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| 3,4-Dihydroxyphenylethanol Chemical Properties |
| Boiling point |
355.4±27.0 °C(Predicted) |
| density |
1.321±0.06 g/cm3(Predicted) |
| refractive index |
1.5810-1.5860 |
| storage temp. |
-20°C |
| solubility |
DMSO (Slightly), Methanol (Slightly) |
| pka |
9.72±0.10(Predicted) |
| BRN |
2208118 |
| Stability: |
Hygroscopic |
| InChIKey |
JUUBCHWRXWPFFH-UHFFFAOYSA-N |
| CAS DataBase Reference |
10597-60-1(CAS DataBase Reference) |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38 |
| Safety Statements |
26 |
| WGK Germany |
3 |
| HS Code |
29072990 |
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| 3,4-Dihydroxyphenylethanol Usage And Synthesis |
| Antioxidant Characteristics |
Hydroxytyrosol displays much more effective antioxidant characteristics, such as the scavenging of free radicals, breaking peroxidative chain reactions, preventing lipid peroxidation, inhibiting hypochlorous acid derived radicals, and so on, compared with other phenolic compounds in olive oil. It could be used in the dermocosmetic industry for the creation of products for protecting the skin from oxidative stress or used as a preservative in the food technology. |
| Description |
3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13 μM, respectively. It does not inhibit, and may actually enhance, COX activity. 3,4-Dihydroxyphenyl ethanol also protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis. |
| Chemical Properties |
Brown Oil |
| Uses |
Tyrosol (T947800) metabolite. |
| Uses |
Hydroxy tyrosol is a tyrosol (T947800) metabolite. It is also a strong anti-oxidant found in olive oil. |
| Definition |
ChEBI: A member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities. |
| General Description |
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
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| Biochem/physiol Actions |
Metabolite of oleuropein. Antioxidant. Inhibits the rate of cancer cell proliferation and induces cancer cell apoptosis. |
| Source |
Hydroxytyrosol is also known as 2-(3,4-dihydroxyphenyl)-ethanol (3,4-DHPEA) and as DOPET. Hydroxytyrosol is mainly found in olive oil as secoiridoid derivatives, as acetate and in free form. Both hydroxytyrosol and its derivatives arise from oleuropein (hydroxytyro- sol esterified with elenolic acid), present in olives during the extraction of olive oil.
Wine has proven to be another important source of hydroxytyrosol in the Mediterranean diet, and is formed in wine from tyrosol during alcoholic fermentation. Hydroxytyrosol was firstly found in Italian wines by Di Tommaso et al., and later in other Italian and Greek wines. Some authors describe a higher concentration in red wines (3.66-4.20 mg/L-1) than in white wines (1.72-1.92mg/L-1). Finally, Minuti et al. obtained hydroxytyrosol concen- trations between 1.8 and 3.1 mg L-1 in red wine. Thus, scientific literature shows that wine is an important source of hydroxytyrosol in the diet, along with olive oil. |
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| 3,4-Dihydroxyphenylethanol Preparation Products And Raw materials |
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