IRRITANT HS Code  29242990 Toxicity LD50 ipr-mus: 430 mg/kg PCJOAU 10,579,76 MSDS Information   2-Phenylacetamide Usage And Synthesis Chemical Properties White flaky crystals. soluble in hot water, ethanol, slightly soluble in cold water, ether and benzene. Uses 2-Phenylacetamide is used as an intermediate in the production of penicillin G and phenobarbital, etc. It is also used in organic synthesis. Uses 2-Phenylacetamide is used as a pharmaceutical intermediate. Definition ChEBI: 2-phenylacetamide is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It has a role as a mouse metabolite. It derives from a phenylacetic acid. Synthesis Reference(s) Journal of the American Chemical Society, 75, p. 740, 1953 DOI: 10.1021/ja01099a504 The Journal of Organic Chemistry, 43, p. 402, 1978 DOI: 10.1021/jo00397a005 Organic Syntheses, Coll. Vol. 4, p. 760, 1963 Biological Activity 2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells. Safety Profile Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx. Purification Methods Crystallise the acetamide repeatedly from absolute EtOH, EtOAc (m 160-161o) or H2O (m 159-160o). Dry it in vacuo over P2O5. [Beilstein 9 H 347, 9 III 2193, 9 IV 1632.]   2-Phenylacetamide Preparation Products And Raw materials Raw materials Benzyl chloride-->Benzeneacetonitrile-->Activated carbon,decolor-->Phenylacetic acid-->AMMONIUM POLYSULFIDE Preparation Products Ethyl phenylacetate-->DIPHACINONE-->Phenobarbital-->ETHYL A-ETHOXYOXALYLPHENYL ACETATE-->3-OXO-4-PHENYL-BUTYRIC ACID METHYL ESTER-->Tetraphenylcyclopentadienone-->Indole-3-carboxaldehyde

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

2-Phenylacetamide Basic information Product Name: 2-Phenylacetamide Synonyms: PHENYLACETAMIDE;2-PHENYLACETAMIDE;ALPHA-TOLUAMIDE;ALPHA-PHENYLACETAMIDE;2-phenyl-acetamid;Acetamide, 2-phenyl-;alpha-toluimidicacid;Benzeneacetamide CAS: 103-81-1 MF: C8H9NO MW: 135.16 EINECS: 203-147-0 Product Categories: Pharmaceutical intermediates;amine series Mol File: 103-81-1.mol   2-Phenylacetamide Chemical Properties Melting point  156 °C Boiling point  280-290 °C (dec.) density  1.1031 (rough estimate) refractive index  1.5589 (estimate) storage temp.  Refrigerator solubility  Soluble in methanol. pka 16.21±0.40(Predicted) form  Solid color  Plates or leaflets Merck  14,7266 InChIKey LSBDFXRDZJMBSC-UHFFFAOYSA-N CAS DataBase Reference 103-81-1(CAS DataBase Reference) NIST Chemistry Reference Benzeneacetamide(103-81-1) EPA Substance Registry System Benzeneacetamide (103-81-1)   Safety Information Hazard Codes  Xi Risk Statements  22-36 Safety Statements  22-24/25-60-36-26 RTECS  AC7705000 Hazard Note  Irritant TSCA  Yes HazardClass  IRRITANT HS Code  29242990 Toxicity LD50 ipr-mus: 430 mg/kg PCJOAU 10,579,76 MSDS Information   2-Phenylacetamide Usage And Synthesis Chemical Properties White flaky crystals. soluble in hot water, ethanol, slightly soluble in cold water, ether and benzene. Uses 2-Phenylacetamide is used as an intermediate in the production of penicillin G and phenobarbital, etc. It is also used in organic synthesis. Uses 2-Phenylacetamide is used as a pharmaceutical intermediate. Definition ChEBI: 2-phenylacetamide is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It has a role as a mouse metabolite. It derives from a phenylacetic acid. Synthesis Reference(s) Journal of the American Chemical Society, 75, p. 740, 1953 DOI: 10.1021/ja01099a504 The Journal of Organic Chemistry, 43, p. 402, 1978 DOI: 10.1021/jo00397a005 Organic Syntheses, Coll. Vol. 4, p. 760, 1963 Biological Activity 2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells. Safety Profile Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx. Purification Methods Crystallise the acetamide repeatedly from absolute EtOH, EtOAc (m 160-161o) or H2O (m 159-160o). Dry it in vacuo over P2O5. [Beilstein 9 H 347, 9 III 2193, 9 IV 1632.]   2-Phenylacetamide Preparation Products And Raw materials Raw materials Benzyl chloride-->Benzeneacetonitrile-->Activated carbon,decolor-->Phenylacetic acid-->AMMONIUM POLYSULFIDE Preparation Products Ethyl phenylacetate-->DIPHACINONE-->Phenobarbital-->ETHYL A-ETHOXYOXALYLPHENYL ACETATE-->3-OXO-4-PHENYL-BUTYRIC ACID METHYL ESTER-->Tetraphenylcyclopentadienone-->Indole-3-carboxaldehyde