China Largest Manufacturer factory Supply Eicosapentaenoic acid CAS 10417-94-4 CAS NO.10417-94-4

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EPA Basic information Product Name: EPA Synonyms: TIMNODONIC ACID;TIMNODONIC ACID(EPA);C20:5 (ALL CIS-5,8,11,14,17) ACID;C20:5 OMEGA-3;CIS-5,8,11,14,17-EICOSAPENTAENOIC ACID;EICOSA-5Z,8Z,11Z,14Z,17Z-PENTAENOIC ACID;EICOSAPENTAENOIC CID;EICOSAPENTAENOIC ACID CAS: 10417-94-4 MF: C20H30O2 MW: 302.45 EINECS:   Product Categories: Mixed Fatty Acids;Biochemistry;Higher Fatty Acids & Higher Alcohols;Unsaturated Higher Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols Mol File: 10417-94-4.mol   EPA Chemical Properties Melting point  −54-−53 °C(lit.) Boiling point  439℃ density  0.943 g/mL at 25 °C(lit.) refractive index  n20/D 1.4977(lit.) Fp  93 °C storage temp.  -20°C solubility  Soluble in methanol form  liquid pka 4.75±0.10(Predicted) color  Colorless to pale yellow Sensitive  Air & Light Sensitive Merck  14,3531 BRN  1714433 Stability: Stable for 1 year as supplied (unopened). After opening, EPA must be stored under inert gas at -80°C. Solutions in DMSO or ethanol should also be stored under inert gas and may be kept at -80°C for up to 2 months. InChIKey RRGOKSYVAZDNKR-ARJAWSKDSA-N   Safety Information Hazard Codes  C Risk Statements  34 Safety Statements  26-36/37/39-45 RIDADR  UN 3265 8/PG 3 WGK Germany  3 F  8-10-23 HazardClass  8 HS Code  29161900 MSDS Information Provider Language SigmaAldrich English   EPA Usage And Synthesis Description Eicosapentaenoic acid is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid. Eicosapentaenoic acid has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases. Eicosapentaenoic acid MaxSpec  standard is a quantitative grade standard of eicosapentaenoic acid (Item No. 90110) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This eicosapentaenoic acid MaxSpec  standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality. Description EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid. EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases. Chemical Properties Colorless Oil Uses Important polyunsaturated fatty acid of the marine food chain that serves as a precursor for the prostaglandin-3 and thromboxane-3 families. It differs from arachidonic acid (the eicosatetraenoic acid that is a precursor for the prostaglandin and thromboxane-2 families) by the extra double bond between the third and fourth carbons from the “methyl end” of the molecule. Antilipemic. Uses cis-5,8,11,14,17-Eicosapentaenoic acid has been used an analytical standard for the synthesis followed by investigation of pharmacological properties of aconitine-derived lipo-alkaloids. Uses cis-5,8,11,14,17-Eicosapentaenoic acid has been used: to test pharmacologic effect on steatosis in hepatocytes as an analytical standard in Raman spectra measurements to characterize human breast cancer samples in lipid peroxidation assay in mouse embryonic fibroblasts and in pre-treatment of cells for cell viability studies Definition ChEBI: An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17. Brand name Decabid (Lilly). General Description Eicosapentaenoic acid (cis-5,8,11,14,17), also known as EPA, is a long-chain omega-3 fatty acid. Studies suggests that EPA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders. This certified solution standard is suitable for use as starting material in the preparation of linearity standards, calibrators, or controls in mass spectrometry-based EPA testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of EPA in nutraceuticals and dietary supplements. Biochem/physiol Actions 5-Lipoxygenase inhibitor; reduces thromboxane A2 production. References 1) Lee et al. (1985), Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function; N. Engl. J. Med., 312 1217 2) Nicholson et al. (2013), The role of marine n-3 fatty acids in improving cardiovascular health: a review; Food Funct., 4 357   EPA Preparation Products And Raw materials Raw materials Urea-->Arachidonic acid-->FISH OIL Preparation Products CIS-5,8,11,14,17-EICOSAPENTAENOIC ACID METHYL ESTER

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

EPA Basic information Product Name: EPA Synonyms: TIMNODONIC ACID;TIMNODONIC ACID(EPA);C20:5 (ALL CIS-5,8,11,14,17) ACID;C20:5 OMEGA-3;CIS-5,8,11,14,17-EICOSAPENTAENOIC ACID;EICOSA-5Z,8Z,11Z,14Z,17Z-PENTAENOIC ACID;EICOSAPENTAENOIC CID;EICOSAPENTAENOIC ACID CAS: 10417-94-4 MF: C20H30O2 MW: 302.45 EINECS:   Product Categories: Mixed Fatty Acids;Biochemistry;Higher Fatty Acids & Higher Alcohols;Unsaturated Higher Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols Mol File: 10417-94-4.mol   EPA Chemical Properties Melting point  −54-−53 °C(lit.) Boiling point  439℃ density  0.943 g/mL at 25 °C(lit.) refractive index  n20/D 1.4977(lit.) Fp  93 °C storage temp.  -20°C solubility  Soluble in methanol form  liquid pka 4.75±0.10(Predicted) color  Colorless to pale yellow Sensitive  Air & Light Sensitive Merck  14,3531 BRN  1714433 Stability: Stable for 1 year as supplied (unopened). After opening, EPA must be stored under inert gas at -80°C. Solutions in DMSO or ethanol should also be stored under inert gas and may be kept at -80°C for up to 2 months. InChIKey RRGOKSYVAZDNKR-ARJAWSKDSA-N   Safety Information Hazard Codes  C Risk Statements  34 Safety Statements  26-36/37/39-45 RIDADR  UN 3265 8/PG 3 WGK Germany  3 F  8-10-23 HazardClass  8 HS Code  29161900 MSDS Information Provider Language SigmaAldrich English   EPA Usage And Synthesis Description Eicosapentaenoic acid is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid. Eicosapentaenoic acid has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases. Eicosapentaenoic acid MaxSpec  standard is a quantitative grade standard of eicosapentaenoic acid (Item No. 90110) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This eicosapentaenoic acid MaxSpec  standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality. Description EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid. EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases. Chemical Properties Colorless Oil Uses Important polyunsaturated fatty acid of the marine food chain that serves as a precursor for the prostaglandin-3 and thromboxane-3 families. It differs from arachidonic acid (the eicosatetraenoic acid that is a precursor for the prostaglandin and thromboxane-2 families) by the extra double bond between the third and fourth carbons from the “methyl end” of the molecule. Antilipemic. Uses cis-5,8,11,14,17-Eicosapentaenoic acid has been used an analytical standard for the synthesis followed by investigation of pharmacological properties of aconitine-derived lipo-alkaloids. Uses cis-5,8,11,14,17-Eicosapentaenoic acid has been used: to test pharmacologic effect on steatosis in hepatocytes as an analytical standard in Raman spectra measurements to characterize human breast cancer samples in lipid peroxidation assay in mouse embryonic fibroblasts and in pre-treatment of cells for cell viability studies Definition ChEBI: An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17. Brand name Decabid (Lilly). General Description Eicosapentaenoic acid (cis-5,8,11,14,17), also known as EPA, is a long-chain omega-3 fatty acid. Studies suggests that EPA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders. This certified solution standard is suitable for use as starting material in the preparation of linearity standards, calibrators, or controls in mass spectrometry-based EPA testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of EPA in nutraceuticals and dietary supplements. Biochem/physiol Actions 5-Lipoxygenase inhibitor; reduces thromboxane A2 production. References 1) Lee et al. (1985), Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function; N. Engl. J. Med., 312 1217 2) Nicholson et al. (2013), The role of marine n-3 fatty acids in improving cardiovascular health: a review; Food Funct., 4 357   EPA Preparation Products And Raw materials Raw materials Urea-->Arachidonic acid-->FISH OIL Preparation Products CIS-5,8,11,14,17-EICOSAPENTAENOIC ACID METHYL ESTER