China Largest Manufacturer factory sales 1,3-Butanediol CAS 107-88-0 CAS NO.107-88-0

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1,3-Butanediol Basic information Description References Product Name: 1,3-Butanediol Synonyms: (±)-butane-1,3-diol;1,3-Butandiol;Methyltrimethylene;Methyltrimethylene glycol;methyltrimethyleneglycol;1-METHYLTRIMETHYLENE GLYCOL;1,3-DIHYDROXYBUTANE;(+/-)-1,3-BUTANEDIOL CAS: 107-88-0 MF: C4H10O2 MW: 90.12 EINECS: 203-529-7 Product Categories: Anhydrous Solvents;Solvent Bottles;Solvent by Application;Solvent Packaging Options;Solvents;Sure/Seal Bottles;Cnbio Mol File: 107-88-0.mol   1,3-Butanediol Chemical Properties Melting point  -54 °C Boiling point  203-204 °C(lit.) density  1.005 g/mL at 25 °C(lit.) vapor density  3.1 (20 °C, vs air) vapor pressure  0.06 mm Hg ( 20 °C) refractive index  n20/D 1.44(lit.) Fp  250 °F storage temp.  Store below +30°C. solubility  >500g/lMiscible form  Liquid pka 14.83±0.20(Predicted) color  Clear colorless to yellow, may discolor to brown on storage Specific Gravity 1.004 – 1.007 PH 6.1 (500g/l, H2O, 20℃) PH Range 6 - 7 at 20 °C explosive limit 1.9-12.6%(V) Water Solubility  SOLUBLE Sensitive  Hygroscopic Merck  14,1567 BRN  1731276 Stability: Stable. Flammable. Hygroscopic - protect from air and moisture. Incompatible with strong oxidizing agents. CAS DataBase Reference 107-88-0(CAS DataBase Reference) NIST Chemistry Reference 1,3-Butanediol(107-88-0) EPA Substance Registry System 1,3-Butylene glycol (107-88-0)   Safety Information Safety Statements  24/25 WGK Germany  1 RTECS  EK0440000 F  3 Autoignition Temperature 741 °F TSCA  Yes HS Code  29053920 Hazardous Substances Data 107-88-0(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 18610 mg/kg LD50 dermal Rabbit > 20000 mg/kg MSDS Information Provider Language 1,3-Butanediol English SigmaAldrich English ACROS English ALFA English   1,3-Butanediol Usage And Synthesis Description 1,3-Butanediol is an organic chemical which belongs to the family of secondary alcohols. At present, 1,3-butanediol is used mainly in surfactants, inks, solvents for natural and synthetic flavoring agents and serves as a co-monomer in manufacturing certain polyurethane and polyester resins. It can also serve as a humectant to prevent loss of moisture in cosmetics, particularly in hair sprays and setting lotions. Besides, 1,3-Butanediol is pharmaceutically involved in the production of colchicine derivatives as a anticancer agent and in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as a hypoglycaemic agent, which is effective for the treatment of diabetes. References #,3-Butanediol # B690010 # # Chemical Properties 1,3-Butylene glycol has a sweet flavor with bitter aftertaste and is odorless when pure. Chemical Properties colourless liquid Chemical Properties Butylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste. Uses 1,3-Butanediol is used in the synthesis of colchicine derivatives as anticancer agents. Also used in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycem ic agents in the treatment of diabetes. Uses Its most extensive use is as an intermediate in the manufacture of polyester plasticisers and other chemical products. It finds some use as a solvent and humectant, a useful chemical intermediate. It has extensive application in the manufacture of structural materials for boats, custom mouldings, and sheets and boards for construction applications. 1,3-Butanediol imparts resistance to weathering plus flexibility and impact resistance. It is also used in the manufacture of saturated polyesters for polyurethane coatings, where the glycol imparts greater flexibility to the polyester molecule. 1,3-Butanediol is currently used in many personal care products. Uses (^+)-1,3-Butanediol acts as a co-monomer in the production of polyurethane and polyester resins. It is used as a humectant (to prevent loss of moisture) in cosmetics, especially in hair sprays and setting lotions. It is used in surfactants, inks, solvents for natural and synthetic flavorings. It is involved in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycemic agents, which is used in the treatment of diabetes. Preparation From formaldehyde and propylene via pressure and a catalyst. Definition ChEBI: A butanediol compound having two hydroxy groups in the 1- and 3-positions. Production Methods Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel. Aroma threshold values Detection: 70 to 100 ppm General Description (±)-1,3-Butanediol (BD) is a 1,3-diol. Its vapor pressure upto 270kPa, liquid-phase densities over a temperature range, two-phase (liquid + vapor) heat capacities, critical temperature and critical density have been determined. The obtained data was employed to derive various thermophysical properties. Pharmaceutical Applications Butylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances. In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at ～8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth. Contact allergens This dihydric alcohol is used for its humectant and preservative potentiator properties in cosmetics, topical medicaments and polyurethane, polyester, cellophane, and cigarettes. It has similar properties, but is less irritant than propylene glycol. Contact allergies seem to be rare. Safety Profile Mdly toxic by ingestion and subcutaneous routes. A skin and eye irritant. See also ETHYLENE GLYCOL. Experimental reproductive effects. Combustible when exposed to heat or flame. Incompatible with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. Safety Butylene glycol is used in a wide variety of cosmetic formulations and is generally regarded as a relatively nontoxic material. It is mildly toxic by oral and subcutaneous routes. In topical preparations, butylene glycol is regarded as minimally irritant. Butylene glycol can cause allergic contact dermatitis, with local sensitivity reported in patch tests. Some local irritation is produced on eye contact. LD50 (guinea pig, oral): 11.0 g/kg LD50 (mouse, oral): 12.98 g/kg LD50 (rat, oral): 18.61 g/kg LD50 (rat, SC): 20.0 g/kg Carcinogenicity There were no tumors found in the 2-year feeding studies on dogs and rats . Thus, it appears that 1,3-butanediol is not carcinogenic. storage Butylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes. Incompatibilities Butylene glycol is incompatible with oxidizing reagents. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (transdermal patches). Included in licensed medicines in the UK (topical gel patches/medicated plasters).   1,3-Butanediol Preparation Products And Raw materials Raw materials PROPYLENE-->Butyraldehyde-->ALDOL

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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1,3-Butanediol Basic information Description References Product Name: 1,3-Butanediol Synonyms: (±)-butane-1,3-diol;1,3-Butandiol;Methyltrimethylene;Methyltrimethylene glycol;methyltrimethyleneglycol;1-METHYLTRIMETHYLENE GLYCOL;1,3-DIHYDROXYBUTANE;(+/-)-1,3-BUTANEDIOL CAS: 107-88-0 MF: C4H10O2 MW: 90.12 EINECS: 203-529-7 Product Categories: Anhydrous Solvents;Solvent Bottles;Solvent by Application;Solvent Packaging Options;Solvents;Sure/Seal Bottles;Cnbio Mol File: 107-88-0.mol   1,3-Butanediol Chemical Properties Melting point  -54 °C Boiling point  203-204 °C(lit.) density  1.005 g/mL at 25 °C(lit.) vapor density  3.1 (20 °C, vs air) vapor pressure  0.06 mm Hg ( 20 °C) refractive index  n20/D 1.44(lit.) Fp  250 °F storage temp.  Store below +30°C. solubility  >500g/lMiscible form  Liquid pka 14.83±0.20(Predicted) color  Clear colorless to yellow, may discolor to brown on storage Specific Gravity 1.004 – 1.007 PH 6.1 (500g/l, H2O, 20℃) PH Range 6 - 7 at 20 °C explosive limit 1.9-12.6%(V) Water Solubility  SOLUBLE Sensitive  Hygroscopic Merck  14,1567 BRN  1731276 Stability: Stable. Flammable. Hygroscopic - protect from air and moisture. Incompatible with strong oxidizing agents. CAS DataBase Reference 107-88-0(CAS DataBase Reference) NIST Chemistry Reference 1,3-Butanediol(107-88-0) EPA Substance Registry System 1,3-Butylene glycol (107-88-0)   Safety Information Safety Statements  24/25 WGK Germany  1 RTECS  EK0440000 F  3 Autoignition Temperature 741 °F TSCA  Yes HS Code  29053920 Hazardous Substances Data 107-88-0(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 18610 mg/kg LD50 dermal Rabbit > 20000 mg/kg MSDS Information Provider Language 1,3-Butanediol English SigmaAldrich English ACROS English ALFA English   1,3-Butanediol Usage And Synthesis Description 1,3-Butanediol is an organic chemical which belongs to the family of secondary alcohols. At present, 1,3-butanediol is used mainly in surfactants, inks, solvents for natural and synthetic flavoring agents and serves as a co-monomer in manufacturing certain polyurethane and polyester resins. It can also serve as a humectant to prevent loss of moisture in cosmetics, particularly in hair sprays and setting lotions. Besides, 1,3-Butanediol is pharmaceutically involved in the production of colchicine derivatives as a anticancer agent and in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as a hypoglycaemic agent, which is effective for the treatment of diabetes. References #,3-Butanediol # B690010 # # Chemical Properties 1,3-Butylene glycol has a sweet flavor with bitter aftertaste and is odorless when pure. Chemical Properties colourless liquid Chemical Properties Butylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste. Uses 1,3-Butanediol is used in the synthesis of colchicine derivatives as anticancer agents. Also used in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycem ic agents in the treatment of diabetes. Uses Its most extensive use is as an intermediate in the manufacture of polyester plasticisers and other chemical products. It finds some use as a solvent and humectant, a useful chemical intermediate. It has extensive application in the manufacture of structural materials for boats, custom mouldings, and sheets and boards for construction applications. 1,3-Butanediol imparts resistance to weathering plus flexibility and impact resistance. It is also used in the manufacture of saturated polyesters for polyurethane coatings, where the glycol imparts greater flexibility to the polyester molecule. 1,3-Butanediol is currently used in many personal care products. Uses (^+)-1,3-Butanediol acts as a co-monomer in the production of polyurethane and polyester resins. It is used as a humectant (to prevent loss of moisture) in cosmetics, especially in hair sprays and setting lotions. It is used in surfactants, inks, solvents for natural and synthetic flavorings. It is involved in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycemic agents, which is used in the treatment of diabetes. Preparation From formaldehyde and propylene via pressure and a catalyst. Definition ChEBI: A butanediol compound having two hydroxy groups in the 1- and 3-positions. Production Methods Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel. Aroma threshold values Detection: 70 to 100 ppm General Description (±)-1,3-Butanediol (BD) is a 1,3-diol. Its vapor pressure upto 270kPa, liquid-phase densities over a temperature range, two-phase (liquid + vapor) heat capacities, critical temperature and critical density have been determined. The obtained data was employed to derive various thermophysical properties. Pharmaceutical Applications Butylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances. In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at ～8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth. Contact allergens This dihydric alcohol is used for its humectant and preservative potentiator properties in cosmetics, topical medicaments and polyurethane, polyester, cellophane, and cigarettes. It has similar properties, but is less irritant than propylene glycol. Contact allergies seem to be rare. Safety Profile Mdly toxic by ingestion and subcutaneous routes. A skin and eye irritant. See also ETHYLENE GLYCOL. Experimental reproductive effects. Combustible when exposed to heat or flame. Incompatible with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. Safety Butylene glycol is used in a wide variety of cosmetic formulations and is generally regarded as a relatively nontoxic material. It is mildly toxic by oral and subcutaneous routes. In topical preparations, butylene glycol is regarded as minimally irritant. Butylene glycol can cause allergic contact dermatitis, with local sensitivity reported in patch tests. Some local irritation is produced on eye contact. LD50 (guinea pig, oral): 11.0 g/kg LD50 (mouse, oral): 12.98 g/kg LD50 (rat, oral): 18.61 g/kg LD50 (rat, SC): 20.0 g/kg Carcinogenicity There were no tumors found in the 2-year feeding studies on dogs and rats . Thus, it appears that 1,3-butanediol is not carcinogenic. storage Butylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes. Incompatibilities Butylene glycol is incompatible with oxidizing reagents. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (transdermal patches). Included in licensed medicines in the UK (topical gel patches/medicated plasters).   1,3-Butanediol Preparation Products And Raw materials Raw materials PROPYLENE-->Butyraldehyde-->ALDOL